Article
Nutrition & Dietetics
Malgorzata Godala, Ewelina Gaszynska, Konrad Walczak, Ewa Malecka-Wojciesko
Summary: This study evaluated the utility of albumin, transferrin, and transthyretin levels in assessing nutritional status and activity of inflammatory bowel disease (IBD). The results found significantly lower albumin levels in IBD patients compared to controls and in Crohn's disease (CD) patients compared to ulcerative colitis (UC) patients. Higher transthyretin levels were found in IBD patients compared to healthy subjects. Albumin levels in IBD patients were associated with disease activity and nutritional status, while further studies are needed to assess the utility of transferrin and transthyretin as markers.
Article
Gastroenterology & Hepatology
Damir Alicic, Dinko Martinovic, Doris Rusic, Piero Marin Zivkovic, Ivana Tadin Hadjina, Marino Vilovic, Marko Kumric, Daria Tokic, Daniela Supe-Domic, Slaven Lupi-Ferandin, Josko Bozic
Summary: Patients with IBD have significantly higher levels of serum UII compared to control subjects, with significant correlations observed between UII levels and high sensitivity C reactive protein, total protein, blood pressure, and endoscopic scores in both Crohn's disease and ulcerative colitis patients. Multiple linear regression analysis further confirmed the associations of UII levels with high sensitivity C reactive protein and systolic blood pressure.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Yuko Akazawa, Tomohito Morisaki, Hiroko Fukuda, Kiyuu Norimatsu, Junya Shiota, Keiichi Hashiguchi, Maiko Tabuchi, Moto Kitayama, Kayoko Matsushima, Naoyuki Yamaguchi, Hisayoshi Kondo, Fumihiko Fujita, Hiroaki Takeshita, Kazuhiko Nakao, Fuminao Takeshima
Summary: This study investigated the significance of palmitoleic acid (PO) levels in the serum of patients with ulcerative colitis (UC) and Crohn's disease (CD). The results showed that serum PO levels were significantly higher in CD patients compared to controls, and were associated with CD activity index and increased risk of surgical intervention requirement during follow-up. Elevated serum PO levels might serve as a marker for local inflammation and prognosis in patients with CD.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Sengul Beyaz, Erdem Akbal
Summary: This study investigated circulating levels of nesfatin-1 in patients with inflammatory bowel diseases (IBD), showing significantly elevated levels during active disease periods with good diagnostic value for IBD. Nesfatin-1 could serve as an additional inflammatory marker for the diagnosis of IBD.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Review
Chemistry, Physical
Qinjuan Ren, Si Sun, Xiao-Dong Zhang
Summary: Maintaining gut microbiota homeostasis is crucial for nutrient metabolism and immune function. Inflammatory bowel disease (IBD) is strongly linked to dysregulation of gut microbiota, with reactive oxygen and nitrogen species playing a detrimental role in causing inflammation and dysbiosis. Redox-active nanoparticles show potential in regulating IBD by scavenging ROS and RNS, but their long-term effects on normal microbiota from widespread use in commercial products need attention.
Article
Gastroenterology & Hepatology
Emma Flanagan, Ralley Prentice, Emily K. Wright, Peter R. Gibson, Alyson L. Ross, Jakob Begun, Miles P. Sparrow, Rimma Goldberg, Ourania Rosella, Megan Burns, Katerina Kiburg, Sally J. Bell
Summary: Ustekinumab levels remain stable in pregnant women with IBD, with a higher level in infants at delivery and complete clearance within 9 weeks. Infants exposed to ustekinumab in utero should avoid live vaccination before 12 months of age.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Markus F. Neurath, Michael Vieth
Summary: Mucosal healing is an important prognostic factor in the management of patients with inflammatory bowel disease. It can predict clinical remission and resection-free survival. There are two levels of mucosal healing: endoscopic healing and histological healing. Drug therapies and new techniques can have an impact on mucosal healing, but cannot provide a definitive cure.
