Article
Biotechnology & Applied Microbiology
Ahmed Makarem, Ahmed Abass, Fangjun Bao, Ahmed Elsheikh
Summary: This study aimed to estimate the material stiffness of the orbital soft tissue (OST) in human orbits using an inverse numerical analysis approach. Clinical data from 185 Chinese participants were collected, and numerical models of the eye globes were built. The results showed weak correlation between OST stiffness and age, as well as significant differences in OST stiffness between different age groups. The study also found that the optimized mechanical properties of the OST were almost four times stiffer than fatty tissue.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Physiology
Hande Gorucu-Coskuner, Mustafa Al-Yassary, Kelly Billiaert, Stavros Kiliaridis, Gregory S. Antonarakis
Summary: This study evaluated the dimensional changes in the internasal and nasopremaxillary sutures, as well as related transverse craniofacial dimensions, in rats from 4 to 38 weeks of age. The endocranial, ectocranial, and mean suture widths of the sutures showed continuous changes during early adulthood, while the widths of these sutures nearly reached their final widths during adolescence.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alexander Vaneev, Victoria Tikhomirova, Natalia Chesnokova, Ekaterina Popova, Olga Beznos, Olga Kost, Natalia Klyachko
Summary: Topical drug delivery for eye therapy is challenging due to short retention time, insufficient contact with epithelium, fast elimination, and difficulties in overcoming ocular tissue barriers. Various conventional and novel drug delivery systems, particularly nanosize carriers, have been developed to improve drug bioavailability and enhance therapeutic action for eye diseases. Promising results have been shown with drug-loaded nanoparticles for sustained drug release and improved efficacy in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Ophthalmology
Longhao Kuang, Min Zhang, Ting Wang, Tao Huang, Jin Li, Run Gan, Mingyu Yu, Wenchao Cao, Xiaohe Yan
Summary: Anterior segment dysgenesis is a severe eye disorder causing blindness in children, and its exact mechanisms are still unclear. Many studies have focused on the genes and signal transduction pathways involved in this condition, including transcription factors, developmental regulators, extracellular matrix genes, membrane-related proteins, cytoskeleton proteins, and others. Although dozens of gene variants have been identified, effective treatments are still lacking. Future advancements in understanding the molecular mechanisms of anterior segment development may lead to new treatments using gene editing and stem cell technologies.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Ophthalmology
Daniel Ruminski, J. Sebag, Raul Duarte Toledo, Alfonso Jimenez-Villar, Jan K. Nowak, Silvestre Manzanera, Pablo Artal, Ireneusz Grulkowski
Summary: This study characterized age-related changes in anterior human vitreous using 3-D swept source optical coherence tomography and found that opacification is associated with increased light scattering and CSF degradation. SS-OCT enables high-resolution optical evaluation of vitreous opacities.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Hetal Buckhurst, Bernard Gilmartin, Robert Cubbidge, Nicola S. Logan
Summary: This study utilized 3D magnetic resonance imaging to investigate the regional variations in surface area and bulbosity of four anterior segment regions of the human eye, and their association with refractive status, axial length, and total ocular volume. The results showed significant regional differences in surface area, with myopic individuals having smaller surface areas in certain quadrants.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Computer Science, Interdisciplinary Applications
Jiaonan Ma, Xueli Xu, Mengdi Li, Yan Zhang, Lin Zhang, Ping Ma, Jie Hou, Yulin Lei, Jianguo Liu, Xiaojin Huangfu, Yang Yang, Xianglong Yi, George Cheng, Ji Bai, Xingwu Zhong, Ximing Xu, Yan Wang
Summary: Aging is a major risk factor for various eye diseases. Changes in eye structures with age vary among individuals, highlighting the need for informative biomarkers for assessing eye aging. In this study, a predictive model of age based on anterior segment morphology showed promising results for assessing eye aging.
JOURNAL OF BIOMEDICAL INFORMATICS
(2021)
Article
Health Care Sciences & Services
Piotr Waz, Katarzyna Zorena, Anna Murawska, Dorota Bielinska-Waz
Summary: A new diagnostic graphical tool called classification maps has been developed to aid in the detection of Age-Related Macular Degeneration (AMD). The maps use an ordinal regression model, with the degree of AMD advancement as the dependent variable and other variables such as CRT, GCC, MPOD, ETDRS, Snellen, and Age as predictors. The study classified 132 eyes into four stages of AMD and created two-dimensional classification maps for each stage. These maps provide a way to classify patients' eyes into specific stages of AMD using the variables represented on the axes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Ophthalmology
Ana Diego, Mohamed Abou Shousha
Summary: The objective of this study was to compare a new prototype for a portable anterior eye segment imaging system with the standard method for ophthalmology examination. The new system showed higher sensitivity and specificity percentages in the evaluations of the anterior eye segment videos compared to the standard webcam assessments. However, statistically significant differences were only observed in cornea, anterior chamber, iris, and lens.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Elham Akbari, Rana Imani, Parvin Shokrollahi, Reyhaneh Jarchizadeh, Saeed Heidari Keshel
Summary: The anterior segment of the eye is prone to various injuries and diseases, which can lead to lasting corneal defects, opacification, and vision loss. Traditional topical drugs like eye drops are commonly used, but they may be inefficient due to quick evaporation and blinking. Advanced ocular drug delivery technologies, particularly hydrogel-based formulations, have been considered as alternative methods to improve drug retention time and bioavailability. This review summarizes recent research progress in drug delivery systems for the anterior segment of the eye, focusing on hydrogel-based formulations and discussing drug loading strategies for commonly used drugs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Oliver Vocking, J. K. Famulski
Summary: In this study, single cell RNA sequencing revealed that anterior segment mesenchyme (ASM) differentiates into corneal epithelium/endothelium/stroma or annular ligament (AL) cell lineages as early as 48 hpf. Clustering analysis indicates common developmental pathways for corneal endothelium/stroma and AL, and distinct pathways for corneal epithelium starting at 48 hpf. The spatial and temporal validation of over 80 genes associated with anterior segment (AS) development demonstrated high conservation with mammalian trabecular meshwork and corneal tissues.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Jeremias G. Galletti, Kaitlin K. Scholand, Claudia M. Trujillo-Vargas, Wolfgang Haap, Tiago Santos-Ferreira, Christoph Ullmer, Zhiyuan Yu, Cintia S. de Paiva
Summary: This study investigated the effects of cathepsin S inhibition on age-related dry eye disease. The results showed that inhibiting cathepsin S or lacking the cathepsin S gene improved conjunctival goblet cell density and cornea mechanosensitivity in aged mice. Further studies are needed to investigate the role of cathepsin S during aging.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Developmental Biology
Akira Kinoshita, Kaname Ohyama, Susumu Tanimura, Katsuya Matsuda, Tatsuya Kishino, Yutaka Negishi, Naoko Asahina, Hideaki Shiraishi, Kana Hosoki, Kiyotaka Tomiwa, Naoko Ishihara, Hiroyuki Mishima, Ryoichi Mori, Masahiro Nakashima, Shinji Saitoh, Koh-ichiro Yoshiura
Summary: Mutations in ITPR1 can lead to ataxia and aniridia in individuals with GLSP. Study revealed a de novo GLSP mutation hotspot in the 3'-region of ITPR1. A specific eye-specific transcript of Itpr1 encoding a 218-amino acid isoform was identified, which may regulate actin fibers directionality and focal adhesion intensity. It was also found that ITPR1 could potentially control nuclear entry of transcriptional regulators and regulate both AES differentiation and muscle contraction in the iris.
Article
Orthopedics
Takuto Akazawa, Naokazu Miyamoto, Hirofumi Nishio, Eri Miyamoto-Mikami, Mayuko Kinoshita, Yohei Kobayashi, Masashi Nagao, Yuji Takazawa
Summary: This study found that hamstring tendon autografts used in ACL reconstruction in young patients carry a high risk of revision and residual instability. The Young's modulus of the hamstring tendon was found to increase with age, indicating a greater compliance in young patients.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Review
Immunology
Jayashree Srinivasan, Jessica N. Lancaster, Nandini Singarapu, Laura P. Hale, Lauren I. R. Ehrlich, Ellen R. Richie
Summary: Thymic epithelial cells and hematopoietic antigen presenting cells play essential roles in central tolerance, inducing negative selection or generation of regulatory T cells. Changes in TEC and HAPC subsets across the lifespan may have potential consequences for central tolerance. Age-associated alterations in T cell and Treg function relate to changes in thymic HAPC and TEC subsets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Ophthalmology
Erika Fernandez-Munoz, Jorge Blanco-Gomez, Rafael Vazquez-Rojas, Katia Camargo-Ibarias, Martha Massaro-Corredor, Roberto Gonzalez-Salinas
Summary: The study found that there was minimal variation in refractive outcomes for patients with mild to moderate keratoconus and cataracts who underwent toric intraocular lens implantation. This suggests good clinical stability and predictability, with no statistically significant postoperative changes in refractive outcomes observed.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Endocrinology & Metabolism
Sanober Kafeel, Khan Muhammad Nangrejo, Roberto Gonzalez-Salinas
Summary: This meta-analysis found a significant association between VEGF gene polymorphisms and susceptibility to diabetic retinopathy, particularly highlighting the potential of VEGF polymorphism rs3025039 as a biomarker for assessing DR risk. Further genome-wide association studies are needed to elucidate the multi-SNP effects of these polymorphisms in the VEGF gene.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2021)
Article
Ophthalmology
Maria F. Golzarri, Rashel Cheja-Kalb, Luz Elena Concha-Del-Rio, Roberto Gonzalez-Salinas, Lourdes Arellanes-Garcia
Summary: The purpose of this study was to identify the risk factors for the development of subretinal fibrosis (SRF) among patients with Vogt-Koyanagi-Harada (VKH) syndrome. The results showed that bullous serous retinal detachment was a significant risk factor for SRF.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Gerardo Valvecchia, Guadalupe Cervantes-Coste, Oscar Asis, Federico Pereyra, Manuel Garza-Leon, Gaston Gomez Caride, Leonardo Ferlini, Roberto Gonzalez-Salinas
Summary: The study evaluated the clinical outcomes of the secondary piggyback add-on intraocular lens (IOL) implantation in pseudophakic patients seeking spectacle-free options. The results showed that this sulcus-designed IOL provided optimal visual outcomes for near and distance vision.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Edel Moreno-Paramo, Santiago Garcia-Arroyo, Grecia Y. Ortiz-Ramirez, Manuel Garza-Leon, Roberto Gonzalez-Salinas
Summary: The study revealed significant differences between the SS-OCT biometer and the Image-Guide System in measuring the main biometric parameters, except for WTW.
SEMINARS IN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Roberto Gonzalez-Salinas, Paul Karpecki, Elizabeth Yeu, Mark Holdbrook, Stephanie N. Baba, Juan Carlos Ceballos, Martha Massaro-Corredor, Claudia Corredor-Ortega, Nallely Ramos-Betancourt, Hugo Quiroz-Mercado
Summary: The use of lotilaner ophthalmic solution has shown to be safe and effective in treating Demodex blepharitis. The improvement in collarette grade and mite density observed during the treatment period persisted for at least two months following treatment cessation.
CONTACT LENS & ANTERIOR EYE
(2022)
Review
Oncology
Juan Carlos Ramos-Martinez, Gerardo Altamirano-Gomez, Ivan Ramos-Martinez, Jorge Valencia, Luis Hernandez-Zimbron, Jesus Hernandez-Juarez, Patricia Echeverria-Vasquez, Leticia L. Hernandez-Gonzalez, Eduardo Perez-Campos, Laura Perez-Campos Mayoral, Edgar Ramos-Martinez
Summary: Galectin expression in breast cancer is not correlated with overall survival, but when considering cellular localization, galectin-3 is associated with overall survival while galectin-7 is associated with disease-free survival/progression-free survival/disease-specific survival.
