A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer

Inactivation of Capicua drives cancer metastasis

(2016) Ross A Okimoto et al.   NATURE GENETICS

DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes

(2016) Si Ho Choi et al.   NUCLEIC ACIDS RESEARCH

CICinactivating mutations identify aggressive subset of 1p19q codeleted gliomas

(2015) Vincent Gleize et al.   ANNALS OF NEUROLOGY

ETV/Pea3 family transcription factor-encoding genes are overexpressed inCIC-mutant oligodendrogliomas

(2015) Vijay Padul et al.   GENES CHROMOSOMES & CANCER

SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains

(2015) Yong-Heng Huang et al.   Scientific Reports

Deficiency of Capicua disrupts bile acid homeostasis

(2015) Eunjeong Kim et al.   Scientific Reports

EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes

(2015) Yinhua Jin et al.   PLoS Genetics

Origins of Context-Dependent Gene Repression by Capicua

(2015) Marta Forés et al.   PLoS Genetics

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

(2015) Yuchen Jiao et al.   Oncotarget

Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity

(2015) Suganthi Chittaranjan et al.   Oncotarget

The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition

(2014) Nate P. Hoverter et al.   NUCLEIC ACIDS RESEARCH

Structure-Function Analysis of the C-clamp of TCF/Pangolin in Wnt/ß-catenin Signaling

(2014) Aditi Ravindranath et al.   PLoS One

Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila

(2014) F. Port et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bipartite Recognition of DNA by TCF/Pangolin Is Remarkably Flexible and Contributes to Transcriptional Responsiveness and Tissue Specificity of Wingless Signaling

(2014) Hilary C. Archbold et al.   PLoS Genetics

Distinct DNA Binding Sites Contribute to the TCF Transcriptional Switch in C. elegans and Drosophila

(2014) Chandan Bhambhani et al.   PLoS Genetics

Undifferentiated Small Round Cell Sarcoma With t(4;19)(q35;q13.1) CIC-DUX4 Fusion

(2013) Eun-Young Karen Choi et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Sox proteins: regulators of cell fate specification and differentiation

(2013) Y. Kamachi et al.   DEVELOPMENT

Kinetics of gene derepression by ERK signaling

(2013) B. Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superficial EWSR1-negative undifferentiated small round cell sarcoma with CIC/DUX4 gene fusion: a new variant of Ewing-like tumors with locoregional lymph node metastasis

(2013) Isidro Machado et al.   VIRCHOWS ARCHIV

CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas

(2012) Felix Sahm et al.   ACTA NEUROPATHOLOGICA

Fusion protein linkers: Property, design and functionality

(2012) Xiaoying Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Therapeutic Effect of γ-Secretase Inhibition in KrasG12V-Driven Non-Small Cell Lung Carcinoma by Derepression of DUSP1 and Inhibition of ERK

(2012) Antonio Maraver et al.   CANCER CELL

Mirror represses pipe expression in follicle cells to initiate dorsoventral axis formation in Drosophila

(2012) M. J. Andreu et al.   DEVELOPMENT

EGFR-dependent downregulation of Capicua and the establishment of Drosophila dorsoventral polarity

(2012) María José Andreu et al.   FLY

The Capicua repressor - a general sensor of RTK signaling in development and disease

(2012) G. Jimenez et al.   JOURNAL OF CELL SCIENCE

A WNT/p21 Circuit Directed by the C-Clamp, a Sequence-Specific DNA Binding Domain in TCFs

(2012) N. P. Hoverter et al.   MOLECULAR AND CELLULAR BIOLOGY

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

Transcriptional interpretation of the EGF receptor signaling gradient

(2012) A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The high mobility group box: the ultimate utility player of a cell

(2012) Christopher S. Malarkey et al.   TRENDS IN BIOCHEMICAL SCIENCES

Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila

(2011) L. Ajuria et al.   DEVELOPMENT

ATXN1 Protein Family and CIC Regulate Extracellular Matrix Remodeling and Lung Alveolarization

(2011) Yoontae Lee et al.   DEVELOPMENTAL CELL

High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas

(2011) Antoine Italiano et al.   GENES CHROMOSOMES & CANCER

The CIC-DUX4 fusion transcript is present in a subgroup of pediatric primitive round cell sarcomas

(2011) Cassandra Graham et al.   HUMAN PATHOLOGY

Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers

(2011) Stephen Yip et al.   JOURNAL OF PATHOLOGY

Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma

(2011) C. Bettegowda et al.   SCIENCE

Exercise and Genetic Rescue of SCA1 via the Transcriptional Repressor Capicua

(2011) J. D. Fryer et al.   SCIENCE

ERK/p90RSK/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa

(2010) Kumara Dissanayake et al.   BIOCHEMICAL JOURNAL

Detailed cytogenetic and array analysis of pediatric primitive sarcomas reveals a recurrent CIC–DUX4 fusion gene event

(2009) Maisa Yoshimoto et al.   CANCER GENETICS AND CYTOGENETICS

Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains

(2009) U. Lohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Wingless Targets Requires Bipartite Recognition of DNA by TCF

(2008) Mikyung V. Chang et al.   CURRENT BIOLOGY