A review on the biocompatibility and potential applications of graphene in inducing cell differentiation and tissue regeneration

Enhanced Migration of Neural Stem Cells by Microglia Grown on a Three-Dimensional Graphene Scaffold

(2016) Ziyun Jiang et al.   ACS Applied Materials & Interfaces

Aligned PLLA nanofibrous scaffolds coated with graphene oxide for promoting neural cell growth

(2016) Kuihua Zhang et al.   Acta Biomaterialia

Graphene-based materials for tissue engineering

(2016) Su Ryon Shin et al.   ADVANCED DRUG DELIVERY REVIEWS

Multilayered Graphene Hydrogel Membranes for Guided Bone Regeneration

(2016) Jiayu Lu et al.   ADVANCED MATERIALS

Cell-Instructive Graphene-Containing Nanocomposites Induce Multinucleated Myotube Formation

(2016) Akhil Patel et al.   ANNALS OF BIOMEDICAL ENGINEERING

Enhanced human bone marrow mesenchymal stem cell chondrogenic differentiation in electrospun constructs with carbon nanomaterials

(2016) Benjamin Holmes et al.   CARBON

Graphene/single-walled carbon nanotube hybrids promoting osteogenic differentiation of mesenchymal stem cells by activating p38 signaling pathway

(2016) Xinxin Yan et al.   International Journal of Nanomedicine

Characterization and toxicological effects of three-dimensional graphene foams in rats in vivo

(2016) Yingying Zha et al.   JOURNAL OF NANOPARTICLE RESEARCH

Myoblast differentiation and protein expression in electrospun graphene oxide (GO)-poly (ε-caprolactone, PCL) composite meshes

(2016) B. Chaudhuri et al.   MATERIALS LETTERS

Construction of a 3D rGO–collagen hybrid scaffold for enhancement of the neural differentiation of mesenchymal stem cells

(2016) Weibo Guo et al.   Nanoscale

Bioactivity of periodontal ligament stem cells on sodium titanate coated with graphene oxide

(2016) Qi Zhou et al.   Scientific Reports

Graphene Oxide-Copper Nanocomposite-Coated Porous CaP Scaffold for Vascularized Bone Regeneration via Activation of Hif-1α

(2016) Wenjie Zhang et al.   Advanced Healthcare Materials

Novel Electrospun Polylactic Acid Nanocomposite Fiber Mats with Hybrid Graphene Oxide and Nanohydroxyapatite Reinforcements Having Enhanced Biocompatibility

(2016) Chen Liu et al.   Polymers

Graphene oxide and sulfonated polyanion co-doped hydrogel films for dual-layered membranes with superior hemocompatibility and antibacterial activity

(2016) Chao He et al.   Biomaterials Science

Graphene scaffolds in progressive nanotechnology/stem cell-based tissue engineering of the nervous system

(2016) Omid Akhavan   Journal of Materials Chemistry B

Biomineralized Poly(l-lactic-co-glycolic acid)/Graphene Oxide/Tussah Silk Fibroin Nanofiber Scaffolds with Multiple Orthogonal Layers Enhance Osteoblastic Differentiation of Mesenchymal Stem Cells

(2016) Weili Shao et al.   ACS Biomaterials-Science & Engineering

Graphene Foam as a Three-Dimensional Platform for Myotube Growth

(2016) Eric Krueger et al.   ACS Biomaterials-Science & Engineering

Biomineralized Poly(l-lactic-co-glycolic acid)/Graphene Oxide/Tussah Silk Fibroin Nanofiber Scaffolds with Multiple Orthogonal Layers Enhance Osteoblastic Differentiation of Mesenchymal Stem Cells

(2016) Weili Shao et al.   ACS Biomaterials Science & Engineering

Graphene Foam as a Three-Dimensional Platform for Myotube Growth

(2016) Eric Krueger et al.   ACS Biomaterials Science & Engineering

Graphene Functionalized Scaffolds Reduce the Inflammatory Response and Supports Endogenous Neuroblast Migration when Implanted in the Adult Brain

