Article
Allergy
Christian Rosas-Salazar, Kyle S. Kimura, Meghan H. Shilts, Britton A. Strickland, Michael H. Freeman, Bronson C. Wessinger, Veerain Gupta, Hunter M. Brown, Seesandra V. Rajagopala, Justin H. Turner, Suman R. Das
Summary: This study found complex associations between SARS-CoV-2 infection and the URT microbiome in adults, with viral load potentially impacting bacterial abundance. Further research is needed to explore how these viral-bacterial interactions can affect the clinical progression of COVID-19.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Konstantina Athanasopoulou, Panagiotis G. G. Adamopoulos, Andreas Scorilas
Summary: Over 10(14) symbiotic microorganisms in a healthy human body are responsible for important synthesis and support of the immune system. However, microbial deregulation can lead to various diseases. The human gastrointestinal tract is a favorable environment for diverse microbes. The gut microbiome, the largest microbiome community in the human body, has been extensively studied for its medical significance. Advances in sequencing techniques have enabled the detection of microbiomes and opened new avenues in studying human microbiota. The present review emphasizes the complexity of the gastrointestinal tract microbiome and its implications in cellular homeostasis and human diseases.
Review
Cell Biology
Carolin Baehren, Eleni Buedding, Aliyah Bellm, Frank Schult, Anton Pembaur, Stefan Wirth, Anja Ehrhardt, Friedrich Paulsen, Jan Postberg, Malik Aydin
Summary: This review discusses the roles of bacteria, fungi, and archaea in the upper respiratory tract microbiome, as well as their relationship with respiratory diseases and atopic disorders. The aim is to summarize the latest contributions in this field published in the past decade and to establish a bridge between basic and clinical science.
Article
Ecology
Zi-Wen Yang, Yu Men, Jing Zhang, Zhi-Hui Liu, Jiu-Yang Luo, Yan-Hui Wang, Wen-Jun Li, Qiang Xie
Summary: The study found that air dried preservation method had poor effects on insect microbiome samples, while RNAlater was not suitable for longer field works. CTAB and ethanol were recommended as more effective and cost-efficient preservatives. Additionally, NGS sequencing of the V4 region of the 16S rRNA gene had lower resolution compared to TGS sequencing, potentially leading to misestimations of microbial community compositions.
Article
Immunology
Gregory L. Damhorst, Max W. Adelman, Michael H. Woodworth, Colleen S. Kraft
Summary: There is increasing recognition of the significance of the gut microbiome in human health and disease. Traditional and modern technologies have advanced our knowledge in this field, but standardizing the language and metrics for characterizing the microbiome is still a work in progress. The capabilities of gut microbiome-based diagnostics are promising for clinical applications, with selected examples demonstrating their potential impact.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Hui Li, Xiaorong Wu, Hong Zeng, Bozhen Chang, Ying Cui, Jingxiang Zhang, Ruixia Wang, Tao Ding
Summary: This study found that respiratory viral infections are associated with viral type-specific disruption of the upper respiratory microbiota. Influenza virus infections are uniquely linked with increased microbial diversity and growth rates of specific pathogens. These findings are important for understanding the differences and dynamics of respiratory microbiota in healthy participants and acute respiratory viral infections, and provide insights into the pathogenesis of viral-host-bacterial interactions for future studies on effective prevention and treatment of respiratory tract infections.
Article
Agronomy
Jiamin Gao, Shi Chen, Yang Wang, Jiejun Qi, Xiaomeng Li, Gehong Wei, Shuo Jiao
Summary: This study revealed the differences in microbial communities in the lateral roots with/without nodules and identified a keystone ecological cluster positively linking with multiple functional cycling.
Article
Biochemical Research Methods
Emira Cherif, Fatou Seck Thiam, Mohammad Salma, Georgina Rivera-Ingraham, Fabienne Justy, Theo Deremarque, Damien Breugnot, Jean-Claude Doudou, Rodolphe Elie Gozlan, Marine Combe
Summary: This article introduces an amplicon-based nanopore sequencing pipeline for analyzing the genetic diversity of SARS-CoV-2 and other pathogens. The pipeline integrates multiple bioinformatics tools, allowing users with minimal bioinformatics skills to perform downstream analysis steps with a simple command line and configuration file.
