Article
Chemistry, Multidisciplinary
Yue Tan, Miaona Chen, Huarui Chen, Juefei Wu, Jinbin Liu
Summary: This study introduces ultrasmall renal-clearable luminescent gold nanoparticles with pH-induced charge reversal and aggregation properties, which enhance ultrasound contrast in injured kidneys through increased tubular reabsorption and in situ aggregation. The tuning elimination pathway of these nanoparticles provides a synergistical fluorescence and ultrasound imaging strategy for diagnosing early kidney injury with precise anatomical information.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Nanoscience & Nanotechnology
Penghui Cheng, Kanyi Pu
Summary: Renal-clearable optical agents (RCOAs) are rapidly excreted from the body via the kidneys, making them suitable for targeted kidney imaging and early kidney injury detection, as well as deep tumor penetration and high-contrast tumor imaging.
NATURE REVIEWS MATERIALS
(2021)
Article
Materials Science, Biomaterials
Dan Mu, Dan Wen, Yan Li, Ling Zhong, Jingya Zhao, Shaobing Zhou
Summary: A magnetic nanoreporter with renal clearable capability and activatable catalytic activity was developed for colorimetric urinalysis of tumors. This technology offers convenience and availability for early cancer screening.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Physical
Jiaguo Huang, Xiaona Chen, Yuyan Jiang, Chi Zhang, Shasha He, Hangxiang Wang, Kanyi Pu
Summary: This study develops activatable polyfluorophore nanosensors that can react with disease-associated proteases to produce fluorescent signals for non-invasive disease diagnosis. These nanosensors show promising results in detecting tumors and diagnosing acute liver allograft rejection in rodent models.
Review
Chemistry, Inorganic & Nuclear
Pengye Du, Ran An, Yuan Liang, Pengpeng Lei, Hongjie Zhang
Summary: The second near-infrared (NIR-II) fluorescence has promising applications in the biological field due to its ability for deep tissue penetration, weak tissue scattering, low autofluorescence, and high temporal and spatial resolution. Lanthanide-doped nanoparticles (LDNPs) are considered highly promising materials for optical bioprobes due to their unique optical properties such as long luminescence lifetimes, large Stokes or anti-Stokes shifts, narrow-band emission, and high resistance to photobleaching and blinking. The abundant loadable and modifiable sites on the surface of LDNPs offer good conditions for functional bioprobes construction. This review summarizes the common synthesis methods, strategies to enhance NIR-II luminescence, and surface functionalization modifications of LDNPs. It also provides an overview of recent research advances in optical sensing, bioimaging, and image-guided therapy using NIR-II luminescent LDNPs. Finally, the opportunities and challenges of NIR-II luminescent bioprobes based on LDNPs in bioapplications are discussed.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Nanoscience & Nanotechnology
Min-Jun Baek, Duy-Thuc Nguyen, Dahan Kim, So-Yeol Yoo, Sang Min Lee, Jae-Young Lee, Dae-Duk Kim
Summary: The study presents the design of a tailored structure for renal-clearable zwitterionic cyclodextrin for selective drug delivery in colorectal cancer. Twenty cyclodextrin derivatives were synthesized and screened for colloidal stability, resulting in five candidates that were evaluated for biodistribution and an optimized structure was identified. The optimized cyclodextrin demonstrated high tumour accumulation and improved antitumour efficacy in colorectal cancer models.
NATURE NANOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jun Wang, Qizhen Li, Hui Zhao, Wentong Yue, Kaiwen Zhang, Xingyu Jiang, Kai Li
Summary: This study introduces a facile synthetic process to fine-tune the size of persistent luminescent nanoparticles (PLNPs) using mesoporous silica nanoparticles (MSNs) as templates, resulting in monodispersed PLNPs suitable for renal clearance. The controlled crystallization of precursor ions in MSNs at high temperature leads to the formation of ultrasmall PLNPs with excellent properties and high potential for biomedical applications.
