Article
Immunology
Qichen Wang, Nadira Nurxat, Lei Zhang, Yao Liu, Yanan Wang, Na Zhao, Yingxin Dai, Ying Jian, Lei He, Hua Wang, Taeok Bae, Min Li, Qian Liu
Summary: Diabetic patients with poorly controlled fasting blood glucose levels are more likely to be colonized by highly virulent Staphylococcus aureus ST7 strains, which are more resistant to antimicrobial peptides and able to form stronger biofilms compared to ST59 strains. The increased colonization of ST7 strains is due to the higher activity of the SaeRS two-component system in a hyperglycemic environment.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Biochemistry & Molecular Biology
Marcus A. Wittekind, Andrew Frey, Abigail E. Bonsall, Paul Briaud, Rebecca A. Keogh, Richard E. Wiemels, Lindsey N. Shaw, Ronan K. Carroll
Summary: Staphylococcus aureus is a Gram-positive bacteria that can cause a variety of infections in humans. The overexpression of a small RNA, tsr37, leads to increased bacterial aggregation, which is dependent on an unannotated protein called ScrA. ScrA activates the SaeRS system and may act as an intermediary between the ArlRS and SaeRS systems.
MOLECULAR MICROBIOLOGY
(2022)
Article
Microbiology
Ying Liu, Wei Gao, Junshu Yang, Haiyong Guo, Jiang Zhang, Yinduo Ji
Summary: Coagulase and its direct regulator SaeRS play a critical role in the pathogenicity of CA-MRSA 923, with null mutations decreasing the virulence of S. aureus. Deletion of SaeRS is associated with increased lethality in CA-MRSA 923 bacteremia, indicating its importance in pathogenesis.
Article
Microbiology
Marcus A. Wittekind, Paul Briaud, Jayanna L. Smith, Julia R. Tennant, Ronan K. Carroll
Summary: Staphylococcus aureus is a pathogen that causes potentially life-threatening infections, thanks to its multitude of toxins and virulence factors. This bacterium's ability to cause a wide range of illnesses is due to its complex regulatory network, which controls various virulence factors.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Shiyu Li, Wei Li, Qiancai Liang, Jizhen Cao, Han Li, Zhicheng Li, Anxing Li
Summary: SaeRS is an important virulence factor in promoting tilapia infection, as it plays a role in decreasing the growth and biofilm formation abilities of S. agalactiae. Additionally, the expression levels of virulence factors were significantly down-regulated in the Delta SaeRS strain. These findings provide a basis for exploring the pathogenic mechanism of S. agalactiae infected with tilapia.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Na Zhao, Yanan Wang, Junlan Liu, Ziyu Yang, Ying Jian, Hua Wang, Mahmoud Ahmed, Min Li, Taeok Bae, Qian Liu
Summary: Research shows that ClpP positively regulates the expression of SaeS L18P in Staphylococcus aureus by destabilizing FtsH and degrading MoeA. Additionally, MoeA has a suppressive effect on the hemolytic activity and virulence of the bacteria.
Article
Immunology
Na Zhao, Danhong Cheng, Ziyu Yang, Yao Liu, Yanan Wang, Ying Jian, Hua Wang, Min Li, Taeok Bae, Qian Liu
Summary: By analyzing S. aureus strains, it was found that the low activity of the SaeRS two-component system is an important factor for S. aureus colonization in the nasal cavity of seniors. Seniors have a nasal environment that favors colonization of S. aureus with higher adhesion and lower virulence.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Biotechnology & Applied Microbiology
Zhanhua Tao, Ke Ke, Deqiang Shi, Libo Zhu
Summary: Here, a dual reporter system capable of monitoring the activities of two major virulence regulators in Staphylococcus aureus, agr and sae, was described. The system showed no significant crosstalk and could be used to monitor the dynamic changes in agr and sae activities during batch growth. The reporter strain was also responsive to virulence inhibitors, making it a valuable tool for screening potential drugs.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Infectious Diseases
Li Liu, Bingjie Wang, Jingyi Yu, Yinjuan Guo, Fangyou Yu
Summary: The study suggests that NWMN2330 may be associated with the virulence of Staphylococcus aureus by increasing the expression of hla and saeRS.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Genetics & Heredity
Lisa Bleul, Patrice Francois, Christiane Wolz
Summary: This review summarizes the current understanding of signal perception by histidine kinases in Staphylococcus aureus and their role in promoting appropriate gene expression in response to environmental challenges.
Article
Chemistry, Multidisciplinary
Nadira Nurxat, Lili Wang, Qichen Wang, Shujing Li, Chen Jin, Yaran Shi, Ayjiamali Wulamu, Na Zhao, Yanan Wang, Hua Wang, Min Li, Qian Liu
Summary: Staphylococcus aureus is a highly pathogenic Gram-positive bacterium responsible for a range of diseases. The emergence of antibiotic-resistant S. aureus has made treatment challenging. Research on the human microbiome suggests that commensal bacteria can be used to combat pathogenic infections. Staphylococcus epidermidis, a common species in the nasal microbiome, can inhibit the colonization of S. aureus. However, S. aureus undergoes evolutionary changes during bacterial competition. Our study shows that nasal colonized S. epidermidis can inhibit the hemolytic activity of S. aureus, and we have identified a mechanism through which S. epidermidis inhibits S. aureus colonization.
