Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species

Iron chemistry at the service of life

(2017) Manu Sánchez et al.   IUBMB LIFE

Reclassification of the Specialized Metabolite Producer Pseudomonas mesoacidophila ATCC 31433 as a Member of the Burkholderia cepacia Complex

(2017) E. Joel Loveridge et al.   JOURNAL OF BACTERIOLOGY

Watasemycin biosynthesis in Streptomyces venezuelae: thiazoline C-methylation by a type B radical-SAM methylase homologue

(2017) Yuki Inahashi et al.   Chemical Science

Melioidosis: Clinical impact and public health threat in the tropics

(2017) Ramar Perumal Samy et al.   PLoS Neglected Tropical Diseases

Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation

(2017) Jennifer Mesureur et al.   PLoS Pathogens

Genome Data Provides High Support for Generic Boundaries in Burkholderia Sensu Lato

(2017) Chrizelle W. Beukes et al.   Frontiers in Microbiology

Burkholderia: an update on taxonomy and biotechnological potential as antibiotic producers

(2016) Eliza Depoorter et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antibiotic resistance in Burkholderia species

(2016) Katherine A. Rhodes et al.   DRUG RESISTANCE UPDATES

Transfer of eleven species of the genus Burkholderia to the genus Paraburkholderia and proposal of Caballeronia gen. nov. to accommodate twelve species of the genera Burkholderia and Paraburkholderia

(2016) Anatoly P. Dobritsa et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Heme Synthesis and Acquisition in Bacterial Pathogens

(2016) Jacob E. Choby et al.   JOURNAL OF MOLECULAR BIOLOGY

Cystic fibrosis

(2016) J Stuart Elborn   LANCET

Structural insight into the role of the Ton complex in energy transduction

(2016) Hervé Celia et al.   NATURE

Genetic and Functional Analysis of the Biosynthesis of a Non-Ribosomal Peptide Siderophore in Burkholderia xenovorans LB400

(2016) María José Vargas-Straube et al.   PLoS One

Crystal structure of bacterial haem importer complex in the inward-facing conformation

(2016) Youichi Naoe et al.   Nature Communications

Burkholderia paludis sp. nov., an Antibiotic-Siderophore Producing Novel Burkholderia cepacia Complex Species, Isolated from Malaysian Tropical Peat Swamp Soil

(2016) Kuan Shion Ong et al.   Frontiers in Microbiology

Comparative genome-wide analysis reveals thatBurkholderia contaminansMS14 possesses multiple antimicrobial biosynthesis genes but not major genetic loci required for pathogenesis

(2016) Peng Deng et al.   MicrobiologyOpen

Burkholderiagenome mining for nonribosomal peptide synthetases reveals a great potential for novel siderophores and lipopeptides synthesis

(2016) Qassim Esmaeel et al.   MicrobiologyOpen

Investigation of the multifaceted iron acquisition strategies of Burkholderia cenocepacia

(2015) J. Tyrrell et al.   BIOMETALS

Intracellular survival of Burkholderia cepacia complex in phagocytic cells

(2015) Miguel A. Valvano   CANADIAN JOURNAL OF MICROBIOLOGY

Plasticity of the Malleobactin Pathway and Its Impact on Siderophore Action in Human Pathogenic Bacteria

(2015) Jakob Franke et al.   CHEMISTRY-A EUROPEAN JOURNAL

Proposal to modify Rule 27 of the International Code of Nomenclature of Prokaryotes

(2015) Aharon Oren et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Long-term social dynamics drive loss of function in pathogenic bacteria

(2015) Sandra Breum Andersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the Burkholderia mallei tonB Mutant and Its Potential as a Backbone Strain for Vaccine Development

(2015) Tiffany M. Mott et al.   PLoS Neglected Tropical Diseases

Curcumin rescues Caenorhabditis elegans from a Burkholderia pseudomallei infection

(2015) Su-Anne Eng et al.   Frontiers in Microbiology

A cell biological view of the siderophore pyochelin iron uptake pathway inPseudomonas aeruginosa

(2014) Olivier Cunrath et al.   ENVIRONMENTAL MICROBIOLOGY

Adaptation of Iron Homeostasis Pathways by a Pseudomonas aeruginosa Pyoverdine Mutant in the Cystic Fibrosis Lung

(2014) A. T. Nguyen et al.   JOURNAL OF BACTERIOLOGY

Within-Host Evolution of Pseudomonas aeruginosa Reveals Adaptation toward Iron Acquisition from Hemoglobin

(2014) R. L. Marvig et al.   mBio

Molecular signatures and phylogenomic analysis of the genus Burkholderia: proposal for division of this genus into the emended genus Burkholderia containing pathogenic organisms and a new genus Paraburkholderia gen. nov. harboring environmental species

