Article
Orthopedics
Zhicong Wang, Hong Wang, Ling Yang, Wei Jiang, Xi Chen, Yuehong Liu
Summary: This study highlights the association between high PLR and increased one year all-cause mortality in elderly hip fracture patients. High PLR remained an independent predictor for mortality in multivariate analysis, and the high PLR group also had a higher mortality rate.
INTERNATIONAL ORTHOPAEDICS
(2021)
Review
Medicine, General & Internal
Enwen Wang, Hui Huang, Long Tang, Ling Tian, Liejun Yang, Sixiong Wang, Huiwen Ma
Summary: The meta-analysis showed that a higher platelet lymphocyte ratio (PLR) was associated with poorer overall survival and progression-free survival in patients with melanoma. This suggests that modulating inflammation and immune responses may be a promising direction for future therapies in melanoma.
Article
Immunology
Wei Fu, Weixia Ye, Xianqiang Liu, Sirui Zhu, Hu Fu, Rui Zhu, Hongmin Li, Haoyun Zeng, Qin Wang
Summary: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are valuable biomarkers for assessing the clinical significance of Henoch-Schonlein purpura (HSP) and its complications, with NLR particularly useful in predicting gastrointestinal complications and renal involvement in HSP patients. Further well-designed and large cohort studies are needed to confirm these findings.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Feng Zhu, Yan Ji, Jiang-Hua Song, Guo-Xiang Huang, Yun-Feng Zhang
Summary: This study investigates the relationship between neutrophil/lymphocyte ratio (NLR) and neutrophil/high-density lipoprotein cholesterol ratio (NHR) and acute ischemic stroke (AIS) severity and short-term prognosis. The findings suggest that NLR and NHR are independent risk factors for stroke severity and poor short-term prognosis in AIS patients. Furthermore, the combination of NLR and NHR shows a strong correlation with disease severity in AIS.
Review
Oncology
Jiali Leng, Fei Wu, Lihui Zhang
Summary: This meta-analysis found that pretreatment neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may serve as biomarkers for predicting poor prognosis in patients with endometrial cancer, while monocyte-lymphocyte ratio (MLR) is not associated with prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Zhixun Gong, Ruomei Xin, Long Li, Liping Lv, Xinni Wu
Summary: This study evaluated the association of platelet-to-lymphocyte ratio (PLR) with clinicopathological features and prognosis in breast cancer patients. The analysis of 20 studies involving 7484 patients revealed that high PLR is associated with poor prognosis, lymph node metastasis, advanced TNM stage, and distant metastasis. Thus, PLR may serve as a potential prognostic biomarker in breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
(2022)
Review
Clinical Neurology
Mi Su, Xiaoxiao Ouyang, Yongyan Song
Summary: This meta-analysis supports the association between depression and inflammation, with NLR being a potential indicator of depression. However, no significant differences were found in PLR and MLR values between depressed subjects and controls. Further large-scale studies are needed to evaluate the role of PLR and MLR in depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Gastroenterology & Hepatology
Hytham K. S. Hamid, Sameh H. Emile, George N. Davis
Summary: This study investigated the prognostic value of lymphocyte-to-monocyte ratio and platelet-to-lymphocyte ratio following curative-intent surgery for rectal cancer. The findings showed that a low lymphocyte-to-monocyte ratio was associated with poorer overall and disease-free survival, while the platelet-to-lymphocyte ratio did not predict survival outcomes.
DISEASES OF THE COLON & RECTUM
(2022)
Review
Oncology
Xianyang Hu, Tengfei Tian, Qin Sun, Wenxiu Jiang
Summary: This meta-analysis study investigated the relationship between high neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and laryngeal cancer prognosis. The results showed that high NLR was associated with poor overall survival, progression-free survival, and disease-free survival, while high PLR was linked to poor overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Chunhua Xu, Fenfang Wu, Lailing Du, Yeping Dong, Shan Lin
Summary: This meta-analysis suggests that high baseline NLR is a reliable predictor of poor prognosis or relapse in HCC patients, especially in high-incidence East Asian populations.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Yuming Long, Yingtian Zhang, Liwei Ni, Xuya Yuan, Yuanliang Liu, Jialong Tao, Yusong Zhang
Summary: In patients with solid tumors, the platelet-to-lymphocyte ratio (PLR) is associated with overall survival and disease-free survival, with low PLR indicating better outcomes. A high PLR is linked to a lower pathological complete response rate after neoadjuvant chemotherapy (NAC) in cancer patients.
Article
Multidisciplinary Sciences
Guoming Hu, Qiannan Ding, Kefang Zhong, Shimin Wang, Songxiang Wang, Liming Huang
Summary: This meta-analysis showed that low pretreatment PNI was significantly associated with worse overall survival and 8-year, 10-year disease-free survival in breast cancer patients. This indicates that pretreatment PNI may serve as a valuable prognostic index and improving the nutritional immune status could be a therapeutic strategy for these patients.
