Review
Pharmacology & Pharmacy
Gina P. Rodriguez-Castano, Frank Rosenau, Ludger Staendker, Carolina Firacative
Summary: Expanding the antifungal drug arsenal is crucial for treating Candida infections, which are increasing in prevalence and often resistant to existing treatments. This review provides a comprehensive summary of antimicrobial peptides (AMPs) with anti-Candida activity that have undergone successful preclinical or clinical trials. The source, mode of action, and animal model of infection or clinical trial for these AMPs are presented. The advantages of combination therapy using AMPs and other drugs to fight Candida infections are also discussed.
Article
Microbiology
Maryam Erfaninejad, Ali Zarei Mahmoudabadi, Elham Maraghi, Mohammad Hashemzadeh, Mahnaz Fatahinia
Summary: Oral candidiasis remains a common opportunistic fungal infection among PLWHA in the era of HAART. Though there is an increasing prevalence of new Candida species, Candida albicans still remains the predominant species. Low BMI and CD4 count <= 200 cells/mm³ are predictors of OC occurrence.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Norma Solis, Rohan S. Wakade, Virginia E. Glazier, Tomye L. Ollinger, Melanie Wellington, Aaron P. Mitchell, Scott G. Filler, Damian J. Krysan
Summary: Oropharyngeal candidiasis (OPC) is a common infection that can range from mild to severe, depending on the patient. The transcriptional regulation of C. albicans biofilm formation on abiotic surfaces involves six key factors, some of which play roles in OPC infectivity in a mouse model. The relationship between fungal burden, hyphae morphogenesis, and infectivity is of significant research interest.
Article
Microbiology
Norma V. Solis, Rohan S. Wakade, Virginia E. Glazier, Tomye L. Ollinger, Melanie Wellington, Aaron P. Mitchell, Scott G. Filler, Damian J. Krysan
Summary: Oropharyngeal candidiasis (OPC) is a common infection that can cause mild or severe disease depending on the patient. The transcriptional regulation of C. albicans biofilm formation on abiotic surfaces is also involved in OPC, but the network characteristics and functional connections during infection are distinct from those observed in vitro.
Article
Microbiology
Norma V. V. Solis, Rohan S. S. Wakade, Scott G. G. Filler, Damian J. J. Krysan
Summary: Candida albicans, a commensal of the human gastrointestinal tract, is a common cause of human fungal disease. This study compared the gene expression profiles of C. albicans during oral infection and disseminated infection of the kidney, revealing niche-specific differences in gene expression. The findings shed light on the interactions between the pathogen and the host.
Article
Infectious Diseases
Anelise Maria Costa Vasconcelos Alves, Beatriz Oliveira Lopes, Ana Caroline Rocha de Melo Leite, Gabriela Silva Cruz, erika Helena Salles de Brito, Laritza Ferreira de Lima, Lucia Cernakova, Nuno Filipe Azevedo, Celia Fortuna Rodrigues
Summary: This study characterized mature biofilms of various Candida species obtained from the oral mucosa of children, adults, and elders. It was found that children were more likely to be infected by non-Candida albicans Candida species (NCACs) and these NCACs formed biofilms richer in matrix components. This finding is clinically important, especially in pediatric care, due to the association of stronger biofilms with antimicrobial resistance, recurrent infections, and higher therapeutic failure.
Article
Microbiology
Lance R. Fredericks, Mark D. Lee, Hannah R. Eckert, Shunji Li, Mason A. Shipley, Cooper R. Roslund, Dina A. Boikov, Emily A. Kizer, Jack D. Sobel, Paul A. Rowley
Summary: Candida glabrata is more susceptible to inhibition by Saccharomyces killer yeasts compared to other species of Candida yeasts, despite showing high resistance to antifungal therapeutics.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Maryam Erfaninejad, Ali Zarei Mahmoudabadi, Elham Maraghi, Mohammad Hashemzadeh, Mahnaz Fatahinia
Summary: Oral candidiasis is a common fungal infection in people living with HIV/AIDS. A study was conducted to analyze the susceptibility profiles of Candida spp. to six antifungal agents. The prevalence of oral Candida infection was 34.06%. The study found low-level resistance to some antifungal agents and identified mixed infections and multidrug resistance in some patients.
