Review
Polymer Science
Mineto Uchiyama, Kotaro Satoh, Masami Kamigaito
Summary: Since the first report of cationic reversible addition-fragmentation chain transfer (RAFT) polymerization in 2015, significant progress has been made in various aspects of cationic RAFT and degenerative chain transfer (DT) polymerizations. This review focuses on the similarities and differences between cationic and radical RAFT polymerizations, discussing the characteristics and expanding potentials of cationic RAFT and DT polymerizations.
PROGRESS IN POLYMER SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Zitang Wei, Xiaokang Wang, Bumjoon Seo, Xuyi Luo, Qixuan Hu, Jack Jones, Matthias Zeller, Kang Wang, Brett M. Savoie, Kejie Zhao, Letian Dou
Summary: This study conducted a systematic investigation into the side chain functionalization of the bis(indandione) derivative system, successfully achieving the production of high molecular weight and stereoregular single crystalline polymers. By precisely engineering the side chains, topochemical reactivity was maintained and the elastic modulus of the resulting polymer single crystals was greatly enhanced. Additionally, insoluble polymer single crystals were processed into robust free-standing thin films using ultrasonication.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Tanmoy Maity, Soumya Paul, Priyadarsi De
Summary: The ability to modify the chemical functionality of side chain amino acid-based polymers allows tailoring their optical, mechanical, and biological properties. In this study, we synthesized a side chain L-leucine pendant homopolymer and incorporated various functional groups through post-polymerization modifications, creating a library of functionalized polymers. The solvatochromic behavior of fluorescence probe-bearing polymers was studied using fluorescence spectroscopy, and the crosslinking ability and mechanical properties of the synthesized gel were examined through rheological studies.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Chemistry, Physical
Rui A. Goncalves, Krister Holmberg, Bjorn Lindman
Summary: This paper provides an overview of the self-assembly, intermolecular interactions, and properties of cationic surfactants, as well as their interactions with other solutes and surfaces. It also discusses the versatile properties of single-chain and double-chain cationic surfactants, as well as other special cationic surfactants, and their relationship with skin toxicity and environmental factors. Furthermore, the paper explores the mixing effects of cationic surfactants with other surfactants, polymers, proteins, and DNA, and outlines established and emerging applications of cationic surfactants.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Polymer Science
Seung Yeon Lee, Sunhee Kim, Ye Rim Lee, Jaebeom Lee, Woo Kyung Cho, Kyung-sun Son
Summary: Surface-initiated reversible addition-fragmentation chain transfer polymerization using oxygen (O2-SI-RAFT) was used to impart chiral properties to substrates. Chiral monomers were synthesized and grown onto titanium and glass substrates, forming polymer brushes. The presence of polymer brushes was confirmed through various analyses, including ellipsometry, water contact angles, X-ray photoelectron spectroscopy, and atomic force microscopy. By polymerizing block copolymer brushes through chain extension, the chirality of the polymer brushes grown on glass substrate was confirmed using circular dichroism spectroscopy.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Physical
Naveed Ahmad, Wenbin Qian, Peixu Sun, Xiaoxiao Wang, Kai Zhang, Xia Xu
Summary: This study investigates the effect of side chains on CO2 absorption in deep eutectic solvents based on amino acids and monoethanolamine. The results show that the functional group types and the number of alkyl groups in amino acids have an impact on the reaction rate of CO2 absorption and the solvent viscosity. The study reveals the reaction mechanism of CO2 capture using deep eutectic solvents.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Biochemistry & Molecular Biology
Samantha A. Miles, Joshua Andrew Nillama, Luke Hunter
Summary: This review summarizes the applications of side chain-fluorinated amino acids in medicinal chemistry and protein science. The paper outlines strategies for incorporating fluorine atoms into amino acid side chains and elaborating these building blocks into more complex fluorinated peptides and proteins. It then describes the diverse benefits of fluorine in amino acid side chains, including enabling 19F NMR and 18F PET imaging applications, enhancing pharmacokinetic properties, controlling molecular conformation, and optimizing target-binding.
