Article
Polymer Science
Xuefei Chen, Qianqian Zhang, Yi Wang, Jie Meng, Meiqin Wu, Huaizhong Xu, Lei Du, Xiaohua Yang
Summary: In this study, tannic acid was successfully loaded into poly(caprolactone) fibers via electrospinning, resulting in uniform and continuous nanofibers. The addition of tannic acid improved the mechanical properties of the scaffolds and enhanced their hydrophilicity and water absorption capacity, which contribute to wound healing acceleration.
Article
Biochemistry & Molecular Biology
Chaojie Xu, Ronge Xing, Song Liu, Yukun Qin, Kecheng Li, Huahua Yu, Pengcheng Li
Summary: This study generated chitosan nanoparticles and examined their effects on dendritic cells, finding that 200kDa NO-CMC-HACC nanoparticles showed strong potential as immunological adjuvants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Polymer Science
Chang Huang, Xizi Xu, Junhao Fu, Deng-Guang Yu, Yanbo Liu
Summary: Bleeding control is crucial in healthcare, which has led to advancements in wound dressing research and development. Electrospun polyacrylonitrile nanofibers offer excellent properties for wound dressings, showing great potential in manufacturing.
Article
Biochemistry & Molecular Biology
Parinaz Nezhad-Mokhtari, Fahimeh Kazeminava, Bahman Abdollahi, Pourya Gholizadeh, Abolfazl Heydari, Faranak Elmi, Mahmoud Abbaszadeh, Hossein Samadi Kafil
Summary: Recently, researchers have developed antibacterial wound dressings based on biomaterials that have shown good biocompatibility and the potential to accelerate wound healing. In this study, eco-friendly and biodegradable nanofibers were prepared by incorporating zeolite imidazolate framework nanoparticles and chamomile essential oil into a chitosan/ poly (& epsilon;-caprolactone) matrix using the electrospinning technique. The fabricated nanofibers demonstrated excellent cytocompatibility, proliferation, and antibacterial activity against common wound pathogens.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Fahimeh Kazeminava, Siamak Javanbakht, Mohammad Nouri, Khosro Adibkia, Khudaverdi Ganbarov, Mehdi Yousefi, Majid Ahmadi, Pourya Gholizadeh, Hossein Samadi Kafil
Summary: In this study, citric acid-based quantum dots were used as a crosslinked agent to synthesize carboxymethyl cellulose/polyvinyl alcohol nanofibers. The resulting nanofibers demonstrated good cytocompatibility and antibacterial efficacy, making them potential wound healing scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Kai Chen, Hua Hu, Yuan Zeng, Hao Pan, Song Wang, Ying Zhang, Lin Shi, Guoxin Tan, Weisan Pan, Hui Liu
Summary: Electrospun nanofibers have emerged as a promising option for wound dressings, with their high porosity, good mechanical properties, and excellent biocompatibility. They can promote wound healing by moisturizing the wound, facilitating cell respiration, and regenerating damaged skin. Furthermore, their ability to encapsulate active substances or incorporate them into their structural design allows them to meet the diverse requirements of wound therapy. This review article provides an overview of the recent developments in electrospun nanofibers as wound dressings, including the use of different polymer materials, their structural characteristics, and their role in promoting wound healing. The article also explores the future prospects of electrospinning in the development of wound dressings.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Paola Campa-Siqueiros, Tomas Jesus Madera-Santana, Jesus Fernando Ayala-Zavala, Jaime Lopez-Cervantes, Maria Monica Castillo-Ortega, Pedro Jesus Herrera-Franco, Patricia Quintana-Owen
Summary: Co-electrospun nanofibers of chitosan, polyvinyl alcohol, and eugenol were prepared and characterized, with gelatin as the shell layer. The nanofibers showed good mechanical properties and antimicrobial activity, making them suitable for wound dressings.
Article
Chemistry, Applied
Tamanna Sultana, Monir Hossain, Sohanur Rahaman, Yong Sik Kim, Jae-Gyoung Gwon, Byong-Taek Lee
Summary: The development of a biomaterial with hemostatic antibacterial features for controlled delivery of lawsone during wound healing was explored. It showed faster degradation and release of lawsone in acidic pH conditions, and demonstrated efficacy in promoting hemostasis and wound closure in a rat model, suggesting potential for functional wound healing applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Fatemeh Shahverdi, Aboulfazl Barati, Ehsan Salehi, Mohammad Arjomandzadegan
Summary: A two-nozzle electrospinning method was used to fabricate hybrid nanofibers based on chitosan/polyvinyl alcohol and poly (epsilon-caprolactone), with CeAlO3 nanoparticles incorporated to improve the nanofiber's properties. The addition of CeAlO3 nanoparticles increased the crystallinity, tensile strength, and modulus of the nanofibers without affecting their biocompatibility. The prepared nanofibers have the potential to be a low-cost and effective wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Alireza Shaabani, Davood Bizari, Hadi Khoshmohabat
Summary: Burn injuries increase the risk of infection and impair skin function. Natural-inspired antibiotic-free nanofibrous wound healing has gained attention. In this study, mPEG-CUR-loaded nanofibers showed antibacterial activity, non-cytotoxicity, and improved wound closure, making them promising for wound healing applications.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Meng Zhang, Guohui Wang, Dong Wang, Yuqi Zheng, Yanxin Li, Wenqiao Meng, Xin Zhang, Feifan Du, Shaoxiang Lee
Summary: This study successfully prepared a bilayer composite dressing for wound healing, with the upper layer possessing antibacterial activity and the lower layer having biocompatibility, the combination of which showed synergistic antibacterial effects and could accelerate wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Erkang Yang, Wen Hou, Kun Liu, He Yang, Wenying Wei, Haifei Kang, Honglian Dai
Summary: A multifunctional hydrogel dressing QCSMA/DAMA/Zn-nWH was developed for the treatment of infected bleeding wounds. It showed good adhesion, antibacterial properties, and biocompatibility, as well as promoting wound healing and hemostasis.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Biomaterials
Trinh Thi-Phuong Ho, Vinh Khanh Doan, Nam Minh-Phuong Tran, Linh Kim-Khanh Nguyen, An Nguyen-My Le, Minh Hieu Ho, Trinh Nhu-Thuy, Toi Van Vo, Lam Dai Tran, Thi-Hiep Nguyen
Summary: This study fabricated an electrospun polycaprolactone (EsPCL) membrane coated with various densities of chitosan oligomers (COS) as a bioactive wound dressing. Results showed that increasing COS density led to enhanced antibacterial activities, faster hemostasis, and affected re-epithelialization and wound healing in mice. The membrane and chitosan oligomers were suggested for further studies in wound dressing applications.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Applied
Haibing Liu, Rong Chen, Pinkai Wang, Jinlang Fu, Zinan Tang, Jiajun Xie, Yanhong Ning, Jian Gao, Qiang Zhong, Xin Pan, Ding Wang, Mingyuan Lei, Xiaoqi Li, Yang Zhang, Jian Wang, Hao Cheng
Summary: In this study, mupirocin and cerium oxide nanoparticles were encapsulated in a polyvinyl alcohol/chitosan polymer to fabricate a nanofiber wound dressing using electrostatic spinning. The dressing released mupirocin, which exhibited rapid and long-lasting bactericidal activity against both methicillin-sensitive S. aureus and methicillin-resistant S. aureus strains. Meanwhile, the cerium oxide nanoparticles in the membrane scavenged reactive oxygen species to maintain a normal physiological level. The dressing showed good biocompatibility in vitro and in vivo, highlighting its potential in the treatment of diabetic wounds.
CARBOHYDRATE POLYMERS
(2023)
Review
Biochemistry & Molecular Biology
Katarina Valachova, Mahmoud Atya El Meligy, Ladislav Soltes
Summary: This review paper provides a comprehensive overview of the electrospinning of hyaluronic acid and chitosan for wound dressing applications. It summarizes the methods of preparation and challenges faced in the electrospinning process, as well as strategies to overcome these difficulties. The review also explains the biological roles and mechanisms of hyaluronic acid and chitosan in wound healing, highlighting the advantages of nanofibers and their potential for drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Hanjun Li, Xiuguo Han, Shengbing Yang, Yongjie Wang, Yang Dong, Tingting Tang
Summary: FOXP1, transactivated by ERK/JNK-c-JUN/c-FOS, drives osteosarcoma development by regulating the p53-P21/RB signaling cascade, suggesting it as a potential therapeutic target.
