Journal
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
Volume 8, Issue 1, Pages 15-19Publisher
WILEY
DOI: 10.1002/alr.22039
Keywords
local; nasal; rhinitis; sensitivity; specific IgE
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Funding
- Institute of Health Carlos III of the Ministry of Economy and Competitiveness (European Regional Development Fund [ERDF]): Red de Reacciones Adversas a Alergenos y Farmacos RIRAAF [RD07/0064]
- ARADyAL (Asma, Reacciones ADversas y ALergicas) [RD16/0006/0001, FIS PI12/00900, FIS PI14/00864]
- Andalusian Regional Ministry Health grant [PI-0346-2016]
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Background: The measurement of nasal specific IgE (NsIgE) in local allergic rhinitis (LAR) patients is challenging and shows variability. The objective of this work was to evaluate a minimally-invasive method of direct detection of NsIgE in patients with LAR to Dermatophagoides pteronyssinus (DP) using an automated immunoassay. Methods: Fifty patients participated (LAR, n = 14; allergic rhinitis (AR), n = 20; healthy controls [HC], n = 16). Detection of NsIgE was performed by direct application of the solid phase of a commercial DP ImmunoCAP (R) test 24 hours after DP nasal provocation. Results: There was no difference in the median volume of secretion absorbed by the solid phase of the ImmunoCAP test in the 3 studied groups (p = 0.17). According to receiver operating characteristic (ROC) curve analysis, NsIgE 0.1450 was the optimal cutoff point, obtaining in LAR patients 42.86% sensitivity with the highest specificity (100%), and 75% sensitivity and 100% specificity for AR. Conclusion: This study demonstrates the detection of NsIgE to DP in LAR by using a simple, commercial device with high specificity. (C) 2017 ARS-AAOA, LLC.
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