Article
Immunology
Lauri E. Markowitz, John T. Schiller
Summary: HPV vaccines are highly effective in preventing HPV-attributable cancers and have been introduced into national immunization programs in over 100 countries. The success of these vaccines has sparked interest in ambitious disease reduction goals.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Junqiu Xiang, Long Han, Yanfei Fan, Bin Feng, Haoqing Wu, Chunmin Hu, Manli Qi, Huiping Wang, Quanzhong Liu, Yuanjun Liu
Summary: HPV prevalence was high among both male and female patients at the STD clinic, with HPV6 being the most common genotype. Single HPV subtype infection was predominant in both sexes.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Sunny Jung Kim, Jenna E. Schiffelbein, Inger Imset, Ardis L. Olson
Summary: This study found that evidence-based messages in social media can effectively change parents' attitudes and behavioral intentions towards HPV vaccination. Messages that provide scientific evidence and correct misinformation are particularly effective in promoting positive perceptions of the HPV vaccine.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Immunology
Frederique J. Vink, Chris J. L. M. Meijer, Albertus T. Hesselink, Arno N. Floore, Birgit Lissenberg-Witte, Jesper H. Bonde, Helle Pedersen, Kate Cuschieri, Ramya Bhatia, Mario Poljak, Anja Ostrbenk Valencak, Peter Hillemanns, Wim G. Quint, Marta del Pino, Gemma G. Kenter, Renske D. M. Steenbergen, Danielle A. M. Heideman, Maaike C. G. Bleeker
Summary: The FAM19A4/miR124-2 methylation test can detect nonproductive, transforming CIN2/3 lesions with high specificity in HPV-positive women under 30 years old, providing valuable information for treatment decisions.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Oncology
Biyuan Xing, Jianfeng Guo, Yuhan Sheng, Gang Wu, Yingchao Zhao
Summary: HPV-negative cervical cancers, predominantly adenocarcinomas, pose challenges in diagnosis and management due to unclear etiology and possible false negative results. It is important to pay greater attention to these cases as they are often diagnosed at advanced stages with poor prognoses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Virology
Sharonjit K. Dhillon, Pui Yan Jenny Chung, Elizaveta Padalko, Marleen Praet, Ana Rita Pereira, Nina Redzic, Davy Vanden Broeck, Marc Arbyn
Summary: The implementation of cervical screening based on HPV is rapidly progressing worldwide, and this study evaluates the reproducibility of the RIATOL-qPCR assay. The study found that this detection method demonstrates good reproducibility both within and between laboratories. The assay fulfills the reproducibility requirement for HPV testing in cervical cancer screening.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Emel Yilmaz, Carina Eklund, Camilla Lagheden, Karin Dahlin Robertsson, Marina Lilja, Miriam Elfstrom, Laila Sara Arroyo Muhr, Joakim Dillner
Summary: This study provides the first global overview of the proficiency of HPV testing services for cervical cancer screening. The results indicate a high level of sensitivity and few false positives, but specificity still needs further improvement.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Oncology
Karoline Andersen, Kasper Holm, Mette Tranberg, Cecilie Lebech Pedersen, Sara Bonlokke, Torben Steiniche, Berit Andersen, Magnus Stougaard
Summary: This study demonstrates the use of a targeted HPV next generation sequencing (NGS) panel for cervical cancer screening. The targeted panel shows similar sensitivity and specificity to commercial HPV assays, but also provides additional advantages such as specific detection of all relevant HPV types and identification of viral integration and variants.