Article
Microbiology
Jakub M. Kwiecinski, Diamond A. Jelani, Ernesto J. Fuentes, Alexander R. Horswill
Summary: This study describes two novel inhibitors of the two-component regulatory system ArlRS in Staphylococcus aureus and demonstrates their high efficacy and specificity. These inhibitors disrupt the signaling pathway of S. aureus and result in the loss of virulence traits, showing significant therapeutic potential.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Carmen Gomez-Arrebola, Sara B. Hernandez, Elizabeth J. Culp, Gerard D. Wright, Cristina Solano, Felipe Cava, Inigo Lasa
Summary: This study investigated the role of the sensory system in Staphylococcus aureus in its susceptibility to the novel antibiotics corbomycin and complestatin. The results provide insights into the coordination between the presence of the antibiotics and the sensory system responsible for cell wall synthesis processes.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Carmen Gomez-Arrebola, Sara B. Hernandez, Elizabeth J. Culp, Gerard D. Wright, Cristina Solano, Felipe Cava, Inigo Lasa
Summary: The overuse of antibiotics has led to the emergence of antimicrobial resistance, stimulating the search for novel antibiotics. This study investigates the role of the VraSR sensory system in Staphylococcus aureus susceptibility to Complestatin and Corbomycin, revealing the important role of spdC and sagB genes in antibiotic resistance.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Zhanhua Tao, Haoren Wang, Ke Ke, Deqiang Shi, Libo Zhu
Summary: The rising antibiotic resistance in Staphylococcus aureus has led to the need for innovative antimicrobial agents. In this study, the impact of flavone on the expression of virulence factors in S. aureus was examined. Flavone was found to significantly downregulate the expression of over 30 virulence factors, suggesting its potential as a broad inhibitory agent.
MICROBIAL PATHOGENESIS
(2023)
Article
Microbiology
Jeffrey W. Hall, Junshu Yang, Haiyong Guo, Yinduo Ji
FRONTIERS IN MICROBIOLOGY
(2015)
Article
Immunology
Jeffrey W. Hall, Junshu Yang, Haiyong Guo, Yinduo Ji
INFECTION AND IMMUNITY
(2017)
Article
Multidisciplinary Sciences
Helmut Hirt, Jeffrey W. Hall, Elliot Larson, Sven-Ulrik Gorr
Article
Multidisciplinary Sciences
Xudong Liang, Jeffrey W. Hall, Junshu Yang, Meiying Yan, Katherine Doll, Russell Bey, Yinduo Ji
Article
Multidisciplinary Sciences
Meiying Yan, Jeffrey W. Hall, Junshu Yang, Yinduo Ji
Article
Immunology
Jeffrey W. Hall, Yinduo Ji
Article
Biochemistry & Molecular Biology
Jeffrey W. Hall, Bruno P. Lima, Gaetan G. Herbomel, Tata Gopinath, LeAnna McDonald, Michael T. Shyne, John K. Lee, Jens Kreth, Karen F. Ross, Gianluigi Veglia, Mark C. Herzberg
Article
Agriculture, Dairy & Animal Science
B. Vecchi, E. Gumina, F. Matte, A. Bata, S. Bata, V Molnar-Nagy, J. W. Hall, X. Hernandez-Velasco, S. Layton
Summary: Two independent trials were conducted to assess the effect of Herbanoplex CP on broiler chicken's performance, showing that HB can promote growth performance in a nondefined challenge model and reduce the severity of intestinal lesions in a necrotic enteritis challenge model.
JOURNAL OF APPLIED POULTRY RESEARCH
(2021)
Article
Veterinary Sciences
Maria Fernanda Jabif, Emanuel Gumina, Jeffrey W. Hall, Xochitl Hernandez-Velasco, Sherry Layton
Summary: The study demonstrates that ESV can induce higher levels of colostrum secretory IgA in pregnant sows, offering protection to neonatal piglets, and can protect piglets as early as 3 days old from ETEC infection.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Emanuel Gumina, W. Jeffrey Hall, Bruno Vecchi, Xochitl Hernandez-Velasco, Brett Lumpkins, Greg Mathis, Sherry Layton
Summary: This study demonstrated that using a subunit coccidia vaccine can significantly improve the growth performance of chickens and provide cross-protection against Eimeria spp. The results showed that vaccinated chickens had enhanced feed efficiency and reduced parasite infection levels compared to control chickens.
Article
Veterinary Sciences
Igor Praxedes-Campagnoni, Bruno Vecchi, Emanuel Gumina, Xochitl Hernandez-Velasco, Jeffrey W. Hall, Sherry Layton
Summary: The study evaluated the impact of a water applied prebiotic on gut barrier failure (Experiment 1) and performance in broiler chickens in commercial conditions (Experiment 2). Results showed that the prebiotic significantly increased mRNA expression of various factors related to gut integrity, reduced serum endotoxin levels, and decreased liver bacterial translocation incidence in treated chickens. Additionally, the prebiotic led to a significant reduction in total mortality in both commercial trials, with a positive economic return.
FRONTIERS IN VETERINARY SCIENCE
(2021)