(2016) Kun Zhou et al.   PLoS One

Akermanite bioceramics promote osteogenesis, angiogenesis and suppress osteoclastogenesis for osteoporotic bone regeneration

(2016) Lunguo Xia et al.   Scientific Reports

Antibacterial ability and hemocompatibility of graphene functionalized germanium

(2016) Hao Geng et al.   Scientific Reports

Enhanced Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells on Graphene Oxide-Incorporated Electrospun Poly(lactic-co-glycolic acid) Nanofibrous Mats

(2015) Yu Luo et al.   ACS Applied Materials & Interfaces

Controlling Differentiation of Adipose-Derived Stem Cells Using Combinatorial Graphene Hybrid-Pattern Arrays

(2015) Tae-Hyung Kim et al.   ACS Nano

Enhanced Physiochemical and Mechanical Performance of Chitosan-Grafted Graphene Oxide for Superior Osteoinductivity

(2015) Jing Ruan et al.   ADVANCED FUNCTIONAL MATERIALS

2D and 3D Hybrid Systems for Enhancement of Chondrogenic Differentiation of Tonsil-Derived Mesenchymal Stem Cells

(2015) Jinhye Park et al.   ADVANCED FUNCTIONAL MATERIALS

In Vitro and In Vivo Tumor Targeted Photothermal Cancer Therapy Using Functionalized Graphene Nanoparticles

(2015) Sung Han Kim et al.   BIOMACROMOLECULES

Graphene and carbon nanocompounds: biofunctionalization and applications in tissue engineering

(2015) Iwona Jesion et al.   BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT

Covalent conjugation of mechanically stiff graphene oxide flakes to three-dimensional collagen scaffolds for osteogenic differentiation of human mesenchymal stem cells

(2015) Seokyung Kang et al.   CARBON

Graphene-oxide-modified β-tricalcium phosphate bioceramics stimulate in vitro and in vivo osteogenesis

(2015) Chengtie Wu et al.   CARBON

Two and three-dimensional graphene substrates to magnify osteogenic differentiation of periodontal ligament stem cells

(2015) Han Xie et al.   CARBON

Extremely low frequency electromagnetic fields enhance neuronal differentiation of human mesenchymal stem cells on graphene-based substrates

(2015) Yoo-Jung Lee et al.   CURRENT APPLIED PHYSICS

Graphene oxide increases the viability of C2C12 myoblasts microencapsulated in alginate

(2015) J. Ciriza et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Stimulated myogenic differentiation of C2C12 murine myoblasts by using graphene oxide

(2015) Min Jeong Kim et al.   JOURNAL OF THE KOREAN PHYSICAL SOCIETY

Thrombogenicity and biocompatibility studies of reduced graphene oxide modified acellular pulmonary valve tissue

(2015) Piotr Wilczek et al.   Materials Science & Engineering C-Materials for Biological Applications

Ocular biocompatibility evaluation of hydroxyl-functionalized graphene

(2015) Mimi Lin et al.   Materials Science & Engineering C-Materials for Biological Applications

Graphene in neurosurgery: the beginning of a new era

(2015) Maria Caffo et al.   Nanomedicine

Reduced graphene oxide-coated hydroxyapatite composites stimulate spontaneous osteogenic differentiation of human mesenchymal stem cells

(2015) Jong Ho Lee et al.   Nanoscale

Graphene oxide nanoflakes incorporated gelatin–hydroxyapatite scaffolds enhance osteogenic differentiation of human mesenchymal stem cells

(2015) Manitha Nair et al.   NANOTECHNOLOGY

Atomistic modeling of epitaxial graphene on Ru(0001) and deposited ruthenium nanoparticles

(2015) G. D. Förster et al.   PHYSICAL REVIEW B

Enzymatic degradation of graphene/polycaprolactone materials for tissue engineering

(2015) Eoin Murray et al.   POLYMER DEGRADATION AND STABILITY

Molecular Hemocompatibility of Graphene Oxide and Its Implication for Antithrombotic Applications

