Article
Pharmacology & Pharmacy
Adrianna Dadej, Aneta Wozniak-Braszak, Pawel Bilski, Hanna Piotrowska-Kempisty, Malgorzata Jozkowiak, Malgorzata Geszke-Moritz, Michal Moritz, Daniela Dadej, Anna Jelinska
Summary: The study aimed to analyze the effect of two different APTES-modified SBA-15 silicas on the release profiles of sulindac and investigate the cytotoxicity of these molecules. The results showed that APTES-modified SBA-15 influenced the release of sulindac, both materials improved the dissolution rate in acidic pH, and exhibited insignificant cytotoxicity towards Caco-2 cells.
Article
Engineering, Environmental
Kaijun Gou, Yumei Wang, Linlin Xie, Xianmou Guo, Yingyu Guo, Jia Ke, Lulu Wu, Sanming Li, Heran Li
Summary: Chiral mesoporous silica nanoparticles (CMSNs) have unique physicochemical properties and advantages in biological behavior, making them valuable in various applications such as chiral catalysis, chiral selectivity, chiral recognition, separation, drug delivery, and medical research. Studies on CMSNs have made significant progress in synthesis, chirality origination mechanisms, structural properties, and practical applications, indicating great potential in the field of pharmaceutical science and beyond.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Applied
Klavdiya A. Naumova, Olga V. Dement'eva, Ivan N. Senchikhin, Victor M. Rudoy
Summary: By using miramistin micelles as a template, mesoporous silica nanocontainers (MSNs) with a high drug encapsulation capacity can be synthesized, and the drug release rate varies depending on the temperatures of solubilizing curcumin and synthesizing MSNs, with a higher rate in acidic medium.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Xianbao Shi, Ping Zhang, Lingqiong Wu, Xiangyu Zhao, Jinzhu Jiang, Jing Li, Bo Yang
Summary: Mesoporous silica synthesized using biomimetic method, particularly the biomimetic large mesoporous silica (BL-MS), shows advantages in drug delivery, such as stronger adsorption capacity and better oral bioavailability, compared to commonly used mesoporous silica nanoparticles (MSNs). The large pores in BL-MS significantly improve the dissolution of poorly water-soluble drugs, demonstrating its potential in enhancing drug delivery efficiency.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2021)
Article
Chemistry, Inorganic & Nuclear
Pranita Rananaware, Varsha P. Brahmkhatria, Debatrayee Dasgupta, Anjali Patel
Summary: The study focuses on the role of 12-tungstophosphoric acid (TPA) functionalized nMCM-48 as a drug delivery carrier for weakly soluble polyphenols, curcumin and quercetin. The TPA functionalized nMCM-48 exhibits high pore volume, pore diameter, and high surface area, which are essential for drug loading and release. Both curcumin and quercetin are successfully encapsulated in TPA-functionalized nMCM-48, resulting in nanocomposites with enhanced antimicrobial efficiency. The drug release studies show a release rate of 69% for C-TPA/nMCM-48 and 67% for Q-TPA/nMCM-48.
JOURNAL OF SOLID STATE CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Marta S. Laranjeira, Tiago P. Ribeiro, Ana I. Magalhaes, Pedro C. Silva, Fernando J. Monteiro, Jo A. M. Santos
Summary: This study developed magnetic silica mesoporous nanoparticles as a carrier for exemestane and as MRI contrast agents for treatment monitoring and tumor detection. The nanoparticles showed concentration-dependent contrast effects and successfully released exemestane in a sustained release pattern. Therefore, these nanoparticles have the potential to be used as theranostics for breast cancer treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Engineering, Biomedical
Yumei Wang, Kaijun Gou, Xianmou Guo, Jia Ke, Sanming Li, Heran Li
Summary: Mesoporous silica nanoparticles (MSNs) have been proven to be an excellent platform for drug delivery, but biological barriers present challenges. The physicochemical parameters of MSNs affect their ability to cross biological barriers, and surface modification is an important strategy for achieving rapid transport.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Christos S. Katsiotis, Michelle Ahlen, Maria Stromme, Ken Welch
Summary: Mesoporous materials incorporated into thermoplastic filaments via FDM printing showed enhanced drug release properties and potential for personalized dosage forms for poorly soluble drugs.
