Article
Clinical Neurology
Guangyao Wang, Jing Jing, Anxin Wang, Xiaoli Zhang, Xingquan Zhao, Zixiao Li, Chunjuan Wang, Hao Li, Liping Liu, Yongjun Wang, Yilong Wang
Summary: The study suggests that non-high-density lipoprotein cholesterol may be a qualified predictor for recurrent ischemic stroke and all-cause death within 1 year in patients with acute ischemic stroke, but not predictive for intracranial hemorrhage.
Article
Neurosciences
Yueqi Zhang, Guangjian Zhang, Xuecong Chen
Summary: The aim of this study is to investigate the correlation between serum calcium levels and clinical severity or functional outcome at discharge in Chinese patients with acute ischemic stroke. The analysis of 339 patients revealed a positive correlation between serum calcium levels and stroke severity, as well as infarct size. Multivariate analysis showed that higher serum calcium levels were associated with a higher risk of unfavorable outcome. This study suggests that calcium may serve as a prognostic biomarker for stroke in Chinese patients.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Xiaojia Tang, Li Jiang, Yuhan Luo, Hongyang Fan, Lilong Song, Peipei Liu, Yingzhu Chen
Summary: Ischaemic stroke often leads to leukoaraiosis in patients, affecting cognitive function, mood, and gait. Although studies suggest that leukoaraiosis has a negative impact on the prognosis of stroke, there are differing opinions among experts.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Clinical Neurology
Diana Slawski, Jeremy J. Heit
Summary: Patients with acute ischemic stroke may have minor neurologic deficits, and decisions on acute treatment depend on the disability from symptoms, radiographic features, and the need for intravenous thrombolysis or endovascular therapy. Identifying patients at risk for neurologic deterioration is crucial for preventing poor outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Yu-Xuan Li, Juan Hou, Wen-Ya Liu
Summary: This study aimed to explore the relationship between sarcopenia defined by temporal muscle thickness and physical function and prognosis of patients with acute ischemic stroke (AIS). The results showed that sarcopenia was associated with stroke risk, stroke severity, functional ability, swallow ability, venous thromboembolism risk, activities of daily living, and survival outcome.
Article
Nutrition & Dietetics
Xiaoyan Han, Jinhua Cai, Youjia Li, Xiaoming Rong, Yi Li, Lei He, Honghong Li, Yuchan Liang, Huiqin Huang, Yongteng Xu, Qingyu Shen, Yamei Tang
Summary: This study demonstrates that CONUT and PNI are promising screening indicators to identify AIS patients with impaired immune-nutritional status who are at higher risk of long-term RIS and MACEs.
Article
Clinical Neurology
Jiejie Li, Yuesong Pan, Jie Xu, Shiyu Li, Mengxing Wang, Kehua Quan, Xia Meng, Hao Li, Jinxi Lin, Yilong Wang, Xingquan Zhao, Liping Liu, Yongjun Wang
Summary: Residual inflammatory risk only may predict recurrent stroke and poor functional outcome in patients with acute ischemic stroke or transient ischemic attack, especially in those with large-artery atherosclerosis.
Article
Medical Laboratory Technology
Min Wang, XuYang Pang, Huaihai Lu, Xudong Wang
Summary: HDAC4 plays a potential clinical role in acute ischemic stroke, by monitoring disease risk, inflammation, and predicting recurrence.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Clinical Neurology
Wenjing Dong, Yaling Lu, Yujia Zhai, Yucong Bi, Yanbo Peng, Zhong Ju, Tan Xu, Xiaoyan Zhong, Yonghong Zhang, Chongke Zhong
Summary: Elevated plasma NPY levels are associated with a decreased risk of cognitive impairment in patients with acute ischemic stroke. Plasma NPY may serve as a predictive factor and potential therapeutic target for post-stroke cognitive impairment (PSCI).