CLINICAL BREAST CANCER
(2022)
Article
Medicine, General & Internal
Guadalupe Cervantes-Coste, Andre Tapia, Claudia Corredor-Ortega, Mariana Osorio, Rafael Valdez, Martha Massaro, Cecilio Velasco-Barona, Roberto Gonzalez-Salinas
Summary: This study investigated the correlations between optical aberrations, angle kappa, angle alpha, and visual outcomes following cataract surgery. The results showed that patients achieved excellent visual outcomes and reported low levels of dysphotopsia. Angle kappa decreased significantly during surgery, while angle alpha remained unchanged. Angle alpha was associated with postoperative higher-order aberrations and had a negative impact on near vision.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Elizabeth Yeu, Mark Holdbrook, Stephanie N. Baba, Juan Carlos Ceballos, Martha Massaro-Corredor, Claudia Corredor-Ortega, Nallely Ramos-Betancourt, Hugo Quiroz-Mercado, Roberto Gonzalez-Salinas
Summary: This study evaluated the efficacy and safety of lotilaner ophthalmic solution, 0.25% eyedrops in the treatment of Demodex blepharitis. The results showed a significantly higher proportion of participants achieving collar cure, mite eradication, and composite cure compared to the control group.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Ophthalmology
Roberto Gonzalez-Salinas, Jovany Jeomar Franco, Jose Luis Reyes-Luis, Valeria Sanchez-Huerta, Guillermo de Wit-Carter, Everardo Hernandez-Quintela, Roberto Pineda
Summary: This study provides a focused review of the literature on cataract surgery in patients with keratoconus (KC), discussing topics essential for the appropriate management of this patient population. It covers the epidemiology and pathophysiology of cataract and KC, intraocular lens power calculation in KC patients, and special management scenarios such as surgical planning in cases requiring corneal stabilization or tissue replacement interventions.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2023)
Review
Biology
Rosario Gulias-Canizo, Maria Elisa Rodriguez-Malagon, Loubette Botello-Gonzalez, Valeria Belden-Reyes, Francisco Amparo, Manuel Garza-Leon
Summary: Body temperature is an important indicator for assessing disease severity, and thermographic cameras have become a valuable tool in evaluating ocular diseases. Ocular surface temperature is influenced by various factors and can be used to assess conditions such as dry eye and allergic conjunctivitis. Thermography has also been used to study corneal diseases, glaucoma, diabetic retinopathy, and other inflammatory eye diseases.
Review
Chemistry, Medicinal
Anuar Salazar-Gomez, Amabile A. Velo-Silvestre, Angel Josabad Alonso-Castro, Luis Fernando Hernandez-Zimbron
Summary: This study investigated medicinal plants used in Mexico for treating symptoms associated with eye conditions. It identified 69 plant species, especially from the Crassulaceae family, with promising therapeutic potential for eye health based on preclinical and clinical studies.
Article
Biology
Astrid Lucero Espinosa Soto, Jimena Ceja Martinez, Rosario Gulias-Canizo, Oscar Guerrero-Berger
Summary: This study evaluated the residual refractive astigmatism using different toric calculators and compared them to the gold-standard Barrett toric calculator. The results showed that the enVista toric calculator incorporating the Emmetropia Verifying Optical calculator provided similar results to the Barrett calculator.
Article
Ophthalmology
Erika Fernandez-Munoz, Yolanda Chavez-Romero, Ricardo Rivero-Gomez, Rebeca Aridjis, Roberto Gonzalez-Salinas
Summary: The purpose of this study was to compare the energy expenditure in phacoemulsification surgery for dense cataract removal using three different techniques: divide and conquer, ultrachopper-assisted divide and conquer, and phaco-chop. The study found that the phaco-chop technique resulted in significantly lower cumulative dissipated energy (CDE) compared to the other two techniques. However, there were no significant differences in postoperative endothelial cell loss among the three groups.
CLINICAL OPHTHALMOLOGY
(2023)