Article
Chemistry, Applied
Shiyuan Peng, Baihao Huang, Yizhen Lin, Gongcui Pei, Lijuan Zhang
Summary: This study investigated the application of mesoporous silica nanoparticles (MSN) in drug delivery. The results showed that the structure and surface modification of MSN affect the drug loading and release properties. Hexagonal pore MSN-NH2 and MSN-PDA demonstrated better combined release performance in terms of pH-responsive performance and sustained release effect.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Engineering, Biomedical
Kaijun Gou, Yumei Wang, Xianmou Guo, Yuxin Wang, Yan Bian, Haiqing Zhao, Yingyu Guo, Yue Pang, Linlin Xie, Sanming Li, Heran Li
Summary: This study aimed to investigate the delivery of poorly water-soluble non-steroidal antiinflammatory drugs (NSAIDs) by carboxyl-functionalized mesoporous silica nanoparticles (MSN-COOH) with high specific surface area. The results showed that MSN-COOH had high drug loading capacity and exhibited good in vitro drug release properties, leading to improved bioavailability and strong anti-inflammatory effects in vivo.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Madhappan Santhamoorthy, Vanaraj Ramkumar, Kokila Thirupathi, Lalitha Gnanasekaran, Vanitha Karuppannan, Thi Tuong Vy Phan, Seong-Cheol Kim
Summary: In this study, L-lysine modified mesoporous silica nanoparticles (MS@Lys NPs) were synthesized for the delivery of the anticancer drug curcumin (Cur) to cancer cells. The functionalization of L-lysine groups onto the mesopore channel surfaces of MS@GPTS NPs was achieved through a ring-opening reaction. The structural properties of MS@Lys NPs were examined using various instrumental techniques. The drug loading and pH-responsive drug delivery behavior of MS@Lys NPs were investigated using curcumin as a model drug, and their cytocompatibility and cell uptake behavior were evaluated using MDA-MB-231 cells. The results suggest that MS@Lys NPs have potential for pH-responsive drug delivery in cancer therapy.
Article
Pharmacology & Pharmacy
Wei Xin, Yumei Wang, Yan Bian, Jiahui Lin, Wenhao Weng, Xinyi Zhao, Kaijun Gou, Xianmou Guo, Heran Li
Summary: In this study, a novel chiral mesoporous silica PEIs@TA-CMS was successfully synthesized and found to have superior drug loading and release capabilities compared to MCM41. It displayed high efficiency in incorporating nimodipine, with a significant dissolution-promoting effect and improved oral absorption rate. PEIs@TA-CMS could effectively prolong the survival time of mice on cerebral anoxia, showing approximately 3.26-fold higher bioavailability.
Article
Materials Science, Multidisciplinary
Yingyu Guo, Lin Cai, Xuan Li, Kai Lin, Xuanjing Wu, Ziqi Wang, Dahai Yu, Jing Li
Summary: Molecular chiral mesoporous silica nanoparticles (MC-MSN) have shown great interest recently for their special functions in chiral environment. This study focused on the chiral recognition ability of MC-MSN in adsorbing and delivering drug molecules, demonstrating its potential as a drug carrier with enhanced drug loading capacity and chiral recognition effect in biological environment.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Fang Wang, Xiaoyong Yue, Qi Ding, Hengwei Lin, Chuanlai Xu, Si Li
Summary: Chiral nanomaterials in biology are vital for maintaining various physiological processes and have potential applications in biosensing, drug delivery, early diagnosis, bio-imaging, and disease therapy. Chiral inorganic nanomaterials, with their unique properties, can be constructed similarly to natural chiral nanomaterials. This review summarizes the research on the bio-functions and bio-applications of chiral inorganic nanomaterials, including their construction methods, classification and properties, and highlights their potential in solving problems in living systems.
Article
Chemistry, Multidisciplinary
Zhiyuan Zhao, Mingjian Li, Luyao Zheng, Ye Yang, Xiuming Cui, Tianrui Xu, Wen Zhang, Chengxiao Wang
Summary: The study developed a noninvasive approach for the transdermal delivery of nanoparticles using deep eutectic solvent. The enhanced skin penetration ability of the nanoparticles was demonstrated, and their presence in the blood circulation was detected for the first time through topical administration routes. This work provides a novel strategy for controlled and sustained delivery of nanoparticles and expands the application of nanoparticle drug carrier systems.
JOURNAL OF CONTROLLED RELEASE
(2022)