Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Obstetrics & Gynecology
Ilaria Fantasia, Sofia Bussolaro, Tamara Stampalija, Daniel L. Rolnik
Summary: Placental insufficiency can lead to various complications in pregnancy, and melatonin may play an important role in this condition, but more research is needed to confirm this. Current studies have found that the circadian pattern of melatonin secretion may be altered in pregnancies complicated by placental insufficiency, and melatonin treatment may be beneficial in prolonging gestation and improving outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Cell Biology
Qinsheng Lu, Dingqian Sun, Sourima Biswas Shivhare, Huomei Hou, Judith N. Bulmer, Barbara A. Innes, Dharani K. Hapangama, Gendie E. Lash
Summary: Appropriate growth and development of the endometrium is crucial for a woman's quality of life and reproductive health, while conditions like heavy menstrual bleeding and recurrent pregnancy loss significantly impact women's quality of life and healthcare systems. TGF beta 1 plays a key role in regulating endometrial vascular maturation and could be a potential therapeutic target for women with HMB and/or RPL.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Teresa Tropea, Carina Nihlen, Eddie Weitzberg, Jon O. Lundberg, Mark Wareing, Susan L. Greenwood, Colin P. Sibley, Elizabeth C. Cottrell
Summary: Nitric oxide (NO) plays a crucial role in regulating fetoplacental vascular tone to ensure proper oxygen and nutrient delivery to the fetus. Reduced fetoplacental blood flow can lead to pregnancy complications and fetal growth restriction. The study found that nitrite-induced vasorelaxation is preserved in FGR, suggesting interventions targeting this pathway could improve blood flow in FGR pregnancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yu-Huei Huang, Lun-Ching Chang, Ya-Ching Chang, Wen-Hung Chung, Shun-Fa Yang, Shih-Chi Su
Summary: Alterations in gut microbiota composition and microbial-encoded metabolic pathways were observed in patients with psoriasis, and the impact of biologics on shaping gut microbiota was explored in this study. The results showed that the gut microbial compositions changed during the treatment period, and the relative abundance of individual taxa differed between patients receiving different inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Gianluca Avallone, Carlo Alberto Maronese, Giulia Murgia, Carlo Giovanni Carrera, Luca Mastorino, Gabriele Roccuzzo, Paolo Dapavo, Silvia Alberti-Violetti, Pietro Quaglino, Simone Ribero, Angelo Valerio Marzano
Summary: This study aimed to compare the efficacy of IL-17 and IL-23 inhibitors in treating pustular and erythrodermic psoriasis. The results showed that IL-17 inhibitors had higher effectiveness in treating these conditions, while the efficacy of IL-23 inhibitors remains unknown.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Akinori Higaki, Ahmad U. M. Mahmoud, Pierre Paradis, Ernesto L. Schiffrin
Summary: Hypertension is partially mediated by immune mechanisms, with IL-23 and IL-17 playing important roles. The IL-23/IL-17 axis has not been a major therapeutic target for hypertension treatment, but shows potential for targeting therapy.
CARDIOVASCULAR RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Ruth Rodriguez-Montano, Alondra del Carmen Ruiz-Gutierrez, Vianeth Maria del Carmen Martinez-Rodriguez, Juan Ramon Gomez-Sandoval, Juan Manuel Guzman-Flores, Julieta Sarai Becerra-Ruiz, Ana Lourdes Zamora-Perez, Celia Guerrero-Velazquez
Summary: This study found that patients with periodontitis have significantly lower levels of IL-17A in plasma, but higher levels of IL-23, IL-17A, and IL-17RA in gingival tissue. Several correlations were also found, suggesting a potential role of the IL-23/IL-17A axis in the progression of periodontitis.
APPLIED SCIENCES-BASEL
(2022)
Article
Medicine, General & Internal
Dorsa Mavedatnia, Jason Tran, Irina Oltean, Vid Bijelic, Felipe Moretti, Sarah Lawrence, Dina El Demellawy
Summary: The study explored how placental pathology affects acute neonatal outcomes in cases of placental abruption, finding that pregnancies with placental pathologies were more likely to result in NICU admission and lower Apgar scores.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Ophthalmology
Zhenyu Zhong, Guannan Su, Aize Kijlstra, Peizeng Yang
Summary: Uveitis is a group of diseases characterized by intraocular inflammation, some of which are driven by auto inflammatory or autoimmune responses, and share the activation of the IL-23/IL-17 pathway. Emerging drugs blocking this pathway have been assessed for the treatment of uveitis.
