A Novel Enterovirus 71 (EV71) Virulence Determinant: The 69th Residue of 3C Protease Modulates Pathogenicity

Genome analysis of enterovirus 71 strains differing in mouse pathogenicity

(2016) Peng Li et al.   VIRUS GENES

Peptidyl Aldehyde NK-1.8k Suppresses Enterovirus 71 and Enterovirus 68 Infection by Targeting Protease 3C

(2015) Yaxin Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Encephalomyocarditis Virus 3C Protease Relieves TRAF Family Member-associated NF-κB Activator (TANK) Inhibitory Effect on TRAF6-mediated NF-κB Signaling through Cleavage of TANK

(2015) Li Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Positively Charged Residues in Enterovirus 71 Capsid Protein VP1 Essential for Production of Infectious Particles

(2015) Shilin Yuan et al.   JOURNAL OF VIROLOGY

MA104 Cell line presents characteristics suitable for enterovirus A71 isolation and proliferation

(2015) Zhi-Hui Li et al.   MICROBIOLOGY AND IMMUNOLOGY

Effect of T68A/N126Y mutations on the conformational and ligand binding landscape of Coxsackievirus B3 3C protease

(2015) Soumendranath Bhakat   Molecular BioSystems

The variations of VP1 protein might be associated with nervous system symptoms caused by enterovirus 71 infection

(2014) Bao Zhang et al.   BMC INFECTIOUS DISEASES

Enterovirus 71 3C Inhibits Cytokine Expression through Cleavage of the TAK1/TAB1/TAB2/TAB3 Complex

(2014) X. Lei et al.   JOURNAL OF VIROLOGY

Attenuation of Human Enterovirus 71 High-Replication-Fidelity Variants in AG129 Mice

(2014) T. Meng et al.   JOURNAL OF VIROLOGY

Enterovirus 68 3C Protease Cleaves TRIF To Attenuate Antiviral Responses Mediated by Toll-Like Receptor 3

(2014) Z. Xiang et al.   JOURNAL OF VIROLOGY

An Inactivated Enterovirus 71 Vaccine in Healthy Children

(2014) Rongcheng Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy, Safety, and Immunogenicity of an Enterovirus 71 Vaccine in China

(2014) Fengcai Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structures ofEnterovirus 713C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir

(2013) Caiming Wu et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Human IgG Subclasses against Enterovirus Type 71: Neutralization versus Antibody Dependent Enhancement of Infection

(2013) Rui-Yuan Cao et al.   PLoS One

Cleavage of Interferon Regulatory Factor 7 by Enterovirus 71 3C Suppresses Cellular Responses

(2012) Xiaobo Lei et al.   JOURNAL OF VIROLOGY

Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility

(2012) Bingqing Li et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of Human Enterovirus 71 3C Protease

(2011) Sheng Cui et al.   JOURNAL OF MOLECULAR BIOLOGY

Cleavage of the Adaptor Protein TRIF by Enterovirus 71 3C Inhibits Antiviral Responses Mediated by Toll-Like Receptor 3

(2011) X. Lei et al.   JOURNAL OF VIROLOGY

Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design

(2011) G. Lu et al.   JOURNAL OF VIROLOGY

Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93

(2011) L. Costenaro et al.   JOURNAL OF VIROLOGY

Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues

(2011) J. Wang et al.   JOURNAL OF VIROLOGY

The 3C Protein of Enterovirus 71 Inhibits Retinoid Acid-Inducible Gene I-Mediated Interferon Regulatory Factor 3 Activation and Type I Interferon Responses

(2010) X. Lei et al.   JOURNAL OF VIROLOGY

Neural pathogenesis of enterovirus 71 infection

(2010) Kuo-Feng Weng et al.   MICROBES AND INFECTION

Producing infectious enterovirus type 71 in a rapid strategy

(2010) Jian-Feng Han et al.   Virology Journal

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

(2009) Cheng-Chung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enterovirus 71 Outbreak in the People's Republic of China in 2008

(2009) F. Yang et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate

(2009) Patricia A. Zunszain et al.   JOURNAL OF MOLECULAR BIOLOGY

Enterovirus 71 3C Protease Cleaves a Novel Target CstF-64 and Inhibits Cellular Polyadenylation

(2009) Kuo-Feng Weng et al.   PLoS Pathogens

Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents

(2008) Chih-Jung Kuo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cleavage of Poly(A)-Binding Protein by Poliovirus 3C Proteinase Inhibits Viral Internal Ribosome Entry Site-Mediated Translation

(2008) J. M. Bonderoff et al.   JOURNAL OF VIROLOGY

Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases

(2008) Sylvain de Breyne et al.   VIROLOGY