Journal
POLYMERS
Volume 9, Issue 11, Pages -Publisher
MDPI AG
DOI: 10.3390/polym9110605
Keywords
cross-linked poly(trimethylene carbonate) networks; enzymatic degradation; initial molecular weight; cross-linker amount; form-stability
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Funding
- National Key Research and Development Program of China [2016YFC1000902]
- National Science Foundation of China [51503093]
- Fundamental Research Funds for the Central Universities [N160504001, N160503001]
- Science and Technology Committee of Liaoning Province [201501116, 20170540491, 20170520185]
- Shenyang Science and Technology Bureau [F16-205-1-37]
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The in vitro enzymatic degradation of cross-linked poly(trimethylene carbonate) networks (PTMC-Ns) was performed in lipase solutions at 37 degrees C, and the effect of the initial molecular weight and cross-linker amount as well as the cross-linker type on the degradation rate of PTMC-Ns was investigated. Due to their denser structure and more hydrophobic surface as well as the higher glass transition temperature, a slower degradation rate was seen for PTMC-Ns with high initial molecular weight at a given cross-linker amount. Similar results could be observed as the cross-linker amount increased, and cross-linker type also influenced the degradation rate of PTMC-Ns. Furthermore, the enzymatic degradation of PTMC-Ns was accelerated by the surfactants role of lipase via surface erosion mechanism, the enzymatic degradation rate was higher than that of hydrolysis case. The results indicated that PTMC-Ns were promising candidates for clinical subcutaneous implants, especially due to their tunable degradation rate and enhanced form-stability as well as no acidic degradation products.
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