Article
Polymer Science
Magdalena Paluch, Dongren Wang, Michael R. Buchmeiser, Marcin K. Chmielewski
Summary: New thermo- and pH-responsive polymers based on pyridin-2-yl monomers were synthesized using reversible addition-fragmentation chain-transfer polymerization. A UV-vis study of intramolecular thermal cyclization in the synthesized polymers confirmed the potential application of rapid and complete elimination of small molecules at high temperatures, making it promising for drug delivery materials design.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Sany Chea, Kristin Schade, Stefan Reinicke, Regina Bleul, Ruben R. Rosencrantz
Summary: The base pairing and melting behavior of oligonucleotides can be utilized to develop smart thermoresponsive and programmable materials. In this study, complementary cytidine (C) and guanosine (G) monomers were blockcopolymerized using RAFT polymerization technique with hydrophilic macro chain transfer agent. The hydrogen bond interactions between C-C, G-G, and C-G were investigated, and the self-assembly of these bioinspired compounds showed potential for future drug delivery systems.
Article
Polymer Science
Wojciech Raj, Krzysztof Jerczynski, Mahdi Rahimi, Ewa Pavlova, Miroslav Slouf, Agata Przekora, Joanna Pietrasik
Summary: In this study, a series of vitamin E-based TPGS-poly(2-(dimethylamino)ethyl methacrylate)-b-poly(3-vinyl benzaldehyde) block copolymer micelles were synthesized, and the anticancer drug DOX was loaded within the micelles. The micelles demonstrated potential as drug delivery systems for cancer treatment, with pH-responsive characteristics. However, increasing the hydrophobic block polymerization degree reduced the cytotoxicity of the micelles.
Article
Biochemistry & Molecular Biology
Azarmidokht Gholamipour-Shirazi, Ian T. Norton, Tom Mills
Summary: A dual temperature and electro responsive kappa- and iota-carrageenan based hydrogel formulation was developed for efficient food material and drug delivery, showing high drug loading and sustained release. This formulation does not rely on 3D printing, but can contribute to feedstocks for 3D printing in the food and pharmaceutical industries, potentially enabling the creation of more complex smart structures and tuning release behavior in the future.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Hana Bouzit, Felix Krusch, Daniel Hermida-Merino, Eduardo Solano, Didier Cot, Jean Pierre Mericq, Stephanie Roualdes, Mona Semsarilar, Damien Quemener, Karim Aissou
Summary: Amphiphilic block copolymer thick films with stimuli-responsive pores are promising for manufacturing next-generation UF membranes. A well-defined terpolymer was prepared via reversible addition-fragmentation chain transfer polymerization. The combination of phase separation and solvent vapor annealing produced nanostructured pH- and thermo-double sensitive thick films.
JOURNAL OF POLYMER SCIENCE
(2023)
Article
Polymer Science
Uddhab Kalita, Sarthik Samanta, Sovan Lal Banerjee, Narayan C. Das, Nikhil K. Singha
Summary: A novel thermoplastic elastomer (TPE) composed of polystyrene and poly(beta-myrcene) was successfully prepared using the RAFT polymerization method. This TPE showed good physical properties and sustainable recyclability.
Article
Chemistry, Multidisciplinary
Maria Tomara, Dimitrios Selianitis, Stergios Pispas
Summary: This study reports the synthesis and self-assembly of a new series of dual-responsive polymers in aqueous solutions. These polymers respond to changes in pH, temperature, and ionic strength, can encapsulate hydrophobic drugs, and show potential applications as nanocarriers for drug delivery.
Review
Biotechnology & Applied Microbiology
Elnaz Khakpour, Saba Salehi, Seyed Morteza Naghib, Sadegh Ghorbanzadeh, Wei Zhang
Summary: Stimuli-responsive drug delivery using graphene-based nanomaterials has gained significant attention. The unique properties of graphene, such as high surface area, mechanical and chemical stability, optical, electrical, and thermal properties, make it an excellent candidate for smart drug delivery. Graphene derivatives and various graphene-based nanomaterials have been extensively studied and modified to enhance their biocompatibility and trigger-sensitive properties. The potential and progress of graphene-based nanomaterials in intelligent drug release in response to different stimuli, both endogenous and exogenous, are discussed in this review.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Polymer Science
Hang Xiao, Quan-Xi Shi, Min Su, Xiao-Li Sun, Hongli Bao, Wen-Ming Wan
Summary: This study demonstrates a one-pot strategy for the molecular design of stimuli-responsive opposite emission/absorption polymer material with unique properties. The nontraditional intrinsic luminescence in the visible region is achieved through reversible addition-fragmentation chain transfer polymerization-induced emission (PIE) of a specific moiety. The opposite emission/absorption properties are derived from the carbocation-quinoid mechanism, enabling fluorescence encryption capability. This work provides a proof of concept for a novel polymer material that might inspire different fields.
Article
Polymer Science
Arman Moini Jazani, Jung Kwon Oh
Summary: A new method for synthesizing multi-stimuli-responsive degradable block copolymers is reported in this study. The copolymer can achieve controlled, sustained, or rapid drug release through different stimuli (acid, reduction, light).
Article
Chemistry, Physical
Olga V. Zaborova, Vadim A. Timoshenko, Corinne Nardin, Sergey K. Filippov
Summary: The mixing of conventional and pH-sensitive lipids was used to design novel stimuli-responsive liposomes (fliposomes) for smart drug delivery. The structural properties of the fliposomes were investigated and the mechanisms involved in a membrane transformation during a pH change were revealed. The pKa value of the trigger-lipid in an aqueous milieu was determined for the first time, which significantly differs from the previously reported values in the literature. Furthermore, a new release model of encapsulated NaCl was proposed and the values of pores self-healing times were obtained for the first time.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Elena Gardey, Fabian H. Sobotta, Stefanie Quickert, Tony Bruns, Johannes C. Brendel, Andreas Stallmach
Summary: Inflammatory bowel disease (IBD) is characterized by increased levels of reactive oxygen species (ROS) in inflamed areas of the gastrointestinal tract and in circulating immune cells. Oxidation-responsive polymeric nanostructures selectively degrade in the presence of H2O2, providing opportunities for targeted drug delivery in IBD patients.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Polymer Science
Xiaowei Fu, Yuanyuan Jiang, Yanjun Wang, Changlin Zhou, Jingxin Lei
Summary: The SBAS TBCPs with dual structural asymmetry were synthesized via RAFT emulsion polymerization, where the interaction between PSt and PBA blocks was tailored by the asymmetry of two outer PSt blocks, leading to changes in the material properties.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
Sk Arif Mohammad, Devendra Kumar, Md Mehboob Alam, Sanjib Banerjee
Summary: This study presents a simple and cost-effective method for ultrafast and recyclable photo-induced polymerization in ionic liquids, yielding low dispersity polymers and well-defined diblock copolymers. The stimuli response of the copolymers to pH and temperature changes has been evaluated, showing potential applications in precise spatiotemporal control. Density functional theory (DFT) calculations rationalize the underlying mechanism of the polymerization process.
Article
Polymer Science
Ankita Mandal, Andreas F. M. Kilbinger
Summary: Vinyl ether based macro-chain transfer agents (m-CTAs) are used to synthesize different di or tri-block copolymers under catalytic living ROMP conditions. The m-CTAs, including polystyrene (PS) vinyl ether m-CTA, polycaprolactone (PCL) m-CTA, and polylactide vinyl ether (PLA) m-CTA, are synthesized via ATRP and ROP methods. The synthesized m-CTAs show high regioselectivity and metathesis activity, enabling the synthesis of metathesis-based A-B diblock copolymers with controlled dispersities (D < 1.4). These degradable ROMP polymers prepared under catalytic living ROMP conditions have potential applications in biomedicine.