Article
Gastroenterology & Hepatology
Stefan Schreiber, Konrad Aden, Joana P. Bernardes, Claudio Conrad, Florian Tran, Hanna Hoeper, Valery Volk, Neha Mishra, Johanna Ira Blase, Susanna Nikolaus, Johannes Bethge, Tanja Kuehbacher, Christoph Roecken, Minhu Chen, Ian Cottingham, Niclas Petri, Birgitte B. Rasmussen, Juliane Lokau, Lennart Lenk, Christoph Garbers, Friedrich Feuerhake, Stefan Rose-John, Georg H. Waetzig, Philip Rosenstiel
Summary: The study on the treatment of IBD patients with the trans-signaling inhibitor olamkicept (sgp130Fc) showed that patients tolerated the treatment well, with 44% showing clinical response and 19% achieving clinical remission. The clinical effectiveness was associated with target inhibition and marked transcriptional changes in the inflamed mucosa.
Review
Gastroenterology & Hepatology
Anna M. Buchner, Yecheskel Schneider, Gary R. Lichtenstein
Summary: Biological therapy targeting tumor necrosis factor-alpha has become crucial in treating patients with inflammatory bowel disease, but high costs limit accessibility. Biosimilars offer the potential to reduce expenditures and increase availability, providing more options for patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mika Nakayama, Yuki Ozato, Yoshiko Tsuji, Yasuko Arao, Chihiro Otsuka, Yumiko Hamano, Genzo Sumi, Ken Ofusa, Shizuka Uchida, Andrea Vecchione, Hideshi Ishii
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa. Recent studies have shown the involvement of RNA modifications in the specific pathogenesis of IBD. RNA modification-targeting reagents have shown promising outcomes in treating colitis. Understanding RNA modifications in IBD could contribute to early diagnosis, disease monitoring, and innovative therapeutic approaches.
Review
Medicine, General & Internal
Elizabeth A. A. Spencer, Manasi Agrawal, Tine Jess
Summary: This article reviews the available predictors of outcomes in IBD patient and emphasizes the importance of global collaborative efforts and tools to support the clinical use of these prognostication tools.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Aaron B. Parrish, Nicole E. Lopez, Adam Truong, Karen Zaghiyan, Gil Y. Melmed, Dermot P. B. McGovern, Christina Ha, Gaurav Syal, Nirupama Bonthala, Anjali Jain, Carol J. Landers, Stephan R. Targan, Phillip Fleshner
Summary: This study found that serum vedolizumab levels do not affect postoperative morbidity in patients with IBD, but may help reduce the incidence of postoperative ileus in patients with Crohn's disease.
DISEASES OF THE COLON & RECTUM
(2021)
Review
Medicine, General & Internal
Elisabetta Antonelli, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo Valerio Marzano, Giovanni Maconi
Summary: This review summarizes the dermatologic manifestations occurring in patients with inflammatory bowel diseases, including specific manifestations, cutaneous disorders associated with IBDs, reactive mucocutaneous manifestations of IBDs, mucocutaneous conditions secondary to treatment, and manifestations due to nutritional malabsorption. An accurate dermatological examination is crucial in all IBD patients, especially in candidates to biologic therapies where drug-induced cutaneous reactions may be clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Article
Environmental Sciences
Jolanta Zalejska-Fiolka, Anna Birkova, Tomasz Wielkoszynski, Beata Hubkova, Beata Szlachta, Rafal Fiolka, Urszula Blaszczyk, Aleksandra Kuzan, Andrzej Gamian, Maria Marekova, Michal Toborek
Summary: The study evaluates the influence of hyperglycemia on weight loss in obese premenopausal women. The results indicate that patients with normoglycemia achieved successful weight loss, while patients with hyperglycemia experienced undesired outcomes. The study highlights the importance of introducing weight reduction strategies early, before the development of hyperglycemia.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Medicinal
Milena J. Szafraniec, Monika Toporkiewicz, Andrzej Gamian
Summary: The study demonstrates that zinc pheophorbide a has strong photodynamic activity against human endothelial cells, making it a promising photosensitizer for vascular-targeted photodynamic therapy for solid tumors. It also shows that endothelial cells are more susceptible to photodynamic treatment compared to tumor cells.
