Article
Health Care Sciences & Services
Marta Wysocka-Mincewicz, Joanna Golebiewska, Marta Baszynska-Wilk, Andrzej Olechowski
Summary: This study aimed to identify gender-specific risk factor sets that could influence OCT results in children with type 1 diabetes. Significant differences were found in risk factors between genders, with factors such as metabolic control, diabetic ketoacidosis, serum creatinine, and duration of continuous insulin infusion being important for retinal thickness and vessel densities in both boys and girls. Additionally, elements of metabolic syndrome and insulin dosage were more pronounced in girls, while serum creatinine and other parameters were more significant in boys.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Endocrinology & Metabolism
Noora Nurminen, Damiano Cerrone, Jussi Lehtonen, Anirudra Parajuli, Marja Roslund, Maria Lonnrot, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Juho Rajaniemi, Olli H. Laitinen, Aki Sinkkonen, Heikki Hyoty
Summary: This study found that early exposure to an agricultural environment is inversely associated with the risk of type 1 diabetes, possibly mediated by early exposure to environmental microbial diversity.
Review
Nutrition & Dietetics
Chiara Garonzi, Gun Forsander, Claudio Maffeis
Summary: Children and adolescents with type 1 diabetes should avoid high fat intake to reduce cardiovascular risk and inflammation, and instead opt for a healthy and balanced diet as recommended by ISPAD and ADA.
Article
Endocrinology & Metabolism
Ionut Bebu, Sareh Keshavarzi, Xiaoyu Gao, Barbara H. Braffett, Angelo J. Canty, William H. Herman, Trevor J. Orchard, Samuel Dagogo-Jack, David M. Nathan, John M. Lachin, Andrew D. Paterson
Summary: Genetic factors, including CAD PRS and individual single nucleotide polymorphisms, are strongly associated with the risk of subsequent cardiovascular disease in individuals with type 1 diabetes, beyond established risk factors like age, lipids, blood pressure, and glycemia.
Article
Multidisciplinary Sciences
Elisabeth Buur Stougaard, Signe Abitz Winther, Hanan Amadid, Marie Frimodt-Moller, Frederik Persson, Tine Willum Hansen, Peter Rossing
Summary: The study aimed to assess the associations between PBR, PBR-hf, and MVHS with cardio-renal risk factors in individuals with type 1 diabetes, as well as compare these dimensions with controls. Results showed that the endothelial glycocalyx dimension was impaired in individuals with T1D compared to controls, but there was no association with albuminuria levels or cardio-renal risk factors. The use of the GlycoCheck device may not contribute significantly to cardio-renal risk stratification in T1D.
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Medicine, General & Internal
Mark A. Sperling, Lori M. Laffel
Summary: A 12.5-year-old pubertal girl is referred to a tertiary medical center for management of new-onset diabetes mellitus. The initial evaluation reveals glucosuria but no ketonuria. She has no family history of type 1 diabetes mellitus and her physical examination is normal except for Tanner stage 3 breast and pubic hair development.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Joshua Chiou, Ryan J. Geusz, Mei-Lin Okino, Jee Yun Han, Michael Miller, Rebecca Melton, Elisha Beebe, Paola Benaglio, Serina Huang, Katha Korgaonkar, Sandra Heller, Alexander Kleger, Sebastian Preissl, David U. Gorkin, Maike Sander, Kyle J. Gaulton
Summary: Genome-wide association studies of type 1 diabetes identified risk variants that were enriched in specific cell types, including cells of the exocrine pancreas. The study highlights the role of the exocrine pancreas in the pathogenesis of T1D and underscores the importance of large-scale genetic studies and single-cell epigenomics in understanding complex diseases.
Article
Endocrinology & Metabolism
Ke Huang, Shuting Si, Ruimin Chen, Chunlin Wang, Shaoke Chen, Yan Liang, Hui Yao, Rongxiu Zheng, Fang Liu, Binyan Cao, Zhe Su, Maimaiti Mireguli, Feihong Luo, Pin Li, Hongwei Du, Min Zhu, Yu Yang, Lanwei Cui, Yunxian Yu, Junfen Fu
Summary: The study in China found that preterm birth increased the risk of childhood T1DM, while high birth weight only affected girls. Early prevention of T1DM may start with prenatal care, and more attention should be paid to children with preterm birth and girls with high birth weight after birth.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Michelle So, Colin O'Rourke, Alyssa Ylescupidez, Henry T. Bahnson, Andrea K. Steck, John M. Wentworth, Brittany S. Bruggeman, Sandra Lord, Carla J. Greenbaum, Cate Speake
Summary: Analyzing the age-varying effect of disease predictors improves understanding and prediction of type 1 diabetes disease progression, and should be leveraged to refine prediction models and guide mechanistic studies.
Article
Endocrinology & Metabolism
Andriani Vazeou, Sascha R. Tittel, Olga Kordonouri, Niels H. Birkebaek, Violeta Iotova, Barbara Piccini, Sebastian Seget, Pravesh Kumar Guness, David M. Maahs, George S. Stergiou
Summary: The prevalence of modifiable cardiovascular risk factors is higher in children and adolescents with type 1 diabetes who have elevated blood pressure/hypertension than in those with normal blood pressure, suggesting the need for early detection and intervention to prevent future morbidity and mortality.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Julie C. Soholm, Marianne Vestgaard, Bjorg Asbjornsdottir, Nicoline C. Do, Berit W. Pedersen, Lone Storgaard, Birgitte B. Nielsen, Lene Ringholm, Peter Damm, Elisabeth R. Mathiesen
Summary: This study aimed to identify potentially modifiable risk factors and causes for preterm delivery in women with type 1 or type 2 diabetes. Results showed that independent risk factors for preterm delivery in diabetic women included pre-existing kidney involvement, higher gestational weight gain, and fetal overgrowth.
Letter
Medicine, General & Internal
Yuki Murata, Morihito Takita, Masahiro Kami
Summary: This study demonstrates that a closed-loop insulin-delivery system is superior to glucose sensor-augmented insulin-pump therapy for glycemic control in children aged 1 to 7 with type 1 diabetes. However, it should be noted that unscheduled contacts with trial staff are more frequent during the closed-loop period.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ryan Wereski, Dorien M. Kimenai, Anda Bularga, Caelan Taggart, David J. Lowe, Nicholas L. Mills, Andrew R. Chapman
Summary: The study compared the risk factors for type 1 and type 2 myocardial infarction, finding that age, hyperlipidaemia, diabetes, abnormal renal function, and known coronary disease were common predictors for both. Sex was not a predictor of type 2 myocardial events, while a prior history of type 2 events was the strongest predictor.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Ryan Wereski, Dorien M. Kimenai, Anda Bularga, Caelan Taggart, David J. Lowe, Nicholas L. Mills, Andrew R. Chapman
Summary: The study found that risk factors for both type 1 and type 2 myocardial infarction were similar, including age, hyperlipidaemia, diabetes, abnormal renal function, and known coronary disease. However, gender was not a predictor for type 2 myocardial infarction.
EUROPEAN HEART JOURNAL
(2022)
Article
Biology
Nabil Joseph Awadalla, Hassan Mohammed Al-Musa
Summary: Insomnia is prevalent among primary care population, and is significantly associated with insufficient income, chronic diseases, and GERD. Daily impairment is a significant problem among insomnia patients.
BIOLOGICAL RHYTHM RESEARCH
(2021)
Article
Environmental Sciences
Abdullah Assiri, Ahmed A. Mahfouz, Nabil J. Awadalla, Ahmed Y. Abolyazid, Medhat Shalaby
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Clinical Neurology
Marwa Elhady, Eman R. Youness, Mones M. AbuShady, Maysa S. Nassar, Ali Abd Elaziz, Mahmoud M. Masoud, Fayez K. Foudaa, Walaa Alshasrany Abu Elhamed
Summary: Circulating levels of GFAP and UCH-L1 are significantly increased in children with epilepsy, especially those with active seizures. GFAP and UCH-L1 are significantly correlated with the severity of seizures in the previous 6 months, with elevated GFAP level predicting active seizures.
CHILDS NERVOUS SYSTEM
(2021)
Article
Clinical Neurology
Marwa Elhady, Rasha Sobhy Elattar, Asmaa Mohamed Ali Elaidy, Naglaa Abdelmoniem Abdallah, Heba A. Elmalt
Summary: Epilepsy is not only limited to seizures, but also includes multiple neuropsychiatric sequelae. This study found a correlation between pro-inflammatory cytokines levels and the co-occurrence of ADHD in children with epilepsy.
APPLIED NEUROPSYCHOLOGY-CHILD
(2022)
Article
Neurosciences
Adel A. Alhazzani, Ahmed A. Mahfouz, Ahmed Y. Abolyazid, Nabil J. Awadalla
Summary: The study aimed to identify modifiable risk factors for first-time stroke in the Aseer region of southwest Saudi Arabia, revealing that hypertension, diabetes mellitus, obesity, and high cholesterol are major risk factors, while regular exercise practice can reduce the risk of stroke.
Article
Pharmacology & Pharmacy
Mohammed A. Alsaleem, Nabil J. Awadalla, Shehata F. Shehata, Awad Saeed Alsamghan, Mohammed A. AlFlan, Marwan M. Alhumaidi, Mohamed S. Alwadai, Fahad S. Althabet, Mohamad S. Alzahrani, Safar A. Alsaleem, Ahmed A. Mahfouz
Summary: The study conducted in Abha city, Saudi Arabia found a high prevalence of GERD among attendants of primary health care centers. Significant independent factors associated with GERD included being unmarried, smoking, fast food intake, and subjective perception of stress. Community level awareness programs are recommended for GERD prevention and management.
