Article
Biochemistry & Molecular Biology
Diptesh Sil, Sudipta Panja, Chinmay M. Jogdeo, Raj Kumar, Ao Yu, Cassandra E. Holbert, Ling Ding, Jackson R. Foley, Tracy Murray Stewart, Robert A. Casero, David Oupicky
Summary: The PG11047 analogs HPGs showed enhanced anticancer activity in various cancer cell lines, with the ability to self-assemble and form nanoparticles.
Article
Polymer Science
Anda Mihaela Craciun, Simona Morariu, Luminita Marin
Summary: This paper focuses on the preparation of chitosan self-healing hydrogels as carriers for local drug delivery. Through varying the ratio of glucosamine units and aldehyde and the water content, 30 hydrogels were prepared using chitosan and pyridoxal 5-phosphate (P5P). The driving forces of hydrogelation, stability, degradability, and self-healing ability were evaluated through various measurements. The results suggest that chitosan crosslinking with pyridoxal 5-phosphate is a suitable method to obtain self-healing hydrogels with good mechanical properties, structural recovery, stability, and pH-controlled degradability.
Article
Food Science & Technology
Mei Yue, Mingyuan Huang, Zongshuai Zhu, Tianran Huang, Ming Huang
Summary: Chitosan, with high hydrophilic properties at low pH, is not suitable as a Pickering emulsion-stabilizer. However, chitosan self-assembled particles (pH 6.6) stabilized Pickering emulsion prepared by ultrasound showed decreased droplet size and viscosity. Ultrasound treatment affected stability mainly by influencing particle size and viscosity of the emulsion, leading to improved stability observed up to 5 minutes of ultrasound treatment.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abraham Garcia-Jimenez, Angelica Roman-Guerrero, Cesar Perez-Alonso, Benoit Fouconnier
Summary: This study investigates the effect of pH and ionic strength on the association interactions and phase separations in polyelectrolyte systems. The results show that the structure and phase transitions can be controlled by modifying the ionization degree, pKa, and charge screening. The findings provide insights into the functional properties of complexed polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Dong Lei, Jing Zhao, Chenhui Zhu, Min Jiang, Pei Ma, Yu Mi, Daidi Fan
Summary: In this study, a shape-memory cryogel was prepared using alkylated chitosan and oxidized dextran, and then combined with a drug-laden and silver-doped mesoporous bioactive glass. The cryogel showed excellent blood absorption capability, promoted wound healing, and exhibited antibacterial activity.
Article
Nanoscience & Nanotechnology
Lingna Yang, Qingxin Han, Xiaoling Ling, Yansong Wang, Miaohua Li, Qingliang Chen, Xuechuan Wang
Summary: A self-assembled fluorescent nanoparticle was designed for the rapid detection of formaldehyde (FA). The nanoprobe exhibited high sensitivity, selectivity, and a wide application range, enabling sensitive detection of FA in aqueous solution, air, leather samples, and living cells.
ACS APPLIED NANO MATERIALS
(2022)
Article
Engineering, Chemical
Lishu Shao, Huan'ai Wan, Lizhi Wang, Jiajia Wang, Zihui Liu, Zhiping Wu, Peng Zhan, Lin Zhang, Xiancheng Ma, Jianhan Huang
Summary: Sodium lignosulphonate, chitosan, and activator were combined into wet gel microbeads, which were then freeze-dried and one-step activated carbonized to obtain novel porous carbon adsorption materials (LC-Cs). The LC-Cs showed large specific surface areas, high microporosity, and rich nitrogen content. They exhibited efficient CO2 capture and high CO2/N2 selectivity, as well as high adsorption capacity for p-nitrophenol (PNP).