Article
Biochemistry & Molecular Biology
Przemyslaw Zdziarski, Andrzej Gamian
Summary: This study investigated the level of monocytes during CMV infection. The results showed that significant monocytosis was observed during the logarithmic phase of CMV infection. The increased count and percentage of monocytes correlated with viral replication in several clinical situations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kinga Gostomska-Pampuch, Jacek R. Wisniewski, Karol Sowinski, Wieslaw Gruszecki, Andrzej Gamian, Magdalena Staniszewska
Summary: The study found that the glycation product MAGE, generated from the reaction of melibiose with a protein, is more efficiently formed under dry conditions compared to aqueous conditions. Different structures of myoglobin with melibiose were identified, including crosslinking and non-crosslinking modifications. The results suggest that MAGE adduct is initiated by coupling melibiose to a model myoglobin protein and can further rearrange into more advanced structures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Piotr Kuropka, Anna Leskow, Katarzyna Malolepsza-Jarmolowska, Maciej Dobrzynski, Malgorzata Tarnowska, Jacek Majda, Maciej Janeczek, Katarzyna Zybura-Wszola, Andrzej Gamian
Summary: This study investigated the immunostimulating effect of levamisole on hematological parameters and its impact on the inflammatory response in the rat pleural cavity. The results showed significant modifications in hematological parameters and a reduction in leukocyte infiltrations in the lungs with single and triple doses of levamisole administration.
Article
Biochemistry & Molecular Biology
Kamil Litwinowicz, Andrzej Gamian
Summary: Microbiome alterations are important factors influencing the course of alcohol use disorder (AUD) and alcoholic liver disease (ALD). This study provides a comprehensive evaluation of microbiome alterations associated with AUD and ALD using advanced bioinformatics methods. The results show consistent changes in the abundance of certain microbial families, reduced butyrate-producing families in AUD and further reduction in ALD. There is also an increase in endotoxin-producing Proteobacteria in AUD, with the largest increase observed in the ALD group. These alterations may contribute to intestinal permeability and inflammation in AUD and ALD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bozena Futoma-Koloch, Michal Malaszczuk, Kamila Korzekwa, Malgorzata Steczkiewicz, Andrzej Gamian, Gabriela Bugla-Ploskonska
Summary: Salmonella enterica is a common pathogen that can be used as a model organism for studying bacterial biology. In this study, the researchers investigated the changes in virulence-related phenotypes of Salmonella enterica strains subjected to consecutive passages in human serum. They found that eight passages may not be enough to develop serum resistance, and observed changes in the composition of membrane proteins and binding of complement components. They also observed the development of multi-drug resistance and tolerance to disinfectants in some strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Kamil Litwinowicz, Ewa Waszczuk, Aleksandra Kuzan, Agnieszka Bronowicka-Szydelko, Kinga Gostomska-Pampuch, Piotr Naporowski, Andrzej Gamian
Summary: The biochemical mechanisms associated with the progression of alcoholic liver disease (ALD) to alcoholic hepatitis (AH) remain a challenge. The study found that the novel advanced glycation end-product AGE10 is significantly associated with AH, and showed acceptable diagnostic performance.
