Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 5, Issue 17, Pages 3186-3194Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb03330j
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Funding
- National Major Research Program of China [2016YFC1100202]
- National Natural Science Foundation of China [31470941, 31271035]
- Science and Technology Commission of Shanghai Municipality [15JC1490100, 15441905100]
- Fundamental Research Funds for the Central Universities [CUSF-DH-D-2017047]
- PhD Programs Foundation of Ministry of Education of China [20130075110005]
- light of textile project [J201404]
- Deanship of Scientific Research at King Saud University [RGP-201]
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To develop an effective nerve guidance conduit with cooperative effects of topological structure and biological cues for promoting Schwann cells' (SCs) proliferation and migration, a laminin-coated and yarn-encapsulated poly(L-lactide-co-glycolide) (PLGA) nerve guidance conduit (LC-YE-PLGA NGC) was fabricated in this study. The PLGA fiber yarns were fabricated through a double-nozzle electrospinning system and then the PLGA fibrous outer layer was collected using a general electrospinning method. Subsequently, laminin was coated on the yarn-encapsulated PLGA NGC through covalent binding. The results showed satisfactory tensile mechanical strength of the laminin-coated PLGA fibers/yarns and good compressive mechanical support of the LC-YE-PLGA NGC. SCs proliferation was significantly superior (p < 0.05) on the PLGA and laminin-coated PLGA yarns than the PLGA fibers. Furthermore, the LC-YE-PLGA NGC performed much better in SCs migration compared with the NGCs without yarn-encapsulation or laminin-coating, indicating the synergistic effect of the three-dimensional yarn structure (topological structure) and the laminin-coating (biological cues) for SCs proliferation and migration. Therefore, the LC-YE-PLGA NGC demonstrated promising potential in promoting SCs proliferation and inducing SCs migration in nerve tissue engineering.
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