Article
Medicine, Research & Experimental
Candace E. Hobson, Joe Saliba, Nopawan Vorasubin, Robert H. Lyles, Bill Mastrodimos, Roberto A. Cueva
Summary: This study shows that the position of vestibular schwannoma relative to the IAC axis can be used along with tumor size to predict postoperative facial outcomes. A greater proportion of tumor posterior to the IAC axis was associated with significantly better facial outcomes.
Article
Otorhinolaryngology
Yin Ren, Bridget MacDonald, Kareem O. Tawfik, Marc S. Schwartz, Rick A. Friedman
Summary: Clinical predictors of facial nerve outcomes after microsurgical resection of vestibular schwannoma were identified, indicating excellent outcomes can be achieved with this procedure. Gross total resection and >= 100-mu V intraoperative FN electromyographic response were found to predict excellent FN outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Oncology
Giuseppe Di Perna, Raffaele De Marco, Bianca Maria Baldassarre, Enrico Lo Bue, Fabio Cofano, Pietro Zeppa, Luca Ceroni, Federica Penner, Antonio Melcarne, Diego Garbossa, Michele Maria Lanotte, Francesco Zenga
Summary: This retrospective study aimed to investigate the impact of morphologic and neurophysiological factors on the short- and long-term facial nerve function after vestibular schwannoma resection. A multiparametric score, Facial Nerve Outcome Score (FNOS), was developed and shown to be a reliable predictor of facial nerve function.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Nickalus R. Khan, Turki Elarjani, Aria M. Jamshidi, Stephanie H. Chen, Clifford S. Brown, Josh Abecassis, Michael A. Silva, Victor M. Lu, Eva Wu, Monica Diaz-Kanelidis, Rita Bhatia, Michael E. Hoffer, Adrien A. Eshraghi, Christine T. Dinh, Simon I. Angeli, Fred F. Telischi, Jacques J. Morcos
Summary: This study retrospectively evaluated the clinical and surgical outcomes of a large surgical series of vestibular schwannoma in North America over 20 years. The study found that facial nerve outcomes were correlated with cerebellopontine angle extension, tumor volume, facial nerve stimulation threshold, facial nerve consistency, preoperative facial nerve function, and history of a prior resection. The data supports a continuation of a strategy of gross total resection, modifiable by intraoperative findings and judgment.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Michael A. Silva, Henry Chang, Ashish H. Shah, Nickalus R. Khan, Clifford S. Brown, Christine T. Dinh, Adrien A. Eshraghi, Fred F. Telischi, Simon Angeli, Jacques J. Morcos
Summary: Intracisternal papaverine irrigation during vestibular schwannoma resection can safely improve immediate postoperative facial nerve outcomes, maintain similar long-term facial nerve outcomes, and is not associated with a significant increase in complications.
WORLD NEUROSURGERY
(2022)
Article
Biotechnology & Applied Microbiology
Gang Xiao, Bin Huang, Ming Guo, Chaoxin Long, Pingan Li, Bin Zhong, Chuncheng Guan
Summary: BRCAT54 is an anti-tumor lncRNA that is downregulated in lung cancer and its role in vestibular schwannoma (VS) is unclear. This study found that BRCAT54 interacts with miR-21 and suppresses cell proliferation in VS.
Article
Otorhinolaryngology
Catherine Sobieski, Daniel E. Killeen, Samuel L. Barnett, Bruce E. Mickey, Jacob B. Hunter, Brandon Isaacson, Joe Walter Kutz
Summary: Facial nerve outcomes one year after microsurgical resection are poorer in patients with NF2 tumors compared to sporadic tumors, particularly for tumors with a volume greater than 3 cm³ and those classified as NF2 tumors.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Felix Arlt, Johannes Kasper, Dirk Winkler, Katja Jaehne, Michael Karl Fehrenbach, Juergen Meixensberger, Caroline Sander
Summary: Intraoperative neurophysiological monitoring is crucial in vestibular schwannoma surgery to prevent nerve injury. Repeated direct nerve stimulation and a detected decreased amplitude might show facial nerve function deterioration.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Michel Heide Talebnasab, Dan Dupont Hougaard
Summary: Vestibular schwannoma is the most common type of intracranial schwannoma, accounting for about 8% of all intracranial tumors in adults with an estimated incidence rate of around 1.3/100,000. The incidence rates of facial nerve schwannomas and cochlear nerve schwannomas are not well-documented. These three types of nerve tumors often present with unilateral hearing loss, tinnitus, and disequilibrium. Facial nerve palsy is common in facial nerve schwannomas but rare in vestibular schwannomas. The symptoms are usually persistent and progressive, leading to interventions that may cause significant morbidity such as deafness and imbalance.
Article
Clinical Neurology
Dong-Won Shin, Sang Woo Song, SangJoon Chong, Young-Hoon Kim, Young Hyun Cho, Seok Ho Hong, Jeong Hoon Kim
Summary: This study evaluated the clinical factors associated with managing hydrocephalus in patients with vestibular schwannoma, finding that severe hydrocephalus, cystic tumors, and partial resection are predictive of treatment failure. Recommendations include attempting near-total tumor resection in patients with VS.
JOURNAL OF CLINICAL NEUROLOGY
(2021)
Article
Clinical Neurology
Mohamed Elsayed, Huan Jia, Baptiste Hochet, Olivier Sterkers, Renato Torres, Yann Nguyen, Isabelle Bernat, Ghizlene Lahlou, Michel Kalamarides
Summary: Decision-making for large sporadic vestibular schwannomas resection can be guided by intraoperative monitoring of maximal facial nerve amplitude and latency response to optimize post-operative results. Tumors were removed through retrosigmoid or translabyrinthine approaches in patients with normal preoperative FN function, achieving some tumor removal while maintaining a certain decrease in amplitude. Good postoperative facial nerve function and significant hearing preservation were achieved after 6 months, with no significant difference observed between TR and NTR+STR procedures.
ACTA NEUROCHIRURGICA
(2021)
Article
Clinical Neurology
Robert J. Macielak, Christine M. Lohse, Katherine P. Wallerius, Skye K. Lawlor, Brian A. Neff, Maria Peris Celda, Jamie J. Van Gompel, Colin L. W. Driscoll, Michael J. Link, Matthew L. Carlson
Summary: Younger age and better immediate postoperative HB grade were found to be significantly associated with complete recovery of facial nerve function to HB Grade I after microsurgical resection of sporadic vestibular schwannoma.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Otorhinolaryngology
Zdenek Fik, Josef Kraus, Zdenek Cada, Martin Chovanec, Alzbeta Fikova, Eduard Zverina, Jan Betka, Jan Plzak
Summary: The study demonstrates the utility of electromyographic follow-up in facial nerve reconstruction, with hemihypoglossal-facial anastomosis being an optimal solution for restoring facial function. Electromyography can predict initial reinnervation activity after reconstructive procedures, aiding in identifying insufficiently recovering patients during follow-up.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Medicine, Research & Experimental
Daniel E. Killeen, Samuel L. Barnett, Bruce E. Mickey, Jacob B. Hunter, Brandon Isaacson, Joe Walter Kutz
Summary: The study revealed that patients with tumor volume >3 cm(3) had worse facial nerve outcomes 12 months following surgical resection. Tumor volume was identified as a key factor affecting facial nerve function outcomes.
Article
Otorhinolaryngology
Sophia Tran, Daniel E. Killeen, Shafeen Qazi, Sanjana Balachandra, Jacob B. Hunter
Summary: This study assessed the impact of medication use, specifically statin, metformin, and aspirin, on the growth of vestibular schwannomas (VSs), and found that metformin is associated with reduced VS growth.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Sanjeet S. Grewal, Erik H. Middlebrooks, Lela Okromelidze, Grant P. Gosden, William O. Tatum, Brian N. Lundstrom, Gregory A. Worrell, Robert E. Wharen, Jamie J. Van Gompel
WORLD NEUROSURGERY
(2020)
Article
Medicine, Research & Experimental
Luis A. Antezana, Matthew L. Carlson, Ernest M. Hoffman, Roberto A. Cueva, Jamie J. Van Gompel
Editorial Material
Education, Scientific Disciplines
Christopher S. Graffeo, Benjamin D. Elder, Jamie J. Van Gompel, David J. Daniels
Article
Clinical Neurology
Benjamin T. Himes, Adip Bhargav, Desmond A. Brown, Timothy J. Kaufmann, Irina Bancos, Jamie J. Van Gompel
NEUROSURGICAL FOCUS
(2020)
Article
Clinical Neurology
Hadi Joud, Ivo Peto, Mohammad Hassan A. Noureldine, Maxim Mokin, Siviero Agazzi
WORLD NEUROSURGERY
(2020)
Article
Clinical Neurology
Elliot Pressman, Mohammad Hassan A. Noureldine, Jay Kumar, Paul R. Krafft, Braden Mantei, Mark S. Greenberg, Siviero Agazzi, Harry van Loveren, Puya Alikhani
WORLD NEUROSURGERY