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Hailong Yu, Xin Chen, Xin Guo, Danni Chen, Li Jiang, Yajie Qi, Jun Shao, Luhang Tao, Jing Hang, Guangyu Lu, Yingzhu Chen, Yuping Li
Summary: This study aimed to investigate the role of serum xanthine oxidase (XO) levels in the pathogenesis of acute ischemic stroke (AIS). The results showed that the serum level of XO was significantly higher in AIS patients compared to healthy controls and was an independent risk factor for AIS. Serum XO level also had predictive value for stroke progression and prognosis in AIS patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gianluca Brugnara, Adrian Engel, Jessica Jesser, Peter Arthur Ringleb, Jan Purrucker, Markus A. Moehlenbruch, Martin Bendszus, Ulf Neuberger
Summary: In this study, the influence of small vessel disease and cortical atrophy on clinical outcome after acute ischemic stroke was assessed using native cranial computed tomography (NCCT). The results showed that pre-existing brain deterioration was significantly correlated with clinical outcome. Both age-related white matter changes (ARWMC) and cortical atrophy were independent predictors of clinical outcome after endovascular treatment (EVT).
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Hyungwoo Lee, Il Hyung Lee, JoonNyung Heo, Minyoul Baik, Hyungjong Park, Hye Sun Lee, Hyo Suk Nam, Young Dae Kim
Summary: Sarcopenia is associated with functional outcomes in patients with acute ischemic stroke, leading to unfavorable functional outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Cheng-Xiang Yuan, Yi-Ni Zhang, Xuan-Yu Chen, Bei-Lei Hu
Summary: This study found that malnutrition risk, as assessed by the CONUT score, was significantly associated with an increased risk of hemorrhagic transformation in patients with AIS. Patients with mild to moderate to severe malnutrition risk had a higher risk of HT compared to those with normal nutritional status.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Fei Liu, Yang Yang, Shuo Wang, Xiao-Li Zhang, An-Xin Wang, Xiao-Ling Liao, Hong-Juan Fang, Yue Qu, Wei-Guo Ma, Ning Zhang, Chun-Xue Wang, Yong-Jun Wang
Summary: This study found that sleep duration shorter than 6 hours before stroke is associated with anxiety and depression after ischemic stroke, while 6-7 hours of sleep is not related to poststroke anxiety and depression.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Wenting Guo, Jiali Xu, Linqing Ma, Jin Ma, Sijie Li, Changhong Ren, Longfei Wu, Chuanjie Wu, Chuanhui Li, Jian Chen, Jiangang Duan, Qingfeng Ma, Haiqing Song, Wenbo Zhao, Xunming Ji
Summary: This study aimed to investigate the impact of different administration routes of a low dose of tirofiban on AIS patients with successful recanalization post EVT. The results showed that a low dose of tirofiban was safe for AIS patients who achieved successful recanalization with EVT, but only IA + IV tirofiban improved clinical outcomes.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Otorhinolaryngology
Lihong Si, Xia Ling, Zheyuan Li, Kangzhi Li, Bo Shen, Xu Yang
Summary: This study investigated the clinical characteristics, diagnosis, and treatment of benign paroxysmal positional vertigo with involvement of multiple canals. The study found that horizontal and posterior canal involvement were the most common types of positional vertigo. Manual reduction was effective in the majority of patients with benign paroxysmal positional vertigo involving multiple canals.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Health Care Sciences & Services
Peng Liu, Shaolin Ma, Guixiang Du, Shengde Sun, Xin Zhang, Peng Tang, Chen Hou, Yue Liu, Jiaxing Zhao, Xiaohui Zhang, Li Chen, Chaochao Gu, Lina Zhang, Li Chong, Xu Yang, Rui Li
Summary: The new practice paradigm of Clinic for Vertigo and Dizziness (CVD) implemented by a multidisciplinary team (MDT) has a positive impact on the medical management and improvement of patient satisfaction for patients with vertigo and dizziness. Common diagnoses, medical costs, and patient satisfaction all showed significant improvement after the establishment of CVD.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Zheyuan Li, Bo Liu, Hongli Si, Kangzhi Li, Bo Shen, Xiang Li, Xia Ling, Xu Yang
Summary: The study aimed to investigate the clinical characteristics of patients with dizziness/vertigo accompanied by loss of the posterior canal(s) (LPC). Results showed that most patients with LPC presented with dizziness or vertigo, with the majority being ILPC and ULPC types, where ULPC patients often had ipsilateral vestibulo-cochlear impairment. The vHIT was found to be a fast and effective method for assessing LPC, able to detect isolated PC dysfunction.