Review
Infectious Diseases
Shantelle Claassen-Weitz, Katherine Y. L. Lim, Christopher Mullally, Heather J. Zar, Mark P. Nicol
Summary: The study found an association between upper respiratory tract bacteria and lower respiratory tract infection in young children, with H. influenzae and Klebsiella spp. showing higher detection rates in cases. Further longitudinal studies are needed to better understand the pathogenesis of childhood lower respiratory tract infections.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Microbiology
Minqiang Su, Yuanhang She, Ming Deng, Yongqing Guo, Yaokun Li, Guangbin Liu, Baoli Sun, Dewu Liu
Summary: This study investigated the effect of capsaicin (CAP) on the health of nursing calves under group housing conditions. The results showed that high doses of CAP decreased calf respiratory scores and improved antioxidant capacity and immune capacity. CAP also improved gut fermentation and regulated the upper respiratory microbiota. These findings suggest that CAP can benefit the healthy growth of calves.
Article
Biochemistry & Molecular Biology
Xiangning Bai, Aswathy Narayanan, Magdalena Skagerberg, Rafael Cena-Diez, Christian G. Giske, Kristoffer Stralin, Anders Sonnerborg
Summary: This study reveals correlations between the upper respiratory tract microbiome and clinical outcomes in COVID-19 patients, particularly a strong association between Moraxella lincolnii and vitamin K2 biosynthesis pathways with better clinical results.
Article
Biochemistry & Molecular Biology
Jana Rihova, Giampiero Batani, Sonia Maria Rodriguez-Ruano, Jana Martinu, Frantisek Vacha, Eva Novakova, Vaclav Hypsa
Summary: The phylogenetic diversity of symbiotic bacteria in sucking lice plays a crucial role, with different obligate symbionts established in different louse groups. Research reveals that lice have a unique capacity to acquire symbionts from diverse groups of bacteria during their evolution.
Article
Microbiology
Tara Davis, Dagmara Bialy, Joy Leng, Roberto La Ragione, Holly Shelton, Klaudia Chrzastek
Summary: The diversity of gut and respiratory microbiota in chickens is related to H9N2 avian influenza virus (AIV) infection. In the acute phase of infection, the diversity of respiratory microbiota decreases, and it does not fully recover to normal levels in the recovery phase after infection. Lactobacillus is associated with the microbiota of infected chickens at different stages of infection. Additionally, the respiratory microbiota in chickens undergoes age-related changes during maturation.
Review
Oncology
Paul Vinu Salachan, Karina Dalsgaard Sorensen
Summary: The role of microbiota in human health and disease, including cancer types, is established, but its specific role in prostate cancer development, progression, and treatment response is less understood. The lack of better risk stratification tools may be due to gaps in knowledge regarding bacterial infections and inflammation signatures as risk factors. Further research is needed to find the biological link between microbiome and prostate carcinogenesis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Microbiology
Da-Ryung Jung, Hye-Young Yoo, Min-Ji Kim, Vineet Singh, Sung-Ha Park, Minsoo Jeong, Byoung-Jun Park, Jae-Ho Shin
Summary: This study investigated the potential link between skin-gut microorganisms and androgenetic alopecia (AGA) by analyzing the scalp and gut microbiomes of individuals with and without AGA. The findings suggest that the appearance of non-inhabitant bacteria in the scalp increases as hair loss progresses. Bacterial functional differences were also observed in the gut microbiomes of AGA patients, indicating a potential involvement in intestinal homeostasis. Additionally, the networks of the scalp and gut microbiomes were more complex and dense in AGA patients.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Otorhinolaryngology
Griet Mertens, Paul Van de Heyning, Olivier Vanderveken, Vedat Topsakal, Vincent Van Rompaey
Summary: The study demonstrates that there is a significant linear correlation between frequency-to-place mismatch and speech perception in noise six months after cochlear implantation. Minimizing this mismatch can lead to better initial speech perception outcomes for cochlear implant recipients. However, the effect seems to disappear after twelve months of experience with the cochlear implant. Additional research is needed to explore tonotopic fitting strategies based on postoperative CT images of electrode contact locations.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Review