Review
Immunology
Zahra Yousefi, Hamid Aria, Farhoodeh Ghaedrahmati, Tahereh Bakhtiari, Mahdieh Azizi, Reza Bastan, Reza Hosseini, Nahid Eskandari
Summary: This review provides a comprehensive overview of HPV vaccines, discussing their types and efficacy. Prophylactic vaccines, which are highly immunogenic and induce neutralizing antibodies, have been approved for targeting high-risk HPV types. Therapeutic vaccines, on the other hand, aim to stimulate cell-mediated immunity against transformed cells. The second generation of prophylactic vaccines, using alternative viral components and cost-effective production strategies, is currently under clinical evaluation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Magdalena R. Vaenesbranden, Johanna Wiik, Katrine Sjoborg, Anne Cathrine Staff, Karin C. Lodrup Carlsen, Guttorm Haugen, Gunilla Hedlin, Katarina Hilde, Bjorn Nordlund, Camilla F. Nystrand, Anbjorg Rangberg, Eva Maria Rehbinder, Knut Rudi, Corina Silvia Rueegg, Yvonne Sandberg, Sigrid Sjelmo, Havard O. Skjerven, Cilla Soderhall, Riyas Vettukattil, Christine M. Jonassen
Summary: This study aimed to identify HPV prevalence and persistence rates in pregnant women, as well as risk factors for infection. The results showed higher HPV prevalence at mid-gestation compared to delivery, with low viral load associated with clearance of HPV infections at delivery. Factors like short pre-conception relationships and alcohol intake during pregnancy increased HPV infection risk.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Joseph E. Tota, Anna R. Giuliano, Stephen E. Goldstone, Brady Dubin, Alfred Saah, Alain Luxembourg, Christine Velicer, Joel M. Palefsky
Summary: The incidence of human papillomavirus (HPV)-related cancer is rising in men, and this study found that the prevalence of HPV infection and seropositivity is higher in men who have sex with men (MSM) compared to heterosexual men (HM). However, overall prevalence is still low. Catch-up vaccination after sexual debut may be beneficial.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Marianna Martinelli, Chiara Giubbi, Laura Saderi, Rosario Musumeci, Federica Perdoni, Biagio Eugenio Leone, Robert Fruscio, Fabio Landoni, Andrea Piana, Giovanni Sotgiu, Clementina Elvezia Cocuzza
Summary: HPV genotyping and viral load may serve as potential diagnostic biomarkers for high-grade cervical lesions. This study evaluated a new HPV test and found that the distribution of HR-HPV genotypes and viral copy numbers differed between women with high- and low-grade cervical lesions. These findings suggest that HPV genotyping and normalized viral load may help identify women at increased risk of cervical lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yongji Yan, Hongfeng Zhang, Chunfan Jiang, Xin Ma, Xueying Zhou, Xun Tian, Yuping Song, Xu Chen, Liyao Yu, Rui Li, Hongwei Chen, Xin Wang, Ting Liu, Zhaohui He, Hongzhao Li
Summary: The study found that HPV infection may contribute to bladder cancer in both men and women, with HPV18, HPV33, HPV16, and HPV39 genotypes potentially representing the predominant oncogenic risk types for bladder carcinogenesis.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Margo Bell, Bo Verberckmoes, Janne Devolder, Heleen Vermandere, Olivier Degomme, Yasmin Medeiros Guimaraes, Luani Rezende Godoy, Elena Ambrosino, Piet Cools, Elizaveta Padalko
Summary: This study demonstrates that the novel Allplex II HPV28 assay has a good diagnostic performance compared to widely used HPV assays. The assay has a user-friendly and automated workflow, an open platform for add-on assays, and provides quick and easy-to-interpret results. It shows potential for simplification and standardization of future diagnostic testing programs.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Loredana Sabina Cornelia Manolescu, Corina Zugravu, Corneliu Nicolae Zaharia, Anca Irina Dumitrescu, Irina Prasacu, Mihaela Corina Radu, Goraneanu Draghici Letitia, Irina Nita, Corina Marilena Cristache, Laurentia Nicoleta Gales
Summary: The aim of this study is to assess the barriers and facilitators of the current Romanian HPV vaccination campaign. The results showed that the inclusion of HPV vaccination in the National Vaccination Program is the most important factor in promoting vaccination. On the other hand, vaccine hesitancy often stems from the high cost of the vaccine and a lack of proper information.
Article
Immunology
Ismail Hendaoui, Ahlem Lahmar, Luca Campo, Sihem Mebarki, Sandrine Bichet, Daniel Hess, Martin Degen, Nidhameddine Kchir, Leila Charrada-Ben Farhat, Rania Hefaiedh, Christian Ruiz, Luigi M. Terracciano, Richard P. Tucker, Lotfi Hendaoui, Ruth Chiquet-Ehrismann
Summary: The study found that tenascin-C and tenascin-W were expressed in all biliary tract tumors, with tenascin-W not detected in normal hepatobiliary tissue. Additionally, the formation and organization of tenascin-W required co-culture of Huh-28 cells with bone marrow-derived stromal cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Athanasios Tampakis, Benjamin Weixler, Silvan Rast, Ekaterini-Christina Tampaki, Eleonora Cremonesi, Venkatesh Kancherla, Nadia Tosti, Christoph Kettelhack, Charlotte K. Y. Ng, Tarik Delko, Savas D. Soysal, Urs von Holzen, Evangelos Felekouras, Nikolaos Nikiteas, Martin Bolli, Luigi Tornillo, Luigi Terracciano, Serenella Eppenberger-Castori, Giulio C. Spagnoli, Salvatore Piscuoglio, Markus von Flue, Silvio Daster, Raoul A. Droeser
Summary: In colorectal cancer patients, high expression of nestin and CD34 in the tumor stroma is associated with better prognosis, possibly by modulating a favorable immune response. Additionally, the high expression of nestin and CD34 is correlated with lower vascular invasion and improved 5-year overall survival.
Article
Medicine, Research & Experimental
Fulvia Milena Cribiu, Roberta Erra, Lorenza Pugni, Carlota Rubio-Perez, Lidia Alonso, Sara Simonetti, Giorgio Alberto Croci, Garazi Serna, Andrea Ronchi, Carlo Pietrasanta, Giovanna Lunghi, Anna Maria Fagnani, Maria Pinana, Matthias Matter, Alexandar Tzankov, Luigi Terracciano, Andres Anton, Enrico Ferrazzi, Stefano Ferrero, Enrico Iurlaro, Joan Seoane, Paolo Nuciforo
Summary: This study found that while SARS-CoV-2 could be detected in half of placental tissues from positive women, its presence was not associated with specific pathological, maternal, or neonatal outcomes. Severe placental damage induced by high viral load of SARS-CoV-2 may harm neonates, but no evidence of vertical transmission was found.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Catherine Jane Messner, Saskia Schmidt, Dilek Ozkul, Carine Gaiser, Luigi Terracciano, Stephan Krahenbuhl, Laura Suter-Dick
Summary: Liver fibrosis is characterized by the accumulation of extracellular matrix, and miRNAs can serve as biomarkers for identifying this condition. In this study, miR-199a-5p, miR-214-3p, miRNA-125a-5p, and miR-99b-5p are identified as potential biomarkers associated with a fibrotic phenotype, with miR-199a-5p also being implicated in HSC activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Respiratory System
Martina Haberecker, Esther Irene Schwarz, Peter Steiger, Karl Frontzek, Felix Scholkmann, Xiankun Zeng, Sylvia Holler, Holger Moch, Zsuzsanna Varga
Summary: Autopsy findings show that severe pulmonary endotheliitis and multi-organ involvement are characteristic features in fatal COVID-19 cases. Thromboembolic events, ischemic events, and bacterial superinfections occur frequently in SARS-CoV-2 infection regardless of outcome.
Article
Oncology
Niels J. Rupp, Sylvia Hoeller, Muriel Brada, Domenic Vital, Gregoire B. Morand, Martina A. Broglie, Martin W. Huellner, Sandra N. Freiberger
Summary: This study delineates the clinicopathological features of three TGFBR3-PLAG1 fusion-positive salivary gland neoplasms, showing a predilection for the deep lobe of the parotid gland. Histopathology revealed high morphological similarities, including encapsulation, polylobular growth pattern, and myoepithelial differentiation.
GENES CHROMOSOMES & CANCER
(2022)
Article
Oncology
John Gallon, Mairene Coto-Llerena, Caner Ercan, Gaia Bianco, Viola Paradiso, Sandro Nuciforo, Stephanie Taha-Melitz, Marie-Anne Meier, Tujana Boldanova, Sofia Perez-Del-Pulgar, Sergio Rodriguez-Tajes, Markus von Flue, Savas D. Soysal, Otto Kollmar, Josep M. Llovet, Augusto Villanueva, Luigi M. Terracciano, Markus H. Heim, Charlotte K. Y. Ng, Salvatore Piscuoglio
Summary: The study reveals that epigenetic priming in chronic liver disease affects the outcomes of hepatocellular carcinomas by influencing their genomic and transcriptomic landscapes. Oncogenic transcriptional and methylation dysregulation is evident in chronic liver disease and compounded in hepatocellular carcinomas, suggesting that the extent of epigenetic priming in chronic liver disease could influence disease outcomes.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Patrick Lebok, Hannah Bonte, Martina Kluth, Christina Moller-Koop, Isabell Witzel, Linn Wolber, Peter Paluchowski, Christian Wilke, Uwe Heilenkotter, Volkmar Muller, Barbara Schmalfeldt, Ronald Simon, Guido Sauter, Luigi Terracciano, Rainer Horst Krech, Albert von der Assen, Eike Burandt
Summary: The study revealed that 6q15 deletion is a common event in breast cancer, statistically associated with unfavorable tumor phenotype and features of genomic instability, but unrelated to patient survival.