Article
Engineering, Environmental
Zisong Cong, Shengjie Xie, Zhuoran Jiang, Shuo Zheng, Weihua Wang, Wenyan Wang, Heng Song
Summary: The new near-infrared cationic polymer DCPN-2 with aggregation-induced emission (AIE) properties shows bright emissions in the NIR region and can effectively generate reactive oxygen species (ROS) under light irradiation, leading to inhibition of tumor growth. This study provides a potential solution for cancer phototherapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Polymer Science
Kazunori Masuko, Chiharu Kumano, Ryo Sugawara, Kazuhiro Nakabayashi, Hideharu Mori
Summary: A variety of amino-acid-based amphiphilic diblock copolymer nano-objects with different morphologies were prepared through RAFT dispersion polymerization of styrene in methanol, utilizing six different hydrophilic poly(N-acryloyl amino acid) macro-chain transfer agents. The effects of polymerization conditions, monomer conversion, and concentration were systematically studied to achieve the formation of nano-objects with various morphologies. By transforming the products from methanol to water, pH-responsive morphological changes were observed in the aqueous solution.
JOURNAL OF POLYMER SCIENCE
(2021)
Article
Polymer Science
Xia Lin, Qianxi Gu, Jiajia Li, Jian Zhu
Summary: In this study, a facile and robust method for living cationic polymerization using zinc wire as a catalyst precursor was developed. Well-defined poly(vinyl ether)s with various molecular weights and narrow molecular weight distributions were obtained at room temperature. The in situ generation of trace zinc ions was found to be the key to the mild conditions of the polymerization. The utilization of zinc wire offered advantages of reusability, easy separation, and low metal residue. Moreover, the method was successfully applied in continuous flow polymerization, showing potential for scalable and efficient industrial production under mild conditions.
Reprint
Biochemistry & Molecular Biology
M. Barany, E. Gaetjens, K. Barany, E. Karp
Summary: Rabbit cardiac myosin contains fewer cysteine residues and has lower Ca++-ATPase activity compared to skeletal myosin. However, the ATPase activities of both cardiac and skeletal myosins are similar at high ionic strength and their abilities to bind with actin are essentially the same.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Riko Kashima, Akito Kajita, Tomohiro Kubo, Masami Kamigaito, Kotaro Satoh
Summary: Novel functional polymers were synthesized in this study using glycerol as a bio-based precursor. These polymers, derived from cyclic vinyl ethers with acetal linkage, exhibited well-defined molecular structures and could be hydrolyzed under acidic conditions to yield water-soluble functional polymers.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biophysics
Chayanan Khotchana, Pongsathon Phapugrangkul, Pakorn Opaprakasit, Dolnapa Kaewpa, Preeyaporn Chaiyasat, Amorn Chaiyasat
Summary: A novel method for preparing PLLA particles and capsules without the use of surfactant was proposed in this study. The nearly monodisperse products showed excellent inhibitory effects on microbial growth and were non-toxic to human cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Physical
Rita Pazmany, Krisztina S. Nagy, Akos Zsembery, Angela Jedlovszky-Hajdu
Summary: In this study, the researchers improved the cell penetration of fibrous hydrogel scaffolds using ultrasonication and enhanced the storing conditions and shelf life through freeze-drying process. The specific load capacity of the scaffold remained stable after ultrasonication, while the elongation break increased.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Nanoscience & Nanotechnology
Hoseon You, Seungjin Lee, Donguk Kim, Hyunbum Kang, Chulhee Lim, Felix Sunjoo Kim, Bumjoon J. Kim
Summary: The effects of introducing alkoxy side chains at different positions in Qx-based polymer acceptors on the materials and device parameters of all-polymer solar cells were investigated. The meta-positioned alkoxy chains showed enhanced electron-withdrawing and electron-conducting properties, leading to a higher power conversion efficiency compared to the para-positioned alkoxy chains.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Subhasish Sahoo, Yulia D. Gordievskaya, Kamal Bauri, Alexey A. Gavrilov, Elena Yu Kramarenko, Priyadarsi De
Summary: A family of nanostructured morphologies made of PCMA-b-PS copolymers were prepared via RAFT dispersion. The morphological transitions and thermoreversible gel-sol transition of the copolymer were studied experimentally and computationally. The results have important implications for understanding the morphological transitions in copolymer solutions.
