Article
Plant Sciences
Declan J. Lafferty, Richard Espley, Cecilia H. Deng, Catrin S. Gunther, Blue Plunkett, Janice L. Turner, Laura Jaakola, Katja Karppinen, Andrew C. Allan, Nick W. Albert
Summary: Members of the Vaccinium genus, such as blueberry and bilberry, have different concentrations and localization of anthocyanins due to the expression of key regulatory genes MYBPA1.1 and MYBA1. Blueberry lacks VcMYBA1 expression, resulting in insufficient VcMYBPA1.1 for anthocyanin regulation, while bilberry expresses VmMYBA1 which up-regulates VmMYBPA1.1 for coordinated regulation of flavonoid biosynthesis genes and anthocyanin accumulation.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Agriculture, Multidisciplinary
Yanfei Liu, Kangxun Ma, Yingwei Qi, Guowen Lv, Xiaolin Ren, Zhande Liu, Fengwang Ma
Summary: This study reveals the involvement of an MYB-bHLH-WD40 complex and multiple regulators in the regulation of anthocyanin synthesis in kiwifruit, including a complex that directly targets anthocyanin synthetic genes and another complex that indirectly regulates anthocyanin accumulation signal amplification.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Declan J. Lafferty, Richard Espley, Cecilia H. Deng, Andrew P. Dare, Catrin S. Guenther, Laura Jaakola, Katja Karppinen, Murray R. Boase, Lei Wang, Henry Luo, Andrew C. Allan, Nick W. Albert
Summary: This study identified activator and repressor transcription factors (TFs) that regulate the production of anthocyanins, pigment compounds that positively affect human health, in blueberry and bilberry fruits. MYBA1 activates the pathway while MYBC2.1 represses it. These TFs operate within a hierarchical regulatory network, and the absence of this module in blueberry flesh results in a lack of anthocyanins.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Jieyu Qian, Lingli Jiang, Hongsheng Qing, Jiahong Chen, Ziyun Wan, Menghan Xu, Jianxin Fu, Chao Zhang
Summary: The petal color in Zinnia elegans is determined by the accumulation of anthocyanins, especially cyanidins. The transcription factor ZeMYB9 from subgroup 6 was identified as a positive regulator of anthocyanin accumulation, and it can activate the expression of ZeF3'H, enhancing cyanidin synthesis and regulating petal color in Z. elegans. ZeMYB9 was also found to interact with the bHLH transcription factor ZeGL3, further promoting the promoter activity of ZeF3'H and inducing anthocyanin accumulation in tobacco leaves.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Dawei Ma, Hao Tang, Michael Reichelt, Eerik-Mikael Piirtola, Juha-Pekka Salminen, Jonathan Gershenzon, C. Peter Constabel
Summary: Flavonoids are important secondary metabolites in plants, regulated by MYB transcription factors. The study identified that the MYB activator MYB117 can enhance anthocyanin accumulation in hybrid poplar by up-regulating F3'5'H1, resulting in increased B-ring hydroxylation.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Plant Sciences
Jieni Li, Quanya Tan, Maosheng Yi, Zhengnan Yu, Qing Xia, Lu Zheng, Jianjun Chen, Xiaoyun Zhou, Xiang-Qian Zhang, He-Rong Guo
Summary: This study analyzed eight cultivars with different spathe colors and found that increased expression of transcription factor AaMYB2 was associated with elevated levels of anthocyanin in spathes, while decreased expression of AaMYB2 and increased expression of AaLAR and AaANR were accompanied with the accumulation of colorless proanthocyanidin, resulting in white spathes. The green spathes were attributed to the higher chlorophyll content and the increased expression of chlorophyll biosynthesis-related genes AaHemB and AaPor. A working model for the formation of white and green spathes was proposed.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Joshua VanderWeide, Rachele Falchi, Alberto Calderan, Enrico Peterlunger, Urska Vrhovsek, Paolo Sivilotti, Paolo Sabbatini
Summary: The grapevine source-to-sink ratio and berry exposure to solar radiation both have an impact on the biosynthesis and accumulation of grape flavonoids. This study compared the effects of these factors on Merlot grapes grown in different locations to understand their sensitivity to environmental conditions. The results showed that solar radiation had a greater influence on flavonoid biosynthesis and accumulation than the source-to-sink ratio, and the vineyard environment determined whether solar radiation was beneficial or detrimental to flavonoid production.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Chitra Bhatia, Subhash Reddy Gaddam, Ashutosh Pandey, Prabodh Kumar Trivedi
Summary: Flavonols, a type of protective compounds, are regulated by light and other environmental factors. MYB12 has been identified as a key gene in Arabidopsis that regulates flavonol accumulation in response to light.
