Article
Critical Care Medicine
Guillaume L. Martin, Theo Trioux, Stephane Gaudry, Florence Tubach, David Hajage, Agnes Dechartres
Summary: A meta-epidemiological approach was used to investigate the differences in mortality intervention effects between blinded and nonblinded randomized controlled trials conducted in critical care. The study found that intervention effect estimates were slightly larger in nonblinded trials compared to blinded trials. It is concluded that blinding of both patients and personnel is important to consider in critical care trials.
CRITICAL CARE MEDICINE
(2021)
Review
Orthopedics
Juuso Heikkinen, Jarkko Jokihaara, Soumen Das De, Kati Jaatinen, Rachelle Buchbinder, Teemu Karjalainen
Summary: This study aims to evaluate the frequency and impact of inadequate methods and reporting in hand surgical randomized controlled trials (RCTs) on the estimation of treatment effects. The results suggest that the internal validity and credibility of hand surgical RCTs can be improved by using established methods and adhering to reporting guidelines.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2022)
Review
Surgery
M. A. Amer, G. P. Herbison, S. H. Grainger, C. H. Khoo, M. D. Smith, J. L. McCall
Summary: The lack of blinding significantly altered the treatment effect estimates in RCTs comparing laparoscopic and open surgery. Blinding of patients, postoperative carers, and outcome assessors had similar effects. Therefore, blinding should be implemented in surgical RCTs whenever possible to avoid systematic bias.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Julia Stadelmaier, Isabelle Roux, Maria Petropoulou, Lukas Schwingshackl
Summary: This study aimed to evaluate the bias associated with certain methodological characteristics in nutrition research. The findings suggest that most characteristics may not exaggerate intervention effect estimates, except for trials with subjective outcomes.
Review
Mathematical & Computational Biology
Camilla Hansen Nejstgaard, David Ruben Teindl Laursen, Andreas Lundh, Asbjorn Hrobjartsson
Summary: This study investigated the association between commercial funding and estimated intervention effects in randomized trials and found no significant relationship between the two. However, in trials with high risk of commercial funding, the intervention effects were exaggerated by 12%.
RESEARCH SYNTHESIS METHODS
(2023)
Review
Integrative & Complementary Medicine
Jie Pan, Kai-Ni Zuo, Xiao-Mei Wang, Meng-Pei Zhang, Zhi-Heng Wang, Hao-Xiang Zhang, Wen-Tao Zhu
Summary: The meta-analysis showed that Fuke Qianjin tablet combined with conventional therapy is significantly more efficacious and safer in treating pelvic inflammatory diseases and related complications, with a lower trend of adverse reaction rates.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Review
Medicine, General & Internal
Arthur Salome, Hakim Harkouk, Dominique Fletcher, Valeria Martinez
Summary: Studies have found that OFA shows advantages in reducing postoperative nausea and vomiting, but does not have significant clinical benefits in terms of postoperative pain and opioid use. More data on the safe use of OFAs should be collected, and caution should be taken in the development of OFA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Multidisciplinary Sciences
Steffen Mickenautsch, Stefan Rupf, Ivana Miletic, Veerasamy Yengopal
Summary: By conducting a survey of current meta-epidemiological studies, we identified trial design characteristics associated with significant over- or underestimation of the treatment effect and used them as a basis for formulating new CQS appraisal criteria.
Review
Nutrition & Dietetics
Jiaqi Yang, Yulin Zhang, Xiaona Na, Ai Zhao
Summary: This study conducted a systematic review and meta-analysis on the associations between beta-carotene supplementation and cardiovascular disease (CVD) risk. The results showed that beta-carotene supplementation had no beneficial effects on CVD incidence and could potentially increase cardiovascular mortality. Smoking behavior was also found to be associated with increased cardiovascular incidence and mortality in the beta-carotene intervention group.
Review
Nutrition & Dietetics
Shuaishuai Zhou, Teng Xu, Xu Zhang, Junjie Luo, Peng An, Yongting Luo
Summary: The supplementation of casein hydrolysate can effectively reduce blood pressure without affecting blood lipids or glycemic status.