Article
Materials Science, Multidisciplinary
Subhasish Sahoo, Bibhas Hazra, Pradip K. Tarafdar, Priyadarsi De
Summary: Accessing the interior of cells is crucial for drug delivery, and cholic acid-based copolymers have shown potential in destabilizing cellular membranes. In this study, cholate-containing amphiphilic copolymers were synthesized and self-organized into nanoaggregates. These copolymers efficiently destabilized liposomes and showed promise in delivering therapeutic drugs.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Materials Science, Biomaterials
Pampa Chowdhury, Arnab Banerjee, Biswajit Saha, Kamal Bauri, Priyadarsi De
Summary: Most traditional luminophores suffer from aggregation-caused quenching (ACQ) effect at high concentration or in the aggregated state, while a few fluorophores exhibit an aggregation-induced emission (AIE) feature. AIE-active polymers have advantages such as tunable emission, excellent photostability, and biocompatibility. Incorporating AIEgens into polymer design allows for diversified polymer systems with fascinating photophysical characteristics. Stimuli-responsive polymers can undergo property changes upon receiving signals. Combining AIE and stimuli responses in a single polymer platform provides a feasible and effective strategy for the development of smart polymers with promising biomedical applications.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Neurosciences
Sutapa Som Chaudhury, Mridula Nandi, Krishna Kumar, Bhuban Ruidas, Tapas Kumar Sur, Parash Prasad, Saikat Chakrabarti, Priyadarsi De, Jaya Sil, Chitrangada Das Mukhopadhyay
Summary: This study investigates the potential therapeutic effects of a novel PEG-based block copolymer on Alzheimer's disease. Results from both animal models and cell lines indicate that the copolymer can alleviate pathological features, behavioral deficits, neuroinflammation, and mitochondrial dysfunction associated with the disease. These findings suggest that the copolymer holds promise for successful clinical trials.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Priyadarsi De, Subhasish Sahoo, Soumya Paul, Swagata Pan, Debasish Pal, Shubham Das, Sankar Maiti, Balaram Mukhopadhyay, Paolo Tecilla
Summary: A multifunctional macromolecular architecture with alternating cholic acid (CA) and glucose pendants was synthesized. The resulting copolymers self-assembled into micellar nanoscaffolds with hydrophobic cores and sugar-coated shells. These nanoparticles encapsulated hydrophobic molecules, exhibited inherent fluorescence, formed inclusion complexes with β-cyclodextrin, and recognized Concanavalin A.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Avisek Bera, Pooja Ghosh, Shilpendu Ghosh, Arindam Mukherjee, Priyadarsi De
Summary: This study demonstrates for the first time the anti-amyloidogenic effect of LA and DHLA incorporated into polymer side chains. The resultant polymers show improved ROS scavenging activity and ability to reduce insulin fibrillation, and can also disintegrate preformed insulin fibrils. The findings suggest that antioxidant polymer-based therapeutic agents can be developed as novel drugs for amyloid-related disorders.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Avisek Bera, Pooja Ghosh, Kalyan Goswami, Priyadarsi De
Summary: In this study, three copolymers containing PEGMA and Boc-protected amino acid monomers (alanine, leucine, and phenylalanine) were synthesized and coated on silver nanoparticles. The inhibitory effect of these nanoparticles on insulin aggregation pathways was investigated using various spectroscopic and microscopic techniques. It was found that phenylalanine-based polymer-coated Ag NPs showed the highest inhibitory effect. Moreover, the coated nanoparticles were able to disintegrate matured insulin fibrils and reduce fibril-induced cytotoxicity.
ACS APPLIED NANO MATERIALS
(2023)
Article
Polymer Science
Tanmoy Maity, Soumya Paul, Priyadarsi De
Summary: The ability to modify the chemical functionality of side chain amino acid-based polymers allows tailoring their optical, mechanical, and biological properties. In this study, we synthesized a side chain L-leucine pendant homopolymer and incorporated various functional groups through post-polymerization modifications, creating a library of functionalized polymers. The solvatochromic behavior of fluorescence probe-bearing polymers was studied using fluorescence spectroscopy, and the crosslinking ability and mechanical properties of the synthesized gel were examined through rheological studies.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Namrata Deka, Avisek Bera, Debmalya Roy, Priyadarsi De
Summary: Engineering materials with specific structural architecture is crucial for applications in stealth and electronic fields, as it affects the transmittance of visible light and microwave radiation. Transparent copolymers of methyl methacrylate (MMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA) were synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization. The copolymers demonstrated high light transmittance (>90%) in the visible range due to the presence of a majority fraction of MMA units. By ionizing the amine functionalities in the copolymers through treatment with dilute acids, conductive MMA-based copolymer salts were obtained, with Cl- counter anions resulting in high conductance of up to 0.939 mS cm-1. Additionally, the optically transparent copolymer salts exhibited strong microwave absorption due to structural and physical anisotropies.
