Article
Infectious Diseases
Amina Ramadhani Issae, Abdul Ahmed Selemani Katakweba, Rose Peter Kicheleri, Augustino Alfred Chengula, Christopher Jacob Kasanga
Summary: This study assessed the knowledge, attitudes, and practices of agropastoral and pastoral communities in Ngorongoro district towards Rift Valley fever (RVF). The findings revealed a lack of knowledge, negative attitudes, and poor practices regarding RVF. Gender, education levels, and locality were important factors related to knowledge. The study highlights the need for health education programs to prevent further RVF outbreaks.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Review
Immunology
Paul Kato Kitandwe, Paul F. McKay, Pontiano Kaleebu, Robin J. Shattock
Summary: RVF is a mosquito-borne viral zoonosis that causes harm to both humans and animals. There is a need for more safe and effective DIVA-compatible vaccines due to limitations of the currently available RVF vaccines.
Article
Infectious Diseases
Henson Kainga, James Mponela, Linda Basikolo, Marvin Collen Phonera, Prudence Mpundu, Muso Munyeme, Edgar Simulundu, Ngonda Saasa
Summary: Livestock farmers in Malawi have poor knowledge, negative attitude, and poor management practices towards RVF. Only a small percentage of participants have sufficient knowledge. The study recommends community sensitization and reporting of suspected cases for better management of RVF.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Letter
Immunology
Mohammad M. Obaidat, James C. Graziano, Maria Morales-Betoulle, Shelley M. Brown, Cheng-Feng Chiang, John D. Klena
Summary: The epidemiology of Rift Valley fever virus (RVFV) and Crimean-Congo hemorrhagic fever virus (CCHFV) in Jordan is unknown. A study found 3% of tested dairy cattle, sheep, and goats were RVFV seropositive and 14% were CCHFV seropositive. Ongoing surveillance is necessary to evaluate the risk to humans and protect public health.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Caitlin M. Cossaboom, Luke Nyakarahuka, Sophia Mulei, Jackson Kyondo, Alex Tumusiime, Jimmy Baluku, Gloria Grace Akurut, Dianah Namanya, Kilama Kamugisha, Hildah Tendo Nansikombi, Alex Nyabakira, Semei Mutesasira, Shannon Whitmer, Carson Telford, Julius Lutwama, Stephen Balinandi, Joel Montgomery, John D. Klena, Trevor Shoemaker
Summary: Seven confirmed Rift Valley fever cases, including one fatality, were reported in Kiruhura District, Uganda in 2021. Our findings underscore the importance of ongoing surveillance for viral hemorrhagic fevers, despite the challenges posed by the COVID-19 pandemic.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Geosciences, Multidisciplinary
N. P. Thomas, A. Anyamba, H. Tubbs, B. Bishnoi
Summary: The African Sahel experienced sustained and extreme flooding during the June-October 2020 growing season, leading to outbreaks of vector borne diseases. Using soil moisture and precipitation data, this study found that the 2020 Sahelian growing season was the most extreme in the past four decades, with average precipitation exceeding climatology by around 300 mm. Rift Valley fever and Chikungunya outbreaks occurred in Chad and Mauritania/Senegal, respectively. Soil moisture was found to be a better indicator of VBD outbreak risk than precipitation, which is commonly used in studies of VBD outbreaks.
GEOPHYSICAL RESEARCH LETTERS
(2022)
Article
Public, Environmental & Occupational Health
Andrew Musa Adamu, Lushakyaa Allam, Anthony K. B. Sackey, Alhaji Bida Nma, Philip Paul Mshelbwala, Salamatu Mambula-Machunga, Sunday Idoko Idoko, Alex Adikwu Adikwu, Wesley Daniel Nafarnda, Bello Sikiti Garba, Olajide Adewale Owolodun, Asabe Adamu Dzikwi, Emmanuel Oluwadare Balogun, Yila Ayo Simon
Summary: The study reveals the presence of RVFV antibodies among camels in Nigeria, with rain-fed croplands being a significant risk factor. Only a minority of respondents knew that RVF is a zoonotic disease, and most pastoralists still rely on ethnoveterinary practices for disease control.