(2015) Kenry et al.   Small

Deciphering the underlying mechanisms of oxidation-state dependent cytotoxicity of graphene oxide on mammalian cells

(2015) Wendi Zhang et al.   TOXICOLOGY LETTERS

Biodegradable CSMA/PECA/Graphene Porous Hybrid Scaffold for Cartilage Tissue Engineering

(2015) JinFeng Liao et al.   Scientific Reports

Subacute Tissue Response to 3D Graphene Oxide Scaffolds Implanted in the Injured Rat Spinal Cord

(2015) Elisa López-Dolado et al.   Advanced Healthcare Materials

Electrospun Collagen Fibers with Spatial Patterning of SDF1α for the Guidance of Neural Stem Cells

(2015) Xiaoran Li et al.   Advanced Healthcare Materials

Graphene-Based Materials in Regenerative Medicine

(2015) Xili Ding et al.   Advanced Healthcare Materials

Directed Neural Stem Cell Differentiation with a Functionalized Graphene Oxide Nanocomposite

(2015) Cassandra L. Weaver et al.   Advanced Healthcare Materials

Controllable synthesis of activated graphene and its application in supercapacitors

(2015) C. Zheng et al.   Journal of Materials Chemistry A

Graphene based metal and metal oxide nanocomposites: synthesis, properties and their applications

(2015) Mujeeb Khan et al.   Journal of Materials Chemistry A

Stimulated myoblast differentiation on graphene oxide-impregnated PLGA-collagen hybrid fibre matrices

(2015) Yong Cheol Shin et al.   JOURNAL OF NANOBIOTECHNOLOGY

Graphene: A Versatile Carbon-Based Material for Bone Tissue Engineering

(2015) Nileshkumar Dubey et al.   Stem Cells International

Stimulating effect of graphene oxide on myogenesis of C2C12 myoblasts on RGD peptide-decorated PLGA nanofiber matrices

(2015) Yong Cheol Shin et al.   Journal of Biological Engineering

Advances in synthesis of calcium phosphate crystals with controlled size and shape

(2014) Kaili Lin et al.   Acta Biomaterialia

Layer-by-Layer Assembly of 3D Tissue Constructs with Functionalized Graphene

(2014) Su Ryon Shin et al.   ADVANCED FUNCTIONAL MATERIALS

Dual Roles of Graphene Oxide in Chondrogenic Differentiation of Adult Stem Cells: Cell-Adhesion Substrate and Growth Factor-Delivery Carrier

(2014) Hee Hun Yoon et al.   ADVANCED FUNCTIONAL MATERIALS

Guiding Stem Cell Differentiation into Oligodendrocytes Using Graphene-Nanofiber Hybrid Scaffolds

(2014) Shreyas Shah et al.   ADVANCED MATERIALS

Flexible bactericidal graphene oxide–chitosan layers for stem cell proliferation

(2014) M. Mazaheri et al.   APPLIED SURFACE SCIENCE

Differentiation of Tonsil-Tissue-Derived Mesenchymal Stem Cells Controlled by Surface-Functionalized Microspheres in PEG-Polypeptide Thermogels

(2014) Eun Jeong Kye et al.   BIOMACROMOLECULES

Effect of nano-structured bioceramic surface on osteogenic differentiation of adipose derived stem cells

(2014) Lunguo Xia et al.   BIOMATERIALS

Graphene-reinforced calcium silicate coatings for load-bearing implants

(2014) Youtao Xie et al.   Biomedical Materials

Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection

(2014) Bo Li et al.   International Journal of Nanomedicine

Graphene oxide coating facilitates the bioactivity of scaffold material for tissue engineering

(2014) Erika Nishida et al.   JAPANESE JOURNAL OF APPLIED PHYSICS

Structural disruption increases toxicity of graphene nanoribbons

(2014) Sayan Mullick Chowdhury et al.   JOURNAL OF APPLIED TOXICOLOGY

Graphene supportsin vitroproliferation and osteogenic differentiation of goat adult mesenchymal stem cells: potential for bone tissue engineering

