Article
Medicine, General & Internal
Grace Mengqin Ge, Edmund C. L. Cheung, Kenneth K. C. Man, Patrick Ip, Wing Cheong Leung, Gloria H. Y. Li, Annie W. C. Kung, Ching-Lung Cheung, Ian C. K. Wong
Summary: The study found that maternal levothyroxine treatment during pregnancy is associated with an increased risk of preterm birth in offspring, but not significantly associated with low birth weight, ADHD, or ASD.
Article
Pediatrics
Mina Park, Gillian E. Hanley, Martin Guhn, Tim F. Oberlander
Summary: The study found that prenatal antidepressant exposure was associated with increased anxious behaviors and lower physical independence in children at kindergarten age, but had no significant effects on other developmental domains. These effects are likely attributable to the severity of underlying maternal mood disorders, emphasizing the importance of maternal mental health for developmental outcomes.
PEDIATRIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Jennifer K. Straughen, Alexandra R. Sitarik, Ganesa Wegienka, Christine Cole Johnson, Tisa M. Johnson-Hooper, Andrea E. Cassidy-Bushrow
Summary: This study examines the association between antimicrobials used during pregnancy and the risk of attention deficit hyperactivity disorder (ADHD) in children. The results show that maternal prenatal antifungal use and frequent prenatal antibiotic use are associated with an increased risk of ADHD in offspring at age 10.
Article
Psychology, Developmental
Courtney Dow, Cedric Galera, Marie-Aline Charles, Barbara Heude
Summary: Evidence suggests a link between maternal obesity during pregnancy and offspring attention-deficit hyperactivity disorder. This study aimed to examine the association between maternal pre-pregnancy body mass index (BMI) and child hyperactivity-inattention symptoms (HIS) at different ages. The results showed that maternal pre-pregnancy obesity was associated with increased likelihood of a high HIS trajectory in children from 3 to 8 years old, while pre-pregnancy overweight was not significantly associated.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Pediatrics
Yu-Chun Lin, Ching-Heng Lin, Ming-Chih Lin
Summary: This study suggests that prenatal exposure to antibiotics may significantly increase the risk of developing Attention deficit hyperactivity disorder (ADHD) in children, while only having a borderline effect on the risk of Autism spectrum disorder (ASD).
Review
Clinical Neurology
Qiuji Tao, Yajun Shen, Yang Li, Huan Luo, Meng Yuan, Jing Gan
Summary: The study found that prenatal antibiotic exposure is associated with an increased risk of ADHD and epilepsy in offspring, but there is no significant association with ASD and CP.
FRONTIERS IN NEUROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Hui Wang, Krisztina D. Laszlo, Mika Gissler, Fei Li, Jun Zhang, Yongfu Yu, Jiong Li
Summary: Maternal hypertensive disorders during pregnancy, especially pre-eclampsia, are associated with increased risks of ADHD, ASD, and ID in offspring. The timing and severity of pre-eclampsia play a significant role in these associations, with early-onset and severe cases showing the strongest links. These associations remain consistent across various subgroups and are independent of shared familial factors.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Obstetrics & Gynecology
Eleni Tsamantioti, Sarka Lisonkova, Giulia Muraca, Anne K. Ortqvist, Neda Razaz
Summary: A population-based study in Sweden found that chorioamnionitis exposure during pregnancy may increase the risk of neurodevelopmental disorders in offspring, particularly through preterm delivery. This association was mainly observed in cerebral palsy, autism, attention deficit hyperactivity disorder, and intellectual disability.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Pediatrics
Li-Fan Pai, Der-Shiun Wang, Wan-Fu Hsu, Shao-Wei Huang, Chi-Hsiang Chung, Shyi-Jou Chen, Wu-Chien Chien, Der-Ming Chu
Summary: This study found that children with ADHD have a higher risk of central precocious puberty. Early referral to a pediatric endocrinologist for evaluation can lead to correct diagnosis. Early intervention treatment with gonadotropin-releasing hormone agonist may improve final height in children with central precocious puberty.
PEDIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Shuang-shuang Ma, Dao-min Zhu, Wan-jun Yin, Jia-hu Hao, Kun Huang, Fang-biao Tao, Rui-xue Tao, Peng Zhu
Summary: The study revealed that toddlers born to mothers with more severe depressive symptoms are more likely to develop ADHD, especially if the toddlers have neonatal vitamin D deficiency. Additionally, the risk of ADHD is significantly increased in toddlers with both maternal depression and neonatal vitamin D deficiency.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Silvia Alemany, Claudia Avella-Garcia, Zeyan Liew, Raquel Garcia-Esteban, Kosuke Inoue, Tim Cadman, Monica Lopez-Vicente, Llucia Gonzalez, Isolina Riano Galan, Ainara Andiarena, Maribel Casas, Katerina Margetaki, Katrine Strandberg-Larsen, Deborah A. Lawlor, Hanan El Marroun, Henning Tiemeier, Carmen Iniguez, Adonina Tardon, Loreto Santa-Marina, Jordi Julvez, Daniela Porta, Leda Chatzi, Jordi Sunyer
Summary: The study found that children prenatally exposed to acetaminophen were more likely to have borderline or clinical ASC and ADHD symptoms in the future. The association was slightly stronger among boys, but postnatal exposure to acetaminophen did not show any significant association with ASC or ADHD symptoms. The results support the need to provide clear information to pregnant women and their partners about the potential risks of acetaminophen use.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Psychiatry
Adrienne Y. L. Chan, Le Gao, Louise M. Howard, Emily Simonoff, Dave Coghill, Patrick Ip, Wallis C. Y. Lau, Katja Taxis, Ian C. K. Wong, Kenneth K. C. Man
Summary: This study evaluated the association between gestational benzodiazepine and/or z-drug exposure and adverse birth and neurodevelopmental outcomes. The findings showed no significant differences in the risk of preterm birth, small for gestational age, ASD, or ADHD between children exposed and not exposed to these medications during pregnancy.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2023)
Letter
Medicine, General & Internal
De-Kun Li
Summary: The study investigated the association between maternal exposure to magnetic field nonionizing radiation during pregnancy and the risk of attention-deficit/hyperactivity disorder in offspring in a longitudinal birth cohort. However, for certain reasons, the study results have been retracted and replaced.
Article
Medicine, General & Internal
Meghan P. Howell, Christopher W. Jones, Cade A. Herman, Celia V. Mayne, Camilo Fernandez, Katherine P. Theall, Kyle C. Esteves, Stacy S. Drury
Summary: The study found that prenatal maternal smoking is associated with telomere shortening in infants, impacting TL trajectory and correlating with symptoms of ADHD in early childhood, especially evident in non-depressed mothers. These findings offer a new mechanistic pathway for understanding the effects of maternal prenatal smoking on infant health.
Article
Psychiatry
Vincent Chin-Hung Chen, Hsiang-Lin Chan, Shu- Wu, Mong-Liang Lu, Michael E. Dewey, Robert Stewart, Charles Tzu-Chi Lee
Summary: This study found that the use of methylphenidate (MPH) is associated with a reduced mortality rate among children with ADHD, while delayed use of MPH is associated with higher mortality.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Clinical
Vanessa W. S. Ng, Le Gao, Esther W. Chan, Ho Ming Edwin Lee, Joseph F. Hayes, David P. J. Osborn, Timothy H. Rainer, Kenneth K. C. Man, Ian C. K. Wong
Summary: This study examined the association between pharmacological treatment and the risk of emergency room admissions due to traumatic injuries among patients with bipolar disorder. The analysis found that there was an increased risk of traumatic injuries before treatment, but the risk decreased after treatment initiation and returned to baseline during maintenance treatment. However, the risk increased again after treatment cessation.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Primary Health Care
Annie Jeffery, Cini Bhanu, Kate Walters, Ian C. K. Wong, David Osborn, Joseph F. Hayes
Summary: This study investigates the association between the number of prescribed medications and early discontinuation of antidepressant treatment in adults with type 2 diabetes. The findings suggest that individuals with higher levels of concurrent polypharmacy are more adherent to treatment, while individuals with lower levels of concurrent polypharmacy may benefit from adherence support.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Letter
Infectious Diseases
Xue Li, Kuan Peng, Franco W. T. Cheng, David C. L. Lam, Ching Lung Cheung, Celine S. L. Chui, Francisco T. T. Lai, Eric Y. F. Wan, Carlos K. H. Wong, Tiantian Ma, Samson H. H. Yum, Esther W. Y. Chan, Jian Dong Huang, Chak Sing Lau, Mary S. M. Ip, Ian C. K. Wong
JOURNAL OF INFECTION
(2023)
Article
Geriatrics & Gerontology
Hyesung Lee, Yeon-Hee Baek, Ju Hwan Kim, Tzu-Chi Liao, Wallis C. Y. Lau, Kenneth K. C. Man, Xiwen Qin, Stephen Wood, Jenni Ilomaeki, J. Simon Bell, Edward Chia-Cheng Lai, Miriam T. Y. Leung, Adrienne Y. L. Chan, Celine S. L. Chui, Ian C. K. Wong, Ju-Young Shin
Summary: Polypharmacy among older people represents a global challenge, with higher prevalence in Asian countries such as Hong Kong, Taiwan, and South Korea. Australia and the United Kingdom have shown decreasing trends in polypharmacy. Monitoring and optimizing medication treatment for older people in Asia is necessary.