Article
Engineering, Biomedical
Minqi Wang, Hanjun Li, Yiqi Yang, Kai Yuan, Feng Zhou, Haibei Liu, Qinghui Zhou, Shengbing Yang, Tingting Tang
Summary: This study demonstrates the creation of a scaffold with dual functions of osteo-induction and bacterial inhibition through the release of BMP2, which significantly promotes osteoblast differentiation and prevents infection. The bioprinted scaffold shows potential for repairing infectious bone defects.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yiqi Yang, Kai Huang, Minqi Wang, Qishan Wang, Haishuang Chang, Yakun Liang, Qing Wang, Jie Zhao, Tingting Tang, Shengbing Yang
Summary: The study presents an intelligent near-infrared-triggered nitric oxide nanogenerator that enhances angiogenesis, inhibits bacterial infection, and maintains the stability of HIF-1 alpha protein for treating diabetic ulcers.
ADVANCED MATERIALS
(2021)
Correction
Engineering, Biomedical
Bo Tian, Tao Jiang, Zhanying Shao, Zanjing Zhai, Haowei Li, Qiming Fan, Xuqiang Liu, Zhengxiao Ouyang, Tingting Tang, Qing Jiang, Minghao Zheng, Kerong Dai, An Qin, Yongping Yu, Zhenan Zhu
Article
Chemistry, Multidisciplinary
Kai Huang, Jinbing Wang, Qinghao Zhang, Kai Yuan, Yiqi Yang, Fupeng Li, Xiaojiang Sun, Haishuang Chang, Yakun Bang, Jie Zhao, Tingting Tang, Shengbing Yang, Yakun Liang
Summary: Persistent bacteria, such as intracellular and biofilm bacteria, pose challenges in clinical treatment due to their resistance to antibiotics. In this study, a nanoscale gallium-based metal-organic framework (GaMOF) was developed to address this issue. The GaMOF nanoparticles could penetrate cell membranes and disrupt bacteria Fe metabolism, enhancing the potency of antibiotics and eradicating the two types of elusive bacteria. The results showed that the synthesized GaMOF had good biosafety and could alleviate inflammation caused by intracellular bacteria in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Correction
Biophysics
Bin 'en Nie, Haiyong Ao, Jianliang Zhou, Tingting Tang, Bing Yue
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Han Qiao, Jingtian Mei, Kai Yuan, Kai Zhang, Feng Zhou, Tingting Tang, Jie Zhao
Summary: This study reveals the crucial roles of zinc and oxygen homeostasis in dendritic cells (DCs) during the immune progression of rheumatoid arthritis (RA). It proposes a DC-targeting immune-regulating strategy using ZnO2/Catalase@liposome-Mannose nanoparticles (ZnCM NPs) to induce the transformation of immunogenic DCs (igDCs) into tolerogenic DCs (tDCs) and inhibit T-cell activation. The study demonstrates the promising potential of DC-targeting nanoplatforms in RA treatment and provides insights into ion homeostasis regulation for immune diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Kai Huang, Fupeng Li, Kai Yuan, Yiqi Yang, Haishuang Chang, Yakun Liang, Xuzhou Yan, Jie Zhao, Tingting Tang, Shengbing Yang
Summary: This study presents a novel nanotheranostic agent that can synergistically detect and eliminate drug-resistant bacteria, while reducing inflammation and promoting wound healing with no obvious adverse effects in vivo.
APPLIED MATERIALS TODAY
(2022)
Article
Orthopedics
Kai Yuan, Kai Zhang, Yiqi Yang, Yixuan Lin, Feng Zhou, Jingtian Mei, Hanjun Li, Jie Wei, Zhifeng Yu, Jie Zhao, Tingting Tang
Summary: This study evaluated the interbody fusion efficacy and biocompatibility of a graft-free cage made of poly-etheretherketone/calcium silicate composite/porous tantalum (PEEK/CS/pTa cage) compared with a PEEK/CS cage with an autogenous bone graft in a goat model. The results showed that the graft-free PEEK/CS/pTa cage demonstrated similar fusion performance to the PEEK/CS cage with autogenous bone graft and had good biological safety.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Chemistry, Multidisciplinary
Kai Yuan, Kai Huang, Yiqi Yang, Yixuan Lin, Yihao Liu, Fupeng Li, Yakun Liang, Haishuang Chang, Yuhui Chen, Tingting Tang, Shengbing Yang
Summary: Increasing evidence highlights the crucial role of antibiotic tolerance in the development of antibiotic resistance, refractory infection, and infection recurrence. This study identifies and confirms the phenotype of increased production of H2S in antibiotic-tolerant Staphylococcus aureus (S. aureus) as essential for maintaining antibiotic tolerance. Furthermore, a photoacoustic probe based on a bismuth metal-organic framework (Bi-MOF) was successfully developed for detecting infection and an antibiotic enhancer that targets bacterial endogenous H2S to eradicate antibiotic-tolerant bacteria. Bi-MOF enables early in situ and precise photoacoustic imaging of infection by generating Bi2S3 inside bacteria. Additionally, Bi-MOF enhances the efficiency of methicillin in eradicating tolerant S. aureus by downregulating intracellular H2S levels.