Article
Chemistry, Analytical
Jun Wang, Menglei Zha, Hui Zhao, Wentong Yue, Decheng Wu, Kai Li
Summary: This research successfully synthesized a class of renal-clearable gadolinium nanoparticles and achieved the diagnosis of kidney dysfunction in a mice model with a damaged kidney through noninvasive magnetic resonance imaging. This provides a new tool for exploring translational strategies for kidney dysfunction.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Difei Jiang, Yifan Pan, Haiyang Yao, Jiamin Sun, Weiwei Xiong, Lingling Li, Fenfen Zheng, Shasha Sun, Jun-Jie Zhu
Summary: Renal-clearable multicolor fluorescent silicon nanodots with excellent biocompatibility have been successfully synthesized using a facile method. These silicon nanodots show great potential in applications such as tumor fluorescence imaging and biomarker sensing.
ANALYTICAL CHEMISTRY
(2022)
Review
Nanoscience & Nanotechnology
Qinpeng Zhang, Rui Yin, Guoqiang Guan, Huiyi Liu, Guosheng Song
Summary: This review provides an overview of recent advancements in the development of renal-clearable magnetic nanoparticles (MNPs) for disease imaging and treatment. Factors influencing renal clearance, types of renal-clearable MNPs, synthesis methods, and biomedical applications are discussed.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Analytical
Difei Jiang, Yifan Pan, Haiyang Yao, Jiamin Sun, Weiwei Xiong, Lingling Li, Fenfen Zheng, Shasha Sun, Jun-Jie Zhu
Summary: In this study, renal-clearable multicolor fluorescent silicon nanodots were synthesized using a one-step hydrothermal method, and their potential applications in tumor fluorescence imaging and H2O2 imaging were demonstrated.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Kai Feng, Zhengtao Xu, Yuhan Wang, Xiyao Wu, Fucheng Xiong, Yiling Ruan, Xiaojing Wu, Linqian Ye, Dong Su, Jing Yu, Xiaolian Sun
Summary: In this study, we developed 14 nm porous hollow copper iron oxide nanoparticles (PHCuFeNPs) as a cisplatin carrier and photothermal therapeutic agent. The PHCuFeNPs showed enhanced chemodynamic therapy and accelerated cisplatin release in a weak acidic tumor microenvironment. Under laser irradiation, the PHCuFeNPs exhibited a synergistic therapy effect. Furthermore, they induced immunogenic cell death and had potential for immunotherapy.
Article
Chemistry, Multidisciplinary
Mengmeng Zhang, Mingzhu Lu, Tianze Qiu, Qiao Wang, Zhenxia Chen, Mingli Deng, Yongtai Yang, Yannan Yang, Wei Li, Yun Ling, Yaming Zhou
Summary: Developing a novel synthetic strategy named gelothermal synthesis, the researchers successfully downsized metal-organic frameworks (MOFs) from polydisperse crystals to monodisperse nanoparticles, which is of great importance for their potential bioapplications. This strategy led to the isolation of MIL-88, CufumDMF, and ZIF-8 nanoparticles. Through extensive studies on gelothermal condition, a possible mechanism was proposed. The monodisperse MIL-88A nanoparticles demonstrated unique advantages over polydisperse ones in terms of in vitro magnetic resonance imaging (MRI), cellular uptake, and drug-carrying properties.
Review
Materials Science, Multidisciplinary
Gaoyang Wang, Hongyu Zhang, Hua Kuang, Chuanlai Xu, Liguang Xu
Summary: Chirality exists widely in nature and is closely related to the origin of life. This paper reviews the different types of chiral nanomaterials and analyzes their chiral mechanism. It also discusses the applications of nanomaterials in chiral testing, cell differentiation, gene shearing, and biological therapy. The potentials and challenges of chiral nanomaterials in the field of biomedicine are reported, along with proposed application strategies and prospects for the future.
