Editorial Material
Biochemistry & Molecular Biology
Rodrigo J. Gonzalez, Ulrich H. von Andrian
Summary: The interaction between GPR35 receptor and 5-HIAA serotonin metabolite promotes the recruitment of neutrophils from blood into inflamed tissues, which is significant for inflammation and anti-microbial host defense.
Article
Cell Biology
Avin Hawez, Dler Taha, Anwar Algaber, Raed Madhi, Milladur Rahman, Henrik Thorlacius
Summary: The study found that miR-155 regulates pulmonary formation of NETs in abdominal sepsis via up-regulation of PAD4 and histone 3 citrullination, suggesting that targeting miR-155 could be an effective approach to reduce pulmonary damage in abdominal sepsis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhiyi Ding, Feifei Du, Richard Garland Averitt, Gabriel Jakobsson, Carl-Fredrik Ronnow, Milladur Rahman, Alexandru Schiopu, Henrik Thorlacius
Summary: Blocking S100A9 function can attenuate neutrophil infiltration and edema formation in sepsis-induced lung injury, inhibit the up-regulation of Mac-1 on neutrophils, and decrease the levels of CXC chemokines in circulation and lungs. These findings suggest that targeting S100A9 could be a useful strategy to protect against excessive inflammation and lung damage in sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Sreelakshmi N. Menon, Farzana Zerin, Emmanuella Ezewudo, Nimi P. Simon, Sreeranjini N. Menon, Morgan L. Daniel, Andrea J. Green, Ajay Pandey, Charles E. Mackay, Sherif Hafez, Nader H. Moniri, Raquibul Hasan
Summary: Neflamapimod effectively inhibits endothelial cell activation, adhesion molecule expression, and leukocyte attachment, thereby reducing vascular inflammation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Feifei Du, Zhiyi Ding, Carl-Fredrik Ronnow, Milladur Rahman, Alexandru Schiopu, Henrik Thorlacius
Summary: Recent evidence suggests that targeting S100A9 could reduce pathological inflammation in abdominal sepsis by triggering ROS-dependent formation of NETs via TLR4 and RAGE signaling in neutrophils.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Stefan J. Schunk, Sarah Triem, David Schmit, Stephen Zewinger, Tamim Sarakpi, Ellen Becker, Gregor Huetter, Selina Wrublewsky, Fabienne Kuting, Mathias Hohl, Dalia Alansary, Leticia Prates Roma, Peter Lipp, Julia Moellmann, Michael Lehrke, Matthias W. Laschke, Michael D. Menger, Rafael Kramann, Peter Boor, Willi Jahnen-Dechent, Winfried Marz, Michael Boehm, Ulrich Laufs, Barbara A. Niemeyer, Danilo Fliser, Emmanuel Ampofo, Thimoteus Speer
Summary: The study found that IL-1 alpha is strongly expressed on the surface of monocytes from patients with AMI and CKD, and is associated with a higher risk for atherosclerotic cardiovascular disease events. In experimental mice, IL-1 alpha mediates leukocyte-endothelial adhesion and promotes accumulation of immune cells in inflamed tissue.
Article
Immunology
Anna Barkaway, Loic Rolas, Regis Joulia, Jennifer Bodkin, Tchern Lenn, Charlotte Owen-Woods, Natalia Reglero-Real, Monja Stein, Laura Vazquez-Martinez, Tamara Girbl, Robin N. Poston, Matthew Golding, Rebecca S. Saleeb, Aude Thiriot, Ulrich H. von Andrian, Johan Duchene, Mathieu-Benoit Voisin, Cleo L. Bishop, David Voehringer, Axel Roers, Antal Rot, Tim Laemmermann, Sussan Nourshargh
Summary: Aging is associated with dysregulated immune functions, affecting neutrophil diapedesis. In aged mice, neutrophils exhibit reverse transendothelial migration, causing remote organ damage.
Article
Ophthalmology
Md Huzzatul Mursalin, Phillip S. Coburn, Frederick C. Miller, Erin T. Livingston, Roger Astley, Michelle C. Callegan
Summary: The absence of CXCL2 or CXCL10 in Bacillus endophthalmitis resulted in retained retinal function and reduced inflammation. The absence of CXCL2 had a better clinical outcome than the absence of CXCL10. Using anti-CXCL2 and anti-CXCL10 limited inflammation during B. cereus endophthalmitis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Food Science & Technology
Bianca C. Zychar, Patricia B. Clissa, Eneas Carvalho, Adilson S. Alves, Cristiani Baldo, Eliana L. Faquim-Mauro, Luis Roberto C. Goncalves
Summary: In this study, different domains of SVMPs were found to induce expression of adhesion molecules similarly, promoting leukocyte recruitment. Despite differences in hemorrhagic activities and domain composition, SVMPs behaved similarly in this aspect.