Review
Medicine, General & Internal
Xiaolu Yang, Tiantian Tang, Tao Zhou
Summary: Patients with MBC have worse prognosis compared to those with TNBC. In terms of clinicopathological characteristics, most MBC patients present at an older age with larger tumors and negative lymph nodes at initial diagnosis. There were no statistically significant differences in the occurrence of distant metastasis, TNM stages III and IV, or histological grade 3.
Article
Otorhinolaryngology
Pei Gao, Wei Peng, Yuan Hu
Summary: This study found that a low LMR in patients with NPC is associated with poor overall survival and reduced disease-free/progression-free survival. It also showed correlations between low LMR and male gender, T3-T4 stage, and tumor stage III-IV.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Oncology
Chengzhi Wei, Zhu Yu, Gonghe Wang, Yiming Zhou, Lei Tian
Summary: This meta-analysis revealed that low albumin-to-globulin ratio (AGR) is associated with worse overall survival and disease-free survival/progression-free survival in gastric cancer patients, and this association remains consistent across different conditions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Anatomy & Morphology
Huiyuan Guan, Xin Wang, Yongxi Song, Peng Gao, Yuan Li, Zhonghua Wu, Jinliang Zhu, Zhenning Wang
Summary: The study found that the expression pattern and prognosis of CSF1R are closely related in colorectal cancer, with expression on the cell membrane reducing its prognostic predictive value.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jaffer A. Ajani, Yan Xu, Longfei Huo, Ruiping Wang, Yuan Li, Ying Wang, Melissa Pool Pizzi, Ailing Scott, Kazuto Harada, Lang Ma, Xiaodan Yao, Jiankang Jin, Wei Zhao, Xiaochuan Dong, Brian D. Badgwell, Namita Shanbhag, Ghia Tatlonghari, Jeannelyn Santiano Estrella, Sinchita Roy-Chowdhuri, Makoto Kobayashi, Jody V. Vykoukal, Samir M. Hanash, George Adrian Calin, Guang Peng, Ju-Seog Lee, Randy L. Johnson, Zhenning Wang, Linghua Wang, Shumei Song
Summary: YAP1 is highly upregulated in peritoneal carcinomatosis tumor cells, contributing to cancer stem cell properties and metastasis. Inhibition of YAP1 can significantly slow tumor growth and eliminate peritoneal carcinomatosis in preclinical models. Pharmacological inhibition of YAP1 can reduce cancer stem cell-like properties and suppress tumor growth, especially in combination with cytotoxic drugs in vivo models.
Article
Gastroenterology & Hepatology
Jin-yu Huang, Wei-lan Zhang, Ya-nan Xing, Wen-bin Hou, Song-cheng Yin, Zhen-ning Wang, Yu-en Tan, Ying-ying Xu, Zhi Zhu, Hui-mian Xu
Summary: High expression of LIPC is associated with poor clinical outcomes and plays an important role in regulating cell migration and invasion in Borrmann type 4 gastric cancer. High LIPC expression correlates with lymph node metastasis, advanced TNM stage, and poor overall survival in Borrmann type 4 gastric cancer patients. By reducing LIPC expression, cell invasion and migration are suppressed and specific gene expression is altered in Borrmann type 4 gastric cancer.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Pengfei Gu, Jingyu Deng, Zhe Sun, Zhenning Wang, Wei Wang, Han Liang, Huimian Xu, Zhiwei Zhou
Summary: The study compared different staging systems for predicting the prognosis of gastric cancer patients, finding that the LODDS staging system was superior to other lymph-node classifications. For predicting the prognosis of GC patients, the modified TLM staging system showed better discriminative ability and optimistic prognostic stratification compared to the 8th TNM or TRM staging systems.
Article
Gastroenterology & Hepatology
Zhi-Feng Miao, Jing-Xu Sun, Mahliyah Adkins-Threats, Min-Jiao Pang, Jun-Hua Zhao, Xin Wang, Kai-Wen Tang, Zhen-Ning Wang, Jason C. Mills
Summary: The study reveals that high expression of DDIT4 in gastric chief cells decreases as cells become metaplastic. DDIT4 deficiency leads to increased mTORC1 levels, exacerbating mitosis of metaplastic cells and tumor formation.
Letter
Infectious Diseases
Wenya Li, Shun Xu, Peiwen Li, Guan Wang, Zhenning Wang
Article
Cell Biology
Zhi-Feng Miao, Charles J. Cho, Zhen-Ning Wang, Jason C. Mills
Summary: Differentiated cells have evolved a conserved program called paligenosis to return to a stem or progenitor state and reenter the cell cycle for tissue repair. Key regulators of paligenosis, such as Ddit4 and Ifrd1, control different stages of the process, providing potential new insights for tissue regeneration and cancer therapy.
