Synergistic interactions with PI3K inhibition that induce apoptosis
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Synergistic interactions with PI3K inhibition that induce apoptosis
Authors
Keywords
-
Journal
eLife
Volume 6, Issue -, Pages -
Publisher
eLife Sciences Organisation, Ltd.
Online
2017-05-31
DOI
10.7554/elife.24523
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
- (2016) John G Doench et al. NATURE BIOTECHNOLOGY
- The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer
- (2015) C Rey et al. ONCOGENE
- An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors
- (2015) Oliver Jonas et al. Science Translational Medicine
- PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways
- (2014) Koremu Meja et al. BRITISH JOURNAL OF HAEMATOLOGY
- Phase Ib Study of Buparlisib plus Trastuzumab in Patients with HER2-Positive Advanced or Metastatic Breast Cancer That Has Progressed on Trastuzumab-Based Therapy
- (2014) C. Saura et al. CLINICAL CANCER RESEARCH
- PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling
- (2014) S E Moody et al. ONCOGENE
- Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer
- (2014) Jinfeng Liu et al. Nature Communications
- Assessing PIK3CA and PTEN in Early-Phase Trials with PI3K/AKT/mTOR Inhibitors
- (2014) Filip Janku et al. Cell Reports
- Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
- (2014) Glenn S Cowley et al. Scientific Data
- BH3 profiling in whole cells by fluorimeter or FACS
- (2013) Jeremy Ryan et al. METHODS
- Sorafenib Suppresses JNK-Dependent Apoptosis through Inhibition of ZAK
- (2013) H. Vin et al. MOLECULAR CANCER THERAPEUTICS
- Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies
- (2013) A. B. Hanker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTORC1 Inhibition Is Required for Sensitivity to PI3K p110 Inhibitors in PIK3CA-Mutant Breast Cancer
- (2013) M. Elkabets et al. Science Translational Medicine
- What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway
- (2013) S. J. Klempner et al. Cancer Discovery
- PIK3CA Mutation H1047R Is Associated with Response to PI3K/AKT/mTOR Signaling Pathway Inhibitors in Early-Phase Clinical Trials
- (2012) F. Janku et al. CANCER RESEARCH
- Frequent Mutational Activation of the PI3K-AKT Pathway in Trastuzumab-Resistant Breast Cancer
- (2012) S. Chandarlapaty et al. CLINICAL CANCER RESEARCH
- PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies HarboringPIK3CAMutations
- (2012) Filip Janku et al. JOURNAL OF CLINICAL ONCOLOGY
- Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis
- (2012) Virginia Silió et al. MOLECULAR BIOLOGY OF THE CELL
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Comprehensive molecular portraits of human breast tumours
- (2012) Daniel C. Koboldt et al. NATURE
- In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases
- (2011) Matthew P. Patricelli et al. CHEMISTRY & BIOLOGY
- Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway–dependent and PI3K pathway–independent mechanisms
- (2011) Pixu Liu et al. NATURE MEDICINE
- Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer
- (2011) José Baselga et al. NEW ENGLAND JOURNAL OF MEDICINE
- Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
- (2011) H. W. Cheung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy
- (2011) T. N. Chonghaile et al. SCIENCE
- A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction
- (2011) A. Vinayagam et al. Science Signaling
- BAD: undertaker by night, candyman by day
- (2009) N N Danial ONCOGENE
- NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations
- (2008) V. Serra et al. CANCER RESEARCH
- CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
- (2008) Ron Firestein et al. NATURE
- Highly parallel identification of essential genes in cancer cells
- (2008) B. Luo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search