Review
Pharmacology & Pharmacy
Le Gao, Kenneth K. C. Man, Min Fan, Grace M. Q. Ge, Wallis C. Y. Lau, Ching-Lung Cheung, David Coghill, Patrick Ip, Kirstie H. T. W. Wong, Ian C. K. Wong
Summary: Animal studies show that methylphenidate treatment for around 3 months may lead to less mineralized and weaker appendicular bones. A systematic review and a self-controlled case series study were conducted to assess the risk of fractures before and after treatment initiation. The findings suggest that methylphenidate treatment may lower the risk of all-cause fractures, but more research is needed to investigate the effects of treatment duration and sex.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Francisco Tsz Tsun Lai, Min Fan, Caige Huang, Celine Sze Ling Chui, Eric Yuk Fai Wan, Xue Li, Carlos King Ho Wong, Ching-Lung Cheung, Ian Chi Kei Wong, Esther Wai Yin Chan
Summary: Extending the interval between doses of mRNA Covid-19 vaccines has been linked with a reduced risk of myocarditis in children and adolescents, but impacts on vaccine effectiveness are not known.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Adrienne Y. L. Chan, Tian-Tian Ma, Wallis C. Y. Lou, Patrick Lp, David Coghill, Le Gao, Yogini H. Jani, Yingfen Hsia, Li Wei, Katja Taxis, Emily Simonoff, David Taylor, Terry Y. Lum, Kenneth K. C. Man, Ian C. K. Wong
Summary: This study evaluated the trends and patterns of ADHD medication consumption across multiple countries. The results showed an overall increase in ADHD medication consumption globally, particularly in high-income countries. However, most middle-income countries had lower rates of ADHD medication consumption, indicating the need to address barriers to diagnosis and treatment.
Article
Medicine, General & Internal
Gloria Hoi-Yee Li, Ching -Lung Cheung, Kathryn Choon-Beng Tan, Annie Wai-Chee Kung, Timothy Chi-Yui Kwok, Wallis Cheuk-Yin Lau, Janus Siu-Him Wong, Warrington W. Q. Hsu, Christian Fang, Ian Chi-Kei Wong
Summary: Sex-specific hip fracture prediction models were developed using electronic health records (EHR) without bone mineral density (BMD) data. The logistic regression (LR) model showed better discrimination and classification performance than machine learning (ML) algorithms in both internal and independent validation cohorts for both females and males. The LR models could be integrated into routine clinical workflow to identify high-risk individuals for DXA scan.
Article
Health Care Sciences & Services
Min Fan, Francisco Tsz Tsun Lai, Franco Wing Tak Cheng, Natalie Tsz Ying Tsie, Xue Li, Eric Yuk Fai Wan, Carlos King Ho Wong, Esther Wai Yin Chan, Kai Hang Yiu, Ian Chi Kei Wong, Celine Sze Ling Chui
Summary: This study assessed the risk of carditis following three doses of BNT162b2 or CoronaVac through a self-controlled case series (SCCS) and a case-control study. The results showed increased carditis risks after all three doses of BNT162b2, especially in individuals below 30 years old and males.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Review
Health Care Sciences & Services
Martin Law, Sam S. H. Ho, Gigi K. C. Tsang, Clarissa M. Y. Ho, Christine M. Kwan, Vincent Ka Chun Yan, Hei Hang Edmund Yiu, Francisco Tsz Tsun Lai, Ian Chi Kei Wong, Esther Wai Yin Chan
Summary: This study systematically evaluated the efficacy and effectiveness of inactivated vaccines against SARS-CoV-2 and found evidence of their efficacy and effectiveness for various outcomes. However, inconsistent reporting of key parameters, high heterogeneity in observational studies, and limitations in study design for certain outcomes undermine the reliability of the findings, highlighting the need for further research to address these limitations.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Letter
Medicine, General & Internal
Eric Yuk Fai Wan, Vincent Ka Chun Yan, Anna Hoi Ying Mok, Ian Chi Kei Wong, Esther Wai Yin Chan
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Primary Health Care
Widya N. Insani, Cate Whittlesea, Chengsheng Ju, Kenneth K. C. Man, Matthew Adesuyan, Sarah Chapman, Li Wei
Summary: This study investigates the impact of ACEIs/ARBs-related ADR consultation on CVD events and all-cause mortality. The findings show that patients with ACEIs/ARBs-related ADR consultation have an increased risk of subsequent CVD events and all-cause mortality. Additionally, patients who continue to use ACEIs/ARBs after ADR consultation have a reduced risk of mortality.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Review
Respiratory System
Chris Wai Hang Lo, Swathi Pathadka, Simon Xiwen Qin, Lydia W. Y. Fung, Vincent Ka Chun Yan, Hei Hang Edmund Yiu, Chloe I. Bloom, Ian Chi Kei Wong, Esther Wai Yin Chan
Summary: This study systematically reviewed the neuropsychiatric events associated with montelukast, finding no significant association with suicide and depression events in asthma patients, but possible associations with anxiety and sleeping disorders, particularly in older adults.
EUROPEAN RESPIRATORY REVIEW
(2023)