Article
Oncology
Yanqiong Liu, Qiulian Wu, Fuyong Zhang, Xue Qin
Summary: This study provides evidence for the first time that the NRF2 gene rs6721961 variation is a potential genetic marker for susceptibility to hepatocellular carcinoma (HCC).
CANCER CELL INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Shuang Zhao, Tianyu Song, Yue Gu, Yihua Zhang, Siyi Cao, Qing Miao, Xiyue Zhang, Hongshan Chen, Yuanqing Gao, Lei Zhang, Yi Han, Hong Wang, Jun Pu, Liping Xie, Yong Ji
Summary: The study suggests that H2S alleviates liver damage by activating Keap1 S-sulfhydration and promoting the activation of Nrf2, leading to increased expression of antioxidant proteins, which may have potential therapeutic benefits for liver diseases.
Review
Biochemistry & Molecular Biology
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Omayma A. Eldahshan, Yasmine M. Abdelkhalek, Magdy El Dahshan, Eman A. Ahmed, Jean-Marc Sabatier, Gaber E. -S. Batiha
Summary: COVID-19 is caused by SARS-CoV-2 and results in pulmonary and extra-pulmonary manifestations due to oxidative stress and hyperinflammation. The Nrf2 pathway plays a crucial role in mitigating viral toxicity and inflammation in COVID-19, and Nrf2 activators could be a potential therapeutic strategy for managing the disease.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Immunology
Wenting Jian, Huigai Ma, Dingming Wang, Peng Yang, Mengbi Jiang, Yu Zhong, Xiang Long, Jingjing Jiang, Yuan Gong
Summary: This study demonstrates that omaveloxolone exerts significant cardioprotective effects in treating sepsis-induced cardiomyopathy by activating the Nrf2 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Xia Wu, Leitao Huang, Jichun Liu
Summary: Diabetic cardiomyopathy is a major cause of death worldwide, with oxidative stress playing a key role in its pathophysiology. NRF2 is a transcription factor that regulates antioxidant gene expression and detoxifying enzymes, helping to maintain cardiac homeostasis and counteract oxidative stress. Targeting the NRF2 signaling pathway may be a potential strategy for preventing and treating DCM and other cardiac diseases.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Daniela Maria Tanase, Alina Georgiana Apostol, Claudia Florida Costea, Claudia Cristina Tarniceriu, Ionut Tudorancea, Minela Aida Maranduca, Mariana Floria, Ionela Lacramioara Serban
Summary: Arterial hypertension is a prevalent disease characterized by increased incidence and heterogeneous pathophysiology. Oxidative stress plays an important role in its development, with excessive levels causing vascular cell damage and promoting hypertension. Transcription factors such as Nrf2 mediate antioxidant response pathways and provide protection.
Article
Fisheries
Yun Wang, Yafei Duan, Jianhua Huang, Jun Wang, Chuanpeng Zhou, Shigui Jiang, Heizhao Lin, Zhe Zhang
Summary: PmNrf2, a member of CNC-bZIP transcription factor family, is constitutively expressed in various tissues of shrimp and responds to bacterial challenge. Knockdown of PmNrf2 results in decreased expression of PmGPx gene, indicating its role in regulating the transcription of antioxidant enzyme genes in shrimp.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Dan-Dan Zhu, Xue-Mei Tan, Li-Qing Lu, Si-Jia Yu, Ru-Li Jian, Xin-Fang Liang, Yi-Xuan Liao, Wei Fan, Luciia Barbier-Torres, Austin Yang, He-Ping Yang, Ting Liu
Summary: COVID-19 caused by SARS-CoV-2 is a global pandemic that not only affects respiratory system but also leads to systemic inflammation and liver damage. NRF2 plays a crucial role in regulating antioxidant proteins in the context of COVID-19-induced inflammation and liver injury.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Huiyan Deng, Miaojian Wan, Huaping Li, Quan Chen, Runxiang Li, Bihua Liang, Huilan Zhu
Summary: The study demonstrates that curcumin can protect the skin from UV damage by regulating the Nrf2 pathway. UV irradiation leads to cell apoptosis and oxidative stress, which can be reversed by adding curcumin. Additionally, curcumin induces Nrf2 nuclear accumulation in Hacat cells to provide protection against UV exposure-induced photodamage.
Article
Plant Sciences
Chuanhong Wu, Feipeng Duan, Ruocong Yang, Yaolan Dai, Xiuping Chen, Shaojing Li
Summary: This study found that 15, 16-Dihydrotanshinone I (DHT) can protect against ferroptosis and ischemic stroke by activating the Nrf2 signaling pathway.
