Article
Cardiac & Cardiovascular Systems
Masaaki Konishi, Eiichi Akiyama, Yasushi Matsuzawa, Ryosuke Sato, Shinnosuke Kikuchi, Hidefumi Nakahashi, Kozo Okada, Noriaki Iwahashi, Masami Kosuge, Toshiaki Ebina, Kiyoshi Hibi, Toshihiro Misumi, Kouichi Tamura, Kazuo Kimura
Summary: The study aims to investigate the association between upper and lower extremity skeletal muscle mass and all-cause mortality in hospitalized patients with heart failure after discharge. The findings suggest that both upper and lower extremity skeletal muscle mass have prognostic implications for mortality in patients with heart failure, despite the potential influence of leg edema on lower extremity skeletal muscle mass.
Article
Medicine, General & Internal
Ana Lopez-de-Andres, Rodrigo Jimenez-Garcia, Valentin Hernandez-Barrera, Javier de Miguel-Diez, Jose M. de Miguel-Yanes, Ricardo Omana-Palanco, David Carabantes-Alarcon
Summary: This study examined trends in the incidence, clinical characteristics, and in-hospital outcomes of lower-extremity amputations among individuals with type 2 diabetes in Spain. The study also assessed possible sex differences in these outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Catherine M. Avitabile, Michael G. McBride, Xuemei Zhang, Steve Ampah, Bryan H. Goldstein, Tarek Alsaied, Samuel G. Wittekind, Kevin K. Whitehead, Babette S. Zemel, Stephen M. Paridon
Summary: Peak work rate and anaerobic activity increased with lower extremity-focused training in adolescents with Fontan circulation. However, leg lean mass did not improve. Additionally, training had no impact on physical activity questionnaire, quality of life scores, exercise cardiac magnetic resonance performance, and peripheral vascular function.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Mary M. McDermott, Sudarshan Dayanidhi, Kate Kosmac, Sunil Saini, Joshua Slysz, Christiaan Leeuwenburgh, Lisa Hartnell, Robert Sufit, Luigi Ferrucci
Summary: Aerobic exercise has positive effects on mitochondrial activity and muscle mass in older adults, but its impact on patients with peripheral artery disease remains unclear. Studies show that walking exercise may increase lower extremity ischemia in PAD patients, and more research is needed to clarify the underlying mechanisms.
CIRCULATION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Jin Hun Park, Mi-Yeon Lee, Hun-Kyu Shin, Kyung Jae Yoon, JunYeop Lee, Jai Hyung Park
Summary: This study aimed to investigate the association between skeletal muscle mass and diabetes incidence/insulin resistance/glycated hemoglobin (HbA1C). A cross-sectional study of 372,399 clinically apparently healthy Korean males and females was conducted, and it revealed negative associations between skeletal muscle mass and diabetes incidence, insulin resistance, and HbA1C levels.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Medicine, General & Internal
Hyun Eui Moon, Tae Sic Lee, Tae-Ha Chung
Summary: In men, the association between appendicular skeletal muscle mass ratio and metabolic syndrome shows a reverse J-curve, while in women it follows a sine curve pattern. Maintaining an optimal ratio of muscle mass between upper and lower appendicular skeletal muscles is important in preventing MetS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kyle J. Edmunds, Ozioma C. Okonkwo, Sigurdur Sigurdsson, Sarah R. Lose, Vilmundur Gudnason, Ugo Carraro, Paolo Gargiulo
Summary: This study utilized nonlinear trimodal regression analysis to investigate the relationship between physical activity and lower extremity function in elderly individuals, identifying muscle amplitude and location as potential mediators. These findings suggest that physical activity protects aging mobility by preserving lean tissue quantity and quality.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Tetsuro Ohba, Go Goto, Nobuki Tanaka, Kotaro Oda, Marina Katsu, Hayato Takei, Kensuke Koyama, Hiroki Oba, Hirotaka Haro
Summary: Limb muscle strength asymmetry has a significant impact on physical abilities. This study quantified limb muscle asymmetry in adolescent idiopathic scoliosis patients, compared different curve types, and examined correlations with radiographic parameters.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Dongmin Lee, Kyengho Byun, Moon-Hyon Hwang, Sewon Lee
Summary: In healthy young males, there were significant positive correlations among skeletal muscle mass, muscle strength, and anaerobic power. Arterial stiffness indicators associated with AIx were negatively correlated with skeletal muscle mass, muscle strength, and anaerobic power, while baPWV showed no correlation with any muscular factors.
APPLIED SCIENCES-BASEL
(2021)
Review
Nutrition & Dietetics
Anna Izzo, Elena Massimino, Gabriele Riccardi, Giuseppe Della Pepa
Summary: Type 2 diabetes mellitus is a major health burden for the elderly, affecting approximately 25% of those over 65 years old. Sarcopenia, characterized by loss of skeletal muscle mass and function, has been identified as a new complication in elderly individuals with T2DM. It is important for researchers and clinicians to understand the risk factors and associations of sarcopenia in T2DM patients in order to provide appropriate therapeutic interventions.
Article
Medicine, General & Internal
Mary M. McDermott, Lydia Bazzano, Charlotte A. Peterson, Robert Sufit, Luigi Ferrucci, Kathryn Domanchuk, Lihui Zhao, Tamar S. Polonsky, Dongxue Zhang, Donald Lloyd-Jones, Christiaan Leeuwenburgh, Jack M. Guralnik, Melina R. Kibbe, Kate Kosmac, Michael H. Criqui, Lu Tian
Summary: The study aimed to investigate whether telmisartan improves walking performance in patients with lower extremity PAD, but the results showed that telmisartan did not significantly improve walking distance at 6-month follow-up.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Nutrition & Dietetics
Fuyuko Takahashi, Yoshitaka Hashimoto, Ayumi Kaji, Ryosuke Sakai, Yuka Kawate, Takuro Okamura, Yuriko Kondo, Takuya Fukuda, Noriyuki Kitagawa, Hiroshi Okada, Naoko Nakanishi, Saori Majima, Takafumi Senmaru, Emi Ushigome, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
Summary: This prospective cohort study aimed to investigate the impact of different vitamin intakes on the loss of muscle mass in older individuals with type 2 diabetes. The study found that vitamin D intake was significantly associated with muscle mass loss, and there was a trend towards a relationship between vitamin B12 intake and muscle mass loss. However, intakes of vitamin A, B2, B6, C, and E were not found to be related to muscle mass loss.
Article
Endocrinology & Metabolism
Shaobo Li, Haoyong Yu, Pin Zhang, Yinfang Tu, Yunfeng Xiao, Di Yang, Yuqian Bao, Junfeng Han, Weiping Jia
Summary: This study found a nonlinear relationship between muscle mass and BMI, and suggested that baseline muscle mass and eFFMI are more reliable predictors of diabetes remission than BMI.
Article
Endocrinology & Metabolism
Shaobo Li, Haoyong Yu, Pin Zhang, Yinfang Tu, Yunfeng Xiao, Di Yang, Yuqian Bao, Junfeng Han, Weiping Jia
Summary: The study found a non-linear relationship between muscle mass and BMI, with psoas muscle mass and eFFMI being better predictors of diabetes remission after Roux-en-Y gastric bypass surgery compared to BMI.
Article
Nutrition & Dietetics
Rena Kawano, Fuyuko Takahashi, Yoshitaka Hashimoto, Takuro Okamura, Akane Miki, Ayumi Kaji, Ryosuke Sakai, Noriyuki Kitagawa, Takufumi Senmaru, Saori Majima, Hiroshi Okada, Naoko Nakanishi, Emi Ushigome, Masahide Hamaguchi, Masahiro Yamazaki, Michiaki Fukui
Summary: Insufficient energy intake is associated with muscle mass loss in older people with type 2 diabetes. It is recommended for older patients to consume enough energy to maintain muscle mass.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Hidetaka Hamasaki, Shingo Morimitsu
Summary: The study found that glucagon levels were positively associated with clinical indicators in patients with diabetes, such as serum C-peptide levels and waist circumference, but negatively associated with duration of diabetes and estimated glomerular filtration rate. Postprandial hyperglucagonemia was also linked to worsening renal function.
CANADIAN JOURNAL OF DIABETES
(2021)
Letter
Endocrinology & Metabolism
Hidetaka Hamasaki
Article
Chemistry, Multidisciplinary
Takuro Shoji, Hidetaka Hamasaki, Akiko Kawaguchi, Yoko Waragai, Hidekatsu Yanai
Summary: The study found that low-intensity resistance exercise can improve short-term glycemic variability in healthy individuals, but has no significant impact on total physical activity and daily glycemic control.
APPLIED SCIENCES-BASEL
(2021)
Review
Endocrinology & Metabolism
Hidetaka Hamasaki
Summary: Hand grip strength (HGS) is recognized as a simple and cost-effective method for evaluating overall skeletal muscle strength and quality, and has been associated with type 2 diabetes (T2D), cardiovascular disease (CVD), and mortality. Measurement of HGS should be included in the assessment of T2D patients along with other basic measurements, and further research on the genetic association between skeletal muscle and T2D is necessary for individualized exercise therapy recommendations.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
(2021)
Review
Chemistry, Multidisciplinary
Hidetaka Hamasaki
Summary: During the COVID-19 pandemic, daily physical activity significantly decreased, with strict public health measures leading to a reduction of 50% or more in physical activity levels.
APPLIED SCIENCES-BASEL
(2021)
Article
Endocrinology & Metabolism
Hidetaka Hamasaki
Summary: This study compared the levels of glucagon between patients with type 1 diabetes (T1DM) and type 2 diabetes (T2DM). The results showed that fasting plasma glucagon levels were significantly lower in T1DM patients compared to T2DM patients, and the glucagon response to a standardized meal also differed between the two groups.
JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Hidetaka Hamasaki, Hidekatsu Yanai
Summary: Handgrip strength is associated with arterial stiffness in patients with type 2 diabetes, independent of other risk factors. Patients with lower handgrip strength are at higher risk for cardiovascular disease and should undergo exercise therapy to reduce this risk.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Endocrinology & Metabolism
Ashraf Al Madhoun, Hidetaka Hamasaki
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Hidetaka Hamasaki
Summary: This paper explores the effect of chronic exercise on myokines in patients with type 2 diabetes (T2D) and/or obesity. The results show that chronic exercise does not change BDNF, irisin, and secreted protein acidic and rich in cysteine levels, but decreases TNF-α levels in patients with T2D. Combined aerobic exercise (AE) and resistance training (RT) or sprint interval training increase IGF-1 levels and decrease IL-6 and IL-15 levels in patients with T2D. Combined AE and RT may also increase IL-15 levels in obese individuals. In addition, RT alone may increase BDNF, IGF-1, and IL-7 levels in overweight individuals. However, AE alone does not change circulating myokine levels in patients with T2D, while it may increase myonectin levels in obese individuals.
CURRENT DIABETES REVIEWS
(2023)
Editorial Material
Endocrinology & Metabolism
Hidetaka Hamasaki
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Review
Health Care Sciences & Services
Hidetaka Hamasaki
Summary: Exercise may have a therapeutic effect on diabetes patients with cardiovascular autonomic neuropathy (CAN), but further research is needed, especially in different patient populations.
Review
Health Care Sciences & Services
Hidetaka Hamasaki
Summary: The systematic review aimed to summarize the current evidence on patient satisfaction with telemedicine in adults with diabetes and discuss future directions. The review found that telemedicine did not significantly increase patient satisfaction compared to conventional face-to-face care.
Review
Medicine, Research & Experimental
Hidetaka Hamasaki
AIMS MEDICAL SCIENCE
(2020)
Article
Endocrinology & Metabolism
Hidetaka Hamasaki, Masashi Furuta, Hidekatsu Yanai
CURRENT DIABETES REVIEWS
(2020)
Article
Endocrinology & Metabolism
Hidetaka Hamasaki
JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2019)