Review
Medicine, Research & Experimental
Jianing Gong, Taoran Shi, Jinfeng Liu, Zerong Pei, Jingbo Liu, Xiaoliang Ren, Fengyun Li, Feng Qiu
Summary: Multidrug resistance (MDR) promotes tumor recurrence and metastasis and reduces anticancer efficiency. Conventional chemotherapy fails to achieve optimal therapeutic effect and accelerates MDR. Dual-drug codelivery nanosystems combine dual-drug administration with nanotechnology to overcome the limitations of free drugs. The characteristics of nanoparticles and the synergistic effect of dual drugs help circumvent various drug-resistant mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Multidisciplinary
Wei Liu, Xin Li, Ting Wang, Fei Xiong, Changrui Sun, Xikuang Yao, Wei Huang
Summary: Platinum (Pt) drugs are widely used in cancer therapy, but their efficacy is compromised by side effects and drug resistance. Precise delivery and release of Pt drugs have become important with the development of immunotherapy and imaging-guided therapy. Targeted delivery of Pt drugs increases accumulation at tumor sites and enhances antitumor efficacy. Combining Pt drugs with other theranostic agents in nanosystems achieves synergistic therapy and real-time monitoring.
Article
Chemistry, Multidisciplinary
Xianxian Yao, Danyang Chen, Bin Zhao, Binru Yang, Zhaokui Jin, Mingjian Fan, Geru Tao, Shucun Qin, Wuli Yang, Qianjun He
Summary: The development of stimuli-responsively degradable porous carriers for controlled drug release is important for clinical translation. In this study, a new type of Fe-MOF nanocrystals is engineered as an acid-degradable drug carrier and hydrogen donor. Fe-MOF nanocrystals exhibit acid-responsive degradation for H-2 generation and simultaneous drug release, and can effectively inhibit cancer metastasis and sensitize MDR cancer cells for enhanced chemotherapy. The high anti-MDR/antimetastasis efficacies and biocompatibility make Fe-MOF nanocrystals and Fe-MOF-based nanomedicine highly promising for clinical translation.
Review
Pharmacology & Pharmacy
Yue Hu, Shan Gao, Abdur Rauf Khan, Xiaoye Yang, Jianbo Ji, Yanwei Xi, Guangxi Zhai
Summary: This review summarizes the strategies for constructing smart, size-tunable nanocarriers based on the characteristic factors of the tumor microenvironment (TME) to enhance the penetration and retention of drugs within tumors.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Review
Chemistry, Multidisciplinary
Gan Lin, Jiajing Zhou, Hongwei Cheng, Gang Liu
Summary: The development of smart nanosystems has attracted significant attention in improving the efficacy of traditional nanomedicines. However, the diversity and scattered knowledge of these nanosystems pose challenges for their rational design. This review provides a summary of biological barriers and the strategies employed by smart nanosystems to overcome them, offering guidelines for the development of new-generation nanomedicines.
Review
Chemistry, Multidisciplinary
Zhichu Xiang, Mouquan Liu, Jun Song
Summary: Biocompatible nanosystems based on polymeric materials show promise as drug delivery nanocarriers for antitumor therapy, but their efficacy is hindered by nonspecific accumulation and drug release in normal tissues. Stimuli-responsive nanosystems triggered by tumor-specific stimuli have recently garnered interest for their controllable drug release properties. This review discusses various polymers and external stimuli for developing stimuli-responsive polymeric nanosystems, and outlines the challenges in designing such Nanomedicine to enhance therapeutic efficacy.