Review
Immunology
Xiao Wang, Yupei Yuan, Yihan Liu, Leiliang Zhang
Summary: This article provides an overview of the pathogenesis of Rift Valley fever (RVF) and the immune evasion competition between the virus and the host. Understanding the host immune response and viral antibodies can help identify new drug targets and potential solutions for current and future epidemics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Cecile Troupin, Isabelle Ellis, Bakary Doukoure, Alimou Camara, Moustapha Keita, Moise Kagbadouno, Jean-Mathieu Bart, Ramadan Diallo, Sandra Lacote, Philippe Marianneau, Martin H. Groschup, Noel Tordo
Summary: This study evaluated the seroprevalence of brucellosis, Q fever, and Rift Valley fever in domestic ruminants in Guinea. The results showed that cattle had the highest seroprevalence for these three diseases, with brucellosis and Q fever being widespread in Guinea. The study highlights the need for improved surveillance and screening for zoonotic diseases in Guinea.
BMC VETERINARY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Nathaniel S. Chapman, Haiyan Zhao, Nurgun Kose, Jonna B. Westover, Birte Kalveram, Robin Bombardi, Jessica Rodriguez, Rachel Sutton, Joseph Genualdi, A. Desiree LaBeaud, Francis M. Mutuku, Phillip R. Pittman, Alexander N. Freiberg, Brian B. Gowen, Daved H. Fremont, James E. Crowe
Summary: By isolating antibodies from B cells of individuals who were naturally infected or vaccinated, researchers found that immune responses to RVFV share similar antigenic sites, with some specific antibodies demonstrating potent neutralizing activities in vitro. These antibodies can inhibit virus-cell fusion process, thereby contributing to antibody-mediated neutralization against RVFV infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Virology
Lingqing Xu, Alden C. Paine, Dominique J. Barbeau, Frances Alencastro, Andrew W. Duncan, Anita K. Mcelroy
Summary: RVFVmiR-122, a recombinant miRNA-targeted virus, specifically limits the replication of RVFV in liver cells. C57BL/6 mice infected with RVFVmiR-122 show a different clinical outcome compared to those infected with RVFVmiR-184, and this difference is eliminated in Mir-122 KO mice.
JOURNAL OF VIROLOGY
(2023)
Article
Veterinary Sciences
Deo B. Ndumu, Barnabas Bakamutumaho, Edward Miller, Jesca Nakayima, Robert Downing, Stephen Balinandi, Fred Monje, Dan Tumusiime, Mary Nanfuka, Natascha Meunier, Eugene Arinaitwe, Chris Rutebarika, Eugene Kidega, Jackson Kyondo, Rose Ademun, Kariuki M. Njenga, Francisco Veas, Jean-Paul Gonzalez
Summary: Prior to the first recorded outbreak of Rift Valley fever in Uganda in March 2016, earlier studies indicated the presence of the RVF virus in the country, but no outbreaks were recorded. The Ministry of Agriculture, Animal Industry, and Fisheries conducted studies to determine RVF sero-prevalence in risk prone areas. The results showed varying levels of sero-prevalence in different regions, with the highest cumulative sero-prevalence in bovines.
BMC VETERINARY RESEARCH
(2021)
Article
Virology
Xue Wang, Cuixia Hu, Wei Ye, Jia Wang, Xiaofei Dong, Jie Xu, Xiaorong Li, Manfeng Zhang, Hongyun Lu, Fanglin Zhang, Wei Wu, Shaodong Dai, Hong-Wei Wang, Zhongzhou Chen
Summary: Rift Valley fever virus (RVFV) is a mosquito-borne virus that causes severe diseases in both humans and livestock. The RNA-dependent RNA polymerase (RdRp) encoded by the L segment of RVFV is essential for viral replication and transcription, and has multiple drug targets. In this study, the structure of RVFV L protein was determined, revealing its distinct priming loop and its role in RNA synthesis initiation.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Kendra N. Johnson, Birte Kalveram, Jennifer K. Smith, Lihong Zhang, Terry Juelich, Colm Atkins, Tetsuro Ikegami, Alexander N. Freiberg
Summary: The antiviral drug Tilorone has been found to effectively inhibit Rift Valley fever virus (RVFV) infection in vitro and in vivo, suggesting its potential use as a therapeutic option for treating RVFV infection.
Article
Microbiology
Mathilde Laureti, Rui-Xue Lee, Amelia Bennett, Lucas Aladar Wilson, Victoria Elena Sy, Alain Kohl, Isabelle Dietrich
Summary: RVFV infection triggers the activation of RNA interference pathways in mosquitoes, which limits viral replication. The study found that RVFV infection may alter mosquito immune responses, potentially affecting viral replication and transmission. Further research in this area could provide valuable information for disease prevention strategies.
Article
Public, Environmental & Occupational Health
Oskar Karlsson, Joacim Rocklov, Alizee P. Lehoux, Jonas Bergquist, Anna Rutgersson, Martin J. Blunt, Linda S. Birnbaum
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Correction
Public, Environmental & Occupational Health
Henrik Sjodin, Anders F. Johansson, Ake Brannstrom, Zia Farooq, Hedi Katre Kriit, Annelies Wilder-Smith, Christofer Astrom, Johan Thunberg, Marten Soderquist, Joacim Rocklov
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Review
Medicine, General & Internal
Nick Watts, Markus Amann, Nigel Arnell, Sonja Ayeb-Karlsson, Jessica Beagley, Kristine Belesova, Maxwell Boykoff, Peter Byass, Wenjia Cai, Diarmid Campbell-Lendrum, Stuart Capstick, Jonathan Chambers, Samantha Coleman, Carole Dalin, Meaghan Daly, Niheer Dasandi, Shouro Dasgupta, Michael Davies, Claudia Di Napoli, Paula Dominguez-Salas, Paul Drummond, Robert Dubrow, Kristie L. Ebi, Matthew Eckelman, Paul Ekins, Luis E. Escobar, Lucien Georgeson, Su Golder, Delia Grace, Hilary Graham, Paul Haggar, Ian Hamilton, Stella Hartinger, Jeremy Hess, Shih-Che Hsu, Nick Hughes, Slava Jankin Mikhaylov, Marcia P. Jimenez, Ilan Kelman, Harry Kennard, Gregor Kiesewetter, Patrick L. Kinney, Tord Kjellstrom, Dominic Kniveton, Pete Lampard, Bruno Lemke, Yang Liu, Zhao Liu, Melissa Lott, Rachel Lowe, Jaime Martinez-Urtaza, Mark Maslin, Lucy McAllister, Alice McGushin, Celia McMichael, James Milner, Maziar Moradi-Lakeh, Karyn Morrissey, Simon Munzert, Kris A. Murray, Tara Neville, Maria Nilsson, Maquins Odhiambo Sewe, Tadj Oreszczyn, Matthias Otto, Fereidoon Owfi, Olivia Pearman, David Pencheon, Ruth Quinn, Mahnaz Rabbaniha, Elizabeth Robinson, Joacim Rocklov, Marina Romanello, Jan C. Semenza, Jodi Sherman, Liuhua Shi, Marco Springmann, Meisam Tabatabaei, Jonathon Taylor, Joaquin Trinanes, Joy Shumake-Guillemot, Bryan Vu, Paul Wilkinson, Matthew Winning, Peng Gong, Hugh Montgomery, Anthony Costello
Article
Public, Environmental & Occupational Health
Marina Romanello, Kim van Daalen, Josep M. Anto, Niheer Dasandi, Paul Drummond, Ian G. Hamilton, Slava Jankin, Vladimir Kendrovski, Rachel Lowe, Joacim Rocklov, Oliver Schmoll, Jan C. Semenza, Cathryn Tonne, Maria Nilsson
Summary: Climate change will have catastrophic effects on the health of present and future generations, with Europe already experiencing more frequent and severe extreme weather events and changes in infectious disease environments. As one of the largest contributors to greenhouse gases, Europe's response is crucial for human health and the planet, necessitating the development of capacity to understand and monitor health impacts of climate change. The Lancet Countdown in Europe aims to establish region-specific indicators to address the main challenges and opportunities in Europe's response to climate change for health, providing valuable information for policy decision making.
LANCET PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Ake Brannstrom, Henrik Sjoedin, Joacim Rockloev
Summary: This article presents a method for estimating the true number of cases in an epidemic and applies it to COVID-19. The study found that the number of unreported COVID-19 infections in March 2020 was likely to be at least ten times higher than the reported cases, with the United Kingdom showing particularly high underestimation.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
M. S. Rahman, Chamsai Pientong, Sumaira Zafar, Tipaya Ekalaksananan, Richard E. Paul, Ubydul Haque, Joacim Rocklov, Hans J. Overgaard
Summary: Mapping the spatial distribution and predicting the abundance of female adult Ae. aegypti in northeastern Thailand is crucial for effective vector control strategies. Urban areas showed higher Ae. aegypti abundance compared to rural areas, while inadequate KAP regarding climate change and dengue were observed in both urban and rural areas. The RF model demonstrated the best predictive performance in estimating Ae. aegypti abundance, with dengue prevention practices identified as the most important predictor.
