Article
Microbiology
Jacob J. J. Haffner, Mitchelle Katemauswa, Therese S. Kagone, Ekram Hossain, David Jacobson, Karina Flores, Adwaita R. R. Parab, Alexandra J. J. Obregon-Tito, Raul Y. Y. Tito, Luis Marin Reyes, Luzmila Troncoso-Corzo, Emilio Guija-Poma, Nicolas Meda, Helene Carabin, Tanvi P. P. Honap, Krithivasan Sankaranarayanan, Cecil M. M. Lewis, Laura-Isobel McCall
Summary: As industrialization progresses, understanding the biological consequences of lifestyle shifts and their impact on human health is crucial. This study characterizes the shared human fecal metabolome across populations from Africa and the Americas, highlighting the influence of industrialization on this metabolome. The findings demonstrate that industrialization significantly affects the human fecal metabolome, but there are still shared features among diverse human lifestyles.
Article
Immunology
Wiwat Chancharoenthana, Supitcha Kamolratanakul, Peerapat Visitchanakun, Supistha Sontidejkul, Thanya Cheibchalard, Naraporn Somboonna, Sarn Settachaimongkon, Asada Leelahavanichkul
Summary: The impacts of metabolomic changes in uremic condition are not fully understood. In a mouse experiment, Candida administration worsened the condition of uremic mice and induced leaky gut, while the administration of SCFA-producing probiotics attenuated these effects. Overall, the use of probiotics in uremia is supported.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Respiratory System
Wen-Wen Wang, Bei Mao, Yang Liu, Shu-Yi Gu, Hai-Wen Lu, Jiu-Wu Bai, Shuo Liang, Jia-Wei Yang, Jian-Xiong Li, Xiao Su, Hai-Yang Hu, Chen Wang, Jin-Fu Xu
Summary: This study utilized a multi-omics approach to identify differences in gut microbiota and metabolic profiles between bronchiectasis patients and healthy volunteers. It revealed the potential of gut microbiota as biomarkers for bronchiectasis.
RESPIRATORY RESEARCH
(2022)
Article
Microbiology
Yun Li, Yuting Cai, Qian Huang, Wei Tan, Bingyan Li, Haixiang Zhou, Zicong Wang, Jingling Zou, Chun Ding, Bing Jiang, Shigeo Yoshida, Yedi Zhou
Summary: This study found significant alterations in gut microbiota and fecal metabolome in a CNV mouse model, with certain microbes showing significant upregulation. Fecal metabolomics identified 73 altered metabolites, with significant correlations between some altered metabolites and gut microbiota genera. KEGG analysis revealed six pathways associated with these altered metabolites.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zheng Zhang, Xiao Chen, Bo Cui
Summary: Manipulating the intestinal microbiome with resistant dextrin shows promise in ameliorating high-fat diet-induced hepatic steatosis, improving hepatic mitochondrial integrity, and reducing oxidative stress. Resistant dextrin alters the fecal microbial composition and metabolites, influencing pathways related to bile acids, tryptophan metabolism, and lipid metabolism, while also decreasing inflammatory cytokine levels and intestinal damage.
Article
Gastroenterology & Hepatology
Zlatan Mujagic, Melpomeni Kasapi, Daisy M. A. E. Jonkers, Isabel Garcia-Perez, Lisa Vork, Zsa Zsa R. M. Weerts, Jose Ivan Serrano-Contreras, Alexandra Zhernakova, Alexander Kurilshikov, Jamie Scotcher, Elaine Holmes, Cisca Wijmenga, Daniel Keszthelyi, Jeremy K. Nicholson, Joram M. Posma, Ad A. M. Masclee
Summary: Combining microbiome and metabolome data can distinguish between irritable bowel syndrome (IBS) patients and healthy controls. Unsupervised clustering based on fecal microbiome-metabolome data revealed distinct subsets of IBS patients. The study also found associations between altered serotonin metabolism, unfavorable stress response related to gastrointestinal symptoms, and IBS, supporting the importance of the microbiome-gut-brain axis in the pathogenesis of IBS.