PROGRESS IN RETINAL AND EYE RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Jiexin Wang, Linxi He, Weihong Li, Shangbin Lv
Summary: Rheumatoid arthritis (RA) is caused by joint inflammation and significantly increases the occurrence of cardiovascular disease. Mortality of RA patients with cardiovascular disease is 1.5-3 times higher than that of RA patients alone. Atherosclerosis is more prevalent and develops rapidly in RA patients, which is a major cause of death in RA. Recent studies have shown that IL-17 expression is upregulated in patients with RA and atherosclerosis, and it plays a role in the development of atherosclerosis through various ways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kamelia Mirdamadi, Jacinda Kwok, Ori Nevo, Howard Berger, Micheline Piquette-Miller
Summary: Th-17 cytokines have an impact on the expression and activity of placental transporters, potentially affecting fetal exposure to endogenous and exogenous substances.
Article
Chemistry, Multidisciplinary
C. M. van Kammen, S. J. van Woudenberg, R. Schiffelers, F. Terstappen, A. T. Lely
Summary: Preeclampsia and fetal growth restriction are pregnancy complications that can be treated with nanomedicines, which regulate drug interaction with the placenta to enhance treatment efficacy and minimize fetal exposure. Liposomes and polymeric drug delivery systems show promising results in preventing trans-placental passage of nanomedicines, while quantum dots and silicon nanoparticles have limited research in placental insufficiency syndromes. Animal studies demonstrate positive effects on maternal and fetal health, but results are influenced by various factors. Further research is needed to understand the pathophysiology of these complex diseases and ensure the safety and efficacy of nanomedicines before clinical implementation.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Dermatology
Mariolina Bruno, Linda Davidson, Hans J. P. M. Koenen, Juul M. P. A. van den Reek, Bram van Cranenbroek, Elke M. G. J. de Jong, Frank L. van de Veerdonk, Bart-Jan Kullberg, Mihai G. Netea
Summary: Biologics that block the Th17 pathway are effective in treating inflammatory diseases like psoriasis but may increase the risk of Candida infections. This study found that patients with psoriasis receiving IL-17 inhibitors had impaired immune responses, leading to reduced antifungal defense and increased susceptibility to candidiasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Obstetrics & Gynecology
Laura A. Magee, Argyro Syngelaki, Ranjit Akolekar, Peter von Dadelszen, Kypros H. Nicolaides
Summary: This study aimed to investigate the role of serum placental growth factor (PlGF) at 19-23 weeks of gestation in risk identification. The results showed that clinical risk factor screening had limitations in detecting adverse outcomes, and PlGF testing alone did not reduce false positives. Therefore, alternative strategies are needed to improve risk identification.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Bogdan Kolarz, Dominika Podgorska, Rafal Podgorski
Summary: Rheumatoid arthritis is a chronic autoimmune disease that affects joints and other organs, leading to disability and premature death if left untreated. Early recognition and treatment are crucial, and the disease can be classified into seropositive and seronegative based on specific antibodies. Ongoing research aims to understand disease mechanisms and identify markers for improved patient treatment.
Article
Multidisciplinary Sciences
Beata Kasztelan-Szczerbinska, Katarzyna Adamczyk, Agata Surdacka, Jacek Rolinski, Agata Michalak, Agnieszka Bojarska-Junak, Mariusz Szczerbinski, Halina Cichoz-Lach
Summary: This study found gender-related differences in the frequencies of PD-1/PD-L1 positive T and B cells in patients with ALD. Upregulation of PD-1+/PD-L1+ lymphocytes paralleled both the severity of alcoholic hepatitis and liver dysfunction in ALD females.
Review
Immunology
Michal K. Zarobkiewicz, Ewelina Wawryk-Gawda, Wioleta Kowalska, Mariola Janiszewska, Agnieszka Bojarska-Junak
Summary: This paper reviews the role of gamma delta T cells in the pathogenesis and exacerbation of asthma, summarizing studies on humans and mouse models. It is found that gamma delta T cells play an important role in the pathogenesis of asthma, with different subsets likely to have opposite functions.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2021)
Article
Oncology
Krzysztof Giannopoulos, Agnieszka Karczmarczyk, Marta Karp, Agnieszka Bojarska-Junak, Kamila Kosior, Malgorzata Kowal, Waldemar Tomczak, Marek Hus, Marcin Machnicki, Tomasz Stoklosa
Summary: The study demonstrated that dasatinib exerts cytotoxic effects on CLL cells, inducing apoptosis, and has anti-leukemic effects on both CML and CLL cells.