(2014) Hoda Elkhenany et al.   JOURNAL OF APPLIED TOXICOLOGY

A unique two-step Hummers method for fabricating low-defect graphene oxide nanoribbons through exfoliating multiwalled carbon nanotubes

(2014) Chih-I Chang et al.   Journal of the Taiwan Institute of Chemical Engineers

Graphene based scaffolds effects on stem cells commitment

(2014) Eriberto Bressan et al.   Journal of Translational Medicine

Biocompatibility of electrospun graphene oxide–poly(ε-caprolactone) fibrous scaffolds with human cord blood mesenchymal stem cells derived skeletal myoblast

(2014) Biswadeep Chaudhuri et al.   MATERIALS LETTERS

TiO2–graphene nanocomposites for enhanced osteocalcin induction

(2014) Kavitha Kandiah et al.   Materials Science & Engineering C-Materials for Biological Applications

Cell-Assembled Graphene Biocomposite for Enhanced Chondrogenic Differentiation

(2014) Wong Cheng Lee et al.   Small

Hydroxyapatite grafted carbon nanotubes and graphene nanosheets: Promising bone implant materials

(2014) Adebola Oyefusi et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Cyto and genotoxicities of graphene oxide and reduced graphene oxide sheets on spermatozoa

(2014) Ehsan Hashemi et al.   RSC Advances

A large-area smooth graphene film on a TiO2 nanotube array via a one-step electrochemical process

(2014) Jiangjun Xian et al.   Journal of Materials Chemistry A

The use of graphene in the self-organized differentiation of human neural stem cells into neurons under pulsed laser stimulation

(2014) Omid Akhavan et al.   Journal of Materials Chemistry B

3D free-standing porous scaffolds made of graphene oxide as substrates for neural cell growth

(2014) M. C. Serrano et al.   Journal of Materials Chemistry B

Enhanced green fluorescent protein-mediated synthesis of biocompatible graphene

(2014) Sangiliyandi Gurunathan et al.   JOURNAL OF NANOBIOTECHNOLOGY

Collagen hydrogels incorporated with surface-aminated mesoporous nanobioactive glass: Improvement of physicochemical stability and mechanical properties is effective for hard tissue engineering

(2013) Ahmed El-Fiqi et al.   Acta Biomaterialia

Self-Supporting Graphene Hydrogel Film as an Experimental Platform to Evaluate the Potential of Graphene for Bone Regeneration

(2013) Jiayu Lu et al.   ADVANCED FUNCTIONAL MATERIALS

Axonal Alignment and Enhanced Neuronal Differentiation of Neural Stem Cells on Graphene-Nanoparticle Hybrid Structures

(2013) Aniruddh Solanki et al.   ADVANCED MATERIALS

Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics

(2013) Kaili Lin et al.   BIOMATERIALS

Graphene nanogrids for selective and fast osteogenic differentiation of human mesenchymal stem cells

(2013) Omid Akhavan et al.   CARBON

Accelerated differentiation of neural stem cells into neurons on ginseng-reduced graphene oxide sheets

(2013) Omid Akhavan et al.   CARBON

Green chemistry approach for the synthesis of biocompatible graphene

(2013) Sangiliyandi Gurunathan et al.   International Journal of Nanomedicine

Bioactive effects of graphene oxide cell culture substratum on structure and function of human adipose-derived stem cells

(2013) Jangho Kim et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Graphene-based nanomaterials for drug delivery and tissue engineering

(2013) Sumit Goenka et al.   JOURNAL OF CONTROLLED RELEASE

Dental Pulp Tissue Engineering in Full-length Human Root Canals

(2013) V. Rosa et al.   JOURNAL OF DENTAL RESEARCH

A facile synthesis of Ag@graphene-nanosheet composite with enhanced antibacterial activity and acceptable environmental safety