Article
Materials Science, Multidisciplinary
Sareh Mosleh-Shirazi, Milad Abbasi, Mostafa Shafiee, Seyed Reza Kasaee, Ali Mohammad Amani
Summary: Renal excretion mechanisms play a crucial role in the effective excretion of substances. Nanotechnology has significant applications in medical fields, particularly in tumor diagnosis and treatment. By controlling the size and properties of nanoparticles, better biocompatibility and clearance performance can be achieved.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yingxiang Ye, Shikai Xian, Hui Cui, Kui Tan, Lingshan Gong, Bin Liang, Tony Pham, Haardik Pandey, Rajamani Krishna, Pui Ching Lan, Katherine A. Forrest, Brian Space, Timo Thonhauser, Jing Li, Shengqian Ma
Summary: This study introduces a novel strategy to promote the separation of C2H2/CO2 mixtures by regulating a hydrogen-bonding nanotrap on the pore surface of three isostructural metal-organic frameworks. Among them, MIL-160 demonstrates an ultrahigh C2H2 storage capacity and superior C2H2/CO2 selectivity due to its multiple hydrogen-bonding interaction with C2H2.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Multidisciplinary
Xiaoxi Luo, Jinbin Liu
Summary: In the past decade, ultrasmall luminescent metal nanoparticles have made rapid progress in addressing challenges in healthcare due to their excellent properties. Surface engineering strategies of ULMNPs, including enhancing disease targeting abilities and self-assembly for multifunctional structures, have significantly advanced biological applications from bioimaging to theranostics. Further research on ratiometric ULMNPs for improved imaging stability in complex biological environments, along with the exploration of phototoxicity and future perspectives, aim to accelerate their clinical applications.
Article
Nanoscience & Nanotechnology
Lingshan Gong, Yingxiang Ye, Ying Liu, Yunbin Li, Zongbi Bao, Shengchang Xiang, Zhangjing Zhang, Banglin Chen
Summary: In this study, a novel ultramicroporous hydrogen-bonded organic framework (HOF-40) constructed from a cyano-based organic building unit was reported. The results showed that HOF-40 exhibited superior separation performance for xenon/krypton mixtures, and the pore confinement effect and abundant accessible binding sites played a synergistic role in this challenging gas separation.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xuewei Liu, Rongkang Gao, Chiyun Chen, Xiaobo Li, Chen Yu, Yejia Chen, Hongbin Liang, Min Xiao, Lei Dai, Shifeng Qiu, Xiaoyu Xin, Liang Song, Jinbin Liu, Chengbo Liu, Jiancheng Xiu
Summary: In this study, noninvasive assessment of alpha v beta 3-integrin expression in atherosclerotic lesions of varying degrees of severity was performed using a customed photoacoustic (PA) computed tomography (PACT)/ultrasound (US) system. The results showed that alpha v beta 3-integrin is an effective indicator of plaque instability, and noninvasive PACT/US molecular imaging assessment of alpha v beta 3-integrin holds promise in detecting high-risk plaques.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Kai Zhou, Wei Cai, Yue Tan, Zhipeng Zhao, Jinbin Liu
Summary: By manipulating the siloxane bridge crosslinking states, water-soluble nanoassemblies with disassembly-induced emission enhancement (DIEE) were successfully fabricated. The disassembled nanoassemblies showed more than 6-fold enhancement in emission and improved renal clearance efficiency, opening up new possibilities for designing highly emissive renal-clearable nanostructures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yue Tan, Wei Cai, Caiming Luo, Jiahao Tang, Ryan T. K. Kwok, Jacky W. Y. Lam, Jianwei Sun, Jinbin Liu, Ben Zhong Tang
Summary: By designing luminescent gold-silver bimetallic nanoparticles that can be rapidly transformed in the hepatic sinusoidal microenvironment, liver sequestration can be avoided, phagocytosis by mononuclear phagocyte system cells can be enhanced, rapid release can be promoted, renal clearance can be improved, and disease targeting can be increased.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Bing Tang, Wenle Xia, Wei Cai, Jinbin Liu
Summary: In this study, luminescent AuNPs with redshifted emission and good biocompatibility were successfully constructed using an amphiphilic block copolymer template. The strategy involved the formation of uniform clusters of NIR-II AuNPs inside the hydrophobic cores of ABC micelles and the generation of rigid NIR-II AuNPs as ABC unimers on the surface, enabling enhanced biological interactions.