FRONTIERS IN MEDICINE
(2021)
Article
Clinical Neurology
Li-Li Chen, Shuang-mei Yan, Wen-Ting Wang, Sai Zhang, Hui-Miao Liu, Xiao-Yang Yuan, Xu Yang, Ping Gu
Summary: The study evaluated the difference in predicting adverse outcomes between anterior circulation and posterior circulation acute ischemic stroke (AIS) using the Totaled Health Risks In Vascular Events (THRIVE) scale. The results showed that THRIVE had a similar predictive effect for short-term and long-term adverse prognosis in both types of AIS.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lihong Si, Bin Cui, Zheyuan Li, Xiang Li, Kangzhi Li, Xia Ling, Bo Shen, Xu Yang
Summary: The study analyzed changes in resting-state brain functional connectivity in patients with CUVP and found significantly decreased FC in the right occipital gyrus and increased FC in the sensorimotor network. Patients with CUVP also showed decreased FC between multiple brain networks, suggesting abnormal integration of multisensory information may contribute to chronic dizziness and instability.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Clinical Neurology
Zhe-Yuan Li, Li-Hong Si, Bo Shen, Xu Yang
Summary: This study aimed to investigate altered patterns of brain network functional connectivity in patients with vestibular migraine (VM), and found significant changes in the sensorimotor network within VM patients, potentially leading to a hypersensitivity state. Additionally, adjustments in functional connectivity between the auditory network and default mode network, as well as salience network, may increase sensitivity to vestibular sensory processing in these patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Otorhinolaryngology
Zhe-Yuan Li, Bo Shen, Li-Hong Si, Xia Ling, Kang-Zhi Li, Xu Yang
Summary: This study investigated the clinical features of patients with definite vestibular migraine (dVM). Among the 91 patients enrolled, 62 had dVM, with a higher prevalence in women. Vestibular symptoms were often accompanied by photophobia and phonophobia. Motion sickness and severe caloric test intolerance were helpful in diagnosing dVM. Some patients with dVM had abnormal immune-related indicators.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lihong Si, Bin Cui, Zheyuan Li, Xiang Li, Kangzhi Li, Xia Ling, Bo Shen, Xu Yang
Summary: This study identified abnormalities in neuronal activity and overall activity synchronization in multiple brain regions in patients with chronic unilateral vestibulopathy, affecting their spatial perception and motor perception. Increased gray matter volume and functional connectivity of the default mode network may be potential imaging biomarkers for chronic symptoms in patients with chronic unilateral vestibulopathy.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Neurosciences
Xintong Guo, Xiaoxuan Liu, Shan Ye, Xiangyi Liu, Xu Yang, Dongsheng Fan
Summary: It has been traditionally believed that eye movements are unaffected in amyotrophic lateral sclerosis (ALS), but recent studies have shown the presence of eye movement abnormalities in ALS patients, particularly in relation to bulbar disabilities. This study utilized videonystagmography to evaluate 60 ALS patients and 30 controls, finding a higher frequency of square-wave jerks and abnormal cogwheeling during smooth pursuit in ALS patients. Subgroup analyses revealed that these abnormalities were more common in ALS patients with bulbar involvement. These findings suggest that eye movement abnormalities may serve as potential clinical markers for evaluating upper brainstem or supratentorial cerebral lesion neurodegeneration in ALS.