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Yunhao Yu, Rui Tian, Yu Zhao, Xudong Qin, Liefeng Hu, Jun-Jie Zou, Ying-Wei Yang, Jian Tian
Summary: Microvascular dysfunction caused by hyperglycemia leads to slow healing of diabetic wounds and increases the risk of bacterial infection. This study developed novel supramolecular photothermal nanoparticles for treating bacterial wound infection, which demonstrated potent photothermal and antimicrobial effects, as well as good biocompatibility. The nanoparticles showed selective targeting towards bacteria and were effective against drug-resistant strains. Overall, this research represents a promising photothermal antibacterial nanoplatform.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Peter Marton, Ors Tamas Nagy, Dorina Kovacs, Beata Szolnoki, Janos Madarasz, Norbert Nagy, Gabriella Stefania Szabo, Zoltan Horvolgyi
Summary: Chitosan coatings with different levels of acetylation were prepared on glass and zinc substrates. The impact of acetylation on the coatings' structure and properties was investigated using various analytical techniques. It was found that increasing the level of acetylation led to a decrease in barrier effect, likely due to changes in the coating's structure and ionization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Analytical
Hebing Pei, Fang Chen, Xiaohui Niu, Qianqian Jia, Ruibin Guo, Nijuan Liu, Zunli Mo
Summary: The CS-SA chiral composite sensing material was prepared using electrostatic self-assembly method, showing specific binding capability to L-tyrosine. The combination of chitosan with sodium alginate significantly improved the efficiency of chiral recognition, providing a new approach for chitosan combination with other materials in chiral recognition applications.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Balaram Mishra, Sabir Hossain, Sibanwita Mohanty, Mukesh Kumar Gupta, Devendra Verma
Summary: A novel strategy of developing chitosan-casein based self-assembled nanofibrous polyelectrolyte complex (PEC) for rapid blood clotting was reported in this study. Increasing the percentage of chitosan in PEC resulted in higher zeta potential and faster clotting efficacy, demonstrating promising hemostatic efficiency in both in vitro and in vivo conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Mengya Li, Hui Liu, Jie Liu, Ying Pei, Xuejing Zheng, Keyong Tang, Fang Wang
Summary: A highly hydrophobic and self-recoverable sponge was prepared using cellulose nanofibrils, N-alkylated chitosan, and poly (vinyl alcohol) via simple thermal chemical vapor deposition, with high hydrophobicity and excellent absorption capacity for oil/water separation. The sponge also demonstrated good stability in various conditions and potential applications in oil/water separation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Tanmay Bharadwaj, Shreya Chrungoo, Devendra Verma
Summary: Chitosan-based thermosensitive bioink has great potential for bone tissue engineering due to its excellent biocompatibility and gelation at physiological temperature without the need for crosslinkers. However, it has limitations in terms of low mechanical strength, poor printability, and low post-printing cell viability. This study incorporated self-assembled nanofibrous aggregates and nanohydroxyapatite into chitosan-based bioinks to improve their printability, mechanical properties, and cell viability. The optimized nanocomposite bioink showed good printability, high cell viability, low water uptake, and degradation in the presence of lysozyme. The bioink also exhibited a suitable elastic modulus and enhanced cellular activity in osteogenic media.
CARBOHYDRATE POLYMERS
(2024)
Article
Biochemistry & Molecular Biology
Giuseppe Cirillo, Manuela Curcio, Cesare Oliviero Rossi, Giovanni De Filpo, Mariafrancesca Baratta, Michele De Luca, Francesca Iemma, Fiore Pasquale Nicoletta
Summary: The conjugation of polyphenols is an effective method to modify the properties of biomedical materials. In this study, curcumin (CUR) was conjugated to sodium alginate (CA) and chitosan (CS) to increase the viscosity of the conjugates and control the release of loaded therapeutics. Calorimetric and rheological analyses confirmed the enhanced rigidity and interconnection between polymer chains in the conjugates. The evaluation of drug delivery performance showed sustained release profiles, indicating the potential for the development of controlled delivery systems.
Article
Engineering, Environmental
Bichong Luo, Xiaoyun Li, Pai Liu, Meng Cui, Guangying Zhou, Jin Long, Xiaoying Wang
Summary: This study introduces NIR-responsive molybdenum disulfide nanosheets (MoS2) to confer antibacterial activity to nanocellulose paper. The MoS2 nanosheets are combined with quaternized chitosan to create a composite paper with excellent photothermal and photodynamic activity, leading to highly efficient antibacterial efficacy.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Environmental
Yi Zhang, Jian Li, Zhen Wang, Ming-Ze Xu, Zhi Zeng, Jin-peng Huang, Yan-Qing Guan
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Nanoscience & Nanotechnology
Xiang Zhou, Zhentao Li, Lihui Tan, Yi Zhang, Yanpeng Jiao
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Engineering, Environmental
Xin Liu, Wenfu Lin, Peng Xiao, Mingjin Yang, Li-Peng Sun, Yi Zhang, Wei Xue, Bai-Ou Guan
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Materials Science, Biomaterials
Li Liu, Mingchao Li, Mingze Xu, Zhen Wang, Zhi Zeng, Yunqing Li, Yi Zhang, Rong You, Chu-Hua Li, Yan-Qing Guan
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Engineering, Environmental
Xiang Zhou, Xiuhong Huang, Bincheng Wang, Lihui Tan, Yi Zhang, Yanpeng Jiao
Summary: The study presented a novel micromotor system that utilized NIR light and gas propulsion to overcome multiple biological barriers in tumor treatment, achieving precise active drug delivery.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biophysics
Xiang Wang, Xin Yan, Bin-cheng Wang, Wei Xue, Chang-ren Zhou, Yi Zhang, Zong-hua Liu
Summary: This study introduces a novel blood lead adsorbent that allows for selective adsorption with real-time monitoring, possessing the ability to resist blood components and be used for treatment and monitoring of lead poisoning.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Materials Science, Composites
Zhi Zeng, Han-bo Feng, Meng-en Hao, Yi Zhang
Summary: A transdermal delivery system for colchicine using a one-pot approach in a microemulsion was proposed in this study, which achieved in situ encapsulation of colchicine during nano-hydroxyapatite formation. The optimal formulation showed high transdermal flux, enhanced drug loading efficiency, and tunable sustained-release behavior, combining the advantages of microemulsion and nano-Hap for controlled drug release. This composite system holds promise as a vehicle for transdermal delivery of colchicine to produce desirable pharmacological effects.
COMPOSITES COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Hua Zhang, Haijie Zhao, Yan Huang, Guodong Sun, Yi Zhang
Summary: Researchers have incorporated mTOR signaling inhibitor rapamycin into a shell-core theranostic nanoplatform to enhance the synergistic effect of chemotherapy and immunotherapy. This nano-platform, with responsive properties regulated by intracellular processes, demonstrates improved blood compatibility, effective tumor accumulation and microenvironment-selective endocytosis.
APPLIED MATERIALS TODAY
(2022)
Article
Materials Science, Multidisciplinary
Xiuhong Huang, Licheng Lin, Xing Yang, Zhentao Li, Yi Wan, Lihua Li, Yanpeng Jiao, Yi Zhang, Changren Zhou
Summary: This study proposes a method using a complex of chitooligosaccharides and europium ions to monitor wound healing, modulate inflammation, and promote vascularization in pressure ulcer injuries. The complex not only monitors wound healing through fluorescence changes, but also demonstrates anti-inflammatory activity and promotes vascularization. The simple construction enables visual monitoring and multi-stage adaptive wound repair.
APPLIED MATERIALS TODAY
(2022)
Article
Biophysics
Xin Liu, Fan Wang, Li Liu, Tiantian Li, Xiangyu Zhong, Hongsheng Lin, Yi Zhang, Wei Xue
Summary: In this study, a nano-spray assisted photothermal imaging system was developed for in vitro cell discrimination and in vivo visualization of tumor position and border in real-time during surgery. Compared to conventional imaging techniques, this approach has the advantages of low cost, convenience, no radiation hazard, and avoiding the adverse effects risk of oral or intravenous contrast agent.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Shuo Liu, Xiaozhen Zhan, Zhenni Lin, Zonghua Liu, Jie Yang, Yi Zhang
Summary: In this study, bacteria-like tumor vaccines with cascade reaction properties were designed to target all key steps of the immune response. The vaccines demonstrated promising anti-tumor effectiveness by effectively loading the antigen, activating and entering antigen presenting cells, escaping the lysosomes, and inducing a potent and continuous anti-tumor cellular immune response.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Analytical
Wei Wang, Jiexuan Cai, Nai-Kei Wong, Meijing Hong, Jianbin Deng, Long Jin, Yang Ran, Yi Zhang, Yaqi Zhou, Bai-Ou Guan
Summary: In this study, two fluorescent probes were successfully synthesized for the detection of NTR activity in cell and in vivo models. One probe showed high selectivity for NTR, strong fluorescence enhancement, and low detection limit in the presence of NADH. The other tumor-targeting probe efficiently detected NTR activity in cancer cells. The liposome-encapsulated probe was successfully applied to visualize NTR during liver inflammation in mice.
Article
Chemistry, Physical
Zhen Wang, Qian Hu, Zhi Zeng, Xiao-Zhen Wang, Yan-Qing Guan, Yi Zhang
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2020)
Article
Materials Science, Biomaterials
Cheng-guang Wu, Xiang Wang, Yun-feng Shi, Bin-cheng Wang, Wei Xue, Yi Zhang
BIOMATERIALS SCIENCE
(2020)
Article
Materials Science, Biomaterials
Li Liu, Bo Yang, Lan-Qing Wang, Jin-Peng Huang, Wu-Ya Chen, Qing Ban, Yi Zhang, Rong You, Liang Yin, Yan-Qing Guan
JOURNAL OF MATERIALS CHEMISTRY B
(2020)