Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury

PARP inhibition attenuates early brain injury through NF-κB/MMP-9 pathway in a rat model of subarachnoid hemorrhage

(2016) Ting Chen et al.   BRAIN RESEARCH

Endogenous hypothermic response to hypoxia reduces brain injury: Implications for modeling hypoxic-ischemic encephalopathy and therapeutic hypothermia in neonatal mice

(2016) Barbara S. Reinboth et al.   EXPERIMENTAL NEUROLOGY

Microglial activation induced by the alarmin S100B is regulated by poly(ADP-ribose) polymerase-1

(2016) Jianguo Xu et al.   GLIA

Suppression of microglia activation after hypoxia–ischemia results in age-dependent improvements in neurologic injury

(2016) Ulas Cikla et al.   JOURNAL OF NEUROIMMUNOLOGY

High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial

(2016) Y. W. Wu et al.   PEDIATRICS

Xenon Combined with Therapeutic Hypothermia Is Not Neuroprotective after Severe Hypoxia-Ischemia in Neonatal Rats

(2016) Hemmen Sabir et al.   PLoS One

Protection of the brain following cerebral ischemia through the attenuation of PARP-1-induced neurovascular unit damage in rats

(2015) Ruixue Zhang et al.   BRAIN RESEARCH

Poly(ADP-Ribose)Polymerase 1 (PARP-1) Activation and Ca2+ Permeable α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Channels in Post-Ischemic Brain Damage: New Therapeutic Opportunities?

(2015) Elisabetta Gerace et al.   CNS & Neurological Disorders-Drug Targets

Early predictors of outcome in infants treated with hypothermia for hypoxic-ischaemic encephalopathy

(2015) Nazakat Merchant et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

The long-term health, social, and financial burden of hypoxic-ischaemic encephalopathy

(2015) Paul Eunson   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

The role of inflammation in perinatal brain injury

(2015) Henrik Hagberg et al.   Nature Reviews Neurology

Protective actions of PJ34, a poly(ADP-ribose)polymerase inhibitor, on the blood–brain barrier after traumatic brain injury in mice

(2015) X. Tao et al.   NEUROSCIENCE

Perinatal Asphyxia Leads to PARP-1 Overactivity, p65 Translocation, IL-1β and TNF-α Overexpression, and Apoptotic-Like Cell Death in Mesencephalon of Neonatal Rats: Prevention by Systemic Neonatal Nicotinamide Administration

(2015) T. Neira-Peña et al.   NEUROTOXICITY RESEARCH

Therapeutic hypothermia and hypoxia–ischemia in the term-equivalent neonatal rat: characterization of a translational preclinical model

(2015) Shyama D. Patel et al.   PEDIATRIC RESEARCH

Hypoxia-Ischemia and Therapeutic Hypothermia in the Neonatal Mouse Brain – A Longitudinal Study

(2015) Jennifer C. Burnsed et al.   PLoS One

Sex differences in mitochondrial (dys)function: Implications for neuroprotection

(2014) Tyler G. Demarest et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Effects of Hypothermia for Perinatal Asphyxia on Childhood Outcomes

(2014) Denis Azzopardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

PARP1 enhances inflammatory cytokine expression by alteration of promoter chromatin structure in microglia

(2014) Ricardo Iván Martínez-Zamudio et al.   Brain and Behavior

Poly(ADP-ribose) polymerase-1-induced NAD+ depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation

(2013) Tiina M. Kauppinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Age-Dependent Microglial Activation in Immature Brains After Hypoxia- Ischemia

(2013) Peter Ferrazzano et al.   CNS & Neurological Disorders-Drug Targets

Concurrent Erythropoietin and Hypothermia Treatment Improve Outcomes in a Term Nonhuman Primate Model of Perinatal Asphyxia

(2013) Christopher M. Traudt et al.   DEVELOPMENTAL NEUROSCIENCE

Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond

(2013) Nicola J. Curtin et al.   MOLECULAR ASPECTS OF MEDICINE

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

(2013) Bridgette D. Semple et al.   PROGRESS IN NEUROBIOLOGY

Which Neuroprotective Agents are Ready for Bench to Bedside Translation in the Newborn Infant?

(2012) Nicola J. Robertson et al.   JOURNAL OF PEDIATRICS

Effects of combination therapy using hypothermia and erythropoietin in a rat model of neonatal hypoxia–ischemia

(2012) Annie Y. Fang et al.   PEDIATRIC RESEARCH

Combined effect of hypothermia and caspase-2 gene deficiency on neonatal hypoxic–ischemic brain injury

(2012) Ylva Carlsson et al.   PEDIATRIC RESEARCH

Immediate Hypothermia Is Not Neuroprotective After Severe Hypoxia-Ischemia and Is Deleterious When Delayed by 12 Hours in Neonatal Rats

(2012) Hemmen Sabir et al.   STROKE

Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase

(2011) F Moroni et al.   BRITISH JOURNAL OF PHARMACOLOGY

Poly(ADP-Ribose) Metabolism in Brain and Its Role in Ischemia Pathology

(2010) Robert Piotr Strosznajder et al.   MOLECULAR NEUROBIOLOGY

Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke

(2009) Mike Yuan et al.   EXPERIMENTAL NEUROLOGY

Cooling Combined with Immediate or Delayed Xenon Inhalation Provides Equivalent Long-Term Neuroprotection after Neonatal Hypoxia—Ischemia

(2009) Marianne Thoresen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage

(2007) F MORONI   CURRENT OPINION IN PHARMACOLOGY