Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research

Activated protein C  -glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury

(2015) E. M. Gleeson et al.   BLOOD

New Missions for an Old Agent: Granulocyte-Colony Stimulating Factor in the Treatment of Stroke Patients

(2015) Ihsan Solaroglu et al.   CURRENT MEDICINAL CHEMISTRY

Solitaire™ with the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT PRIME) Trial: Protocol for a Randomized, Controlled, Multicenter Study Comparing the Solitaire Revascularization Device with IV tPA with IV tPA Alone in Acute Ischemic Stroke

(2015) Jeffrey L. Saver et al.   International Journal of Stroke

Neuroprotective effects of cutamesine, a ligand of the sigma-1 receptor chaperone, against noise-induced hearing loss

(2015) Daisuke Yamashita et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST): a phase 2, randomised, open-label, blinded endpoint study

(2015) Xuya Huang et al.   LANCET NEUROLOGY

Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial: Rationale and Design

(2015) Kevin N. Sheth et al.   Neurocritical Care

Endovascular vs medical management of acute ischemic stroke

(2015) Ching-Jen Chen et al.   NEUROLOGY

Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke

(2015) Mayank Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection

(2015) Bruce C.V. Campbell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined Approach to Lysis Utilizing Eptifibatide and Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke-Full Dose Regimen Stroke Trial

(2015) Opeolu Adeoye et al.   STROKE

A primer on clinical trial design

(2015) Chad Ellimoottil et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Clinical Trials in Acute Ischemic Stroke

(2014) Kiyoshi Kikuchi et al.   CNS DRUGS

Phase 1 Safety, Tolerability and Pharmacokinetics of 3K3A-APC in Healthy Adult Volunteers

(2014) Patrick Lyden et al.   CURRENT PHARMACEUTICAL DESIGN

Effects of edaravone on early outcomes in acute ischemic stroke patients treated with recombinant tissue plasminogen activator

(2014) Tomoki Wada et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Phase II Trial of the Sigma-1 Receptor Agonist Cutamesine (SA4503) for Recovery Enhancement After Acute Ischemic Stroke

(2014) Roman Urfer et al.   STROKE

Molecular and Cellular Immune Responses to Ischemic Brain Injury

(2014) Hilary A. Seifert et al.   Translational Stroke Research

Safety, Tolerability and Pharmacokinetics of MCI-186 in Patients with Acute Ischemic Stroke: New Formulation and Dosing Regimen

(2013) Markku Kaste et al.   CEREBROVASCULAR DISEASES

Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity

(2013) L. O. Mosnier et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Glyburide is Associated with Attenuated Vasogenic Edema in Stroke Patients

(2013) W. Taylor Kimberly et al.   Neurocritical Care

SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models

(2013) Yoko Ono et al.   NEUROSCIENCE LETTERS

Combined Approach to Lysis Utilizing Eptifibatide and Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke–Enhanced Regimen Stroke Trial

(2013) Arthur M. Pancioli et al.   STROKE

Safety, Pharmacokinetics, and Pharmacodynamics of Escalating Repeat Doses of GSK249320 in Patients With Stroke

(2013) Steven C. Cramer et al.   STROKE

Activated Protein C Analog Protects From Ischemic Stroke and Extends the Therapeutic Window of Tissue-Type Plasminogen Activator in Aged Female Mice and Hypertensive Rats

(2013) Yaoming Wang et al.   STROKE

Granulocyte Colony–Stimulating Factor in Patients With Acute Ischemic Stroke

(2013) E. Bernd Ringelstein et al.   STROKE

Pilot Study of Intravenous Glyburide in Patients With a Large Ischemic Stroke

(2013) Kevin N. Sheth et al.   STROKE

Disruption of Ion Homeostasis in the Neurogliovascular Unit Underlies the Pathogenesis of Ischemic Cerebral Edema

(2013) Arjun Khanna et al.   Translational Stroke Research

Pathobiology of injury after stroke: the neurovascular unit and beyond

(2012) Ulrich Dirnagl   Annals of the New York Academy of Sciences

First-Time-in-Human Study With GSK249320, a Myelin-Associated Glycoprotein Inhibitor, in Healthy Volunteers

(2012) B Abila et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Sigma-1 Receptor Agonists as Therapeutic Drugs for Cognitive Impairment in Neuropsychiatric Diseases

(2012) Tomihisa Niitsu et al.   CURRENT PHARMACEUTICAL DESIGN

ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia–ischemia in rats

(2012) F.J. Ortega et al.   EXPERIMENTAL NEUROLOGY

Phase I Study of Intravenous Low-dose Granulocyte Colony-stimulating Factor in Acute and Subacute Ischemic Stroke