(2013) Guang-Yu He et al.   MONATSHEFTE FUR CHEMIE

Flash photo stimulation of human neural stem cells on graphene/TiO2 heterojunction for differentiation into neurons

(2013) Omid Akhavan et al.   Nanoscale

Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells

(2013) Spencer W. Crowder et al.   Nanoscale

Minimal oxidation and inflammogenicity of pristine graphene with residence in the lung

(2013) Anja Schinwald et al.   Nanotoxicology

Oxygenated Functional Group Density on Graphene Oxide: Its Effect on Cell Toxicity

(2013) Soumen Das et al.   PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

Delivery of a Therapeutic Protein for Bone Regeneration from a Substrate Coated with Graphene Oxide

(2013) Wan-Geun La et al.   Small

Culture of neural cells and stem cells on graphene

(2013) Seungmi Ryu et al.   Tissue Engineering and Regenerative Medicine

Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells

(2013) Ning Li et al.   Scientific Reports

In Vitro Hematological and In Vivo Vasoactivity Assessment of Dextran Functionalized Graphene

(2013) Sayan Mullick Chowdhury et al.   Scientific Reports

Ultrasound-free preparation of graphene oxide from mechanochemically oxidized graphite

(2013) Oleg Yu. Posudievsky et al.   Journal of Materials Chemistry A

Differentiation of human neural stem cells into neural networks on graphene nanogrids

(2013) Omid Akhavan et al.   Journal of Materials Chemistry B

Graphene-incorporated chitosan substrata for adhesion and differentiation of human mesenchymal stem cells

(2013) Jangho Kim et al.   Journal of Materials Chemistry B

Graphene: an emerging material for biological tissue engineering

(2013) Sang Kyu Lee et al.   Carbon Letters

Size-Dependent Cell Uptake of Protein-Coated Graphene Oxide Nanosheets

(2012) Qingxin Mu et al.   ACS Applied Materials & Interfaces

Amine-Modified Graphene: Thrombo-Protective Safer Alternative to Graphene Oxide for Biomedical Applications

(2012) Sunil K. Singh et al.   ACS Nano

Extracellular matrix protein adsorption to phosphate-functionalized gels from serum promotes osteogenic differentiation of human mesenchymal stem cells

(2012) Navakanth R. Gandavarapu et al.   Acta Biomaterialia

Complexation-Induced Biomimetic Long Range Fibrous Orientation in a Rigid-Flexible Block Copolymer Thermogel

(2012) Min Hee Park et al.   ADVANCED FUNCTIONAL MATERIALS

Unraveling Stress-Induced Toxicity Properties of Graphene Oxide and the Underlying Mechanism

(2012) Wendi Zhang et al.   ADVANCED MATERIALS

Size-dependent genotoxicity of graphene nanoplatelets in human stem cells

(2012) Omid Akhavan et al.   BIOMATERIALS

Osteogenesis and angiogenesis induced by porous β-CaSiO3/PDLGA composite scaffold via activation of AMPK/ERK1/2 and PI3K/Akt pathways

(2012) Chen Wang et al.   BIOMATERIALS

Myoblast differentiation on graphene oxide

(2012) Sook Hee Ku et al.   BIOMATERIALS

Covalently linked biocompatible graphene/polycaprolactone composites for tissue engineering

(2012) Sepidar Sayyar et al.   CARBON

Recent advances in graphene family materials toxicity investigations

(2012) Agnieszka Maria Jastrzębska et al.   JOURNAL OF NANOPARTICLE RESEARCH

Graphene oxide modified TiO2 nanotube arrays: enhanced visible light photoelectrochemical properties

(2012) Peng Song et al.   Nanoscale

Review on the latest design of graphene-based inorganic materials

(2012) Na Li et al.   Nanoscale

Enhanced Cartilage Formation via Three-Dimensional Cell Engineering of Human Adipose-Derived Stem Cells

(2012) Hee Hun Yoon et al.   TISSUE ENGINEERING PART A

Cytotoxicity of Graphene Oxide and Graphene in Human Erythrocytes and Skin Fibroblasts