Article
Environmental Sciences
Yuan-yuan Wei, Hui-ru Wang, Yi-meng Fan, Jin-hua Gu, Xiu-ying Zhang, Xu-hao Gong, Zhi-hui Hao
Summary: The study evaluated the effect and underlying mechanism of GDK aqueous extract in alleviating acute liver injury caused by CCl4. The results showed that GDK effectively inhibited liver damage and restored the structure and function of the liver. It achieved this by suppressing liver fibrosis, blocking the NFicB pathway, inhibiting hepatic inflammatory response, reducing oxidative stress, inhibiting ferroptosis, and alleviating hepatocyte injury caused by CCl4. In conclusion, this study provides insights into the potential complex mechanism of GDK against acute liver injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Clinical Neurology
Xin-Jiang Yan, Cheng-Peng Zhan, Yao Lv, Dan-Dan Mao, Ri-Cheng Zhou, Yong-Min Xv, Guo-Feng Yu
Summary: This study found that increased serum Nrf2 levels in severe traumatic brain injury (sTBI) patients are associated with traumatic severity and prognosis. Serum Nrf2 levels may serve as an important prognostic marker for sTBI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Food Science & Technology
Chengyu Lv, Yuqiu Li, Rong Liang, Wei Huang, Yechen Xiao, Xinqi Ma, Yongjun Wang, Haoyang Zou, Fen Qin, Chang Sun, Tiezhu Li, Jie Zhang
Summary: This study investigated the effect of tangeretin on the Nrf2/ARE pathway and its potential molecular mechanisms. It was observed that tangeretin bound to Keap1 Kelch domain and activated the Nrf2-ARE pathway. It also induced the expressions of Nrf2-mediated targets and effectively scavenged DPPH free radicals. Therefore, tangeretin may be a potential antioxidant.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Shengqiang Li, Zhen Lei, Meng Zhao, Yonghao Hou, Di Wang, Xingli Xu, Xiaowen Lin, Jingxin Li, Shuhai Tang, Jingui Yu, Tao Meng
Summary: Propofol can reduce myocardial I/R injury by activating PKC/NRF2 pathway, leading to increased antioxidant enzyme expression and decreased levels of lactate dehydrogenase and creatine kinase-MB.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Gastroenterology & Hepatology
Vidyasagar Naik Bukke, Archana Moola, Gaetano Serviddio, Gianluigi Vendemiale, Francesco Bellanti
Summary: Oxidative stress is a key driver in the development and progression of various diseases, including MAFLD. NRF2, a master regulator of redox homeostasis, plays a crucial role in every step of MAFLD development. NRF2 activators regulate lipid metabolism and oxidative stress, alleviating fatty liver disease by inducing the expression of cytoprotective genes.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Medicine, Research & Experimental
Zhuo Li, Jia Li, Xiao Miao, Wenpeng Cui, Lining Miao, Lu Cai
Summary: AMP-activated protein kinase (AMPK) plays a crucial role in obesity-related renal injury, exerting renal protection by modulating lipid metabolism, autophagy, oxidative stress, and other pathways. Further investigation is needed to explore the mechanisms of AMPK in renal diseases.
Article
Medicine, Research & Experimental
Lihua Liu, Aosong Duan, Qiaoyan Guo, Guangdong Sun, Wenpeng Cui, Xuehong Lu, Hongyu Yu, Ping Luo
Summary: The study found that the levels of miR-33a-5p in the serum, urine, and kidney tissues of IgA nephropathy (IgAN) patients were significantly lower compared to healthy individuals. Furthermore, the levels of miR-33a-5p decreased with the severity of renal injury and the progression of renal failure in IgAN patients. This suggests that miR-33a-5p detected in the serum and urine could serve as a non-invasive biomarker to reflect the progression of renal injury and renal failure in IgAN patients.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Hematology
Qiaoyan Guo, Yangyang Chen, Liming Yang, Xueyan Zhu, Xiaoxuan Zhang, Qiao Zhao, Xiaohua Zhuang, Yanfeng Wu, Ping Luo, Wenpeng Cui
Summary: The occurrence of early-onset peritonitis (EOP) is significantly associated with lower rates of PDAP-related death and poorer clinical outcomes in patients with diabetes undergoing PD.
BLOOD PURIFICATION
(2022)
Article
Biochemistry & Molecular Biology
Feng Xu, Man Wu, Xuehong Lu, Hong Zhang, Lin Shi, Yue Xi, Huifen Zhou, Junhong Wang, Lining Miao, Da-Wei Gong, Wenpeng Cui
Summary: The study found that ELA treatment can reduce tissue damage, ROS production, and apoptosis caused by renal ischemia/reperfusion injury. ELA can also inhibit cell apoptosis and restore cell proliferation induced by IRI.
Article
Hematology
Lingfei Meng, Liming Yang, Xueyan Zhu, Zhanshan Sun, Xiaoxuan Zhang, Xinyang Li, Siyu Cheng, Shizheng Guo, Xiaohua Zhuang, Hongbin Zou, Ping Luo, Wenpeng Cui
Summary: Older age, hypoproteinemia, hyperglycemia, higher eGFR, and severe heart failure were independent predicting factors for early death in patients who underwent urgent-start peritoneal dialysis (USPD).