Article
Chemistry, Multidisciplinary
Wei Cai, Yue Tan, Kui He, Bing Tang, Jinbin Liu
Summary: A precise control of nanoparticle size in the sub-nanometer regime is crucial for understanding nano-bio interactions and advancing nanomedicine. This study presents a simple Mn2+-guided centrifugation strategy to synthesize large-scale ultrasmall AuNPs with precise size gradient at the sub-nanometer regime. The researchers discovered that [Mn(OH)](+) nanoparticles, particularly Mn-0@[Mn(OH)](+), can selectively interact with larger AuNPs to form aggregates, leading to the efficient synthesis of water-soluble atomically precise Au-25 within a short time. Moreover, the study demonstrates the significant impact of sub-nanometer size differences on non-specific phagocytosis, elimination rate, and nanotoxicology of AuNPs in macrophages.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Analytical
Zhipeng Zhao, Huarui Chen, Kui He, Jincheng Lin, Wei Cai, Yidan Sun, Jinbin Liu
Summary: This study develops a facile in vivo ligand exchange strategy to achieve renal-clearable activatable luminescent gold nanoparticles (AuNPs), which are independent of biomarkers for sensitive and long-time imaging of early kidney injury.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Kui He, Yuan-Fu Ding, Zhipeng Zhao, Ben Liu, Wenyan Nie, Xiaoxi Luo, Hua-Zhong Yu, Jinbin Liu, Ruibing Wang
Summary: This study reports a strategy to achieve liver or kidney-specific delivery by altering the surface chemistry of nanocarriers. The results demonstrate that ultrasmall nanocarriers can effectively deliver drugs to injured kidneys and achieve improved therapeutic outcomes. This organ-specific delivery strategy provides a new approach for improving drug delivery efficiency and personalized treatments.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Wenyan Nie, Kui He, Zhipeng Zhao, Xiaoxi Luo, Jinbin Liu
Summary: We developed a facile in situ strategy to precisely control DNA aptamer valences on the surface of luminescent gold nanoparticles (AuNPs) with emission in the second near-infrared window. We further demonstrated that not only the tumor-targeting efficiencies but also the subcellular transport of AuNPs show precise valence dependence.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yue Tan, Di Huang, Caiming Luo, Jiahao Tang, Ryan T. K. Kwok, Jacky W. Y. Lam, Jianwei Sun, Jinbin Liu, Ben Zhong Tang
Summary: In this study, clearable mercaptosuccinic acid (MSA) coated Au-Ag bimetallic nanoparticles (NPs) were designed to enhance reactive oxygen species (ROS) production. The strong COO-Ag coordination bonds between MSA and Ag atoms on the NPs restricted intrananoparticle motions, leading to enhanced ROS generation. The bimetallic NPs also exhibited pH-responsive self-assembly capability, further boosting ROS production and showing high tumor targeting efficiency and effective cancer cell destruction.
Article
Chemistry, Physical
Lingshan Gong, Ying Liu, Junyu Ren, Abdullah M. Al-Enizi, Ayman Nafady, Yingxiang Ye, Zongbi Bao, Shengqian Ma
Summary: This study demonstrates that the cationic metal-organic framework, FJU-55, shows highly efficient performance in separating xenon/krypton mixtures. FJU-55 possesses uniform three-dimensional interconnection channels and electro-positive features, resulting in excellent selectivity and adsorption capacity for xenon.
Article
Chemistry, Multidisciplinary
Jiayi Zhu, Zhipeng Zhao, Huarui Chen, Xinglin Chen, Jinbin Liu
Summary: This study demonstrates that renal-clearable nanomedicines show a more sensitive response to injection dose and have improved tumor-targeting efficiency compared to nonrenal-clearable nanoparticles.
Article
Chemistry, Multidisciplinary
Yue Tan, Wei Cai, Caiming Luo, Jiahao Tang, Ryan T. K. Kwok, Jacky W. Y. Lam, Jianwei Sun, Jinbin Liu, Ben Zhong Tang
Summary: The rapid transformation of luminescent gold-silver bimetallic nanoparticles in the hepatic sinusoidal microenvironment can help avoid MPS phagocytosis, promote fast release from the liver, prolong blood circulation, enhance renal clearance, and increase disease targeting, turning liver sequestration into a beneficial storage mechanism for nanomedicines.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