Review
Immunology
Gael Galli, Maya Saleh
Summary: Macrophages play crucial roles in tissue homeostasis, inflammation, and host defense by recognizing microbial or danger signals and eliciting immune responses. The interaction between cellular metabolism and macrophage innate immunity involves metabolic adaptations that modulate immune signaling and macrophage function. Intracellular bacterial pathogens can exploit macrophage metabolic pathways to evade immune defenses. This review highlights recent evidence on host-bacterial immunometabolic interactions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Thomas Bromberger, Sarah Klapproth, Ina Rohwedder, Jasmin Weber, Robert Pick, Laura Mittmann, Soo Jin Min-Weissenhorn, Christoph A. Reichel, Christoph Scheiermann, Markus Sperandio, Markus Moser
Summary: Beta 2 integrins play a crucial role in leukocyte trafficking by mediating the processes of slow rolling and firm arrest through conformational changes, which are regulated by interactions with Rap1 and Riam. The loss of both pathways simultaneously results in a rolling phenotype similar to talin1 deficient neutrophils, suggesting that these two pathways primarily regulate beta 2 integrin.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yuqian Pang, Lanxi Wu, Cheng Tang, Hongna Wang, Yongjie Wei
Summary: Inflammation is a crucial immune response against infections, but dysfunctional autophagy can lead to uncontrolled inflammatory responses. Investigating the crosstalk between autophagy and inflammation can provide insights into the mechanisms by which the body balances autophagy and inflammation during infections.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Jessica A. Ferreira, Karla Z. Kantorski, Nileshkumar Dubey, Arwa Daghrery, J. Christopher Fenno, Yuji Mishina, Hsun-Liang Chan, Gustavo Mendonca, Marco C. Bottino
Summary: This study developed personalized antibiotic-laden scaffolds for periodontitis treatment using electrospinning techniques. Evaluation through chemo-morphological analyses, cytocompatibility assessment, and antimicrobial validation showed promising results for promoting new bone formation, reducing bone loss, and lowering inflammatory response. The fabrication of defect-specific antibiotic-laden scaffolds holds potential for personalized medication and regenerative properties.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Laura Soriano-Romani, Fayaz A. Mir, Niharika Singh, Ian Chin, Ali Hafezi-Moghadam, Sharmila Masli
Summary: This study investigates the role of thrombospondin (TSP)-1 in regulating leukocyte recruitment and VCAM-1 expression in mouse models of uveitis. The results show that TSP-1 deficiency can reduce retinal leukocyte adhesion in LPS-mediated acute uveitis, while TSP-1-derived CD47-binding peptide can reduce the clinical disease course and retinal leukocyte adhesion in chronic uveitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Mustafa Yalcinkaya, Panagiotis Fotakis, Wenli Liu, Kaori Endo-Umeda, Huijuan Dou, Sandra Abramowicz, Tong Xiao, Peter Libby, Nan Wang, Alan R. Tall, Marit Westerterp
Summary: This study reveals that IL-1β derived from macrophages promotes neutrophil extracellular trap formation in atherosclerotic plaques. This effect is achieved by increasing neutrophil accumulation in plaques and promoting neutrophil NLRP3 inflammasome activation.
CARDIOVASCULAR RESEARCH
(2023)
Article
Immunology
Surendra K. Sharma, Brajesh Kumar Jha, Abhishek Sharma, V. Sreenivas, Vishwanath Upadhyay, Chandrita Jaisinghani, Rohit Singla, Hemant Kumar Mishra, Manish Soneja
INDIAN JOURNAL OF MEDICAL RESEARCH
(2016)
Article
Cell Biology
Hemant K. Mishra, Timothy J. Johnson, Davis M. Seelig, Bruce Walcheck
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Oncology
Hemant K. Mishra, Nabendu Pore, Emil F. Michelotti, Bruce Walcheck
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)
Article
Immunology
Grant Theron, Lancelot Pinto, Jonny Peter, Hemant Kumar Mishra, Hridesh Kumar Mishra, Richard van Zyl-Smit, Surendra Kumar Sharma, Keertan Dheda
CLINICAL INFECTIOUS DISEASES
(2012)
Article
Infectious Diseases
S. K. Sharma, B. K. Jha, A. Sharma, V. Sreenivas, V. Upadhyay, C. Jaisinghani, R. Singla, H. K. Mishra, M. Soneja
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2014)
Article
Cell Biology
Hemant K. Mishra, Chunmei Long, Nooshin S. Bahaie, Bruce Walcheck
JOURNAL OF LEUKOCYTE BIOLOGY
(2015)
Article
Clinical Neurology
Swastik Agrawal, Surendra Kumar Sharma, Vishnubhatla Sreenivas, Ramakrishnan Lakshmy, Hemant K. Mishra
SLEEP AND BREATHING
(2012)
Article
Clinical Neurology
H. K. Mishra, S. K. Sharma, V. Sreenivas
SLEEP AND BREATHING
(2013)
Article
Clinical Neurology
Surendra K. Sharma, Emmadi V. Reddy, Abhishek Sharma, Tamilarasu Kadhiravan, Hridesh K. Mishra, Vishnubhatla Sreenivas, Hemant K. Mishra, Ramakrishnan Lakshmy
Article
Immunology
Kristin M. Snyder, Robert Hullsiek, Hemant K. Mishra, Daniel C. Mendez, Yunfang Li, Allison Rogich, Dan S. Kaufman, Jianming Wu, Bruce Walcheck
FRONTIERS IN IMMUNOLOGY
(2018)
Review
Cell Biology
Jianming Wu, Hemant K. Mishra, Bruce Walcheck
JOURNAL OF LEUKOCYTE BIOLOGY
(2019)
Meeting Abstract
Oncology
Hemant K. Mishra, Wu Jianming, Nabendu Pore, Bruce Walcheck
CANCER IMMUNOLOGY RESEARCH
(2018)
Meeting Abstract
Oncology
Hemant K. Mishra, Jianming Wu, Dan S. Kaufman, Bruce Walcheck
Article
Immunology
Surendra K. Sharma, S. Sinha, K. A. Danishad, U. Sharma, H. Sharma, H. K. Mishra, H. Mishra, T. Kadhiravan, V. V. Reddy, V. Sreenivas, N. R. Jagannathan
INDIAN JOURNAL OF MEDICAL RESEARCH
(2010)