Otorhinolaryngology
Marie-Helene Uwents, Catherine Jorissen, Angelique van Ombergen, Bieke Dobbels, Raymond van de Berg, Sebastien Janssens de Varebeke, Marc Lammers, Veerle Ross, Olivier Vanderveken, Tom Brijs, Vincent van Rompaey
Summary: The systematic review aimed to identify and evaluate studies on driving performance of dizzy patients or patients with a vestibular disorder. Most included studies reported a negative impact of dizziness or vestibular disorders on self-reported driving ability and car accidents, but some studies did not find any impairment of driving ability. Further research is needed to establish a causal relationship between dizziness and driving ability.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Clinical Neurology
Pien F. N. Bosschieter, Nico de Vries, Reena Mehra, Shalini Manchanda, Tapan A. Padhya, Olivier M. Vanderveken, M. J. L. Ravesloot
Summary: Based on data from the ADHERE Registry, this study found that upper airway stimulation (UAS) is an effective treatment for patients with obstructive sleep apnea (OSA) and an apnea-hypopnea index (AHI) of 15 events/h or higher. The study also concluded that there are no significant differences in self-reported outcomes and treatment success among different subgroups based on OSA severity.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Clinical Neurology
Daniel Vena, Luigi Taranto-Montemurro, Ali Azarbarzin, Sara Op de Beeck, Melania Marques, Olivier M. Vanderveken, Bradley A. Edwards, Laura Gell, Nicole Calianese, Lauren B. Hess, Reza Radmand, Garun S. Hamilton, Simon A. Joosten, Johan Verbraecken, Marc Braem, David P. White, Susan Redline, Scott A. Sands, Andrew Wellman
Summary: Among several candidates, event depth, Fhypopneas, and apnea index were identified as preferred pharyngeal collapsibility surrogates for use in the clinical arena.
Article
Medicine, Research & Experimental
Sara Demoen, Laure Jacquemin, Annick Timmermans, Vincent Van Rompaey, Olivier Vanderveken, Hanne Vermeersch, Iris Joossen, Julie Van Eetvelde, Winfried Schlee, Wim Marneffe, Janis Luyten, Annick Gilles, Sarah Michiels
Summary: This study aims to investigate the effectiveness and cost-effectiveness of a blended physiotherapy program for somatic tinnitus, incorporating both physiotherapy treatment and a smartphone application for exercise therapy compliance and tinnitus counselling. A randomized controlled trial will be conducted with adult patients diagnosed with ST, with primary outcome measure being the change in Tinnitus Functional Index (TFI) score. The study expects to empower ST patients to improve their health and potentially reduce economic costs associated with tinnitus burden.
Article
Infectious Diseases
Cindy Simoens, Tarik Gheit, Ruediger Ridder, Ivana Gorbaslieva, Dana Holzinger, Eric Lucas, Susanne Rehm, Peter Vermeulen, Martin Lammens, Olivier M. Vanderveken, Rekha Vijay Kumar, Nitin Gangane, Alessandro Caniglia, Fausto Maffini, Maria Belen Lloveras Rubio, Devasena Anantharaman, Susanna Chiocca, Paul Brennan, Madhavan Radhakrishna Pillai, Rengaswamy Sankaranarayanan, Johannes Bogers, Michael Pawlita, Massimo Tommasino, Marc Arbyn
Summary: This study analyzed the accuracy of three testing strategies for diagnosing HPV-induced oropharyngeal cancer. Single hrHPV DNA PCR and p16(INK4a) IHC showed high sensitivity, but low specificity, while combined testing had higher sensitivity and specificity.
BMC INFECTIOUS DISEASES
(2022)
Article
Otorhinolaryngology
J. Mortier, J. van den Ende, F. Declau, H. Vercruysse, W. Wuyts, G. Van Camp, O. Vanderveken, An Boudewyns
Summary: This study describes the phenotype of children with unilateral isolated microtia and congenital aural atresia (CAA) and searches for a common genetic cause through DNA analysis. The most common phenotype observed was type III microtia combined with type 2b CAA. Copy number variant (CNV) analysis did not reveal any abnormalities.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Clinical Neurology
Clemens Heiser, Armin Steffen, Patrick J. Strollo, Claire Giaie-Miniet, Olivier M. Vanderveken, Benedikt Hofauer
Summary: This study compared the effectiveness of hypoglossal nerve stimulation (HNS) and positive airway pressure (PAP) therapy for treating obstructive sleep apnea (OSA). Through propensity score matching, no significant differences in outcomes were found between the two treatments. However, patients treated with HNS experienced significantly greater improvements in daytime sleepiness after 12 months.