Article
Clinical Neurology
Zhe-Yuan Li, Li-Hong Si, Bo Shen, Xia Ling, Xu Yang
Summary: This study aimed to investigate the alterations in resting-state functional brain activity in patients with definite vestibular migraine (dVM). The results showed that compared to the healthy controls, dVM patients had significantly increased ALFF values in the right temporal lobe and increased ReHo values in the right superior, middle, and inferior temporal gyrus. Compared to migraine patients, dVM patients had significantly increased fALFF values in the right parietal lobe and right frontal lobe and significantly increased ReHo values in the right thalamus.
NEUROLOGICAL SCIENCES
(2023)
Article
Behavioral Sciences
Tong-tong Zhao, Meng-lu Zhang, Yu-fei Feng, Qian-qian Wang, Ning Song, Xu Yang, Xiao-hong Ba
Summary: The study investigates the value of vestibular graviceptive pathway (VGP) evaluation in the diagnosis of unilateral peripheral vestibular dysfunction (UPVD) patients. Results show that alterations in subjective visual vertical (SVV), subjective visual horizontal (SVH), ocular torsion (OT), and skew deviation (SD) are related to dynamic vestibular compensation in UPVD patients. Correlations between VGP evaluation results and cochleovestibular function test results suggest that VGP evaluation is helpful for the diagnosis of the affected side in UPVD. The presence of contralesional VGP (c-VGP) may be associated with bilateral labyrinth lesions or endolymphatic hydrops on the affected side, and autoimmune mechanisms should also be considered.
BRAIN AND BEHAVIOR
(2023)
Review
Clinical Neurology
Hongyuan Chu, Xinyu Zhang, Jie Shi, Zhirui Zhou, Xu Yang
Summary: This study compared the efficacy and safety of antiseizure medications (ASMs) for idiopathic generalized epilepsies (IGEs) and related entities. The results showed that all ASMs were more effective than placebo. Valproate monotherapy ranked best overall for IGEs, while ethosuximide ranked best for childhood absence epilepsy (CAE). Topiramate was the most effective as an adjunctive therapy for generalized tonic-clonic seizures alone (GTCA) and overall for IGEs, while levetiracetam was the best for myoclonic seizures. Perampanel had the best tolerability.
JOURNAL OF NEUROLOGY
(2023)
Article
Otorhinolaryngology
Yuexia Wu, Xia Ling, Ning Song, Shuangmei Yan, Wenting Wang, Xu Yang, Ping Gu
Summary: This study aimed to compare the clinical characteristics and vestibular function test results between Vestibular Migraine (VM) and Meniere's Disease (MD) patients. The results showed that MD patients had more severe vestibular symptoms and autonomic responses compared to VM patients during attacks. The diagnosis of VM can be differentiated through vestibular symptoms and vestibular function test results during attacks, while the diagnosis of MD can be differentiated through vestibular symptoms and the results of Caloric Test and Video Head Impulse Test.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Ning Song, Yuexia Wu, Xiang Li, Qianqian Wang, Xinyan Ma, Xu Yang
Summary: This study compared the clinical features, risk factors, distribution of BPPV subtypes, and effectiveness of canalith repositioning between geriatric and non-geriatric patients with BPPV. It was found that the geriatric group had a higher proportion of males and a higher prevalence of diseases associated with atherosclerosis. The non-geriatric group had a higher prevalence of migraine and posterior canal BPPV. The effectiveness of canalith repositioning decreased with increasing age.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2023)
Article
Clinical Neurology
Xia Ling, Hyo-Jung Kim, Jong-Hee Lee, Jeong-Yoon Choi, Xu Yang, Ji-Soo Kim
Summary: The study confirms the diagnostic value of SHH for PC-BPPV, which can be performed before the Dix-Hallpike maneuver.
JOURNAL OF CLINICAL NEUROLOGY
(2021)