Article
Plant Sciences
Felix J. Martinez-Rivas, Rosario Blanco-Portales, Maria P. Serratosa, Pablo Ric-Varas, Victor Guerrero-Sanchez, Laura Medina-Puche, Lourdes Moyano, Jose A. Mercado, Saleh Alseekh, Jose L. Caballero, Alisdair R. R. Fernie, Juan Munoz-Blanco, Francisco J. J. Molina-Hidalgo
Summary: In this study, the strawberry transcription factor FaMYB123 was found to be regulated by ABA and auxin, and it plays a crucial role in the biosynthesis of anthocyanins/flavonoids.
Article
Nutrition & Dietetics
Yanjun Zhou, Ke Gu, Fengying Zhou
Summary: Cancer is a major global cause of death, and adequate intake of fruits and vegetables, which are rich in nutrients like flavonoids, can effectively prevent cancer. However, the specific impact of different flavonoids on cancer mortality and the population that benefits from increased flavonoid intake are still controversial and unknown. A study was conducted on 14,029 participants to explore the association between flavonoid intake and cancer mortality. The results revealed that higher intake of flavonols and specific flavonoids was associated with decreased cancer mortality, especially in certain age groups, genders, and other subpopulations. These findings suggest that personalized nutrition based on flavonoid intake can potentially improve outcomes for cancer patients.
Article
Plant Sciences
Chengcai Zhang, Huadong Ren, Xiaohua Yao, Kailiang Wang, Jun Chang
Summary: This study investigated the molecular mechanisms underlying flavonoid biosynthesis in pecan nuts and identified key genes and transcription factors that showed high correlation with flavonoid content. These findings are important for understanding the biosynthesis of flavonoids and accelerating the breeding of high-quality pecan varieties.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Yuhui Liu, Yuanming Li, Zhen Liu, Lei Wang, Kui Lin-Wang, Jinyong Zhu, Zhenzhen Bi, Chao Sun, Junlian Zhang, Jiangping Bai
Summary: The transcriptomic and metabolomic profile of potato tubers from three colored potato clones at three developmental phases were analyzed to explore the control mechanism of potato tuber flavonoid accumulation and flesh pigmentation. Differential abundance of flavonoids was found in pigmented flesh, including anthocyanins, flavonols, and flavones. The study also identified the involvement of R2R3-MYB repressor StMYB3 and R3-MYB repressor StMYBATV in the modulation of anthocyanin biosynthesis during tuber development.
Review
Biochemistry & Molecular Biology
Huiling Yan, Xiaona Pei, Heng Zhang, Xiang Li, Xinxin Zhang, Minghui Zhao, Vincent L. Chiang, Ronald Ross Sederoff, Xiyang Zhao
Summary: Anthocyanins play a crucial role in providing different visual effects to plants through various biosynthetic pathways, attracting pollinators and seed dispersers. MYB transcription factors are key regulators in anthocyanin biosynthesis, controlling the enrichment and sedimentation of anthocyanins. The study discusses the regulation of anthocyanin biosynthetic mechanisms by MYB-TFs and analyzes the role of the environment in controlling the anthocyanin biosynthesis network.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Naizhe Ji, Qianyu Wang, Shanshan Li, Jiaxin Wen, Liangsheng Wang, Xiaohao Ding, Shiwei Zhao, Hui Feng
Summary: This study focused on the formation of petal blotch in the rose cultivar 'Sunset Babylon Eyes' and found that only cyanidin 3,5-O-diglucoside (Cy3G5G) contributed to the blotch pigmentation. The amount of Cy3G5G varied at different developmental stages. Only flavonols but no flavone were found in blotch and non-blotch parts. Key enzyme genes and regulatory genes, such as RC7G0058400 (F3'H), RC6G0470600 (DFR), RC7G0212200 (ANS), RC7G0019000 (MYB), and RC1G0363600 (WRKY), were identified in the formation and color deepening of the blotch.
Review
Nutrition & Dietetics
Robert Kubina, Kamil Krzykawski, Agata Kabala-Dzik, Robert D. Wojtyczka, Ewa Chodurek, Arkadiusz Dziedzic
Summary: Diet plays a crucial role in maintaining homeostasis, and plants and spices rich in flavonoids have been widely used in traditional medicine. Flavonols in our diet may prevent cancer by modulating important enzymes and receptors involved in various signaling pathways. Fisetin, a type of flavonol, has been extensively studied for its anticancer activity. This review summarizes the evidence-based research on fisetin's effects on different types of cancer, including its preventive and therapeutic effects, molecular targets, and mechanisms. It suggests that fisetin has the potential to become a complementary drug in cancer prevention and treatment, but more in-depth research is needed before entering clinical trials.