Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2015, Issue 16, Pages 3587-3608Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201500275
Keywords
Medicinal chemistry; Natural products; Total synthesis; Ring-closing metathesis; Cross-coupling; Macrocycles
Categories
Funding
- Fonds der Chemischen Industrie
- Rhineland Palatinate Center for Natural Product Research
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Various synthetic approaches to the oxacyclododecindione-type macrolactones, known for their potent anti-inflammatory activity, are presented. These include an attempted carbonylative ring closure, a hydroacylation route, and an approach by ring-closing metathesis and double bond isomerization, as well as a strategy including ring-closing metathesis/unsaturation. The last route allowed the preparation of a bioactive analogue of the recently described 14-deoxyoxacyclododecindione.
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