Journal
BIOMED RESEARCH INTERNATIONAL
Volume 2017, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2017/5071786
Keywords
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Funding
- CMU studentship
- Neuroscience and Mental Health Research Institute
- Wellcome (DEFINE Strategic Award)
- Hodge Foundation (Centre Grant)
- MRC Centre Grant
- TWF Changing Minds Programme
- CMU fellowship
- Hodge Foundation
- Waterloo Foundation studentship
- Medical Research Council [MR/L010305/1] Funding Source: researchfish
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Neuroinflammation is recognised as one of the potential mechanisms mediating the onset of a broad range of psychiatric disorders and may contribute to nonresponsiveness to current therapies. Both preclinical and clinical studies have indicated that aberrant inflammatory responses can result in altered behavioral responses and cognitive deficits. In this review, we discuss the role of inflammation in the pathogenesis of neuropsychiatric disorders and ask the question if certain genetic copy-number variants (CNVs) associated with psychiatric disorders might play a role in modulating inflammation. Furthermore, we detail some of the potential treatment strategies for psychiatric disorders that may operate by altering inflammatory responses.
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