Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways

(2016) Anna M. Blokhuis et al.   ACTA NEUROPATHOLOGICA

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

(2016) Ji-Man Park et al.   Autophagy

C9orf72 isoforms in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration

(2016) Shangxi Xiao et al.   BRAIN RESEARCH

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death

(2016) Chantal Sellier et al.   EMBO JOURNAL

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

(2016) Christopher P Webster et al.   EMBO JOURNAL

C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling

(2016) Joseph Amick et al.   MOLECULAR BIOLOGY OF THE CELL

Introducing STRaNDs: shuttling transcriptional regulators that are non-DNA binding

(2016) Min Lu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit

(2016) Jacob Stewart-Ornstein et al.   Cell Reports

Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling

(2016) Janet Ugolino et al.   PLoS Genetics

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy

(2016) M. Yang et al.   Science Advances

The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway

(2016) Peter M. Sullivan et al.   Acta Neuropathologica Communications

The integration of autophagy and cellular trafficking pathways via RAB GAPs

(2015) Andreas Kern et al.   Autophagy

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates

(2015) Nolan J. Hoffman et al.   Cell Metabolism

TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic

(2015) C. A. Lamb et al.   EMBO JOURNAL

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

(2015) Jennifer Jung et al.   MOLECULAR AND CELLULAR BIOLOGY

TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export

(2015) Daniela Stadel et al.   MOLECULAR CELL

CUL3-KBTBD6/KBTBD7 Ubiquitin Ligase Cooperates with GABARAP Proteins to Spatially Restrict TIAM1-RAC1 Signaling

(2015) Heide Marika Genau et al.   MOLECULAR CELL

Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130

(2015) Justin Joachim et al.   MOLECULAR CELL

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

JPred4: a protein secondary structure prediction server

(2015) Alexey Drozdetskiy et al.   NUCLEIC ACIDS RESEARCH

Amyotrophic Lateral Sclerosis: Review

(2015) Johnny Salameh et al.   SEMINARS IN NEUROLOGY

Solution Structure of the Atg1 Complex: Implications for the Architecture of the Phagophore Assembly Site

(2015) Jürgen Köfinger et al.   STRUCTURE

Direct link between Atg protein and small GTPase Rab: Atg16L functions as a potential Rab33 effector in mammals

(2014) Mitsunori Fukuda et al.   Autophagy

RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy

(2014) Natalie Spang et al.   Autophagy

TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy

(2014) D. Popovic et al.   EMBO REPORTS

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

The SUMO-Specific Isopeptidase SENP3 Regulates MLL1/MLL2 Methyltransferase Complexes and Controls Osteogenic Differentiation

(2014) Arnab Nayak et al.   MOLECULAR CELL

VMP1 is a new player in the regulation of the autophagy-specific phosphatidylinositol 3-kinase complex activation

(2013) Maria I. Molejon et al.   Autophagy

The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs

(2013) Timothy P. Levine et al.   BIOINFORMATICS

The TBC/RabGAP Armus Coordinates Rac1 and Rab7 Functions during Autophagy

(2013) Bernadette Carroll et al.   DEVELOPMENTAL CELL

Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy

(2013) J. P. Chua et al.   HUMAN MOLECULAR GENETICS

Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

(2013) R. Goold et al.   JOURNAL OF CELL SCIENCE

Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs

(2013) Marine Gilabert et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization

(2013) Zsuzsanna Szatmári et al.   MOLECULAR BIOLOGY OF THE CELL

ZKSCAN3 Is a Master Transcriptional Repressor of Autophagy

(2013) Santosh Chauhan et al.   MOLECULAR CELL

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

Regulation of autophagy by stress-responsive transcription factors

(2013) Federico Pietrocola et al.   SEMINARS IN CANCER BIOLOGY

Rab27 Effectors, Pleiotropic Regulators in Secretory Pathways

(2013) Mitsunori Fukuda   TRAFFIC

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

BLOC-2, AP-3, and AP-1 Proteins Function in Concert with Rab38 and Rab32 Proteins to Mediate Protein Trafficking to Lysosome-related Organelles

(2012) Jarred J. Bultema et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLC33A1/AT-1 Protein Regulates the Induction of Autophagy Downstream of IRE1/XBP1 Pathway

(2012) Mariana Pehar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

(2012) Andrea Longatti et al.   JOURNAL OF CELL BIOLOGY

Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D

(2012) Kevin Moreau et al.   JOURNAL OF CELL BIOLOGY

Rab GTPase-Activating Proteins in Autophagy: Regulation of Endocytic and Autophagy Pathways by Direct Binding to Human ATG8 Modifiers

(2012) D. Popovic et al.   MOLECULAR AND CELLULAR BIOLOGY

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets

(2012) Anoop Kumar G. Velikkakath et al.   MOLECULAR BIOLOGY OF THE CELL

Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function

(2012) N. Jaber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MMS19 Assembles Iron-Sulfur Proteins Required for DNA Metabolism and Genomic Integrity

(2012) O. Stehling et al.   SCIENCE

Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease

(2012) Dapeng Zhang et al.   Frontiers in Genetics

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation

(2011) Takashi Itoh et al.   JOURNAL OF CELL BIOLOGY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

FYCO1: Linking autophagosomes to microtubule plus end-directing molecular motors

(2010) Serhiy Pankiv et al.   Autophagy

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

(2010) Hannah E.J. Polson et al.   Autophagy

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

Regulation of autophagy by phosphatidylinositol 3-phosphate

(2010) Chloe Burman et al.   FEBS LETTERS

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

(2010) Serhiy Pankiv et al.   JOURNAL OF CELL BIOLOGY

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

(2009) Carol A. Mercer et al.   Autophagy

High-throughput functional screening for autophagy-related genes and identification ofTM9SF1as an autophagosome-inducing gene

(2009) Pengfei He et al.   Autophagy

Atg101, a novel mammalian autophagy protein interacting with Atg13

(2009) Nao Hosokawa et al.   Autophagy

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

Golgi-resident Small GTPase Rab33B Interacts with Atg16L and Modulates Autophagosome Formation

(2008) Takashi Itoh et al.   MOLECULAR BIOLOGY OF THE CELL

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH