Article
Nutrition & Dietetics
Juan J. Lopez-Gomez, Jose L. Perez-Castrillon, Isabel Garcia de Santos, Maria Perez-Alonso, Olatz Izaola-Jauregui, David Primo-Martin, Daniel A. De Luis-Roman
Summary: This study examined the differences in bone metabolism between postmenopausal women with and without obesity, and compared the risk of fracture at five years between these groups.
Article
Chemistry, Medicinal
Naheed Aryaeian, Fatemehsadat Amiri, Seyedeh Tayebeh Rahideh, Jamileh Abolghasemi, Shima Jazayeri, Afsaneh Gholamrezayi, Manijeh Motevalian, Masoud Solaymani-Dodaran, Mohsen Taghizadeh, Elaheh Heshmati, Shahnaz Rimaz
Summary: The study suggests that C. mas extract may decrease BAP, PTH, and hsCRP levels in postmenopausal women, but has no beneficial effect on OC and TC.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Klisic, Milena Cojic, Dimitrios Patoulias, Ana Ninic
Summary: This study examined the potential relationship between 25-hydroxyvitamin D [25(OH)D] and type 2 diabetes (T2D) in postmenopausal women in Montenegro. It found that the relationship between [25(OH)D] and T2D is influenced by central obesity and inflammation in these women. Additionally, the study suggested that a set of biomarkers may provide better information for assessing the risk of T2D in postmenopausal women, rather than using [25(OH)D] alone.
Article
Biochemistry & Molecular Biology
Mickael de Paiva Sousa, Larissa Cristina Fontenelle, Thayanne Gabryelle Visgueira de Sousa, Loanne Rocha dos Santos, Kyria Jayanne Climaco Cruz, Tamires da Cunha Soares, Debora Cavalcante Braz, Joao Marcelo de Castro e Sousa, Gilberto Simeone Henriques, Vladimir Costa Silva, Carlos Henrique Nery Costa, Dilina do Nascimento Marreiro
Summary: This study aims to analyze the relationship between markers of chronic inflammation and copper nutritional status in obese women. The results showed that obese women had higher serum IL-6 concentrations, higher plasma copper concentrations, lower erythrocyte copper concentrations, and lower erythrocyte SOD activity compared to eutrophic women. Additionally, there was a significant negative correlation between TNF-alpha and IL-10 concentrations and SOD activity in the obese group.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Nutrition & Dietetics
Patricia Paula da Fonseca Grili, Camila Vilarinho Vidigal, Geise Ferreira da Cruz, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Taisa Sabrina Silva Pereira, Valdete Regina Guandalini
Summary: This study aimed to identify nutrient patterns (NPs) and their association with bone mineral density (BMD) categories in postmenopausal women. The results showed that lower consumption of NP1 and NP2 was associated with an increased risk of osteopenia, but not osteoporosis.
Article
Health Care Sciences & Services
Malgorzata Jamka, Edyta Madry, Pawel Bogdanski, Jakub Krysciak, Radoslaw Madry, Aleksandra Lisowska, Elnara Ismagulova, Anna Gotz-Wieckowska, Izabela Chudzicka-Strugala, Ainur Amanzholkyzy, Jaroslaw Walkowiak
Summary: The study compared the effects of endurance training and endurance-strength training on bone density and mass in abdominally obese postmenopausal women, showing a significant increase in whole-body bone density with endurance-strength training. There was a significant difference in lumbar spine bone mass changes between the two groups, but both training programs similarly improved physical capacity.
Article
Nutrition & Dietetics
Pavel Marozik, Alena Rudenka, Katsiaryna Kobets, Ema Rudenka
Summary: This study demonstrated significant effects of VDR gene variants ApaI rs7975232, BsmI rs1544410, TaqI rs731236, and Cdx2 rs11568820 on bone mineral density, 25-hydroxyvitamin D level, and osteoporosis risk in Belarusian women. The findings suggest the importance of genetic markers for personalized medicine strategies.
Article
Biochemistry & Molecular Biology
Larissa Cristina Fontenelle, Mickael de Paiva Sousa, Loanne Rocha Dos Santos, Bruna Emanuele Pereira Cardoso, Thayanne Gabryelle Visgueira de Sousa, Tamires da Cunha Soares, Stefany Rodrigues de Sousa Melo, Jennifer Beatriz Silva Morais, Thaline Milany da Silva Dias, Francisco Erasmo de Oliveira, Debora Cavalcante Braz, Joao Marcelo de Castro e Sousa, Francisco Leonardo Torres-Leal, Gilberto Simeone Henriques, Dilina do Nascimento Marreiro
Summary: This study aimed to evaluate the relationship between markers of selenium nutritional status and low-grade chronic inflammation in obese women. The results showed that obese women had higher dietary selenium intake but lower selenium concentrations in plasma and erythrocytes. Additionally, obese women had higher concentrations of IL-6 and lower concentrations of IL-8, IL-1 beta, and TNF alpha. Erythrocyte selenium was found to be an independent predictor of IL-8 concentrations in obese women, reflecting the anti-inflammatory action of this micronutrient.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Immunology
Alexander Leonardo Silva-Junior, Nadja Pinto Garcia, Evilazio Cunha Cardoso, Stephanny Dias, Andrea Monteiro Tarrago, Nelson Abrahim Fraiji, Matheus Souza Gomes, Laurence Rodrigues Amaral, Andrea Teixeira-Carvalho, Olindo Assis Martins-Filho, Erich Vinicius De Paula, Allyson Guimaraes Costa, Adriana Malheiro
Summary: Sickle Cell Anemia (SCA) is characterized by genetic mutation in the beta-globin gene leading to increased hemolysis rate and involvement of immunological molecules. This study analyzed levels of various molecules in SCA patients in different clinical conditions, identifying a pro-inflammatory profile in steady-state patients and highlighting specific molecules in VOC patients. PDGF-BB and IL-1ra were important markers for transitioning from acute to chronic stage, showing significant decrease after crisis inflammation and statistical difference in different patient groups.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Jeongmin Lee, Jin-Hyung Jung, Jinyoung Kim, Chaiho Jeong, Jeonghoon Ha, Min-Hee Kim, Jung-Min Lee, Sang-Ah Chang, Ki-Hyun Baek, Kyungdo Han, Dong-Jun Lim
Summary: This study investigated the associations between body composition, including body mass index (BMI) and waist circumference (WC), and fracture risk in postmenopausal women with different levels of bone mineral density (BMD). The findings suggest that general obesity and central obesity do not protect against fractures, vertebral fractures (VFs), and hip fractures (HFs) in postmenopausal women with osteopenia or osteoporosis.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Rossella Tozzi, Davide Masi, Fiammetta Cipriani, Savina Contini, Elena Gangitano, Maria Elena Spoltore, Ilaria Barchetta, Sabrina Basciani, Mikiko Watanabe, Enke Baldini, Salvatore Ulisse, Carla Lubrano, Lucio Gnessi, Stefania Mariani
Summary: This study evaluated the relationship between SIRT1 and sclerostin with bone mass and quality, finding a negative correlation between SIRT1 and bone density, and a negative correlation between sclerostin and bone mass. The results suggest that blood measurement of SIRT1 and sclerostin, taking into account weight and adiposity, can provide a more accurate assessment of bone health.
Article
Endocrinology & Metabolism
Wenting Qi, Yan Jiang, Wei Liu, Yue Chi, Ruizhi Jiajue, Qianqian Pang, Ou Wang, Mei Li, Xiaoping Xing, Wei Yu, Weibo Xia
Summary: Obesity is associated with improved areal bone mineral density, bone geometry, and bone microarchitecture in postmenopausal Chinese women. Except for a lower level of osteocalcin, no significant differences in bone turnover markers were found among the groups.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Swati Sucharita Mohanty, Prafulla Kumar Mohanty
Summary: Breast cancer is the second most prevalent cancer globally, with a significant relationship between obesity and increased risk of developing the disease. Premature menopause and premenopausal obesity decrease the risk, while postmenopausal obesity amplifies it due to adipose tissue being a major reservoir for estrogen biosynthesis. High estrogen levels in overweight postmenopausal women are seen as a major factor in breast cancer development.
Article
Multidisciplinary Sciences
Hyun-Bum Kim, Geun-Jeon Kim, Kyung-do Han, Young-Hoon Joo
Summary: The study found that changes in MetS status were associated with the risk of laryngeal cancer. The group that developed MetS had a higher risk of laryngeal cancer compared to the MetS-free group, with abdominal obesity posing the highest risk among MetS components.
Article
Endocrinology & Metabolism
Shannon Clare, Alexander Dash, Yi Liu, Jonathan Harrison, Katelyn Vlastaris, Seth Waldman, Robert Griffin, Paul Cooke, Vijay Vad, Ellen Casey, Richard S. Bockman, Joseph Lane, Donald McMahon, Emily M. Stein
Summary: This study investigated the acute changes in bone turnover following epidural steroid injections (ESIs) in postmenopausal women. Results showed a significant decrease in bone formation markers one week after ESI, which lasted for at least 12 weeks. Further investigation into the long-term skeletal consequences of these injections is warranted, considering the large population of older adults who receive ESIs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Vlasta Masanova, Zora Krivosikova, Monika Ursinyova, Iveta Uhnakova, Anton Kebis, Patricia Kramarova, Ladislava Wsolova, Martin Gajdos
Summary: This study investigated the impact of estrogen deficiency and physical activity on bone and blood concentrations of macrominerals and microminerals in a high-fat diet-induced obesity rat model, finding that diet and exercise can influence these mineral concentrations.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Jana Tulinska, Zora Krivosikova, Aurelia Liskova, Miroslava Lehotska Mikusova, Vlasta Masanova, Eva Rollerova, Kornelia Stefikova, Ladislava Wsolova, Andrea Babelova, Lubomira Tothova, Milena Busova, Janka Babickova, Iveta Uhnakova, Radka Alacova, Maria Dusinska, Mira Horvathova, Michaela Szabova, Zbynek Vecera, Pavel Mikuska, Pavel Coufalik, Kamil Krumal, Lukas Alexa, Pavel Piler, Vojtech Thon, Bohumil Docekal
Summary: Exposure to lead oxide nanoparticles resulted in undesired stimulation of the immune system, oxidative stress in the intestine, inflammation, and pro-fibrotic response in the kidneys, as well as massive accumulation of lead in bones.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Immunology
Jana Tulinska, Miroslava Lehotska Mikusova, Aurelia Liskova, Milena Busova, Vlasta Masanova, Iveta Uhnakova, Eva Rollerova, Radka Alacova, Zora Krivosikova, Ladislava Wsolova, Maria Dusinska, Mira Horvathova, Michaela Szabova, Norbert Lukan, Martina Stuchlikova, Daniel Kuba, Zbynek Vecera, Pavel Coufalik, Kamil Krumal, Lukas Alexa, Lucie Vrlikova, Marcela Buchtova, Jana Dumkova, Pavel Piler, Vojtech Thon, Pavel Mikuska
Summary: The ingestion of copper oxide nanoparticles (CuO NPs) can have negative effects on the immune system and antioxidant defense in mice, causing an increase in lymphocyte proliferation and secretion functions, impairment of granulocyte phagocytic activity, and decreased concentration of reduced glutathione.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Marcello Ceppi, Bozena Smolkova, Marta Staruchova, Alena Kazimirova, Magdalena Barancokova, Katarina Volkovova, Andrew Collins, Anton Kocan, Zuzana Dzupinkova, Alexandra Horska, Verona Buocikova, Jana Tulinska, Aurelia Liskova, Miroslava Lehotska Mikusova, Zora Krivosikova, Ladislava Wsolova, Daniel Kuba, Elise Runden-Pran, Naouale El Yamani, Eleonora Martha Longhin, Erika Halasova, Soterios Kyrtopoulos, Stefano Bonassi, Maria Dusinska
Summary: As part of a large human biomonitoring study, occupational monitoring was conducted in a glass fibre factory in Slovakia, comparing the exposure of shopfloor workers and administrators to glass fibres and PAHs. The study investigated the impact of exposure on various genetic factors and found that even low levels of exposure to these fibres can cause significant genetic damage.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2023)
Article
Chemistry, Multidisciplinary
Miroslava Lehotska Mikusova, Milena Busova, Jana Tulinska, Vlasta Masanova, Aurelia Liskova, Iveta Uhnakova, Maria Dusinska, Zora Krivosikova, Eva Rollerova, Radka Alacova, Ladislava Wsolova, Mira Horvathova, Michaela Szabova, Norbert Lukan, Zbynek Vecera, Pavel Coufalik, Kamil Krumal, Lukas Alexa, Vojtech Thon, Pavel Piler, Marcela Buchtova, Lucie Vrlikova, Pavel Moravec, Dusan Galanda, Pavel Mikuska
Summary: This study investigated the potential adverse effects of inhaling titanium dioxide nanoparticles (TiO2 NPs) using a whole-body inhalation chamber model. The results showed that TiO2 NPs had a dose-dependent effect on the innate immune system, stimulating phagocytic activity of monocytes at low doses and suppressing monocyte secretory function (IL-18) at high doses. The adaptive immune system in exposed mice showed a decrease in T-cell percentage, a reduction in T-helper cells, and a dose-dependent decrease in lymphocyte cytokine production, indicating possible immunosuppression. The increase in glutathione (GSH) concentration and GSH/GSSG ratio in whole blood demonstrated stimulated antioxidant defense against TiO2 NP-induced oxidative stress.
Article
Biochemistry & Molecular Biology
Katarina Sebekova, Marta Staruchova, Csilla Mislanova, Aurelia Liskova, Mira Horvathova, Jana Tulinska, Miroslava Lehotska Mikusova, Michaela Szabova, Radana Gurecka, Ivana Koborova, Melinda Csongova, Tamas Tabi, Eva Szoko, Katarina Volkovova
Summary: Oxidative stress and sterile inflammation are crucial factors in the development and progression of MetS. This study analyzed markers of oxidative and inflammatory status in a cohort of 170 women categorized based on the presence of MetS components. The results showed that markers of oxidative damage were similar across the groups, while markers of inflammation were significantly different. Levels of C-reactive protein, uric acid, and interleukin-6 were consistently associated with MetS components. Further studies are needed to determine whether additional markers can improve the prognosis of individuals with early-stage MetS.