Letter
Public, Environmental & Occupational Health
Ying Liu, Joacim Rockloev
JOURNAL OF TRAVEL MEDICINE
(2022)
Review
Infectious Diseases
Jan C. Semenza, Joacim Rocklov, Kristie L. Ebi
Summary: Climate change adversely affects the burden of infectious diseases worldwide, particularly vector-borne diseases and other climate-sensitive diseases. The changing climate can alter disease distribution and transmission, increasing the risk of outbreaks.
INFECTIOUS DISEASES AND THERAPY
(2022)
Article
Parasitology
Prasad Liyanage, Yesim Tozan, Hasitha Aravinda Tissera, Hans J. Overgaard, Joacim Rocklov
Summary: Dengue is a major public health problem in Sri Lanka, and the association between Aedes larval indices and dengue incidence is poorly understood. This study analyzed the data of Aedes larval indices and dengue cases in Kalutara district, and found that all three larval indices were associated with dengue risk and identified threshold values. The study demonstrated the potential of vector surveillance information in developing a warning system for control strategies.
PARASITES & VECTORS
(2022)
Article
Medicine, General & Internal
Marina Romanello, Claudia Di Napoli, Paul Drummond, Carole Green, Harry Kennard, Pete Lampard, Daniel Scamman, Nigel Arnell, Sonja Ayeb-Karlsson, Lea Berrang Ford, Kristine Belesova, Kathryn Bowen, Wenjia Cai, Max Callaghan, Diarmid Campbell-Lendrum, Jonathan Chambers, Kim R. van Daalen, Carole Dalin, Niheer Dasandi, Shouro Dasgupta, Michael Davies, Paula Dominguez-Salas, Robert Dubrow, Kristie L. Ebi, Matthew Eckelman, Paul Ekins, Luis E. Escobar, Lucien Georgeson, Hilary Graham, Samuel H. Gunther, Ian Hamilton, Yun Hang, Risto Hanninen, Stella Hartinger, Kehan He, Jeremy J. Hess, Shih-Che Hsu, Slava Jankin, Louis Jamart, Ollie Jay, Ilan Kelman, Gregor Kiesewetter, Patrick Kinney, Tord Kjellstrom, Dominic Kniveton, Jason K. W. Lee, Bruno Lemke, Yang Liu, Zhao Liu, Melissa Lott, Martin Lotto Batista, Rachel Lowe, Frances MacGuire, Maquins Odhiambo Sewe, Jaime Martinez-Urtaza, Mark Maslin, Lucy McAllister, Alice McGushin, Celia McMichael, Zhifu Mi, James Milner, Kelton Minor, Jan C. Minx, Nahid Mohajeri, Maziar Moradi-Lakeh, Karyn Morrissey, Simon Munzert, Kris A. Murray, Tara Neville, Maria Nilsson, Nick Obradovich, Megan B. O'Hare, Tadj Oreszczyn, Matthias Otto, Fereidoon Owfi, Olivia Pearman, Mahnaz Rabbaniha, Elizabeth J. Z. Robinson, Joacim Rocklov, Renee N. Salas, Jan C. Semenza, Jodi D. Sherman, Liuhua Shi, Joy Shumake-Guillemot, Grant Silbert, Mikhail Sofiev, Marco Springmann, Jennifer Stowell, Meisam Tabatabaei, Jonathon Taylor, Joaquin Trinanes, Fabian Wagner, Paul Wilkinson, Matthew Winning, Marisol Yglesias-Gonzalez, Shihui Zhang, Peng Gong, Hugh Montgomery, Anthony Costello
Article
Public, Environmental & Occupational Health
Kim R. van Daalen, Marina Romanello, Joacim Rockloev, Jan C. Semenza, Cathryn Tonne, Anil Markandya, Niheer Dasandi, Slava Jankin, Hicham Achebak, Joan Ballester, Hannah Bechara, Max W. Callaghan, Jonathan Chambers, Shouro Dasgupta, Paul Drummond, Zia Farooq, Olga Gasparyan, Nube Gonzalez-Reviriego, Ian Hamilton, Risto Hanninen, Aleksandra Kazmierczak, Vladimir Kendrovski, Harry Kennard, Gregor Kiesewetter, Simon J. Lloyd, Martin Lotto Batista, Jaime Martinez-Urtaza, Carles Mila, Jan C. Minx, Mark Nieuwenhuijsen, Julia Palamarchuk, Marcos Quijal-Zamorano, Elizabeth J. Z. Robinson, Daniel Scamman, Oliver Schmoll, Maquins Odhiambo Sewe, Henrik Sjodin, Mikhail Sofiev, Balakrishnan Solaraju-Murali, Marco Springmann, Joaquin Trinanes, Josep M. Anto, Maria Nilsson, Rachel Lowe