Review
Biochemistry & Molecular Biology
Michal K. Zarobkiewicz, Izabela Morawska, Adam Michalski, Jacek Rolinski, Agnieszka Bojarska-Junak
Summary: NKT cells, especially iNKT cells, may play a key role in autoimmune diseases. Researchers summarized the results of NKT-oriented studies in major neurological autoimmune diseases such as multiple sclerosis, myasthenia gravis, and Guillain-Barre syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Michal K. Zarobkiewicz, Wioleta Kowalska, Izabela Morawska, Pawel Halczuk, Konrad Rejdak, Agnieszka Bojarska-Junak
Summary: The study found a subset of IL-15+ gamma delta T cells in the blood of multiple sclerosis patients that correlates with disease severity. Further functional studies are needed to fully understand the importance of these cells in the pathogenesis of multiple sclerosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Justyna Wos, Sylwia Chocholska, Wioleta Kowalska, Waldemar Tomczak, Agata Szymanska, Agnieszka Karczmarczyk, Agnieszka Szuster-Ciesielska, Agnieszka Wojciechowska, Agnieszka Bojarska-Junak
Summary: TEMs, characterized by the phenotype of CD14+CD16+Tie2+, have been identified as a new immunosuppressive force in tumors and are associated with unfavorable prognosis in CLL patients. Despite not being an independent predictor of survival, TEM can serve as an important complement to other prognostic indicators in CLL patients.
Article
Cell Biology
Michal K. Zarobkiewicz, Agnieszka A. Bojarska-Junak
Summary: CLL is the most common leukemia among adults, and currently there is no cure. Despite the dysfunction of gamma delta T cells in CLL patients, they can still be used for immunotherapy.
Article
Biochemistry & Molecular Biology
Wioleta Kowalska, Michal Zarobkiewicz, Waldemar Tomczak, Justyna Wos, Izabela Morawska, Agnieszka Bojarska-Junak
Summary: Monocytes, particularly non-classical subpopulations, may play an important role in chronic lymphocytic leukemia (CLL) pathogenesis. This study assessed monocyte subsets divided based on SLAN and CD16 expression in CLL patients. The findings suggest an increased percentage of non-classical monocytes producing TNF and IL-12, while intermediate monocytes showed a higher percentage of cells synthesizing anti-inflammatory IL-10. The percentage of CD14(dim)CD16(+)SLAN(+) monocytes producing TNF and IL-12 decreased with CLL stage and correlated with prognostic factors. Notably, CLL patients requiring treatment had a lower percentage of CD14(dim)CD16(+)SLAN(+) monocytes producing TNF and IL-12, potentially indicating a beneficial effect of non-classical monocytes on anti-tumor response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Marek Ciesla, Bogdan Kolarz, Dorota Darmochwal-Kolarz
Summary: This study found no association between two polymorphisms of the PADI4 gene and levels of anti-PAD4, ACPA, and RF antibodies. Therefore, the genetic variants PADI4_94 and PADI4_104 may not be clinically relevant as prognostic factors in patients with established RA.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Michal K. Zarobkiewicz, Izabela Morawska, Wioleta Kowalska, Pawel Halczuk, Jacek Rolinski, Agnieszka A. Bojarska-Junak
Summary: This study found differential expression of PECAM-1 on γδT cells and a significant downregulation of CD3 expression during relapse in patients with multiple sclerosis, which may indicate overall activation of γδT cells.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Dominika Podgorska, Marek Ciesla, Bogdan Kolarz
Summary: This study analyzed the association between FCER1G gene methylation and RA activity. The results showed that RA patients have lower levels of methylation of the FCER1G gene, suggesting that FCER1G gene methylation may be a new potential epigenetic marker of RA that is independent of disease activity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sylwia Chocholska, Michal Zarobkiewicz, Agata Szymanska, Natalia Lehman, Justyna Wos, Agnieszka Bojarska-Junak
Summary: The aim of this study was to investigate the expression of miR-17 similar to 92 cluster members in CLL patients. The study provides new evidence regarding the heterogeneity of miR-17 similar to 92 cluster members' expression in CLL patients. High miR-20a expression can be considered an independent favorable prognostic factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Natalia Lehman, Wioleta Kowalska, Michal Zarobkiewicz, Marek Mazurek, Karolina Mrozowska, Agnieszka Bojarska-Junak, Radoslaw Rola
Summary: Monocyte subpopulations in glioma patients' peripheral blood were analyzed based on CD14, CD16, and SLAN expression. The study found different profiles of monocytes with varying cytokine expression. The presence of these different profiles might hinder the effectiveness of immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Agnieszka Bojarska-Junak, Wioleta Kowalska, Sylwia Chocholska, Agata Szymanska, Waldemar Tomczak, Michal Konrad Zarobkiewicz, Jacek Rolinski, Daniela De Totero, Paolo Giannoni
Summary: This study explores the potential role of Galectin-9 (Gal-9) as a novel prognostic biomarker in chronic lymphocytic leukemia (CLL). Through quantification of Gal-9 mRNA expression in purified B-lymphocytes of 100 CLL patients, the study reveals the upregulation of Gal-9 mRNA in malignant B-cells, which is closely associated with unfavorable prognostic markers and a shorter time to treatment. Furthermore, the study suggests that EBV coinfection may worsen prognosis in CLL by inducing upregulation of Gal-9 expression.