Article
Chemistry, Applied
Xiaoyan Li, Xinsheng Niu, Yaowei Chen, Kai Yuan, Wenjun He, Shengbing Yang, Tingting Tang, Deng-Guang Yu
Summary: Chitosan-functionalized nanosilica was electrosprayed on a spin-coated base layer to form a composite coating with a micro-nano protruding surface, showing good antibacterial properties and sustained release effect. Nanosilica with uniform size was prepared by sol-gel method and coated with quaternized chitosan. The composite coating exhibited a unique micro-nano surface structure and the contact sterilization of chitosan quaternary ammonium salt played a synergistic effect, resulting in good sterilization effect on drug-resistant Staphylococcus aureus and controlled sustained release of quaternized chitosan.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Engineering, Biomedical
Yixuan Lin, Yiqi Yang, Kai Yuan, Shengbing Yang, Shuhong Zhang, Hanjun Li, Tingting Tang
Summary: This study reports a three-dimensional bioprinted osteosarcoma model that incorporates osteosarcoma cells and a mimicked extracellular matrix. Compared to traditional models, this model shows significant differences in cell cycle, metabolism, and other cellular pathways, and is more sensitive to therapies targeting the autophagy pathway.
BIOACTIVE MATERIALS
(2022)
Article
Cell Biology
Yiqi Yang, Kai Yuan, Yihao Liu, Qishan Wang, Yixuan Lin, Shengbing Yang, Kai Huang, Tianyou Kan, Yuxin Zhang, Mingming Xu, Zhifeng Yu, Qiming Fan, Yugang Wang, Hanjun Li, Tingting Tang
Summary: In this study, the researchers identified AMPKa1 as a critical factor regulating the senescence and lineage commitment of mesenchymal stem cells (MSCs) and found that AMPKa1 activation can prevent age-related bone loss and promote MSC osteogenic commitment with increased IGF-1 secretion. The study provides mechanistic insight into the protective effect of AMPKa1 against skeletal aging by promoting bone-derived IGF-1 secretion.
CELL PROLIFERATION
(2023)
Article
Engineering, Biomedical
Fupeng Li, Kai Huang, Jinbing Wang, Kai Yuan, Yiqi Yang, Yihao Liu, Xianhao Zhou, Keyu Kong, Tao Yang, Jian He, Chunjie Liu, Haiyong Ao, Fengxiang Liu, Qian Liu, Tingting Tang, Shengbing Yang
Summary: This study developed a biocompatible titanium alloy with antibiofilm and anti-aseptic loosening properties by utilizing gallium as a component. The alloy exhibited outstanding antibiofilm properties both in vitro and in vivo, and it could also inhibit osteoclast differentiation by targeting iron metabolism, thus preventing aseptic loosening.
BIOMATERIALS RESEARCH
(2023)
Article
Cell & Tissue Engineering
Yiqi Yang, Yixuan Lin, Minqi Wang, Kai Yuan, Qishan Wang, Pei Mu, Jingke Du, Zhifeng Yu, Shengbing Yang, Kai Huang, Yugang Wang, Hanjun Li, Tingting Tang
Summary: Diabetic osteoporosis (DOP) is characterized by osteocyte death through iron-dependent programmed cell death called ferroptosis. The diabetic microenvironment enhances osteocyte ferroptosis by promoting lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. Heme oxygenase-1 (HO-1) is upregulated in ferroptotic osteocytes in DOP, and its expression is controlled by the interaction between the transcription factors NRF2 and c-JUN. Targeting ferroptosis or HO-1 effectively rescues osteocyte death in DOP and improves trabecular deterioration.