Review
Environmental Sciences
Iga Gromny, Katarzyna Neubauer
Summary: This study investigated the impact of celiac disease (CD) on the risk of pancreatic cancer (PC) through a systematic review and meta-analysis. The results indicated that patients with CD are more prone to develop PC when they have other malignancies. The association between CD and PC remains uncertain and further research is needed.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Microbiology
Agnieszka Razim, Sabina Gorska, Andrzej Gamian
Summary: CD is a Gram-positive, anaerobic bacterium that primarily infects hospitalized and elderly individuals who have undergone long-term antibiotic therapy. The increasing elderly population and antibiotic usage suggest that CD infections will continue to rise. Currently, there is no vaccine available for CD. Clinical trials using toxin-based antigens have shown limited efficacy in preventing colonization and transmission between patients. Therefore, a CD vaccine should include antigens from the bacterium or its spores to effectively combat toxins and inhibit patient colonization.
Review
Gastroenterology & Hepatology
Dan Dumitrascu, Igor Bakulin, Annalisa Berzigotti, Marilia Cravo, Laura Gombosova, Milan Lukas, Anna Pietrzak, Jose Maria Remes-Troche, Manuel Romero-Gomez, Mercedes Amieva Balmori, Tiago Curdia Goncalves, Lamine Hamzaoui, Radovan Juricek, Leticia Moreira, Katarzyna Neubauer, Teodora Surdea-Blaga, Igor N. Tikhonov, Jan Trna, Gianluca Ianiro, Francesca Romana Ponziani, Antonio Gasbarrini
Summary: Various environmental factors can lead to gut microbial imbalance and the development of diseases. Hepatic encephalopathy, irritable bowel syndrome, and diverticular disease are all related to dysfunction of the gut-liver-brain axis, but the pathophysiology differs for each condition.
JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
(2023)
Article
Microbiology
Monika Kozinska, Ewa Augustynowicz-Kopec, Andrzej Gamian, Anna Chudzik, Mariola Pasciak, Przemyslaw Zdziarski
Summary: Cutaneous tuberculosis is a rare disease that accounts for a small percentage of extrapulmonary tuberculosis cases. Its clinical manifestations are diverse and may resemble other dermatoses, making diagnosis challenging. It is important to note that most extrapulmonary tuberculosis cases, including skin tuberculosis, can indicate systemic involvement. This paper presents a case of an immunocompromised patient diagnosed with cutaneous tuberculosis almost a year after the initial dermatological lesions appeared on the lower extremities. Concurrently, a diagnosis of pulmonary tuberculosis was made due to respiratory symptoms, and radiological and microbiological confirmations were obtained.
Article
Infectious Diseases
Ewa Brzozowska, Tomasz Lipinski, Agnieszka Korzeniowska-Kowal, Karolina Filik, Andrzej Gorski, Andrzej Gamian
Summary: Bacteriophages are viruses that infect bacteria and are widely present in the environment, food, and normal microflora. The human microbiome is a complex network of bacteria, bacteriophages, and human cells. This study aimed to determine the levels of naturally generated antibodies specific to a bacteriophage in human serum using an ELISA-based assay. The results showed that the average level of anti-I11mO19 phage antibodies in human serum was 190 μg/mL, but cross-reactivity with other E. coli phages was also observed.
Article
Biochemistry & Molecular Biology
Joanna Piechowicz, Andrzej Gamian, Ositadima Chukwu, Dorota Polak-Jonkisz
Summary: This study evaluated the levels of various metabolites related to NO synthesis in the plasma of children with different stages of CKD and identified significant differences between control and CKD groups. Children with CKD showed disturbances in most metabolites of NO synthesis, with ADMA levels being a potential indicator of CKD progression, supported by a negative correlation with eGFR.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Review
Medicine, General & Internal
Dominika Wietrzykowska-Grishanovich, Ewa Pawlik, Katarzyna Neubauer
Summary: This study conducted a systematic review to explore the potential application of biochemical biomarkers in the diagnostic algorithms of pancreatic cystic lesions (PCLs). The findings revealed that intracystic glucose and carcinoembryonic antigen (CEA) are the most widely studied fluid biochemical markers in PCLs, with glucose demonstrating better diagnostic accuracy than CEA.
MEDICINA-LITHUANIA
(2022)