(2020)
Article
Clinical Neurology
Ivo Peto, Mohsen Nouri, Siviero Agazzi, David Langer, Amir R. Dehdashti
OPERATIVE NEUROSURGERY
(2020)
Article
Clinical Neurology
Matthew L. Carlson, Michael J. Link, Colin L. W. Driscoll, David S. Haynes, Heather A. Billings, Christine M. Lohse, Elissa R. Hall, Siviero Agazzi, Frederick G. Barker, Derald E. Brackmann, Roberto A. Cueva, John G. Golfinos, Richard K. Gurgel, Douglas Kondziolka, J. Walter Kutz, Brian A. Neff, Jason P. Sheehan, Jamie J. Van Gompel, Chung Ping Yu
OTOLOGY & NEUROTOLOGY
(2020)
Article
Clinical Neurology
Robert S. Heller, Hadi Joud, Gabriel Flores-Milan, Ryan Franzese, Jonathan Ford, Jay Nelson, Summer Decker, Rahul Mhaskar, Harry van Loveren, Siviero Agazzi
Summary: The study observed 19 patients with vestibular schwannomas using MRI scans post-surgery, finding that tumors decreased in size by an average of 35% in the first 3 months and 46% in the first year post-resection. Six cases showed absence of contrast enhancement on immediate post-resection MRI, which returned on subsequent studies.
WORLD NEUROSURGERY
(2021)
Article
Oncology
Sukwoo Hong, Nadia Laack, Anita Mahajan, Erin K. O'Brien, Janalee K. Stokken, Jeffrey R. Janus, Garret Choby, Jamie J. Van Gompel
Summary: The introduction of a multidisciplinary team has shown to effectively treat clival chordoma, resulting in higher tumor resection rate, lower recurrence rate, and reduced post-operative complications. After 2013, the endoscopic approach became more commonly used, leading to greater tumor resections and lower incidence of new cranial nerve deficits.
Article
Clinical Neurology
Matthew Udine, Davide Croci, Jacob Wasserman, Mohammad Hassan A. Noureldine, Molly Monsour, Kunal Vakharia, Siviero Agazzi
Summary: This article provides a thorough description of the diagnosis, imaging, treatment, and management of Vein of Galen Malformations (VoGM) in adults through a systematic review and case report. The results indicate that adult VoGM patients have different clinical presentations, treatment modalities, and outcomes compared to pediatric or neonate VoGM patients, and generally have more favorable outcomes.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Oncology
Garrett Ni, Carlos D. Pinheiro-Neto, Ehiremen Iyoha, Jamie J. Van Gompel, Michael J. Link, Maria Peris-Celda, Eric J. Moore, Janalee K. Stokken, Mauricio Gamez, Garret Choby
Summary: This study examines patient outcomes after recurrence of esthesioneuroblastoma and describes patterns of salvage therapeutic interventions. The 5-year overall survival after recurrence was found to be 63% and the 5-year progression-free survival was 56%. The time to develop a secondary recurrence was shorter than the time to develop the first recurrence, and patients with secondary recurrences were older at the time of their primary tumor diagnosis.
Article
Clinical Neurology
Davide Marco Croci, Paul McBride, Kunal Vakharia, Siviero Agazzi
Summary: This article describes a case of a 6-year-old boy with an asymptomatic and neurologically intact cerebral pial arteriovenous fistula. The patient underwent surgical treatment and imaging examinations, which achieved satisfactory results.
OPERATIVE NEUROSURGERY
(2023)
Article
Oncology
Simona Serioli, Mariagrazia Nizzola, Pedro Plou, Alessandro De Bonis, Jenna Meyer, Luciano C. P. C. Leonel, Andrea A. Tooley, Lilly H. Wagner, Elizabeth A. Bradley, Jamie J. Van Gompel, Maria Elena Benini, Iacopo Dallan, Maria Peris-Celda
Summary: This study aims to provide a detailed description of the anatomy to understand the potential and limitations of transorbital approaches (TOAs). Measurements of the orbit region and surrounding areas were performed on CT scans and dry skulls, and dissection was done on specimens to illustrate the TOA. Three clinical cases were presented to highlight the surgical applications.
Meeting Abstract
Clinical Neurology
Amy Swanson, Dana Erickson, Diane Donegan, Sarah Jenkins, Jamie Van Gompel, Caterina Giannini
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2020)