The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress

CDK Substrate Phosphorylation and Ordering the Cell Cycle

(2016) Matthew P. Swaffer et al.   CELL

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity

(2016) Pavel Moudry et al.   JOURNAL OF CELL BIOLOGY

Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics

(2016) Rosie Elizabeth Ann Gutteridge et al.   MOLECULAR CANCER THERAPEUTICS

Direct Visualization of DNA Replication Dynamics in Zebrafish Cells

(2015) Kenji Kuriya et al.   Zebrafish

Checkpoint regulation of replication forks: global or local?: Figure 1

(2015) Divya Ramalingam Iyer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Interaction between Rad9–Hus1–Rad1 and TopBP1 activates ATR–ATRIP and promotes TopBP1 recruitment to sites of UV-damage

(2014) Eiji Ohashi et al.   DNA REPAIR

A rapid, comprehensive system for assaying DNA repair activity and cytotoxic effects of DNA-damaging reagents

(2014) Nan Jia et al.   Nature Protocols

Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing

(2014) Hongqing Liang et al.   Nature Communications

Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally

(2013) M. Yekezare et al.   JOURNAL OF CELL SCIENCE

Regulation of the DNA Damage Response by Cyclin-Dependent Kinases

(2013) Camilla Trovesi et al.   JOURNAL OF MOLECULAR BIOLOGY

Efficient Initiation of DNA Replication in Eukaryotes Requires Dpb11/TopBP1-GINS Interaction

(2013) S. Tanaka et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis for the inhibition of Polo-like kinase 1

(2013) Jun Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The DNA damage checkpoint response to replication stress: A Game of Forks

(2013) Rachel Jossen et al.   Frontiers in Genetics

The conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1

(2012) Shizhou Liu et al.   CELL CYCLE

Rad9B responds to nucleolar stress through ATR and JNK signalling, and delays the G1-S transition

(2012) A. J. Perez-Castro et al.   JOURNAL OF CELL SCIENCE

Plk1 Phosphorylation of Orc2 and Hbo1 Contributes to Gemcitabine Resistance in Pancreatic Cancer

(2012) B. Song et al.   MOLECULAR CANCER THERAPEUTICS

Plk1 and CK2 Act in Concert to Regulate Rad51 during DNA Double Strand Break Repair

(2012) Keiko Yata et al.   MOLECULAR CELL

Regulation of DNA Replication through Sld3-Dpb11 Interaction Is Conserved from Yeast to Humans

(2011) Dominik Boos et al.   CURRENT BIOLOGY

Plk1 Phosphorylation of Orc2 Promotes DNA Replication under Conditions of Stress

(2011) B. Song et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of the initiation step of DNA replication by cyclin-dependent kinases

(2010) Seiji Tanaka et al.   CHROMOSOMA

Mouse Rad9b is essential for embryonic development and promotes resistance to DNA damage

(2010) Corinne Leloup et al.   DEVELOPMENTAL DYNAMICS

Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1

(2010) Yukimasa Takeishi et al.   GENES TO CELLS

DDK Phosphorylates Checkpoint Clamp Component Rad9 and Promotes Its Release from Damaged Chromatin

(2010) Kanji Furuya et al.   MOLECULAR CELL

Chk1 promotes replication fork progression by controlling replication initiation

(2010) E. Petermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

(2010) Marcel A. T. M. van Vugt et al.   PLOS BIOLOGY

DNA replication as a target of the DNA damage checkpoint

(2009) Philip Zegerman et al.   DNA REPAIR

The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms

(2009) Vasundhara M. Navadgi-Patil et al.   MOLECULAR CELL

The Basic Cleft of RPA70N Binds Multiple Checkpoint Proteins, Including RAD9, To Regulate ATR Signaling

(2008) X. Xu et al.   MOLECULAR AND CELLULAR BIOLOGY

A chemical method for fast and sensitive detection of DNA synthesis in vivo

(2008) A. Salic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA