Structural insights into the molecular mechanisms of myasthenia gravis and their therapeutic implications

X-ray structure of the human α4β2 nicotinic receptor

(2016) Claudio L. Morales-Perez et al.   NATURE

AChR-specific immunosuppressive therapy of myasthenia gravis

(2015) Jie Luo et al.   BIOCHEMICAL PHARMACOLOGY

Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain

(2014) Marios Zouridakis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Direct Proof of the In Vivo Pathogenic Role of the AChR Autoantibodies from Myasthenia Gravis Patients

(2014) Gregory Kordas et al.   PLoS One

Structural characterization of the main immunogenic region of the Torpedo acetylcholine receptor

(2013) Stuart W. Morell et al.   MOLECULAR IMMUNOLOGY

Antibodies against the main immunogenic region of the acetylcholine receptor correlate with disease severity in myasthenia gravis

(2012) Tomoko Masuda et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

(2011) Shu-Xing Li et al.   NATURE NEUROSCIENCE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Antibody effector mechanisms in myasthenia gravis—Pathogenesis at the neuromuscular junction

(2010) Alejandro M. Gomez et al.   AUTOIMMUNITY

Main Immunogenic Region Structure Promotes Binding of Conformation-Dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity

(2009) J. Luo et al.   JOURNAL OF NEUROSCIENCE

In pursuit of the high-resolution structure of nicotinic acetylcholine receptors

(2009) Lin Chen   JOURNAL OF PHYSIOLOGY-LONDON

Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity

(2009) Matthew N Meriggioli et al.   LANCET NEUROLOGY

Antigen-specific Apheresis of Pathogenic Autoantibodies from Myasthenia Gravis Sera

(2008) Socrates J. Tzartos et al.   Annals of the New York Academy of Sciences

Roles of Accessory Subunits in  4 2* Nicotinic Receptors

(2008) A. Kuryatov et al.   MOLECULAR PHARMACOLOGY