SLEEP AND BREATHING
(2023)
Article
Otorhinolaryngology
Margot Baudelet, Frederic Duprez, Leen Van den Steen, Sandra Nuyts, Daan Nevens, Ann Goeleven, Caroline Vandenbruaene, Hanne Massonet, Alice Vergauwen, Heleen Bollen, Sarah Deschuymer, Kristien Wouters, Marc Peeters, Carl Van Laer, Steven Marien, Michiel Van den Brekel, Lisette van der Molen, Tom Vauterin, Joost van Dinther, Hilde Verstraete, Isabel Hutsebaut, Sabine Meersschout, Olivier Vanderveken, Marc De Bodt, Gwen Van Nuffelen
Summary: This multicenter RCT investigated the effect of three different service-delivery modes on patients' adherence to prophylactic swallowing exercises during radiotherapy. The study found that adherence decreased over time in all groups, but the therapist-supported group achieved the highest adherence rates. Increasing face-to-face contact with a speech-language therapist can overcome the problem of low adherence in this population.
Review
Clinical Neurology
Zhengfei Huang, Ning Zhou, Frank Lobbezoo, Fernanda R. Almeida, Peter A. Cistulli, Marijke Dieltjens, Nelly T. Huynh, Takafumi Kato, Gilles J. Lavigne, Jean-Francois Masse, Benjamin T. Pliska, Liza van de Rijt, Kate Sutherland, Magdalini Thymi, Olivier M. Vanderveken, Ralph de Vries, Ghizlane Aarab
Summary: This scoping review identified previously unidentified dental sleep-related conditions and highlighted the significant role of oral healthcare providers in the prevention, assessment, and management of dental sleep-related conditions in adults.
SLEEP MEDICINE REVIEWS
(2023)
Review
Health Care Sciences & Services
Sara Demoen, Antonios Chalimourdas, Annick Timmermans, Vincent Van Rompaey, Olivier M. Vanderveken, Laure Jacquemin, Winfried Schlee, Wim Marneffe, Janis Luyten, Annick Gilles, Sarah Michiels
Summary: This systematic review aimed to provide an overview of the research concerning the effectiveness of telerehabilitation interventions for self-management of tinnitus. The results showed that telerehabilitation interventions can effectively reduce the severity and distress of tinnitus, but high dropout rates and study bias need to be addressed.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Otorhinolaryngology
Ellen Andries, Joyce Bosmans, Sebastiaan Engelborghs, Patrick Cras, Olivier M. Vanderveken, Marc J. W. Lammers, Paul H. van de Heyning, Vincent Van Rompaey, Griet Mertens
Summary: This study demonstrates that cochlear implantation can improve cognitive functioning and speech perception in older adults with severe hearing loss who are at risk for mild cognitive impairment (MCI).
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Review
Otorhinolaryngology
Vincent Van Rompaey, Hanne Gommeren, Joyce Bosmans, Dorien Verdoodt, Sebastien Janssens de Varebeke, Erik de Vrieze, Ronald Pennings, Raymond Van de Berg, Marc Lammers, Olivier Vanderveken, Erik Fransen, Guy Van Camp, Erwin Van Wijk
Summary: DeaFNess Autosomal Dominant 9 is a form of autosomal dominant hereditary non-syndromic hearing loss often accompanied by vestibular dysfunction. It is caused by pathogenic variants in the COCH gene. The recent discovery of homozygous pathogenic variants in the COCH gene has led to the identification of a new autosomal recessive disorder called DFNB110. Cochlear implantation should be considered for patients who no longer benefit from a hearing aid. This review highlights recent insights and future perspectives related to DeaFNess Autosomal Dominant 9 and DFNB110.
Meeting Abstract
Critical Care Medicine
S. Op De Beeck, D. Vena, D. Mann, A. Azarbarzin, L. Gell, E. Van De Perck, R. M. Alex, M. Dieltjens, M. Willemen, J. Verbraecken, D. Wellman, O. M. Vanderveken, S. A. Sands
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Otorhinolaryngology
Gilles Van Haesendonck, Catherine Jorissen, Marc Lammers, Ibrahim Ocak, Tomas Menovsky, Sorcha Ni Dhubhghaill, Olivier M. Vanderveken, Vincent Van Rompaey, Callum Faris
Summary: The aim of this study was to provide a concise review of international standards in the initial management of facial palsy and give guidelines and indications for referral to a tertiary facial nerve center. While facial nerve palsy is rare, accurate diagnosis and early treatment are crucial in order to avoid harmful consequences and ensure timely intervention. The complexity of facial palsy management necessitates a multidisciplinary team with specific focus.