(2012) Yusuke Moriya et al.   Journal of Stroke & Cerebrovascular Diseases

A Randomized Trial of Tenecteplase versus Alteplase for Acute Ischemic Stroke

(2012) Mark Parsons et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of the Sigma-1 Receptor Agonist 1-(3,4-Dimethoxyphenethyl)-4-(3-Phenylpropyl)-Piperazine Dihydro-Chloride on Inflammation after Stroke

(2012) Karsten Ruscher et al.   PLoS One

An Activated Protein C Analog With Reduced Anticoagulant Activity Extends the Therapeutic Window of Tissue Plasminogen Activator for Ischemic Stroke in Rodents

(2012) Yaoming Wang et al.   STROKE

RIGOR Guidelines: Escalating STAIR and STEPS for Effective Translational Research

(2012) Paul A. Lapchak et al.   Translational Stroke Research

Challenges in Acute Ischemic Stroke Clinical Trials

(2012) Anthony J. Furlan   Current Cardiology Reports

Glycoprotein IIb/IIIa inhibitors: an update on the mechanism of action and use of functional testing methods to assess antiplatelet efficacy

(2011) Giuseppe Lippi et al.   Biomarkers in Medicine

Glibenclamide ameliorates ischemia–reperfusion injury via modulating oxidative stress and inflammatory mediators in the rat hippocampus

(2011) Dalaal M. Abdallah et al.   BRAIN RESEARCH

Novel Antiplatelet Drug Revacept (Dimeric Glycoprotein VI-Fc) Specifically and Efficiently Inhibited Collagen-Induced Platelet Aggregation Without Affecting General Hemostasis in Humans

(2011) Martin Ungerer et al.   CIRCULATION

Enhancing Recovery After Acute Ischemic Stroke with Donepezil as an Adjuvant Therapy to Standard Medical Care: Results of a Phase IIa Clinical Trial

(2011) Kevin M. Barrett et al.   Journal of Stroke & Cerebrovascular Diseases

Mobilisation of Hematopoietic CD34+ Precursor Cells in Patients with Acute Stroke Is Safe - Results of an Open-Labeled Non Randomized Phase I/II Trial

(2011) Sandra Boy et al.   PLoS One

Decoding Hippocampal Signaling Deficits After Traumatic Brain Injury

(2011) Coleen M. Atkins   Translational Stroke Research

Granulocyte-colony-stimulating Factor for Acute Ischemic Stroke: A Randomized Controlled Trial (STEMTHER)

(2011) Andrey Marisovich Alasheev et al.   Translational Stroke Research

Mayo Acute Stroke Trial for Enhancing Recovery (MASTER) Protocol

(2010) James F. Meschia et al.   Journal of Stroke & Cerebrovascular Diseases

Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome

(2010) Amjad Shehadah et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Caffeinol at the Receptor Level

(2010) Xiurong Zhao et al.   STROKE

New Approaches to Neuroprotective Drug Development

(2010) M. Fisher   STROKE

AXIS

(2010) Wolf R. Schäbitz et al.   STROKE

High-Dose Lovastatin for Acute Ischemic Stroke: Results of the Phase I Dose Escalation Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART)

(2009) Mitchell S.V. Elkind et al.   CEREBROVASCULAR DISEASES

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

(2009) Huang Guo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation

(2009) Silvia Carloni et al.   EXPERIMENTAL NEUROLOGY

Combined Neuroprotective Modalities Coupled with Thrombolysis in Acute Ischemic Stroke: A Pilot Study of Caffeinol and Mild Hypothermia

(2009) Sheryl Martin-Schild et al.   Journal of Stroke & Cerebrovascular Diseases

An Open-Label Pilot Study of Acetylcholinesterase Inhibitors to Promote Functional Recovery in Elderly Cognitively Impaired Stroke Patients

(2008) Ellen M. Whyte et al.   CEREBROVASCULAR DISEASES

The Neuroprotection with Statin Therapy for Acute Recovery Trial (Neustart): An Adaptive Design Phase I Dose-Escalation Study of High-Dose Lovastatin in Acute Ischemic Stroke

(2008) Mitchell S. V. Elkind et al.   International Journal of Stroke

The C ombined Approach to L ysis Utilizing E ptifibatide a nd r t-PA in Acute Ischemic Stroke

(2008) Arthur M. Pancioli et al.   STROKE