LETTERS IN APPLIED MICROBIOLOGY
(2023)
Article
Microbiology
Suresh Ambati, Tuyetnhu Pham, Zachary A. Lewis, Xiaorong Li, Richard B. Meagher
Summary: This study found that targeting antifungal drugs to fungal glycans can improve drug efficacy and reduce drug dosage, which is of great significance for various invasive fungal infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Medical Laboratory Technology
Hadis Jafarian, Maral Gharaghani, Seyed Saeed Seyedian, Ali Zarei Mahmoudabadi
Summary: This study revealed that C. albicans remains the most common isolate from patients with esophageal candidiasis, with genotype A and white phenotype being predominant and exhibiting strong hemolysin activity. Sensitivity to amphotericin and fluconazole was the greatest.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Microbiology
Junwen Lei, Jian Huang, Caiyan Xin, Fangyan Liu, Jinping Zhang, Yuxin Xie, Yingyu Mao, Wenbi Chen, Zhangyong Song
Summary: Oropharyngeal candidiasis (OPC) is a common infection caused by Candida albicans, with high mortality rates. The limited treatment options and increasing drug resistance highlight the need for new drugs. This study confirmed that riboflavin (RF) has broad-spectrum anti-Candida activity by inhibiting hyphae and biofilm formation. Mechanistically, RF disrupts membrane and cell wall integrity and promotes reactive oxygen species and pyruvate accumulation. RF also targets multiple essential pathways. In a mouse model of OPC, RF exhibited therapeutic efficacy and potential benefits in treating OPC.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Min Pan, Qirui Wang, Yulong Liu, Nan Xiao, Xiaojia Niu, Daqiang Wu, Tianming Wang, Guiming Yan, Jing Shao
Summary: Oropharyngeal candidiasis (OPC) is a type of oral infection caused by Candida albicans. This study found that the combination therapy of paeonol (PAE) plus fluconazole (FLU) or amphotericin B (AmB) can reduce fungal burden, restore mucosal integrity, and decrease the hypoxic microenvironment and inflammation in OPC mice. Furthermore, the drug combinations can also rectify the abnormal expression of hypoxia-inducible factor (HIF)-1 alpha, IL-17A, and IL-23 mRNA.
Article
Microbiology
Roberto Vazquez-Munoz, Angela Thompson, Takanori Sobue, Anna Dongari-Bagtzoglou
Summary: Oral bacteria can influence the virulence of Candida albicans in causing oropharyngeal candidiasis (OPC). A prebiotic diet enriched with xylo-oligosaccharides (XOS) can modulate the oral microbiome composition and attenuate Candida infection in an OPC mouse model.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Maisa Santos Fonseca, Kathleen Ramos Deegan, Luiz Marcelo Tome, Marcos Antonio Mendonca, Ana Rita Sokolonski, Leane Queiroz Gondim, Vasco Azevedo, Roberto Meyer, Ljubica Tasic, Aristoteles Goes-Neto, Ricardo Wagner Portela
Summary: This study examines a novel pathogen, Candida haemulonii, causing cutaneous infection in a Boa constrictor snake. The fungus was identified and its drug sensitivity was tested, revealing strong inhibition for all drugs except fluconazole and itraconazole. A biogenic silver nanoparticle-based ointment successfully treated the clinical symptoms in the snake. The presence of these infections in snakes near human habitats highlights the importance of wildlife health monitoring for emerging and opportunistic diseases in peri-urban environments.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Mengli Chen, Ting Cheng, Chen Xu, Min Pan, Jiadi Wu, Tianming Wang, Daqiang Wu, Guiming Yan, Changzhong Wang, Jing Shao
Summary: Candida albicans and Candida glabrata play critical roles in biofilm formation, and combination therapy with antifungal agents can effectively alleviate oropharyngeal candidiasis by inhibiting hyphal growth and reducing fungal burden in tissues.