Article
Oncology
Nicola Personeni, Tiziana Pressiani, Antonio D'Alessio, Maria Giuseppina Prete, Silvia Bozzarelli, Luigi Terracciano, Arianna Dal Buono, Antonio Capogreco, Alessio Aghemo, Ana Lleo, Romano Fabio Lutman, Massimo Roncalli, Laura Giordano, Armando Santoro, Luca Di Tommaso, Lorenza Rimassa
Summary: Hepatitis is a common immune-related adverse event in patients with hepatocellular carcinoma receiving immunotherapy, with risk factors including high baseline ALT levels and infectious HCC etiology. However, high-grade hepatitis has a benign course, allowing safe resumption of treatment without affecting treatment outcomes. Further investigation on biological features reminiscent of the HCC immune class is warranted to better understand and prevent high-grade hepatitis development in these patients.
Article
Oncology
Alexandros Lalos, Ornella Neri, Caner Ercan, Alexander Wilhelm, Sebastian Staubli, Alberto Posabella, Benjamin Weixler, Luigi Terracciano, Salvatore Piscuoglio, Sylvia Stadlmann, Giulio C. Spagnoli, Raoul A. Droeser, Gad Singer
Summary: Ovarian cancer is the most aggressive and fatal malignancy of the female reproductive system. The tumor microenvironment plays a critical role in tumorigenesis, progression, prognosis, and response to chemotherapy. High density of CD16-expressing tumor-infiltrating immune cells in recurrent ovarian cancer is associated with better recurrence-free survival and overall survival, indicating a potential interaction between standard chemotherapy and immune cell infiltration.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ricardo Donners, Carmen Zaugg, Julian E. Gehweiler, Tuyana Boldanova, Markus H. Heim, Luigi M. Terracciano, Daniel T. Boll
Summary: This study compared CT and MRI analyses to differentiate between liver steatosis, steatohepatitis, cirrhosis, and normal liver parenchyma. The results showed that multiparametric analyses were effective in distinguishing between different liver parenchymal conditions.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Pathology
Baptiste Ameline, Michaela Nathrath, Karolin H. Nord, Felix Haglund de Flon, Judith V. M. G. Bovee, Andreas H. Krieg, Sylvia Hoeller, Juergen Hench, Daniel Baumhoer
Summary: Rearrangements of transcription factors FOS and FOSB are identified as genetic driver events for osteoid osteoma and osteoblastoma. Immunohistochemical testing may have limitations in diagnosing osteoblastoma. Methylation and copy number profiling can provide additional support for the diagnosis of osteoblastoma, but the methylation cluster lacks specificity.
Article
Surgery
Jennifer M. Klasen, Caspar J. Peterson, Lana L. Fourie, Tuyana Boldanova, Luigi M. Terracciano, Andreas Holbro, Otto Kollmar
Summary: This case report illustrates a young patient developing severe gastric ischemia after oral intake of sodium polystyrene sulfonate (SPS), leading to extensive full thickness gastric necrosis requiring total gastrectomy. Histopathology revealed kayexalate crystals in the gastric wall, indicating SPS-related ischemic gastritis. Although effective in treating hyperpotassemia, the use of SPS remains controversial due to rare but serious adverse events like the formation of kayexalate crystal residues in the gastrointestinal tract.
JOURNAL OF SURGICAL CASE REPORTS
(2021)
Meeting Abstract
Urology & Nephrology
P. Colombo, P. A. Zucali, C. De Carlo, G. M. Elefante, R. Hurle, M. Lazzeri, F. D'Antonio, M. Cieri, L. Giordano, M. Perrino, V. Belsito, A. Santoro, G. Guazzoni, L. M. Terracciano
Article
Immunology
Tiziano A. Schweizer, Srikanth Mairpady Shambat, Clement Vulin, Sylvia Hoeller, Claudio Acevedo, Markus Huemer, Alejandro Gomez-Mejia, Chun-Chi Chang, Jeruscha Baum, Sanne Hertegonne, Eva Hitz, Thomas C. Scheier, Daniel A. Hofmaenner, Philipp K. Buehler, Holger Moch, Reto A. Schuepbach, Silvio D. Brugger, Annelies S. Zinkernagel
Summary: The study found that in severely ill COVID-19 patients, neutrophils exhibit a necroptosis-sensitive phenotype, characterized by cell lysis, increased release of DAMPs, elevated RIPK1 levels, and involvement of MLKL. This necroptosis is induced by the TNFRI/TNF-alpha axis. Furthermore, reduced sFasL levels in COVID-19 patients directly increase RIPK1 levels, exacerbate TNF-induced necroptosis, and correlate with disease severity, which is abolished in patients treated with glucocorticoids.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
