Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Article
Orthopedics
Bradley Wetzell, Julie B. McLean, Kimberly Dorsch, Mark A. Moore
Summary: The study found that V-CBA group compared to the rhBMP-2 group, showed significantly lower cumulative mean hospitalization charges in the 24-month follow-up period, with no differences in lengths of stay. In the full cohort, V-CBA patients also had higher rates of subsequent lumbar fusion procedures.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yi-ding Zhang, Ao-bo Ma, Lu Sun, Jun-duo Chen, Guang Hong, Hong-kun Wu
Summary: This study explores an easy and sound way to modify the biological behavior of microspheres for bone tissue regeneration. Nanoclay can successfully sediment on the surface of microspheres, binding with either positively or negatively charged proteins. These properties facilitate cell proliferation and minimize the use of BMP-2.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Wenbo Zhang, Pu Xu, Yanan Cheng, Yanlan Yang, Qiuhua Mao, Zuogeng Chen
Summary: A nanopearl powder/C-HA/rhBMP-2 composite artificial bone material was prepared and evaluated for its biological properties. The composite material exhibited good pore structure, high porosity, and compressive strength, and it promoted cell proliferation and differentiation while upregulating the expression of osteogenesis-related genes.
Review
Biotechnology & Applied Microbiology
Sung-Woon On, Sang-Yoon Park, Sang-Min Yi, In-Young Park, Soo-Hwan Byun, Byoung-Eun Yang
Summary: This review presents the current status of recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillofacial surgery, including its clinical application, efficacy, safety, and limitations. Studies have shown that rhBMP-2 has potential in reducing donor site complications and increasing bone height, but it may not be as effective as autogenous bone grafts. In the treatment of medication-related osteonecrosis of the jaw, rhBMP-2 has promising results but requires further investigation for long-term safety. In maxillofacial trauma, it is limited to large defect restoration. Safety concerns include postoperative edema and the theoretical risk of carcinogenesis. Limitations include the lack of an ideal carrier, high cost, and optimal dosing regimen.
BIOENGINEERING-BASEL
(2023)
Article
Chemistry, Physical
Tianyi Bao, Zheng Zhou, Peng Gao, Xiaohan Dong, Jian Chen, Shujie Zhao, Pingsheng Liu, Guoyong Yin
Summary: This study designed a multilayer polyelectrolyte coating that can promote the integration of metallic implants with bone and possess antibacterial properties. Stable coatings were constructed on titanium alloy substrates using a layer-by-layer technology, allowing for the sustained release of bone morphogenetic protein 2 and promotion of cell differentiation. Additionally, the polycationic component in the coating significantly improved the antibacterial properties of the titanium alloy surface.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yueh-Ling Chao, Tong-Mei Wang, Hao-Hueng Chang, Li-Deh Lin
Summary: The study investigated the potential of low-dose rhBMP-2 combined with a composite material in repairing peri-implant critical size defects, with results showing that HAp/TCP/Col +0.2 mg/ml rhBMP-2 demonstrated strong osteogenic potential and improved implant stability.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hyun Seok, Hee-Youl Kim, Dong-Cheol Kang, Jung-Ho Park, Jong Hoon Park
Summary: The study compared the bone regeneration ability of bone scaffolds using particle and block bones with rhBMP-2, showing that rhBMP-2 with block bones resulted in significantly higher bone volume but also led to the formation of adipose tissue and void spaces.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ji-In Ryu, Byoung-Eun Yang, Sang-Min Yi, Hyo-Geun Choi, Sung-Woon On, Seok-Jin Hong, Ho-Kyung Lim, Soo-Hwan Byun
Summary: The study demonstrated that 3D-printed custom HA/TCP graft with rhBMP-2 showed bone regeneration effects similar to that of particulate Bio-Oss with rhBMP-2, suggesting its potential application in various fields of bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Pei Kai Shi, Wan Tong Zhou, Jing Bo Dong, Shu Jun Li, Peng Jun Lv, Chenxi Liu
Summary: The objective of this study was to investigate the potential of bioglass combined with rhBMP-9 on BMSCs in vitro and compare the bone regeneration effects of different carrier systems in a rat alveolar bone preservation model in vivo. The results showed that bioglass effectively absorbed and released rhBMP9, and the combination of bioglass and rhBMP9 promoted cell viability, adhesion, proliferation, and osteogenic differentiation. The combination of bioglass and rhBMP9 with BG showed improved bone formation parameters compared to bioglass with BG alone, indicating their potential in bone regeneration.
Review
Dentistry, Oral Surgery & Medicine
Maria Elisa Galarraga-Vinueza, Shayan Barootchi, Marc L. Nevins, Myron Nevins, Richard J. Miron, Lorenzo Tavelli
Summary: Contemporary oral tissue engineering strategies involve the use of recombinant human growth factors to stimulate cellular processes and promote tissue regeneration. Growth factor-mediated surgical approaches have shown advantages in severe oral tissue defects. Recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and recombinant human bone morphogenetic proteins (rhBMPs) have been extensively studied for their clinical applications, but the evidence regarding their benefits compared to conventional therapies is inconclusive. This review explores the current applications and outcomes of rhPDGF-BB and rhBMPs for oral tissue regeneration.
PERIODONTOLOGY 2000
(2023)
Article
Multidisciplinary Sciences
Ho-Kyung Lim, Yeh-Jin Kwon, Seok-Jin Hong, Hyo-Geun Choi, Sung-Min Chung, Byoung-Eun Yang, Jong-Ho Lee, Soo-Hwan Byun
Summary: The study evaluated the effects of different concentrations of PDRN and rhBMP-2 on bone regeneration and mechanical properties of HA/TCP scaffolds. Results showed that rhBMP-2 significantly increased bone formation, while PDRN showed no significant effect; when used at optimal concentrations, HA/TCP scaffolds demonstrated sufficient bone regeneration capacity and mechanical strength.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Sang-Hyon Kim, Hye-Jung Choi, Dae Sung Yoon, Chang-Nam Son
Summary: The serial administration of rhBMP-2 and ALN increased the expression of differentiation-related factors and differentiation ability of osteoblasts. Serial treatment with rhBMP-2 followed by ALN showed the highest differentiation effect. This study suggests that the upregulation of Runx2 and OPN may play a key role in the osteogenic effects of rhBMP-2 and ALN on osteoblastic cells.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Orthopedics
Joseph A. Panos, Michael J. Coenen, Christopher V. Nagelli, Erin B. McGlinch, Aysegul Atasoy-Zeybek, Consuelo Lopez De Padilla, Rodolfo E. De la Vega, Christopher H. Evans
Summary: This study compared the bone regeneration in a rat femoral defect model under native, impaired, and growth factor-stimulated conditions. Native bone regeneration resulted in a fully healed defect, while impaired bone regeneration led to fibrofatty consolidation resembling an atrophic non-union. Treatment with rhBMP2 promoted rapid bone formation but resulted in inferior mechanical properties compared to natural healing. Technologies favoring endochondral regenerative ossification would improve clinical outcomes.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ronald E. Jung, Marionna N. Kovacs, Daniel S. Thoma, Christoph H. F. Hammerle
Summary: The long-term outcomes of implants placed in conjunction with guided bone regeneration (GBR) with or without recombinant human bone morphogenetic protein-2 (rhBMP-2) were assessed. The study showed that after at least 17 years, the implant survival rate was 100% and the clinical and radiographic results were excellent.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)