Article
Polymer Science
Arnab Banerjee, Rhituparna Nandi, Meghna Ghoshal, Pampa Chowdhury, Arindam Khatua, Alakesh Bisai, Priyadarsi De
Summary: In this study, copolymers containing dehydroabietate side-chain pendents were synthesized and their self-assembly behavior in aqueous solution was investigated. The presence of nanoaggregates with cationic surface charge was confirmed, and the water-soluble copolymers showed potential for drug encapsulation.
POLYMER INTERNATIONAL
(2023)
Article
Polymer Science
Subhasish Sahoo, Asmita Dey, Paolo Tecilla, Priyadarsi De
Summary: Synthetic anion transporters have potential therapeutic applications for various cellular ailments. Cationic macromolecular amphiphiles are being rediscovered due to their easy synthesis and ability to facilitate ion transport through cell membranes. This study demonstrates the efficiency of side chain alanine containing cationic polymer amphiphiles with steroid/fatty acid decoration as anion-selective artificial ionophores. The assembly of cholic acid containing copolymers greatly enhances transmembrane anion transport, with the highest selectivity observed for NO2- ions.
JOURNAL OF POLYMER SCIENCE
(2023)
Article
Polymer Science
Asmita Dey, Ujjal Haldar, Tota Rajasekhar, Rudolf Faust, Priyadarsi De
Summary: Artificial functional ionophores are crucial for selective transmembrane ion transport for the treatment of various illnesses caused by disruption of ion transport through biological membranes. This study investigates the ion transport activity of charge variable polyisobutylene-based amphiphilic block copolymers through an artificial membrane. The amphiphilic copolymers exhibit aggregation behavior in an aqueous medium, and the ion selectivity is influenced by the nature of the ions and the charge on the hydrophilic side chains of the block copolymer.
Article
Materials Science, Multidisciplinary
Subhasish Sahoo, Soumya Paul, Swagata Pan, Debasish Pal, Shubham Das, Sankar Maiti, Balaram Mukhopadhyay, Paolo Tecilla, Priyadarsi De
Summary: This article reports the design and synthesis of a multifunctional macromolecular architecture with alternating cholic acid and glucose pendants. The architecture was prepared through reversible addition-fragmentation chain-transfer copolymerization using a polyethylene glycol-conjugated chain transfer agent. The resulting copolymers formed self-assembled micellar nanoscaffolds in aqueous media, encapsulated hydrophobic molecules, formed inclusion complexes with β-cyclodextrin, and recognized Concanavalin A. The study offers a simple way to prepare a multifunctional alternating copolymer with various capabilities.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Materials Science, Biomaterials
Avisek Bera, Pooja Ghosh, Soumen Barman, Sagnik Bhattacharya, Babu Sudhamalla, Kalyan Goswami, Priyadarsi De
Summary: Block copolymers composed of protected leucine and glucose pendant moieties were synthesized using the RAFT polymerization method. These polymers self-assembled into nanoaggregates in water, inhibiting the fibrillation of insulin protein. Hydrophobic, electrostatic, and hydrogen bonding interactions were involved in the inhibition process, as confirmed by various biophysical techniques.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Asmita Dey, Ujjal Haldar, Tota Rajasekhar, Pooja Ghosh, Rudolf Faust, Priyadarsi De
Summary: This study investigates a family of amphiphilic diblock copolymers containing hydrophobic PIB and hydrophilic blocks with sugar pendants, discovering their potential in inhibiting insulin fibrillation. The results demonstrate the crucial role of hydrophobic and glycosidic cluster effects in the inhibition process.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