(2011) Ken-Hsuan Liao et al.   ACS Applied Materials & Interfaces

Protein Corona-Mediated Mitigation of Cytotoxicity of Graphene Oxide

(2011) Wenbing Hu et al.   ACS Nano

Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells

(2011) Tapas R. Nayak et al.   ACS Nano

Thrombus Inducing Property of Atomically Thin Graphene Oxide Sheets

(2011) Sunil K. Singh et al.   ACS Nano

Origin of Enhanced Stem Cell Growth and Differentiation on Graphene and Graphene Oxide

(2011) Wong Cheng Lee et al.   ACS Nano

Gradient biomaterials for soft-to-hard interface tissue engineering

(2011) Azadeh Seidi et al.   Acta Biomaterialia

Structure–process–property relationship of the polar graphene oxide-mediated cellular response and stimulated growth of osteoblasts on hybrid chitosan network structure nanocomposite scaffolds

(2011) D. Depan et al.   Acta Biomaterialia

Silicate bioceramics induce angiogenesis during bone regeneration

(2011) Wanyin Zhai et al.   Acta Biomaterialia

Biological Interactions of Graphene-Family Nanomaterials: An Interdisciplinary Review

(2011) Vanesa C. Sanchez et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Fabrication of Dense Hydroxyapatite Nanobioceramics with Enhanced Mechanical Properties via Two-Step Sintering Process

(2011) Kaili Lin et al.   International Journal of Applied Ceramic Technology

Wrapping Bacteria by Graphene Nanosheets for Isolation from Environment, Reactivation by Sonication, and Inactivation by Near-Infrared Irradiation

(2011) O. Akhavan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Minimizing Oxidation and Stable Nanoscale Dispersion Improves the Biocompatibility of Graphene in the Lung

(2011) Matthew C. Duch et al.   NANO LETTERS

Cytotoxicity Effects of Graphene and Single-Wall Carbon Nanotubes in Neural Phaeochromocytoma-Derived PC12 Cells

(2010) Yongbin Zhang et al.   ACS Nano

In Vivo Pharmacokinetics, Long-Term Biodistribution, and Toxicology of PEGylated Graphene in Mice

(2010) Kai Yang et al.   ACS Nano

Graphene-Based Antibacterial Paper

(2010) Wenbing Hu et al.   ACS Nano

Toxicity of Graphene and Graphene Oxide Nanowalls Against Bacteria

(2010) Omid Akhavan et al.   ACS Nano

Graphene substrates promote adherence of human osteoblasts and mesenchymal stromal cells

(2010) Marie Kalbacova et al.   CARBON

Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration

(2010) Xiaoyong Zhang et al.   CARBON

Erratum: Neural stem cell systems: physiological players or in vitro entities?

(2010) Luciano Conti et al.   NATURE REVIEWS NEUROSCIENCE

In vitro toxicity evaluation of graphene oxide on A549 cells

(2010) Yanli Chang et al.   TOXICOLOGY LETTERS

The chemistry of graphene oxide

(2009) Daniel R. Dreyer et al.   CHEMICAL SOCIETY REVIEWS

Simple Method of Preparing Graphene Flakes by an Arc-Discharge Method

(2009) K. S. Subrahmanyam et al.   Journal of Physical Chemistry C

Layer Area, Few-Layer Graphene Films on Arbitrary Substrates by Chemical Vapor Deposition

(2009) Alfonso Reina et al.   NANO LETTERS

Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics

(2008) Songfeng Xu et al.   BIOMATERIALS

Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells

(2008) Danielle S. W. Benoit et al.   NATURE MATERIALS

Measurement of the Elastic Properties and Intrinsic Strength of Monolayer Graphene

(2008) C. Lee et al.   SCIENCE

Quasiparticle properties of graphene in the presence of disorder

(2008) A. Qaiumzadeh et al.   SOLID STATE COMMUNICATIONS