Review
Clinical Neurology
Michele Fornaro, Anna Maria Mondin, Martina Billeci, Andrea Fusco, Michele De Prisco, Claudio Caiazza, Fausta Micanti, Raffaella Calati, Andre Ferrer Carvalho, Andrea de Bartolomeis
Summary: This study conducted a systematic review and meta-analysis on the weight and affective psychopathology outcomes of major eating disorders. The results showed that different drugs have varying efficacy in different eating disorders, suggesting the need for further research.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Gastroenterology & Hepatology
Saurabh Chandan, Babu P. Mohan, Shahab R. Khan, Neil Bhogal, Daryl Ramai, Mohammad Bilal, Muhammad Aziz, Aun R. Shah, Harmeet S. Mashiana, Lokesh K. Jha, Ishfaq Bhat, Shailender Singh, Douglas G. Adler
Summary: Randomized controlled trials showed that additional inspection and polypectomy during both insertion and withdrawal phases of colonoscopy did not increase adenoma detection rate or polyps detected per patient.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Medicine, General & Internal
Wei-Juan Gang, Wen-Cui Xiu, Lan-Jun Shi, Qi Zhou, Rui-Min Jiao, Ji-Wei Yang, Xiao-Shuang Shi, Xiao-Yue Sun, Zhao Zeng, Claudia M. Witt, Lehana Thabane, Ping Song, Long-Hui Yang, Gordon Guyatt, Xiang-Hong Jing, Yu-Qing Zhang
Summary: The study aims to identify factors and assess their impact on the treatment effect of acupuncture therapies. Through the analysis of 584 acupuncture randomized controlled trials, it was found that factors such as quality of life, pain, and function have a significant impact on the treatment effect. The study suggests that patients, clinicians, and policy-makers should consider penetrating acupuncture and more frequent treatment sessions when choosing acupuncture treatment.
Review
Food Science & Technology
Mohammad Hassan Sohouli, Abolfazl Lari, Somaye Fatahi, Farzad Shidfar, Mihnea-Alexandru Gaman, Nathalia Sernizon Guimaraes, Ghufran Abdullatif Sindi, Rasha Abdulaziz Mandili, Ghaida Rashed Alzahrani, Rahaf Abdulrashid Abdulwahab, Alhanouf Mohammed Almuflihi, Faris Mohammed Alsobyani, Amna Malik Albu Mahmud, Osama Nazzal, Lama Alshaibani, Shouq Elmokid, Ahmed Abu-Zaid
Summary: This study comprehensively evaluated the potential effects of soy milk consumption on cardiometabolic risk factors in adults. The results showed that soy milk consumption significantly reduced blood pressure, cholesterol levels, waist circumference, inflammation markers, among others. However, there were no significant differences in other factors between the soy milk and control groups.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Clinical Neurology
Tingting Wu, Chenyang Lv, Lishui Wu, Wenjun Chen, Meina Lv, Shaojun Jiang, Jinhua Zhang
Summary: DOACs have a lower risk of ICH compared to VKAs, LMWHs, and aspirin, but rivaroxaban may increase the risk of ICH. DOACs have a lower risk of ICH compared to warfarin for secondary prevention stroke.
JOURNAL OF NEUROLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Huda Alkuhl, Rebecca Morgan, Despina Koletsi, Katerina Kavvadia
Summary: The study found that individuals who are not sensitive to PROP exhibit higher levels of caries experience, with overall very low quality of evidence.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Filippos Mikelis, Giorgos N. Tzanetakis, Despina Koletsi
Summary: Appropriate methodology and rigorous practices for appraisal of publication bias are underreported in orthodontic systematic reviews since 2010, while other established methodologies like search strategies for unpublished data or communication with authors are currently suboptimal.
EUROPEAN JOURNAL OF ORTHODONTICS
(2022)
Article
Health Care Sciences & Services
Loukia M. Spineli
Summary: The study proposed an improved UME model that can handle multiarm trials better and visualize all observed evidence in complex intervention networks. Using multiple complementary plots to investigate deviance helps draw more informed conclusions about the possibility of global inconsistency in the network.
MEDICAL DECISION MAKING
(2022)
Editorial Material
Dentistry, Oral Surgery & Medicine
Loukia M. Spineli, Nikolaos Pandis
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Despina Koletsi, Alexandra K. Papadopoulou
Summary: This study assessed the representation of female scientists as speakers in the European Orthodontic Society (EOS) conferences between 2015 and 2020 and examined the association with various study- and author-related characteristics. The findings revealed that while there was an almost equal distribution of male and female speakers in oral presentations, there was a substantial gender gap among invited speakers, with significantly fewer women being invited. The study highlights the importance of efforts to ensure equal representation of female scientists and calls for a shift from theory to practice.