SAUDI PHARMACEUTICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Ali A. Asseri, Ibrahim AlHelali, Emad Elbastawisi, Abdelwahid S. Ali, Saleh M. Al-Qahtani, Ayed A. Shati, Nabil J. Awadalla
Summary: The study presented 5 pediatric patients with MIS-C associated with SARS-CoV-2 infection, exhibiting symptoms such as persistent fever, respiratory issues, gastrointestinal involvement, and elevated inflammatory markers. One patient died from multiorgan failure and shock, while the other 4 patients were discharged with improved conditions.
Article
Environmental Sciences
Fuad Abbag, Saeed A. Abu-Eshy, Ahmed A. Mahfouz, Mohammed A. Alsaleem, Safar A. Alsaleem, Ayyub A. Patel, Tarek M. Mirdad, Ayed A. Shati, Nabil J. Awadalla
Summary: The study revealed a high prevalence of stunting and a widespread iodine deficiency issue among school children in the Aseer region. Continuous monitoring and interventions are necessary to reduce the risk of stunting among students.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Pediatrics
Ali A. Asseri, Nasim Khattab, Dima Ezmigna, Nabil J. Awadalla, Cori Daines, Wayne Morgan
Summary: Cultures of nasopharyngeal swabs show higher sensitivity in detecting PBB pathogens in children under 5 with chronic wet cough, but positive results do not accurately predict lower airway infections. Flexible bronchoscopy should be considered for patients with a history or clinical pointers of PBB.
Article
Clinical Neurology
Ibrahim Alnaami, Abdullah M. Aseeri, Ahmed Albinali, Shahd Dlboh, Awadh Alqahtani, Nabil J. Awadalla
Summary: This study examines the association between anesthesia type and recurrence of chronic subdural hematoma (CSDH) surgery, finding that surgery under local anesthesia may lead to a higher recurrence rate. However, the authors recommend individualized treatment options based on the patient's status.
INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT
(2021)
Article
Multidisciplinary Sciences
Nabil J. Awadalla, Abdullah A. Alsabaani, Mohammed A. Alsaleem, Safar A. Alsaleem, Ayoub A. Alshaikh, Suliman H. Al-Fifi, Ahmed A. Mahfouz
Summary: This study evaluates the impact of the COVID-19 pandemic on perceived stress levels among medical students. The study found that the prevalence of high perceived stress during the pandemic was significantly higher than before the pandemic, and female students, younger students, and those in lower academic grades are the most at risk of having high stress.
Article
Infectious Diseases
Ali Alsuheel Asseri, Mohammed Assiri, Mohammed Abdullah Alshehri, Malak Asseri, Abdelwahid Saeed Ali, Nabil J. Awadalla
Summary: COVID-19-related encephalopathy in a pediatric patient is reported for the first time in Saudi Arabia. Clinicians should be aware of potential neurological complications associated with COVID-19.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Badr Rashed Al-Ghamdi, Fakhreldin Mohamed Omer, Nabil J. Awadalla, Ahmed A. Mahfouz
Summary: The prevalence of current rhinitis (CR) is high in southwestern regions of Saudi Arabia, and it is strongly associated with sensitization to outdoor aeroallergens, particularly herbaceous grass and their pollens. Total IgE levels and eosinophil count are significantly higher in adults with CR.
Article
Medicine, General & Internal
Mohammed A. Alsaleem, Safar A. Alsaleem, Sarah Al Shehri, Nabil J. Awadalla, Tarek M. Mirdad, Fuad Abbag, Ahmed A. Mahfouz
Summary: This study revealed that university students commonly experience high levels of perceived stress, with females and healthcare students at a higher risk. High perceived stress is correlated with smoking, lower GPA scores, and perceived insufficient family income.
Article
Biodiversity Conservation
Fakhreldin M. Omer, Nabil J. Awadalla, Safar Abadi Alsaleem, Mohammed Abadi Alsaleem, Riyad A. Moosa, Mohamed A. Alqahtani, Abdulmageed A. Asiri, Ebtesam M. Alahmari, Amal N. Alqahtani, Ahmed A. Mahfouz
Summary: The study revealed a lack of knowledge and awareness among medical practitioners in Aseer, south-western Saudi Arabia regarding toxocariasis, with less than 30% of participants being aware of the disease spectrum. This lack of awareness was seen across different specialties and years of experience, highlighting the potential risk of misdiagnosis and inappropriate treatment due to insufficient understanding of Toxocara infection.