(2014) Amandeep Sawana et al.   Frontiers in Genetics

The P. aeruginosa Heme Binding Protein PhuS Is a Heme Oxygenase Titratable Regulator of Heme Uptake

(2013) Maura J. O’Neill et al.   ACS Chemical Biology

Nitro versus Hydroxamate in Siderophores of Pathogenic Bacteria: Effect of Missing Hydroxylamine Protection in Malleobactin Biosynthesis

(2013) Jakob Franke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequestration and Scavenging of Iron in Infection

(2013) Nermi L. Parrow et al.   INFECTION AND IMMUNITY

Pseudomonas aeruginosa Uses Multiple Pathways To Acquire Iron during Chronic Infection in Cystic Fibrosis Lungs

(2013) Anna F. Konings et al.   INFECTION AND IMMUNITY

The ferrous iron transporter FtrABCD is required for the virulence ofBrucella abortus2308 in mice

(2013) Ahmed E. M. Elhassanny et al.   MOLECULAR MICROBIOLOGY

A novel siderophore-independent strategy of iron uptake in the genusBurkholderia

(2013) Anugraha Mathew et al.   MOLECULAR MICROBIOLOGY

Response of Burkholderia cenocepacia H111 to Micro-Oxia

(2013) Gabriella Pessi et al.   PLoS One

Proteomic Profiling of Burkholderia cenocepacia Clonal Isolates with Different Virulence Potential Retrieved from a Cystic Fibrosis Patient during Chronic Lung Infection

(2013) Andreia Madeira et al.   PLoS One

Burkholderia mallei and Burkholderia pseudomallei Cluster 1 Type VI Secretion System Gene Expression Is Negatively Regulated by Iron and Zinc

(2013) Mary N. Burtnick et al.   PLoS One

Ferrous Iron Is a Significant Component of Bioavailable Iron in Cystic Fibrosis Airways

(2013) R. C. Hunter et al.   mBio

Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans

(2013) Mélissa Caza et al.   Frontiers in Cellular and Infection Microbiology

Role and regulation of heme iron acquisition in gram-negative pathogens

(2013) Laura J. Runyen-Janecky   Frontiers in Cellular and Infection Microbiology

Molybdenum enzymes, their maturation and molybdenum cofactor biosynthesis in Escherichia coli

(2012) Chantal Iobbi-Nivol et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Proteomic profiling of Pseudomonas aeruginosa AES-1R, PAO1 and PA14 reveals potential virulence determinants associated with a transmissible cystic fibrosis-associated strain

(2012) Nathan J Hare et al.   BMC MICROBIOLOGY

Identification and characterization of a periplasmic trilactone esterase, Cee, revealed unique features of ferric enterobactin acquisition inCampylobacter

(2012) Ximin Zeng et al.   MOLECULAR MICROBIOLOGY

Iron and pH-responsive FtrABCD ferrous iron utilization system ofBordetellaspecies

(2012) Timothy J. Brickman et al.   MOLECULAR MICROBIOLOGY

Cystic fibrosis: a mucosal immunodeficiency syndrome

(2012) Taylor Sitarik Cohen et al.   NATURE MEDICINE

Melioidosis

(2012) W. Joost Wiersinga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Catecholate Siderophores Protect Bacteria from Pyochelin Toxicity

(2012) Conrado Adler et al.   PLoS One

Burkholderia pseudomallei Known Siderophores and Hemin Uptake Are Dispensable for Lethal Murine Melioidosis

(2012) Brian H. Kvitko et al.   PLoS Neglected Tropical Diseases

Pseudomonas siderophores in the sputum of patients with cystic fibrosis

(2011) Lois W. Martin et al.   BIOMETALS

Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis

(2011) Matthew E Wand et al.   BMC MICROBIOLOGY

The Cluster 1 Type VI Secretion System Is a Major Virulence Determinant inBurkholderia pseudomallei

(2011) Mary N. Burtnick et al.   INFECTION AND IMMUNITY

Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery

(2011) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Iron homeostasis and management of oxidative stress response in bacteria

(2011) Pierre Cornelis et al.   Metallomics

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

Genomic Expression Analysis Reveals Strategies of Burkholderia cenocepacia to Adapt to Cystic Fibrosis Patients' Airways and Antimicrobial Therapy

(2011) Nuno P. Mira et al.   PLoS One

Burkholderia cenocepacia differential gene expression during host–pathogen interactions and adaptation to the host environment

(2011) Eoin O’Grady   Frontiers in Cellular and Infection Microbiology

TonB-Dependent Transporters: Regulation, Structure, and Function

(2010) Nicholas Noinaj et al.   Annual Review of Microbiology

Iron acquisition with the natural siderophore enantiomers pyochelin and enantio-pyochelin in Pseudomonas species