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Hematology
Qiaoyan Guo, Yangyang Chen, Ren Wu, Liming Yang, Xueyan Zhu, Qiao Zhao, Xiaohua Zhuang, Yanfeng Wu, Ping Luo, Wenpeng Cui
Summary: Early-onset peritonitis in elderly PD patients is significantly associated with poorer clinical outcomes, including multiple episodes of PD-associated peritonitis (PDAP), technique failure, and all-cause death.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Review
Pharmacology & Pharmacy
Wen Li, Jing Sun, Xiaoxi Zhou, Yue Lu, Wenpeng Cui, Lining Miao
Summary: Pyroptosis is a lytic programmed cell death that plays a crucial role in diabetic complications. Research has identified various signaling pathways associated with pyroptosis, and explored the potential value of pyroptosis inhibitors in the treatment of diabetic nephropathy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Dan Gao, Yan Lou, Yingchun Cui, Shengmao Liu, Wenpeng Cui, Guangdong Sun
Summary: According to the current evidence, preoperative serum calcium, preoperative ALP, and preoperative iPTH were significant predictors of hypocalcemia in patients with SHPT after PTX. More attention should be given to patients with these risk factors for the prevention of postoperative hypocalcemia.
Article
Urology & Nephrology
Xi Wen, Liming Yang, Zhanshan Sun, Xiaoxuan Zhang, Xueyan Zhu, Wenhua Zhou, Xiaoqing Hu, Shichen Liu, Ping Luo, Wenpeng Cui
Summary: The study aimed to investigate the safety of initiating peritoneal dialysis (PD) within 24 hours. The results showed that initiating PD within 24 hours of catheter insertion was not associated with increased mechanical complications, infectious complications, or technique failures.
Article
Hematology
Feng Xu, Yue Yang, Man Wu, Wenhua Zhou, Dongxue Wang, Wenpeng Cui
Summary: Chinese patients with diabetes and end-stage renal disease have similar survival rates whether they undergo hemodialysis or peritoneal dialysis. The choice of dialysis modality should be individualized based on patients' physical condition and local practices.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Article
Endocrinology & Metabolism
Si-Yu Cheng, Li-Ming Yang, Zhan-Shan Sun, Xiao-Xuan Zhang, Xue-Yan Zhu, Ling-Fei Meng, Shi-Zheng Guo, Xiao-Hua Zhuang, Ping Luo, Wen-Peng Cui
Summary: This retrospective cohort study aimed to identify risk factors for mortality during high-risk periods in patients with diabetes undergoing urgent-start peritoneal dialysis (USPD). The results showed that cardiovascular disease was the leading cause of mortality within 6 months and after 6 months. Patients with more obvious baseline heart failure symptoms had a higher risk of mortality both within the first 6 months and after. Independent risk factors for mortality within the first 6 months were advanced age, lower baseline serum creatinine level, higher baseline serum phosphorus level, and baseline NYHA class III-IV. Independent risk factors for mortality after 6 months were advanced age and baseline NYHA class III-IV.
WORLD JOURNAL OF DIABETES
(2022)
Article
Hematology
Siyu Cheng, Liming Yang, Zhanshan Sun, Xiaoxuan Zhang, Xueyan Zhu, Lingfei Meng, Shizheng Guo, Xiaohua Zhuang, Ping Luo, Wenpeng Cui
Summary: This study suggests that initiating peritoneal dialysis within 24 hours after catheter insertion is feasible in elderly patients with ESRD, and the break-in period does not increase the risk of complications.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Article
Pharmacology & Pharmacy
Shunyun Xie, Feng Xu, Yue Lu, Yixian Zhang, Xinyang Li, Mengyuan Yu, Wenpeng Cui
Summary: Peritoneal fibrosis is a common complication in patients receiving peritoneal dialysis, and effective treatment is currently unavailable. ELA and APLN have potential therapeutic effects on PD-related fibrosis. ELA-32 can interfere with the EMT of HPMCs by inhibiting the activation of the TGF-beta 1/SMAD2/3, ERK1/2, and AKT pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Urology & Nephrology
Pei-Ting Luo, Wei Li, Xin-Yang Li, Yu Zhang, Bing Du, Wen-Peng Cui
Summary: This study conducted a systematic review and meta-analysis to determine the impact of peritoneal dialysis (PD) modality, specifically automated peritoneal dialysis (APD) and continuous ambulatory peritoneal dialysis (CAPD), on all-cause mortality and PD failure. The findings indicate that APD significantly reduces the risk of all-cause mortality compared to CAPD. However, APD and CAPD have similar effectiveness in terms of PD survival. These results support the increased utilization of APD globally, particularly in developing nations where reimbursement for care has been a barrier.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Hematology
Shichen Liu, Liming Yang, Xueyan Zhu, Xiaoxuan Zhang, Lingfei Meng, Xinyang Li, Jing Zhao, Xiaohua Zhuang, Wenpeng Cui
Summary: This study found that the duration of peritoneal dialysis, previous episodes of peritonitis, high dialysate white cell count, Pseudomonas aeruginosa, and polymicrobial infections were all associated with catheter removal. The prevalence of polymicrobial peritonitis and fungal peritonitis has increased.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
