Article
Multidisciplinary Sciences
Cheng Su, Xiao Zheng, Yanjin He, Li Long, Wenchuan Chen
Summary: This study identified aberrant expression of circRNAs in hUCMSCs during osteogenic differentiation, constructed competing endogenous RNA networks using bioinformatics tools, elucidated underlying mechanisms, and validated the osteogenic-promoting effect of a specific circRNA.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Juan C. Henao, Adriana Grismaldo, Alfonso Barreto, Viviana M. Rodriguez-Pardo, Claudia Camila Mejia-Cruz, Efrain Leal-Garcia, Rafael Perez-Nunez, Patricio Rojas, Ramon Latorre, Ingrid Carvacho, Yolima P. Torres
Summary: The study demonstrates that TRPM8 channels are expressed in human bone marrow MSCs and are involved in osteogenic differentiation, with agonists promoting osteogenic differentiation and antagonists leading to a decrease in osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Keng-Fan Liu, Rong-Fu Chen, Yun-Ting Li, Yun-Nan Lin, Dar-Jen Hsieh, Srinivasan Periasamy, Sin-Daw Lin, Yur-Ren Kuo
Summary: This study demonstrates that scDBM is an excellent scaffold for enhancing the attachment and recruitment of mesenchymal stem cells, leading to accelerated new bone formation when seeded with ASCs.
Review
Dentistry, Oral Surgery & Medicine
Wen Wen, Yu Pang, Yuyang Tian, Chunmei Xu, Jun Wang, Yafei Wu, Xudong Xie
Summary: Periodontitis causes tooth loss through destruction of alveolar bone. Understanding the mesenchymal stem cell (MSC) populations involved in alveolar bone formation can contribute to regenerative therapies. MSCs in bone marrow, periosteum, periodontal ligament (PDL), and gingiva are considered osteogenic progenitors. Specific markers like Gli1, Axin2, PTHrP, LepR, and alpha-SMA have been studied to understand their contribution to alveolar bone formation. This review discusses the MSCs involved in alveolar bone development, remodeling, injury repair, and regeneration.
Article
Biotechnology & Applied Microbiology
Yue Ke, Yu Ye, Jintao Wu, Yanxia Ma, Yuxin Fang, Fei Jiang, Jinhua Yu
Summary: A phosphoserine-loaded chitosan membrane was synthesized to improve the osteogenic effect of chitosan membranes. The incorporation of phosphoserine into chitosan membranes was confirmed and the phosphoserine-chitosan membranes significantly stimulated bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cell Biology
Yuan Liu, Christina Holmes
Summary: This review explores the tissue regeneration potential of EVs isolated from bone marrow and adipose tissue, the two most common clinical sources of adult MSCs, focusing on their angiogenic, osteogenic, and immunomodulatory potentials. Other important issues in the development of MSC-derived EV based therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Yanran Yang, Daiyun Chen, Yilin Li, Jinghua Zou, Ruiqi Han, Hongkun Li, Jun Zhang
Summary: Puerarin has a positive impact on the proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells, and promotes new bone formation. In a rat RME model, puerarin solution enhances osteogenesis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Lei Qi, Weiwen Ge, Cancan Pan, Weidong Jiang, Dan Lin, Lei Zhang
Summary: Stem cell senescence causes functional declines and disrupts bone environment homeostasis. Stem cell-derived exosomes are a promising therapy for aging-related osseous diseases. This study demonstrates the potential of osteoinductive exosomes in bone repair for aging individuals and highlights the importance of considering endocytic mechanisms and avoiding negative effects in future therapeutic design for aging populations.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Zhikang Su, Ding Chen, Jiangyon Huang, Zitian Liang, Wen Ren, Zeyu Zhang, Qianzhou Jiang, Tao Luo, Lvhua Guo
Summary: This study found that isoliquiritin (ISL) can improve osteoporosis by promoting autophagy and regulating the MAPK signaling pathway. The experimental results showed that ISL has a therapeutic effect in promoting bone formation without inducing toxicity to vital organs.