Summary: In the past few decades, Europe has made significant progress in public health, but is facing challenges such as the COVID-19 pandemic, the Russian invasion of Ukraine, the migrant crisis, environmental degradation, and inequality. As a major economy, Europe has the responsibility and opportunity to lead the transition to a low-carbon economy and a healthier society. The Lancet Countdown in Europe aims to monitor the links between health and climate change in Europe and support measures to protect human health.
LANCET PUBLIC HEALTH
(2022)
Article
Veterinary Sciences
Osama Ahmed Hassan, Katinka de Balogh, Andrea Sylvia Winkler
Summary: This paper proposes a One Health Early Warning and Response System (OH-EWRS) to improve the surveillance and notification of zoonotic diseases by strengthening 'bottom-up' approaches and systems for early detection in hot spot areas. The OH-EWRS advocates for collaboration among relevant stakeholders and considers the priorities and objectives of different stakeholders, while emphasizing the need for trust, transparency, and mutual benefits.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Health Care Sciences & Services
Joacim Rockloev, Jan C. Semenza, Shouro Dasgupta, ElizabethJ. Z. Robinson, Ahmed Abd El Wahed, Tilly Alcayna, Cristina Arnes-Sanz, Meghan Bailey, Till Baernighausen, Frederic Bartumeus, Carme Borrell, Laurens M. Bouwer, Pierre-Antoine Bretonniere, Aditi Bunker, Chloe Chavardes, Kim R. van Daalen, Joao Encarnacao, Nube Gonzalez-Reviriego, Junwen Guo, Katie Johnson, Marion P. G. Koopmans, Maria Manez Costa, Antonios Michaelakis, Tomas Montalvo, Anna Omazic, John R. B. Palmer, Raman Preet, Marina Romanello, Mohammad Shafiul Alam, Reina S. Sikkema, Marta Terrado, Marina Treskova, Rachel Lowe
Summary: Climate change is a driver of infectious disease outbreaks and expansions in Europe. A proposed framework aims to develop indicators and decision support tools to track and assess climate-induced disease risks, improve early warning and response systems, and evaluate adaptation and mitigation measures. The approach involves multi-level engagement, innovative methodologies, and novel data streams with the goal of reducing the knowledge-to-action gap for improved health system resilience.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Environmental Sciences
Prasad Liyanage, Yesim Tozan, Hans J. Overgaard, Hasitha Aravinda Tissera, Joacim Rocklov
Summary: This study aimed to quantify the effect of weather variability on dengue vector indices in Kalutara, Sri Lanka. The findings showed that rainfall, temperature, and El Nino events were associated with an increased relative risk of dengue vector indices. Container index was found to be less sensitive to temperature and El Nino, and rainfall.
LANCET PLANETARY HEALTH
(2022)
Article
Health Care Sciences & Services
Zia Farooq, Joacim Rockloev, Jonas Wallin, Najmeh Abiri, Maquines Odhiambo Sewe, Henrik Sjodin, Jan C. Semenza
Summary: The study used advanced artificial intelligence to analyze the eco-climatic drivers of West Nile virus outbreaks in Europe. The research found that anomalies in summer/spring temperatures, lower water availability index (NDWI), and drier winter conditions were the main determinants of WNV outbreaks across Europe. The AI-based framework showed high discriminatory power in predicting WNV-endemic areas and can be used for timely surveillance and control measures.
LANCET REGIONAL HEALTH-EUROPE
(2022)