Article
Genetics & Heredity
Chuan Qin, Zhenghao Chen, Rui Cao, Mingjun Shi, Ye Tian
Summary: This study identified significant dysregulation of gut microbiomes and metabolites in Chinese bladder cancer patients, presenting potential causative relationships between gut dysbiosis, dysregulated metabolites, and bladder cancer. The integrative analysis revealed interactions between gut microbiota and metabolites as well as associations between specific gut microbiomes and metabolites.
Article
Microbiology
Jingjing Liu, Mingyang Qi, Chengchao Qiu, Feng Wang, Shaofei Xie, Jian Zhao, Jing Wu, Xiaofeng Song
Summary: The gut microbiome and its interaction with the host play important roles in the pathogenesis of colorectal cancer (CRC). This study investigated the compositions of gut bacteria and their interactions with the host during the early stages of inflammation and CRC. The results revealed significant variations in gut microbiota abundance and composition, as well as specific fecal metabolome profiling in CRC and inflammation. The identification of potential biomarkers for CRC and inflammation contributes to the diagnosis of these conditions. The integrated microbiome and metabolomic analysis suggests that microbes facilitate tumorigenesis of CRC through interfering with host metabolism.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Hewei Xu, Nebiyu Elias Tamrat, Jie Gao, Jie Xu, Yiduo Zhou, Sicong Zhang, Zhengsen Chen, Yunpeng Shao, Liucheng Ding, Baixin Shen, Zhongqing Wei
Summary: The study used microbiome and metabolome analysis to investigate urine signatures in IC patients, revealing upregulation of opportunistic pathogen genera and altered metabolite signatures. These findings suggest potential diagnostic markers for IC in the combined signatures of urine microbiome and metabolome.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
So-Young Choi, Bong-Hwan Choi, Ji-Hye Cha, Yeong-Jo Lim, Sunirmal Sheet, Min-Ji Song, Min-Jeong Ko, Na-Yeon Kim, Jong-Seok Kim, Seung-Jin Lee, Seok-Il Oh, Won-Cheoul Park
Summary: This study investigated the differences in fecal microbiome between different growth stages of Jindo dogs and discovered compositional and functional variations between genes of the gut microbial population in juveniles and adults. These microbial community profiles can be used as references for future research on the microbiome associated with health and development in the canine population.
Article
Evolutionary Biology
Dayong Li, Wancai Xia, Xinyuan Cui, Mei Zhao, Kai Huang, Xueyu Wang, Jian Shen, Hua Chen, Lifeng Zhu
Summary: Physiological adaptations of animals living in high-altitude environments might be associated with gut microbial response, as observed in high concentration of stercobilin in the feces of macaques from high-altitude regions. The high-altitude mammal population showed enrichment of gut microbes involved in urobilinogen reduction compared to the low-altitude population. The spatial-temporal change in gut microbial function was more profound in low-altitude macaques, possibly due to changes in food resources.
EVOLUTIONARY APPLICATIONS
(2023)
Article
Physiology
Xinhao Du, Qing Li, Zhenzhen Tang, Li Yan, Ling Zhang, Qiao Zheng, Xianghao Zeng, Guimei Chen, Huawen Yue, Jun Li, Ming Zhao, Yuan-Ping Han, Xiangsheng Fu
Summary: The gut microbiota and fecal metabolome of colorectal cancer patients were significantly different from those of normal controls. Specific changes in microbial composition and metabolite levels were associated with the progression of colorectal cancer.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Ylaine Gerardin, Sonia Timberlake, Jessica R. Allegretti, Mark B. Smith, Zain Kassam
Summary: The transfer of live gut microbes may revolutionize the treatment of various diseases, with fecal microbiota transplantation showing early success in certain infections. The development of microbiome drugs is now being driven by these clinical advances, although challenges remain in terms of safety, consistency, and delivery.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemical Research Methods
Tao Sun, Mengci Li, Xiangtian Yu, Dandan Liang, Guoxiang Xie, Chao Sang, Wei Jia, Tianlu Chen
Summary: In this study, we designed and developed a comprehensive platform, 3MCor, for the correlation analysis of metabolome and microbiome. The platform integrates multiple correlation analysis methods and provides three different pipelines for inter-correlation analysis. The network analysis function facilitates the rapid identification of clusters and key nodes in complex correlation networks. The platform is easy to use and provides numerical results and figures as outputs.