PHYTOTHERAPY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Chiara Mazziotta, Carmen Lanzillotti, Maria Rosa Iaquinta, Francesca Taraballi, Elena Torreggiani, John Charles Rotondo, Lucia Oton-Gonzalez, Elisa Mazzoni, Francesca Frontini, Ilaria Bononi, Monica De Mattei, Mauro Tognon, Fernanda Martini
Summary: MSCs are important source for bone regeneration and play a crucial role in osteogenic differentiation. MiRNAs regulate gene expression in osteogenic differentiation of MSCs and are involved in controlling important signaling pathways such as TGF-beta/BMP and Wnt/beta-catenin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiao Jiang, Xin-Rui Lai, Jin-Qiang Lu, Ling-Zhi Tang, Jin-Rong Zhang, Hong-Wei Liu
Summary: DAT interacts with various types of MSCs to achieve adipose regeneration. It provides an inductive microenvironment for adipogenesis and supports the expression of PPARg. The presence of multiple adipogenic proteins in DAT plays a vital role in adipose regeneration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Maria Yoshida, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Keisuke Morimoto, Yoshiki Tanaka, Kensuke Sasaki, Satoshi Maeda, Takao Masaki
Summary: Both adipose-derived and bone marrow-derived mesenchymal stem cells (ADSCs and BMSCs) can suppress renal fibrosis, with ADSCs showing a stronger effect under serum-containing culture conditions. However, ADSC infusion in mice may lead to a higher death rate from pulmonary embolism. Therefore, the selection of ADSCs or BMSCs for clinical applications should consider the target disease and culture method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Laura Alves, Vanessa Machado, Joao Botelho, Jose Joao Mendes, Joaquim M. S. Cabral, Claudia L. da Silva, Marta S. Carvalho
Summary: Cell-based therapies using PDLSC may be a promising alternative to MSC(M) and MSC(AT) for periodontal regeneration, as PDLSC showed enhanced proliferative and osteogenic potential. PDLSC expressed osteogenic markers and had higher calcium content and upregulated osteogenic/periodontal genes compared to MSC(M) and MSC(AT). CD146 was specifically expressed by PDLSC, which also had a higher proliferative capacity. However, alkaline phosphatase activity did not increase in PDLSC.
Article
Materials Science, Biomaterials
Bangguo Wei, Wenrui Wang, Xiangyu Liu, Chenxi Xu, Yanan Wang, Ziqi Wang, Jinnuo Xu, Jianzhong Guan, Pinghui Zhou, Yingji Mao
Summary: This study developed an innovative bone engineering scaffold based on GelMA hydrogel loaded with Res-SLNs, which demonstrated improved osteogenic differentiation of BMSCs, particularly with the optimal 0.02 Res-SLNs/GelMA scaffold. The slow and steady release of Res from the scaffold showed potential for application in bone tissue engineering.
REGENERATIVE BIOMATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Salma El-Habashy, Hoda Eltaher, Ahmed Gaballah, Radwa Mehanna, Amal H. El-Kamel
Summary: This study successfully developed a novel composite nanoparticle system that integrates doxycycline into biomaterials to improve its cytotoxicity and enhance osteogenic activity. The experimental results showed that this composite system can control the release of doxycycline and significantly ameliorate its toxicity to bone marrow stem cells, while promoting the maturation of osteogenic cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Xiuming Bu, Jipeng Li, Siwei Yang, Jing Sun, Yuan Deng, Yuchen Yang, Gang Wang, Zheng Peng, Peng He, Xianying Wang, Guqiao Ding, Junhe Yang, Xiaoming Xie
ACS APPLIED MATERIALS & INTERFACES
(2016)
Review
Medicine, Research & Experimental
Jipeng Li, Mingjiao Chen, Xianqun Fan, Huifang Zhou
JOURNAL OF TRANSLATIONAL MEDICINE
(2016)
Article
Chemistry, Multidisciplinary
Jianyong Yu, Zhanhui Yuan, Liwei Wang, Shuo Chen, Weiwei Wei, Fan Zhang
Summary: In this study, a simple fabrication method was used to prepare porous films with abundant interfacial structures and excellent electrical conductivity. These films exhibited outstanding capacitance behavior and efficient electromagnetic interference shielding effectiveness.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Dong Lei, Yang Yang, Zenghe Liu, Binqian Yang, Wenhui Gong, Shuo Chen, Shaofei Wang, Lijie Sun, Benyan Song, Huixia Xuan, Xiumei Mo, Binbin Sun, Sen Li, Qi Yang, Shixing Huang, Shiyan Chen, Yiding Ma, Wenguang Liu, Chuanglong He, Bo Zhu, Eric M. Jeffries, Feng-Ling Qing, Xiaofeng Ye, Qiang Zhao, Zhengwei You
MATERIALS HORIZONS
(2019)
Article
Chemistry, Multidisciplinary
Dong Lei, Yang Yang, Zenghe Liu, Shuo Chen, Benyan Song, Ao Shen, Binqian Yang, Sen Li, Zhize Yuan, Quan Qi, Lijie Sun, Yifan Guo, Han Zuo, Shixing Huang, Qi Yang, Xiumei Mo, Chuanglong He, Bo Zhu, Eric M. Jeffries, Feng-Ling Qing, Xiaofeng Ye, Qiang Zhao, Zhengwei You
MATERIALS HORIZONS
(2019)
Article
Materials Science, Biomaterials
Yifan Guo, Ziying Lv, Yiru Huo, Lijie Sun, Shuo Chen, Zenghe Liu, Chuanglong He, Xiaoping Bi, Xianqun Fan, Zhengwei You
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)