Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway

Inhibitors of oxygen sensing prolyl hydroxylases regulate nuclear localization of the transcription factors Smad2 and YAP/TAZ involved in CTGF synthesis

(2016) Felix Preisser et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Capture‐C reveals preformed chromatin interactions between HIF‐binding sites and distant promoters

(2016) James L Platt et al.   EMBO REPORTS

Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer

(2016) Johannes Schödel et al.   EUROPEAN UROLOGY

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

(2016) Steffen Grampp et al.   Nature Communications

Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41

(2016) Pierre Bigot et al.   Nature Communications

Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer

(2015) Rafik Salama et al.   PLoS One

Common Variation at 1q24.1 (ALDH9A1) Is a Potential Risk Factor for Renal Cancer

(2015) Marc Y. R. Henrion et al.   PLoS One

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

(2014) Marco Gerlinger et al.   NATURE GENETICS

Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci

(2014) Dennis J. Hazelett et al.   PLoS Genetics

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2

(2013) Hani Choudhry et al.   EMBO REPORTS

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

A common variant at 8q24.21 is associated with renal cell cancer

(2013) Julius Gudmundsson et al.   Nature Communications

Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer

(2012) Marc Henrion et al.   HUMAN MOLECULAR GENETICS

SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

(2012) Marco Montagner et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression

(2012) Johannes Schödel et al.   NATURE GENETICS

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts

(2012) Ruth E. Schietke et al.   PLoS One

Distinct Mesenchymal Alterations in N-Cadherin and E-Cadherin Positive Primary Renal Epithelial Cells

(2012) Christof Keller et al.   PLoS One

The VHL/HIF axis in clear cell renal carcinoma

(2012) Chuan Shen et al.   SEMINARS IN CANCER BIOLOGY

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

(2011) Xifeng Wu et al.   HUMAN MOLECULAR GENETICS

The chromosome 2p21 region harbors a complex genetic architecture for association with risk for renal cell carcinoma

(2011) Summer S. Han et al.   HUMAN MOLECULAR GENETICS

Mapping and analysis of chromatin state dynamics in nine human cell types

(2011) Jason Ernst et al.   NATURE

Genetic and Functional Studies Implicate HIF1  as a 14q Kidney Cancer Suppressor Gene

(2011) C. Shen et al.   Cancer Discovery

Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

(2010) Mark P Purdue et al.   NATURE GENETICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation of active regulatory elements from eukaryotic chromatin using FAIRE (Formaldehyde Assisted Isolation of Regulatory Elements)

(2009) Paul G. Giresi et al.   METHODS

HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma

(2008) John D. Gordan et al.   CANCER CELL