Journal
BIOMED RESEARCH INTERNATIONAL
Volume 2017, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2017/9747010
Keywords
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Funding
- EU [607868]
- Clinical Research Priority Program of the University of Zurich (CRPP: From Basic Research to the Clinic: Novel Tissue-Engineered Skin Grafts for Zurich)
- Foundation Gaydoul
- Vontobel Foundation
- Werner Spross Foundation
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Perception of the adipose tissue has changed dramatically over the last few decades. Identification of adipose-derived stem cells (ASCs) ultimately transformed paradigmof this tissue froma passive energy depot into a promising stem cell source with properties of self-renewal and multipotential differentiation. As compared to bone marrow-derived stem cells (BMSCs), ASCs are more easily accessible and their isolation yields higher amount of stemcells. Therefore, the ASCs are of high interest for stem cell-based therapies and skin tissue engineering. Currently, freshly isolated stromal vascular fraction (SVF), which may be used directly without any expansion, was also assessed to be highly effective in treating skin radiation injuries, burns, or nonhealing wounds such as diabetic ulcers. In this paper, we review the characteristics of SVF and ASCs and the efficacy of their treatment for skin injuries and disorders.
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