Article
Pharmacology & Pharmacy
Carlos Jose Dias, Herikson Araujo Costa, Carlos Alberto Alves Dias-Filho, Andressa Coelho Ferreira, Bruno Rodrigues, Maria Claudia Irigoyen, Antonio Carlos Romao Borges, Vicenilma de Andadre Martins, Flavia Castello Branco Vidal, Rachel Melo Ribeiro, Natalino Salgado Filho, Cristiano T. Mostarda
Summary: The use of carvacrol in spontaneously hypertensive rats (SHR) showed antihypertensive effects and increased expression of MAS receptors in kidney tissue.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andressa Coelho Ferreira, Carlos Alberto Alves Dias-Filho, Nivaldo de Jesus Silva Soares Junior, Carlos Jose Dias, Sally Cristina Moutinho Monteiro, Rafael Martins Andrade, Cristiano Teixeira Mostarda
Summary: Cardiac channelopathies are a group of inherited cardiac diseases that are associated with mutations in genes encoding cardiac ion channels. The two main hereditary arrhythmias in children and adolescents, Brugada Syndrome and Long QT Syndrome, show different clinical manifestations. Brugada Syndrome is more commonly observed in this population and is characterized by episodes of syncope or sudden cardiac death. On the other hand, Long QT Syndrome has a milder phenotype but requires monitoring and correction of electrolyte disturbances.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemical Research Methods
Lina M. Marin, Jaime A. Cury, Walter L. Siqueira
Summary: In this study, an in vitro cariogenic Streptococcus mutans biofilm model was modified and validated by assessing the dose-response effect of fluoride on enamel demineralization. The model demonstrated a dose-response effect of fluoride in influencing enamel demineralization, showing the potential for assessing novel biotechnological strategies for caries prevention.
JOURNAL OF MICROBIOLOGICAL METHODS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sreenath Madathil, Walter L. Siqueira, Lina M. Marin, Farisa Banu Sanaulla, Nancy Faraj, Carlos R. Quinonez, Mary McNally, Michael Glogauer, Paul Allison
Summary: This study estimated the COVID-19 incidence rates among Canadian dentists and found a low infection rate, which should be reassuring to both dentists and the general community. It emphasizes the importance of continued disease surveillance data collection.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Patricia Luciana Serra Nunes, Filipe Atahide Fonseca, Luiz Renato Paranhos, Cauane Blumenberg, Valentim Adelino Ricardo Barao, Elizabeth Soares Fernandes, Rebeca Garcia Ferreira, Walter Luiz Siqueira, Michelle Foigel Siqueira, Eduardo Buozi Moffa
Summary: Mucopolysaccharidosis (MPS) is a rare genetic disorder resulting from deficiency of lysosomal enzymes. The study found that the salivary levels of nitric oxide (NO) products can be used to monitor MPS disorders.
BRAZILIAN ORAL RESEARCH
(2022)
Article
Infectious Diseases
Aline Michelle Silva Mendonca, Cristina de Andrade Monteiro, Roberval Nascimento Moraes-Neto, Andrea Souza Monteiro, Renata Mondego-Oliveira, Camila Evangelista Carnib Nascimento, Luis Claudio Nascimento da Silva, Lidio Goncalves Lima-Neto, Rafael Cardoso Carvalho, Eduardo Martins de Sousa
Summary: The study found that pomegranate extracts have antifungal and antibiofilm effects, with promising potential for reducing Candida phospholipase production.
Review
Medicine, General & Internal
Pedro Urquiza Jayme Silva, Millena Barroso Oliveira, Walbert Vieira, Sergio Vitorino Cardoso, Cauane Blumenberg, Ademir Franco, Walter Luiz Siqueira, Luiz Renato Paranhos
Summary: The outcomes of this study suggest that the occurrence of oral pigmentation induced by chloroquine or hydroxychloroquine is associated with the dosage and treatment length, with a higher risk observed in long-term treatment with higher dosages.
Article
Microbiology
Lina Maria Marin, Yizhi Xiao, Jaime Aparecido Cury, Walter Luiz Siqueira
Summary: The engineered salivary peptide DR9-RR14 has been shown to effectively reduce enamel demineralization, but has no significant impact on biofilm biomass or the expression of cariogenic bacterial proteins. This suggests that DR9-RR14 may primarily control caries development through a physicochemical mechanism.
Article
Clinical Neurology
Nivaldo de Jesus Silva Soares Junior, Carlos Alberto Alves Dias-Filho, Andressa Coelho Ferreira, Sally Cristina Moutinho Monteiro, Henrique de Oliveira Castro, Mayra Santos Silva, Cristiano T. Mostarda
Summary: This study aimed to examine the impact of physical activity on heart rate variability and cardiovascular parameters in adolescents. The results showed that adolescents who regularly engaged in physical activity had better heart rate variability and sleep quality compared to sedentary adolescents.