APPLIED SCIENCES-BASEL
(2021)
Review
Immunology
Yi Shi, Meng-Lu Zhu, Qian Wu, Yi Huang, Xiao-Ling Xu, Wei Chen
Summary: Sepsis is a major immune response disorder caused by infection with high mortality rates, currently treated mainly with antibiotics, anti-inflammatory, and antioxidant drugs. The emergence of drug delivery nanosystems can significantly improve infection treatment outcomes, but clinical translation remains challenging, requiring solutions to key obstacles such as tissue distribution, bacterial resistance, and single treatment modes. Rigorous optimization of drug delivery nanosystems is expected to hold great potential for sepsis therapy.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Peng Wang, Mili Li, Fang Zhou, Yue Yang, Xia Yin, Xiao-Bing Zhang, Guosheng Song
Summary: A new click-activated prodrug, CA4V, and a bioorthogonal nanoreactor, CA4V/ZIF-90@TzCOF@Apt, are reported. The nanoreactor, consisting of a ZIF-90 core, COF shells, and an aptamer polymer coating, induces a nanoconfined bioorthogonal reaction, enhancing the activation efficiency of CA4V and its therapeutic effects in vivo.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Eman Elhassan, Nikita Devnarain, Mahir Mohammed, Thirumala Govender, Calvin A. Omolo
Summary: Hybrid nanoparticles are considered superior alternatives for delivering antibiotics and targeting infections, resulting in eradication of bacterial infections and overcoming antimicrobial resistance. This review provides an up-to-date overview of various types of hybrid nanoparticles and their design approaches, nanomaterial construction, drug release mechanisms, and enhanced antibacterial efficacy. Future strategies to improve hybrid nanosystems for treating bacterial infections and overcoming antibiotic resistance are also highlighted.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Materials Science, Multidisciplinary
Zhenyu Zhao, Qimanguli Saiding, Zhengwei Cai, Ming Cai, Wenguo Cui
Summary: The article introduces the application of advanced ultrasound technology and functional biomaterials in achieving precision drug therapy. It discusses the use of ultrasound in triggering and delivering drugs with precision treatment, and explores the key information and challenges in combining ultrasound technology with biological materials for precision therapy. The article also provides a prospective outlook on the development and application of ultrasound-functional biomaterials for drug precision therapy.
Article
Polymer Science
Carmelo Corsaro, Giulia Neri, Angela Maria Mezzasalma, Enza Fazio
Summary: Traditional pharmacotherapy has limitations such as antibiotic resistances, while functional hybrid nanomaterials and synthetic polyelectrolytes have shown potential in improving drug release efficiency under remote control. Nanofiber-based drug delivery systems offer faster response time and better control over release rate compared to colloids. The Weibull distribution function indicates that nanofibers follow Fick's first law for drug release mechanisms, while a non-Fickian character is observed in colloids.
Article
Engineering, Biomedical
Xinyu Sun, Lihua Li, Hui Zhang, Mengna Dong, Jiao Wang, Pei Jia, Tong Bu, Xin Wang, Li Wang
Summary: A collaborative precise antibacterial wound healing therapy nanoplatform integrating CA with PTT was presented. The NIR-mediated Cu-GA-CA-PDA NRs demonstrated excellent sterilization performance in vitro/in vivo, as well as antioxidant, anti-inflammatory, and anti-infection capacities. The multifunctional biological activities of NIR-mediated Cu-GA-CA-PDA NRs provide a highly competitive strategy for curing bacteria-infected wounds.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Chendi Ding, Chunbo Chen, Xiaowei Zeng, Hongzhong Chen, Yanli Zhao
Summary: Prodrugs are inactive drug molecules that are converted to active drugs after administration. They play a crucial role in drug treatment, especially in cancer therapy. Current research focuses on stimuli-responsive activation mechanisms, regulation of stimuli intensity in vivo, and the design of nanoscale prodrug formulations.
Article
Nanoscience & Nanotechnology
Xiao Wang, Yiyao Qi, Zhenrong Hu, Lijun Jiang, Fei Pan, Zhen Xiang, Zuquan Xiong, Wenwen Jia, Jingzhou Hu, Wei Lu
Summary: This study successfully developed a nanostructure for precise magnetic hyperthermia/chemo synergistic therapy, which has the functions of on-demand heating, magnetic-responsive drug release, and MRI T2 signal enhancement. Both in vitro and in vivo experiments demonstrated excellent therapeutic effects, providing a new strategy for clinical precision medicine of cancers.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2022)
Review
Chemistry, Applied
Haiting Xu, Wenbiao Nie, Linxin Dai, Ruifeng Luo, Dasheng Lin, Minyue Zhang, Jinming Zhang, Fei Gao
Summary: This article reviews the recent progress of polysaccharides in the field of cancer phototherapy, including the advantages of polysaccharides as nanocarrier materials to deliver phototherapeutic agents (PAs), the main mechanism for the preparation of PAs-loaded polysaccharides nanoformulation, and the construction of polysaccharides-based nano-drug delivery systems (NDDS) for delivery of PAs and its functional modification strategy, aiming to improve the therapeutic effect of phototherapy against cancer.
CARBOHYDRATE POLYMERS
(2023)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)