Article
Biochemistry & Molecular Biology
David S. Wishart, Eponine Oler, Harrison Peters, AnChi Guo, Sagan Girod, Scott Han, Sukanta Saha, Vicki W. Lui, Marcia LeVatte, Vasuk Gautam, Rima Kaddurah-Daouk, Naama Karu
Summary: The Human Microbial Metabolome Database (MiMeDB) is a comprehensive multi-omic microbiome resource that connects microorganisms, microbial genomes, microbial metabolites, the human exposome, and human health. It contains detailed taxonomic and microbiological data on human microbes, linked to genomic and proteomic sequence data. The database also includes information about metabolites, reactions, enzymes, and exposure sources, as well as health effects and protein targets. MiMeDB aims to enable comprehensive multi-omic integration and is designed to be easy to search, browse, and navigate.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Neurosciences
Honghuang Lin, Claudia Satizabal, Zhijun Xie, Qiong Yang, Tianxiao Huan, Roby Joehanes, Chengping Wen, Peter J. Munson, Alexa Beiser, Daniel Levy, Sudha Seshadri
MOLECULAR NEURODEGENERATION
(2017)
Article
Biochemistry & Molecular Biology
Lin Huang, Duoli Xie, Yiran Yu, Huanlong Liu, Yan Shi, Tieliu Shi, Chengping Wen
NUCLEIC ACIDS RESEARCH
(2018)
Article
Chemistry, Organic
Yi Li, Li Wei, Jie-Ping Wan, Chengping Wen
Review
Oncology
Lin Huang, Haichang Li, Duoli Xie, Tieliu Shi, Chengping Wen
Article
Pharmacology & Pharmacy
Yang Zhang, Lifeng Shen, Zhujun Mao, Nani Wang, Xuping Wang, Xiaowen Huang, Ying Hu, Dan Shou, Chengping Wen
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Cell Biology
Yimin Yang, Ying Zhang, Yanhua Li, Lili Ding, Lulu Sheng, Zhijun Xie, Chengping Wen
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Pharmacology & Pharmacy
Xueqin Huang, Chengping Wen, Hua Wei
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2018)
Article
Chemistry, Medicinal
Xuping Wang, Rongzong Zheng, Xiaowen Huang, Zhujun Mao, Nani Wang, Hongyu Li, Chengping Wen, Dan Shou
PHYTOTHERAPY RESEARCH
(2018)
Article
Chemistry, Organic
Jie-Ping Wan, Shuo Cao, Changfeng Hu, Chengping Wen
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Immunology
Jie Yu, Haimei Lu, Jia Zhou, Zhijun Xie, Chengping Wen, Zhenghao Xu
INFLAMMOPHARMACOLOGY
(2018)
Article
Chemistry, Organic
Lu Yang, Yuwei Wu, Yiming Yang, Chengping Wen, Jie-Ping Wan
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Duoli Xie, Lin Huang, Guanghui Zhao, Yiran Yu, Jiawei Gao, Haichang Li, Chengping Wen
SCIENTIFIC REPORTS
(2017)
Correction
Immunology
Jie Yu, Haimei Lu, Jia Zhou, Zhijun Xie, Chengping Wen, Zhenghao Xu
INFLAMMOPHARMACOLOGY
(2019)
Article
Integrative & Complementary Medicine
Sun Jing, Shao Tie-juan, Zhang Dong-yu, Huang Xue-qin, Xie Zhi-jun, Wen Cheng-ping
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2018)