(2010) Zeb A. Youard et al.   BIOMETALS

Siderophore uptake in bacteria and the battle for iron with the host; a bird’s eye view

(2010) Byron C. Chu et al.   BIOMETALS

Transcriptional response of Burkholderia cenocepacia J2315 sessile cells to treatments with high doses of hydrogen peroxide and sodium hypochlorite

(2010) Elke Peeters et al.   BMC GENOMICS

The struggle for iron - a metal at the host-pathogen interface

(2010) Manfred Nairz et al.   CELLULAR MICROBIOLOGY

Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence

(2010) P. Drevinek et al.   CLINICAL MICROBIOLOGY AND INFECTION

A Decade of Burkholderia cenocepacia Virulence Determinant Research

(2010) S. A. Loutet et al.   INFECTION AND IMMUNITY

Burkholderia cenocepacia Creates an Intramacrophage Replication Niche in Zebrafish Embryos, Followed by Bacterial Dissemination and Establishment of Systemic Infection

(2010) A. C. Vergunst et al.   INFECTION AND IMMUNITY

The Ferrichrome Uptake Pathway in Pseudomonas aeruginosa Involves an Iron Release Mechanism with Acylation of the Siderophore and Recycling of the Modified Desferrichrome

(2010) M. Hannauer et al.   JOURNAL OF BACTERIOLOGY

A Novel Sialic Acid Utilization and Uptake System in the Periodontal Pathogen Tannerella forsythia

(2010) S. Roy et al.   JOURNAL OF BACTERIOLOGY

Pulmonary Proteases in the Cystic Fibrosis Lung Induce Interleukin 8 Expression from Bronchial Epithelial Cells via a Heme/Meprin/Epidermal Growth Factor Receptor/Toll-like Receptor Pathway

(2010) Sonya Cosgrove et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene expression of Pseudomonas aeruginosa in a mucin-containing synthetic growth medium mimicking cystic fibrosis lung sputum

(2010) C. Fung et al.   JOURNAL OF MEDICAL MICROBIOLOGY

The pobA gene of Burkholderia cenocepacia encodes a Group I Sfp-type phosphopantetheinyltransferase required for biosynthesis of the siderophores ornibactin and pyochelin

(2010) A. H. Asghar et al.   MICROBIOLOGY-SGM

Identification of Potential Therapeutic Targets for Burkholderia cenocepacia by Comparative Transcriptomics

(2010) Deborah R. Yoder-Himes et al.   PLoS One

The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts

(2010) Eric P. Skaar   PLoS Pathogens

Role of lung iron in determining the bacterial and host struggle in cystic fibrosis

(2009) D. W. Reid et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

New insights into the metal specificity of thePseudomonas aeruginosapyoverdine-iron uptake pathway

(2009) Armelle Braud et al.   ENVIRONMENTAL MICROBIOLOGY

Identification of Specific and Universal Virulence Factors in Burkholderia cenocepacia Strains by Using Multiple Infection Hosts

(2009) S. Uehlinger et al.   INFECTION AND IMMUNITY

Biocide susceptibility of the Burkholderia cepacia complex

(2009) H. Rose et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis

(2009) M Kolpen et al.   THORAX

Detection of Anaerobic Bacteria in High Numbers in Sputum from Patients with Cystic Fibrosis

(2008) Michael M. Tunney et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Gene expression changes linked to antimicrobial resistance, oxidative stress, iron depletion and retained motility are observed when Burkholderia cenocepaciagrows in cystic fibrosis sputum

(2008) Pavel Drevinek et al.   BMC INFECTIOUS DISEASES

Cystic fibrosis and innate immunity: how chloride channel mutations provoke lung disease

(2008) Gerd Döring et al.   CELLULAR MICROBIOLOGY

The Genome of Burkholderia cenocepacia J2315, an Epidemic Pathogen of Cystic Fibrosis Patients

(2008) M. T. G. Holden et al.   JOURNAL OF BACTERIOLOGY

Burkholderia cenocepacia-induced delay of acidification and phagolysosomal fusion in cystic fibrosis transmembrane conductance regulator (CFTR)-defective macrophages

(2008) J. Lamothe et al.   MICROBIOLOGY-SGM

Pleiotropic roles of iron-responsive transcriptional regulator Fur in Burkholderia multivorans

(2008) S. Yuhara et al.   MICROBIOLOGY-SGM

New substrates for TonB-dependent transport: do we only see the ‘tip of the iceberg’?

(2008) Kristine Schauer et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural biology of bacterial iron uptake

(2007) Karla D. Krewulak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES