Article
Multidisciplinary Sciences
Teresa Curiel Garcia, Alberto Ruano-Ravina, Cristina Candal-Pedreira, Rafael Lopez-Lopez, Maria Torres-Duran, Jose Ramon Enjo-Barreiro, Mariano Provencio, Isaura Parente-Lamelas, Iria Vidal-Garcia, Cristina Martinez, Jesus Hernandez-Hernandez, Ihab Abdulkader-Nallib, Olalla Castro-Anon, Maria Pineiro-Lamas, Leonor Varela-Lema, Alberto Fernandez-Villar, Juan Barros-Dios, Monica Perez-Rios
Summary: Small cell lung cancer (SCLC) is a subtype of lung cancer accounting for approximately 10% of cases. While tobacco is the main risk factor, occupation also appears to play a role in SCLC risk. Through a case-control study, it was found that working in known-risk occupations for lung cancer was associated with a 2.17 times increased risk of SCLC. This risk was further heightened when combined with moderate to heavy smoking.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
M. Torres-Duran, M. T. Curiel-Garcia, A. Ruano-Ravina, M. Provencio, I Parente-Lamelas, J. Hernandez-Hernandez, A. Fernandez-Villar, J. M. Barros-Dios, M. Perez-Rios
Summary: Characteristics of SCLC in never-smokers were not associated with indoor radon exposure, and the survival rate of this aggressive lung cancer in never-smokers remains low.
Article
Dermatology
Paulo Muller Ramos, Alessandra Anzai, Bruna Duque-Estrada, Debora Cadore Farias, Daniel Fernandes Melo, Fabiane Mulinari-Brenner, Giselle Martins Pinto, Leonardo Spagnol Abraham, Leopoldo Duailibe Nogueira Santos, Rodrigo Pirmez, Helio Amante Miot
Summary: The study found that high cumulative exposure to HCTZ is associated with an increased risk of keratinocyte carcinoma, particularly invasive SCC. Users of HCTZ also had an increased risk of SCCis and BCC. However, the study also pointed out limitations in adjusting for all potential factors.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Jonas A. Adalsteinsson, Sonal Muzumdar, Reid Waldman, Chaoran Hu, Rong Wu, Desiree Ratner, Jonathan Ungar, Jonathan I. Silverberg, Gudridur H. Olafsdottir, Arni Kjalar Kristjansson, Laufey Tryggvadottir, Jon Gunnlaugur Jonasson
Summary: The study found that a cumulative dose of hydrochlorothiazide above 37,500 mg was associated with an increased risk of invasive SCC. Users of hydrochlorothiazide also had a higher risk of SCCis and BCC.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Oncology
Yosuke Shionoya, Akito Hattori, Taro Hanada, Michihiro Fujino
Summary: This study describes a case of immune-related encephalitis in a patient with ES-SCLC, demonstrating the effectiveness of steroid therapy in treating durvalumab-induced encephalitis. The patient experienced neurological complications after durvalumab treatment, but showed significant improvement in symptoms after receiving steroid therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Cheng Shen, Guowei Che
Summary: Combined small cell lung carcinoma is a rare tumor that mainly consists of small cell lung cancer and non-small cell lung cancer components. We reported a case of an elderly patient diagnosed with combined small cell lung carcinoma with adenocarcinoma and summarized the clinical features of this disease.
FRONTIERS IN SURGERY
(2022)
Article
Dermatology
Jennifer R. Dusendang, Ekama Carlson, David S. Lee, Sangeeta Marwaha, Shabnam Madani, Stacey E. Alexeeff, Allison Webber, Nelson B. Goes, Lisa J. Herrinton
Summary: This study aimed to evaluate the risk of cutaneous squamous cell carcinoma (cSCC) in solid organ transplant recipients (SOTRs) using immunosuppressive medications. The results showed that the annual incidence of cSCC was higher in SOTRs compared to persons without transplantation. Lung transplant and the use of voriconazole were associated with an increased risk of cSCC, while belatacept and other immunosuppressive medications were not.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Oncology
Jennifer W. Carlisle, Ticiana Leal
Summary: Small cell lung cancer (SCLC) is a rapidly progressive neuroendocrine carcinoma that has limited effective treatments. Advances in DNA sequencing and whole transcriptomics have identified key subtypes, leading to the development of chemoimmunotherapy as the standard of care for advanced disease. Ongoing research is focused on incorporating immunotherapy into limited stage settings and exploring combination strategies with radiation.
Article
Oncology
Diming Wang, Wei Ye, Dongmei Chen, Qingming Shi, Dongchun Ma
Summary: We report a rare case of a patient with primary lung squamous cell carcinoma transforming into small cell lung cancer following immunotherapy. This transformation is uncommon in immunotherapy but more common in epidermal growth factor receptor tyrosine kinase inhibitor treatment for lung adenocarcinoma.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Respiratory System
Angeles Rodriguez-Martinez, Alberto Ruano-Ravina, Maria Torres-Duran, Mariano Provencio, Isaura Parente-Lamelas, Iria Vidal-Garcia, Cristina Martinez, Jesus Hernandez-Hernandez, Ihab Abdulkader-Nallib, Olalla Castro-Anon, Leonor Varela-Lema, Maria Pineiro-Lamas, Paula Sales Fidalgo, Alberto Fernandez-Villar, Juan Barros-Dios, Monica Perez-Rios
Summary: Residential radon exposure is associated with an increased risk of small cell lung cancer, with a linear dose-response pattern. Smokers exposed to higher radon concentrations have a higher risk of SCLC compared to smokers exposed to lower indoor radon concentrations.
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Article
Dermatology
Filippos Giannopoulos, Martin Gillstedt, Marta Laskowski, Kasper Bruun Kristensen, Sam Polesie
Summary: A study reveals a slightly increased risk of cutaneous squamous cell carcinoma associated with methotrexate exposure in psoriasis patients, which seems to be linked to disease severity, other antipsoriatic treatments, and UV exposure.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Endocrinology & Metabolism
Jiahao Zhu, Gang Wu, Yutian Zhao, Bo Yang, Qingqing Chen, Jianwei Jiang, You Meng, Shengjun Ji, Ke Gu
Summary: This study analyzed the incidence, clinicopathologic characteristics, and prognostic factors of primary small cell breast carcinoma (SCBC). The results showed that SCBC is a rare and aggressive breast neoplasm, with tumor stage being associated with poor prognosis. The main treatment for SCBC is a combination of surgery and chemotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Respiratory System
Taisuke Jo, Nobuaki Michihata, Hayato Yamana, Kojiro Morita, Miho Ishimaru, Yasuhiro Yamauchi, Wakae Hasegawa, Hirokazu Urushiyama, Kazuaki Uda, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Takahide Nagase
Summary: The study identified six drug categories significantly associated with an increased occurrence of DILD, including epidermal growth factor receptor inhibitors and class III antiarrhythmic drugs, while statins were associated with a reduced risk of DILD. The findings provide valuable information for physicians to prevent and treat DILD.
Article
Immunology
Akshay J. Patel, Naeem Khan, Alex Richter, Babu Naidu, Mark T. Drayson, Gary W. Middleton
Summary: B cells play a key role in lung cancer pathogenesis and response to immunotherapy. The B cell repertoire differs between tumor and circulation, with a diverse range of plasma cell and memory cell phenotypes in lung cancer. The influence of smoking and tumor type on the B cell repertoire is limited.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Jin-Dong Li, Cheng-Yan Jin, Yan Zhang, Hang Guo, Guang-Lei Zhang, Chun-Guang Wang
Summary: This case report describes a patient with lung cancer who experienced histopathological transformation from squamous-cell carcinoma to large cell neuroendocrine carcinoma with a small fraction of small cell carcinoma.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Letter
Rheumatology
Sindhu R. Johnson, Martin Aringer
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Biology
Ramon C. Hermida, Artemio Mojon, Jose R. Fernandez, Ramon G. Hermida-Ayala, Juan J. Crespo, Maria T. Rios, Manuel Dominguez-Sardina, Alfonso Otero, Michael H. Smolensky
Summary: Elevated asleep blood pressure and blunted sleep-time relative systolic blood pressure decline are significant prognostic markers of cardiovascular disease risk. Current hypertension guidelines overlook the importance of asleep blood pressure and recommend diagnosis based on office blood pressure measurements. Studies have shown that taking blood pressure-lowering medications at bedtime results in greater reduction of blood pressure and improved cardiovascular outcomes compared to morning intake.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Letter
Respiratory System
Maria Estrella Lopez-Pardo, Cristina Candal-Represas, Luis Valdes-Cuadrado, Cristina Represas-Represas, Alberto Ruano-Ravina, Monica Perez-Rios
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Review
Oncology
Lucia Robado de Lope, Estela Sanchez-Herrero, Roberto Serna-Blasco, Mariano Provencio, Atocha Romero
Summary: Cancer is considered an evolutionary disease where tumor cells adapt to the environment and eventually form metastasis. Communication between tumor cells and the surrounding microenvironment via extracellular vesicles (EVs) is crucial for the success of the metastatic process. Recent studies suggest that tumor-derived EVs not only modify the microenvironment to facilitate tumor progression but also induce malignant transformation in cells outside the primary tumor. Further research is needed to understand the role of EVs in cancer progression and metastasis, which may have implications for novel cancer treatments.
MOLECULAR ONCOLOGY
(2023)
Article
Environmental Sciences
Alberto Ruano-Ravina, Orlando Acosta, David Diaz Perez, Ciro Casanova, Valle Velasco, German Peces-Barba, Esther Barreiro, Ana Canas, Argelia Castano, Maria Jesus Cruz Carmona, Carmen Diego, Judith Garcia-Aymerich, Cristina Martinez, Maria Molina-Molina, Xavier Munoz, Francisco Javier Sanchez-Inigo, Cristina Candal-Pedreira
Summary: This study aims to assess the short-, medium-, and long-term respiratory health effects of exposure to volcanic emissions from the eruption in different population groups. The study will employ multiple designs, including a cohort study on the general population, highly exposed population, and childhood population, as well as a pre-post quasi-experimental study on subjects with previously diagnosed respiratory diseases. Information will be collected through personal interviews, biologic specimens, air pollution data, and medical records, among other methods, with a planned follow-up of five years.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Cristina Candal-Pedreira, Joseph S. Ross, Ana Marusic, Alberto Ruano-Ravina
Summary: Research misconduct refers to unethical practices in research and publication, leading to article retractions and public scepticism. A joint effort by the scientific community, academic institutions, journals, and funders is needed to identify and prevent research misconduct. This paper evaluates current efforts and proposes actions for academic institutions and scientific journals, emphasizing the need for a larger multistakeholder approach.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Review
Cardiac & Cardiovascular Systems
Carlota Rodriguez Garcia, Alberto Ruano-Ravina, Monica Perez Rios, Lucia Martin Gisbert, Leonor Varela-Lema, Cristina Candal-Pedreira, Cristina Represas-Represas, Julia Rey-Brandariz, Luis Valdes-Cuadradoa, Alvar Agusti
Summary: Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of death worldwide. While smoking is a major risk factor, COPD also occurs in individuals who have never smoked (NS). However, there is limited evidence on the risk factors, clinical characteristics, and natural history of COPD in NS. This study aimed to address this knowledge gap through a systematic review of the literature.
RESPIRATORY MEDICINE
(2023)
Article
Substance Abuse
Carla Guerra-Tort, Esther Lopez-Vizcaino, Maria I. Santiago-Perez, Julia Rey-Brandariz, Cristina Candal-Pedreira, Leonor Varela-Lema, Anna Schiaffino, Alberto Ruano-Ravina, Monica Perez-Rios
Summary: This study aimed to validate a small-area model for estimating smoking prevalence. The results showed that the small-area model applied to national survey data accurately estimated smoking prevalence by sex and age group, enabling the study of risk factors at a subnational level.
TOBACCO INDUCED DISEASES
(2023)
Review
Oncology
Alberto Ruano-Ravina, Lucia Martin-Gisbert, Karl Kelsey, Monica Perez-Rios, Cristina Candal-Pedreira, Julia Rey-Brandariz, Leonor Varela-Lema
Summary: The aim of this study is to provide an overview of research on indoor radon and lung cancer, with a focus on Spanish investigations. Early studies established the link between radon and lung cancer, and later case-control studies confirmed this association in the general population. Spain has contributed extensive evidence, including multiple studies exploring various aspects such as the effect of radon on never-smokers, molecular pathways, survival rates, mortality burden, and occupational exposure. The causal association between radon and lung cancer is well-established, but further research is needed to understand the potential molecular pathways and other health effects.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Respiratory System
Marta Nunez-Fernandez, Cristina Ramos-Hernandez, Francisco Garcia-Rio, Alexandre Perez-Gonzalez, Amara Tilve-Gomez, Paula Rodriguez-Fernandez, Andres Nodar-Germinas, Alberto Fernandez-Garcia, Alberto Ruano-Ravina, Alberto Fernandez-Villar
Summary: This study is the first to assess the lung diffusing capacity in patients with COVID-19 pneumonia 12 months after discharge. The study found improvements in exercise tolerance, extent of ground-glass opacity, and lung function test results between 3 and 12 months after discharge, but no decrease in dyspnea or self-perceived health condition. DLNO was the most significantly altered parameter at 12 months, with improvement mainly observed in alveolar units and their vascular component.
RESPIRATORY RESEARCH
(2023)
Article
Respiratory System
Cristina Candal-Pedreira, Alberto Ruano-Ravina, Virginia Calvo de Juan, Manuel Cobo, Jose Manuel Trigo, Enric Carcereny, Marc Cucurull, Rafael Lopez Castro, Eduardo Solis Garcia, Amparo Sanchez-Gastaldo, Bartomeu Massuti, Delvys Rodriguez-Abreu, Anna Estival, Maria Guirado Risueno, Maria Pamies Ramon, Rosario Garcia Campelo, Guillermo Alonso-Jaudenes, Carlos Camps, Edel del Barco Morillo, Clara Gonzalez Ojea, Manuel Domine, Alfredo Sanchez-Hernandez, Joaquim Bosch-Barrera, Maria Angeles Sala Gonzalez, Mariano Provencio
Summary: Over one-third of lung cancer cases in Spain cannot be detected through screening due to not meeting the most recent inclusion criteria. The degree of fulfilment in a potential nationwide screening programme should be analyzed, with the aim of establishing inclusion criteria in line with each country's context.
Article
Medical Ethics
Cristina Candal-Pedreira, Ali Ghaddar, Monica Perez-Rios, Leonor Varela-Lema, Carlos Alvarez-Dardet, Alberto Ruano-Ravina
Summary: This study examines the perceptions, attitudes, and experiences of Spanish researchers regarding scientific misconduct in the field of biomedicine. The results show a high frequency of scientific misconduct among Spanish biomedical researchers, with 43.3% admitting to engaging in some form of misconduct. False authorship is the most common type of misconduct. There are variations in the types of misconduct based on gender and the type of research institution.
ACCOUNTABILITY IN RESEARCH-ETHICS INTEGRITY AND POLICY
(2023)
Article
Environmental Sciences
Lucia Martin-Gisbert, Cristina Candal-Pedreira, Marta Garcia-Talavera San Miguel, Monica Perez-Rios, Juan Barros-Dios, Leonor Varela-Lema, Alberto Ruano-Ravina
Summary: The study aimed to describe workplace radon exposure in Spain and its influencing factors. The results showed that approximately one-fifth of workplaces in radon prone areas had radon concentrations above the standard limit of 300 Bq/m3. Radon concentration varied significantly by floor level, working sector, and location. The highest radon concentrations were found in the Education & Culture sector.
ENVIRONMENTAL RESEARCH
(2023)
Meeting Abstract
Oncology
J. C. Sanchez Gonzalez, B. Nunez Garcia, M. Blanco Clemente, V. Calvo de Juan, B. Cantos Sanchez de Ibarguen, M. Mendez Garcia, R. Aguado Noya, D. Ruiz de Domingo, A. Gonzalez Sanchez, M. Provencio
JOURNAL OF THORACIC ONCOLOGY
(2022)