Review
Oncology
Junyan Zhang, Zhi Zhu, Zhifeng Miao, Xuanzhang Huang, Zhe Sun, Huimian Xu, Zhenning Wang
Summary: REG4, a member of the calcium-dependent lectin gene superfamily, is abnormally expressed in various cancers and is associated with poor prognosis and clinicopathologic features. REG4-positive cancer cells show resistance to chemoradiotherapy, participate in various aspects of carcinogenesis, and may serve as potential diagnostic, prognostic biomarkers and therapeutic targets in cancer patients. This review summarizes the advances of REG4 in cancer, providing new directions for future cancer research.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Yuan Li, Zhenning Wang, Jaffer A. Ajani, Shumei Song
Summary: Therapy resistance is a significant challenge in treating cancer patients, with intrinsic and acquired factors contributing to the development of resistance. CSCs play a key role in therapy resistance, as they are inherently resistant to anticancer treatments and can easily adapt to changes in the tumor microenvironment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Medicine, Research & Experimental
Qiong Xiao, Peng Gao, Xuanzhang Huang, Xiaowan Chen, Quan Chen, Xinger Lv, Yu Fu, Yongxi Song, Zhenning Wang
Summary: tRFs are small non-coding RNAs derived from specific tRNA cleavage events with key regulatory functions. Through identifying tRF-mRNA pairs and analyzing key features, a prediction model was constructed using genetic algorithm and support vector machine, which showed high accuracy in predicting tRF target genes. The user-friendly prediction tool, tRFTars, is available online for researchers to predict tRF targets in humans.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Xiaochuan Dong, Shumei Song, Yuan Li, Yibo Fan, Lulu Wang, Ruiping Wang, Longfei Huo, Ailing Scott, Yan Xu, Melissa Pool Pizzi, Lang Ma, Ying Wang, Jiangkang Jin, Wei Zhao, Xiaodan Yao, Randy L. Johnson, Linghua Wang, Zhenning Wang, Guang Peng, Jaffer A. Ajani
Summary: Genetic alterations in ARID1A were found in over 30% of gastric adenocarcinoma cases, and the loss of ARID1A leads to activation of the mTOR pathway and increased sensitivity to mTOR inhibitors, suggesting a new therapeutic strategy for targeting the mTOR pathway in patients with gastric adenocarcinoma with ARID1A deficiency.
Article
Oncology
Jia-Yi Li, Xuan-Zhang Huang, Peng Gao, Yong-Xi Song, Xiao-Wan Chen, Xing-Er Lv, Yv Fu, Qiong Xiao, Shi-Yv Ye, Zhen-Ning Wang
Summary: The study found that patients with rectal cancer achieving pathologic complete response (pCR) had significantly higher 10-year overall survival and 5-year disease-free survival compared to those in the non-pCR group. Improvement in tumor regression after neoadjuvant therapy was associated with increased overall survival and disease-free survival, and the pCR group had longer overall survival and disease-free survival than the non-pCR group. The results suggest a positive relationship between better tumor regressions and improved survival benefits, highlighting the importance of achieving pCR in the treatment of rectal cancer.
Article
Multidisciplinary Sciences
Xuan-Zhang Huang, Min-Jiao Pang, Jia-Yi Li, Han-Yu Chen, Jing-Xu Sun, Yong-Xi Song, Hong-Jie Ni, Shi-Yu Ye, Shi Bai, Teng-Hui Li, Xin-Yu Wang, Jing-Yuan Lu, Jin-Jia Yang, Xun Sun, Jason C. C. Mills, Zhi-Feng Miao, Zhen-Ning Wang
Summary: Peritoneal metastasis is the leading cause of death for gastrointestinal cancers. By analyzing the single-cell transcriptomes of ascites cancer/immune cells from patients with/without gastric cancer peritoneal metastasis, this study reveals the increase of monocyte-like dendritic cells (DCs) during GCPM progression, the evolution of monocyte-like DCs and regulatory and proliferative T cells following therapy, and the high-plasticity GC clusters that exhibit a propensity to shift to a high-proliferative phenotype. The study also identifies autophagy-related genes as potential biomarkers of prognosis and demonstrates the role of autophagy inhibitors in inducing apoptosis in patient-derived organoids.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Hanwei Huang, Mingyang Liu, Mengchi Sun, Shijie Duan, Siwei Pan, Pengfei Liu, Zhenguo Cheng, Onder Ergonul, Fusun Can, Zhenning Wang, Zhiqing Pang, Funan Liu
Summary: Preventing the interaction between oncolytic adenoviruses (OVs) and key virus-protein corona components in the plasma can significantly prolong circulation time and improve tumor distribution, leading to enhanced antitumor efficacy. This finding provides a new perspective on intravenous delivery of OVs.
Article
Chemistry, Multidisciplinary
Zhonghua Wu, Bicheng Qu, Minxian Yuan, Jingjing Liu, Cen Zhou, Mingwei Sun, Zhexu Guo, Yaqing Zhang, Yongxi Song, Zhenning Wang
Summary: The overexpression of cysteine-rich intestinal protein-1 (CRIP1) in gastric cancer promotes lymphangiogenesis and lymphatic vessel permeability, leading to lymphatic metastasis. This study uncovers the role and mechanism of CRIP1 in mediating gastric cancer lymphatic metastasis, providing potential targets for future therapeutics.