Article
Biochemistry & Molecular Biology
Mojtaba Abbasian, Mehdi Jaymand, Pouneh Niroomand, Amir Farnoudian-Habibi, Saber Ghasemi Karaj-Abad
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2017)
Article
Biochemistry & Molecular Biology
Mojtaba Abbasian, Mohammad-Mahdi Roudi, Farideh Mahmoodzadeh, Morteza Eskandani, Mehdi Jaymand
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Materials Science, Biomaterials
Somayyeh Fallah Iri Sofla, Mojtaba Abbasian, Mortaza Mirzaei
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2019)
Article
Materials Science, Biomaterials
Somayyeh Fallah Iri Sofla, Mojtaba Abbasian, Mortaza Mirzaei
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2019)
Article
Engineering, Biomedical
Somayyeh Fallah Iri Sofla, Mojtaba Abbasian, Mortaza Mirzaei
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2019)
Article
Materials Science, Multidisciplinary
Mojtaba Abbasian, Mojtaba Bakhshi, Mehdi Jaymand, Saber Ghasemi Karaj-Abad
JOURNAL OF ELASTOMERS AND PLASTICS
(2019)
Article
Materials Science, Biomaterials
Farideh Mahmoodzadeh, Mojtaba Abbasian, Mehdi Jaymand, Roya Salehi, Elnaz Bagherzadeh-Khajehmarjan
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Polymer Science
Bakhshali Massoumi, Mojtaba Abbasian, Rahim Mohammad-Rezaei, Amir Farnudiyan-Habibi, Mehdi Jaymand
POLYMERS FOR ADVANCED TECHNOLOGIES
(2019)
Article
Polymer Science
Mojtaba Abbasian, Parvaneh Bighlari, Farideh Mahmoodzadeh, Metin Hayri Acar, Mehdi Jaymand
JOURNAL OF APPLIED POLYMER SCIENCE
(2019)
Article
Polymer Science
Hamid Rafiei, Mojtaba Abbasian, Reza Yegani
IRANIAN POLYMER JOURNAL
(2020)
Article
Materials Science, Multidisciplinary
Mina Maghsoudi, Mojtaba Abbasian, Khalil Farhadi
Summary: A novel chitosan-based nanocomposite containing mesoporous nanosilica MCM-41 was synthesized and investigated as an effective adsorbent for Pb(II) ions removal by coordination bonds. Maximum removal of Pb(II) ions was achieved at pH 6, with optimal conditions of 60 mg L(-1) of Pb(II) concentration and 75 min of reaction time. Kinetics studies showed good fit with Langmuir isotherm and followed pseudo-second order kinetics for the adsorption process. The synthesized nanocomposite shows promising prospects in the field of wastewater treatment.
JOURNAL OF ELASTOMERS AND PLASTICS
(2021)
Article
Chemistry, Multidisciplinary
Mina Maghsoudi, Mojtaba Abbasian, Khalil Farhadi, Farideh Mahmoodzadeh, Marjan Ghorbani, Mehdi Hoseinzadeh
Article
Polymer Science
Hamid Rafiei, Mojtaba Abbasian, Reza Yegani
Summary: A comparative study was conducted on the mechanical, thermal, and fouling properties of membranes on a neat PVDF and a (TFN)PVDF/PVP-g-TiO2 thin film nanocomposite. Results showed improved membrane performance with the addition of 2.0% (wt) nanoparticles, but further increase in NP content diminished performance. Surface roughness and thermal stability of membranes were enhanced with the addition of PVP-g-TiO2GNPs.
IRANIAN POLYMER JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Mojtaba Abbasian, Farideh Mahmoodzadeh, Azra Khalili, Roya Salehi
ADVANCED PHARMACEUTICAL BULLETIN
(2019)