SLEEP AND BREATHING
(2023)
Article
Biotechnology & Applied Microbiology
Andressa Coelho Ferreira, Maria Rosa Quaresma Bomfim, Carlos Henrique de Barros da Costa Sobrinho, Daniela Talissa Lobo Boaz, Railane Da Silva Lira, Valeria Costa Fontes, Mariana Oliveira Arruda, Patricia Maria Wiziack Zago, Carlos Alberto Alves Dias Filho, Carlos Jose Moraes Dias, Marilene Oliveira da Rocha Borges, Rachel Melo Ribeiro, Cicero Wellington Brito Bezerra, Rosiane Silva Penha
Summary: This study aims to produce, characterize, and assess the antimicrobial activity and cytotoxicity of polymer blends based on chitosan and fish collagen. The results showed that these polymer blends have good biocompatibility and antimicrobial activity, making them suitable for biomedical applications.
Review
Dentistry, Oral Surgery & Medicine
Paras Ahmad, Ahmed Hussain, Alonso Carrasco-Labra, Walter L. Siqueira
Summary: Salivary proteins play an important role in the repair of damaged tissues and the maintenance of oral health. This systematic review aimed to assess the association between caries and salivary proteins by comparing caries-free (CF) and caries-active (CA) individuals. The results showed that the levels of certain salivary proteins were significantly increased in CA patients, while others were significantly increased in CF subjects. However, there were conflicting results regarding the salivary levels of immunoglobulin-A and total proteins among CA and CF subjects. Due to significant heterogeneity among the included studies, no meta-analysis could be performed. Therefore, larger prospective studies are needed to verify the diagnostic value of salivary proteins as biomarkers for caries.
Article
Biochemistry & Molecular Biology
Anderson Franca da Silva, Josivan Regis Farias, Danielle Cristine Gomes Franco, Andrea Araruna Galiza, Elizangela Pestana Motta, Aluisio da Silva Oliveira, Cleydlenne Costa Vasconcelos, Maria do Socorro de Sousa Cartagenes, Claudia Quintino da Rocha, Mayara Cristina Pinto da Silva, Alberto Jorge Oliveira Lopes, Flavia Raquel Fernandes do Nascimento, Cristina Andrade Monteiro, Rosane Nassar Meireles Guerra
Summary: This study investigated the antifungal activity of ononin using in silico and in vitro assays as well as an alternative in vivo model. The results suggested that ononin has anti-Candida albicans activity and could be a potential candidate for new therapeutic alternatives.
Article
Infectious Diseases
Elizangela Pestana Motta, Josivan Regis Farias, Arthur Andre Castro da Costa, Anderson Franca da Silva, Alberto Jorge Oliveira Lopes, Maria do Socorro Sousa Cartagenes, Roberto Nicolete, Afonso Gomes Abreu, Elizabeth Soares Fernandes, Flavia Raquel Fernandes Nascimento, Claudia Quintino da Rocha, Cristina Andrade Monteiro, Rosane Nassar Meireles Guerra
Summary: This study evaluated the anti-Candida activity of the hydroalcoholic extract from the leaves of Vismia guianensis and found that it inhibited the virulence factors of the fungi. The main compound responsible for this activity was identified as vismione D.
Article
Chemistry, Medicinal
Monaliza Teresa Campos Sodre, Fernanda Avelino Ferraz, Amanda Karoline Vieira Alencar, Karinny Farias Silva, Douglas Henrique dos Santos Silva, Lucas dos Santos Silva, Jessica Silva dos Santos Araujo Carneiro, Cristina Andrade Monteiro, Luis Claudio Nascimento Silva, Andrea de Souza Monteiro
Summary: This study evaluated the potential of lactic acid bacteria (LAB) in developing alginate-based gel formulations to inhibit Staphylococcus aureus. The highest activity was observed with Lactiplantibacillus plantarum ATCC 14917. The formulated alginate gel with 10% L. plantarum ATCC 14917 showed inhibitory effects on S. aureus growth.
Article
Clinical Neurology
Carlos Jose Dias, Rodrigo Barroso, Carlos Alberto Alves Dias-Filho, Andressa Coelho Ferreira, Christian Emmanuel Torres Cabido, Carlos C. Crestani, Mayra Santos Silva, Alcimar Nunes Pinheiro, Bruno Rodrigues, Tiano Teixeira Mostarda
Summary: This study found that vitamin D deficiency has a negative impact on sleep quality, depression, anxiety, and physiological stress in patients with chronic obstructive pulmonary disease (COPD).
