Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 767, Issue -, Pages 82-93Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2015.10.011
Keywords
Neuroinflammation; Neuroprotection; Microglia; Sesquiterpene dimer; Reactive oxygen species
Categories
Funding
- National Key Technology R & D Program New Drug Innovation of China [2012ZX09301002-002-002]
- National Natural Science Foundation of China [81303253, 30873072]
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This work aims to evaluate the anti-neuroinflammatory effects of natural sesquiterpene dimer caruifolin D from Artemisia absinthium L., which is an edible vegetable or traditional medicinal food in East Asia due to its sedation, anti-asthma and antipruritic effects. In this study, we reported that caruifolin D significantly inhibited the productions of various neuroinflammatory mediators from microglia in response to bacterial lipopolysaccharide stimulation. Moreover, anti-inflammatory mechanism study showed that caruifolin D markedly suppressed the production of intracellular reactive oxygen species, which was an important player involved in neuroinflammation, leading to inhibitory effects on the activations of protein kinase C (PKC) and c-Jun N-terminal kinase (INK), which were two major neuroinflammatory signaling pathways in the brains. Furthermore, caruifolin D protected neurons against microglia-mediated neuronal inflammatory damages by up-regulating neuronal viability and maintaining healthy neuronal morphology. Taken together, these results expanded our knowledge about the anti-neuroinflammatory and neuroprotective mechanism of Artemisia absinthium L., and also suggested that caruifolin D was a major anti-inflammatory component from Artemisia absinthium L., which might be developed as a drug candidate for neuroinflammation-related diseases. (C) 2015 Elsevier B.V. All rights reserved.
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