EUROPEAN JOURNAL OF ORTHODONTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Loukia M. Spineli, Nikolaos Pandis
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Despina Koletsi, Nearchos Panayi, Christodoulos Laspos, Athanasios E. Athanasiou, Spiros Zinelis, Theodore Eliades
Summary: In this study, the surface roughness of in-house 3D-printed orthodontic aligners was compared to Invisalign(R) appliances. It was found that intra-oral exposure of 3D-printed aligners resulted in an increase in all tested parameters. Significant differences were also observed between the retrieved 3D-printed aligners and Invisalign(R) appliances.
JOURNAL OF ORTHODONTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Loukia M. Spineli, Nikolaos Pandis
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Filippos Mikelis, Despina Koletsi
Summary: The study assessed the quality of reporting in Scoping Reviews (ScRs) in Orthodontics using the PRISMA Extension Checklist for Scoping Reviews (PRISMA-ScR). It also examined publication characteristics associated with reporting quality. A total of 40 ScRs were analyzed, with an average reporting quality score of 73.0%. The study found that adherence to reporting guidelines improved reporting quality, but year of publication, journal, and study registration did not significantly predict reporting quality. The overall reporting quality of the examined orthodontic ScRs was suboptimal.
EUROPEAN JOURNAL OF ORTHODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Giorgos Tzanetakis, Aleksandar Jakovljevic, Despina Koletsi, Jelena Jacimovic, Venkateshbabu Nagendrababu, Henry Fergus Duncan, Paul Michael Howell Dummer
Summary: This study aimed to evaluate the reporting quality of animal studies in the field of endodontics. The results showed that most of the studies had moderate reporting quality. It was concluded that adherence to PRIASE 2021 guidelines can improve the reporting quality of animal studies.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Review
Dentistry, Oral Surgery & Medicine
Luiza de Almeida Queiroz Ferreira, Ivana Marcia Alves Diniz, Rogeli Tiburcio Ribeiro da Cunha Peixoto, Natalia Aparecida Gomes, Camila de Sousa Caneschi, Loukia Maria Spineli, Carolina Castro Martins
Summary: Selective caries removal aims to remove carious tissue in deep dentin lesions, and there is a discussion on the value of antiseptics and chemomechanical adjuvant methods to reduce bacterial load on residual caries lesions. This systematic review compares the antimicrobial efficacy of available methods using antiseptic or chemomechanical agents before restoring dentin carious lesions.
FRONTIERS IN ORAL HEALTH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Athanasios Fasoulas, Georgios Keratiotis, Loukia Spineli, Nikos Pandis, Mieke A. A. De Bruyne, Roeland J. G. De Moor, Maarten A. Meire
Summary: The purpose of this study was to compile and analyze all relevant evidence from randomized controlled trials (RCTs) on different materials used in pulpotomy or direct pulp capping in carious teeth. The results showed that Mineral Trioxide Aggregate (MTA) had higher clinical and radiographic success rates compared to calcium hydroxide (CH) in mature teeth and direct pulp capping cases. The importance of this study lies in providing clinicians with evidence-based material selection.
CLINICAL AND EXPERIMENTAL DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Geraldine Kummer, Theodore Eliades, Despina Koletsi
Summary: This study aimed to determine how gender effects are assessed in orthodontic research articles and whether there are significant differences in treatment outcomes based on gender.
EUROPEAN JOURNAL OF ORTHODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sandrine Janine Lasance, Despina Koletsi, George Eliades, Theodore Eliades
Summary: The aim of this study was to assess the degree of cure of resin composite attachments used for aligner treatment. The study found that the degree of cure was lower for attachments cured under aligners compared to the control group.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2023)
Article
Nursing
Celeste M. Vincent, Loukia M. Spineli, Patricia Barlow, Mechthild M. Gross
Summary: The study found that certain characteristics seem to be associated with unplanned visits for nulliparous and multiparous women, and spontaneous visits may be driven by a perceived need for care rather than urgent or unfavorable medical conditions specifically.
EUROPEAN JOURNAL OF MIDWIFERY
(2022)