Article
Plant Sciences
Nina Reis Soares, Caio Tulio Rodrigues Correa, Jhonata Costa da Silva, Jacson Rondinelli da Silva Negreiros, Vania Helena Techio, Giovana Augusta Torres
Summary: The species Piper hispidinervum, Piper aduncum, and Piper affinis hispidinervum have essential oils with different compounds, and their taxonomy is controversial due to morphological similarities. Detailed analysis of their karyotypes and rDNA sites revealed similar traits, indicating difficulty in differentiation. Genomic hybridization showed high similarity in repetitive DNA fraction among the species, emphasizing the need for further genomic studies to resolve taxonomic controversy.
Article
Plant Sciences
Ygor Jesse Ramos, Jessica Sales Felisberto, Joao Gabriel Gouvea-Silva, Ulisses Carvalho de Souza, Claudete da Costa-Oliveira, George Azevedo de Queiroz, Elsie Franklin Guimaraes, Nicholas John Sadgrove, Davyson de Lima Moreira
Summary: This study tested the hypothesis that clonal chemical heritability is crucial for the conservation of chemical uniformity in controlled monoclonal cultivation of Piper essential oils. The results showed that while clonal heritability is important for chemical homology, significant chemical plasticity can occur when cultivated from wild specimens.
Article
Chemistry, Applied
Midia Rodrigues de Oliveira, Laenir Anjos da Silva, Roosalyn Santos Da Silva, Cesar Castelo Branco de Queiroz, Renata Takeara
Summary: Species of the Piper genus, commonly used in the treatment of chronic diseases in the Amazon, produce essential oils with larvicidal, antioxidant, and anticholinesterase properties. Recent articles provide information on the chemical composition and biological activities of these essential oils, guiding future research in this area.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mathieu Weil, Jean Michel Leong PockTsy, Harizoly Razafimandimby
Summary: This study characterized two species of Piper from Madagascar and one from Reunion Island through a multidisciplinary approach combining botany, genetics, and chemistry, providing authentication keys. The tri-disciplinary approach showed that the three peppers studied are very different from Piper nigrum L, with Reunionese Piper borbonense and M3 Malagasy pepper clearly differing from the M1 Malagasy morphotype. A distinction could possibly be made at the variety or form level based on morphometry and piperine content for chemistry.
Article
Agricultural Engineering
Jeferson Adriano e Silva Assuncao, Diego da Silva Marcelino, Jessica Regina Sales Felisberto, Elsie Fraklin Guimaraes, George de Azevedo Queiroz, Ygor Jesse Ramos, Davyson de Lima Moreira
Summary: This study aimed to assess the post-harvest impact of UV-C irradiation on the metabolic profile of essential oils (EOs) from fresh leaves of Piper aduncum cultivated in Southeastern Brazil. The results showed that UV-C radiation can alter the relative percentage of specific chemical constituents, with a significant increase in the relative percentage of the compound dillapiole. This study suggests that UV-C irradiation may be a promising technique for enriching the dillapiole content in the essential oil of P. aduncum.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Hui Chen, Ying Zhu, Ya-Lun Zhang, Meng-Nan Zeng, Yan-Gang Cao, Pan-Ting Sun, Bing Cao, Kun Du, Xuan Zhao, Xiao-Wei Wang, Xiao-Ke Zheng, Wei-Sheng Feng
Summary: This study isolated new neolignans and amide alkaloids from the stems of Piper kadsura, with 8 compounds showing significant neuroprotective effects against Aβ(25-35)-induced cell damage in PC12 cells, with low EC50 values. Furthermore, 3 of these compounds have the potential to reduce apoptosis and enhance autophagy.
Article
Chemistry, Medicinal
Fan Yang, Hua Li, Yan-Qiu Yang, Yue Hou, Dong Liang
Summary: In this study, four new lignanamides and four known analogs were isolated from the stems of Piper hancei Maxim. These compounds exhibited potential inhibitory effects on NO production in BV-2 microglial cells and moderate cytotoxic activities against certain types of cells.
Article
Biochemistry & Molecular Biology
Carlos Eduardo P. Maduro, Rebeca G. de Camargo, Ana Paula P. K. Hendges, Aurea P. Ferriani, Allan R. da Silva, Marta Cristina T. Duarte, Wanderlei do Amaral, Beatriz Helena L. N. Sales Maia
Summary: This study evaluated the seasonal variation of the chemical composition and antimicrobial activity of Piper caldense and Piper xylosteoides leaves essential oils. Different seasons and plant species have an impact on the composition and activity of the essential oils.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Chemistry, Medicinal
Fan Yang, Hua Li, Yan-Qiu Yang, Yue Hou, Dong Liang
Summary: Four new lignanamides and four known analogs were isolated from the stems of Piper hancei Maxim. These compounds showed potential inhibitory effects on NO production in LPS-induced BV-2 microglial cells, and exhibited moderate cytotoxic activities against various cancer cell lines.
Article
Plant Sciences
Jorge Ramirez, Maria Daniela Andrade, Giovanni Vidari, Gianluca Gilardoni
Summary: This study analyzed the essential oil and major non-volatile secondary metabolites from the leaves of Piper subscutatum collected in the Ecuadorian Amazon. The essential oil contained compounds like (E)-beta-caryophyllene and beta-chamigrene, while the non-volatile fraction consisted of lignans. Enantioselective analysis showed different enantiomeric combinations in the oil.
Article
Biochemistry & Molecular Biology
Eutrophe Le Doux Kamto, Olivier Placide Note, Mc Jesus Kinyok, Anke Wilhelm, Josephine Ngo Mbing, Cyril Antheaume, Alex de Theodore Atchad, Dieudonne Emmanuel Pegnyemb, Derek Tantoh Ndinteh, Mohamed Haddad, Susan L. Bonnet
Summary: This study identified three previously undescribed triterpenoid saponins from P. guineense, marking a new discovery in the field.
CARBOHYDRATE RESEARCH
(2021)
Article
Plant Sciences
Yu Juan Chai, Younghoon Go, Hai Qi Zhou, Hong Xu Li, Sun Joo Lee, Yeo Jin Park, Wahyu Widowatib, Rizal Rizal, Young Ho Kim, Seo Young Yang, Wei Li
Summary: Three undescribed bicyclo[3.2.1]octanoid neolignan glucosides, along with a known neolignan, were isolated from Piper crocatum leaves. Their chemical structures were elucidated through spectroscopic analyses and compared with previous data. Two compounds showed strong inhibitory effects against pyruvate dehydrogenase E1 alpha S300 phosphorylation in comparison to the positive control.
Article
Biochemistry & Molecular Biology
Julia Karla A. M. Xavier, Rafaela C. S. da Trindade, Edith Cibelle Moreira, Pablo Luis B. Figueiredo, Jose Guilherme S. Maia, William N. Setzer, Joyce Kelly R. da Silva
Summary: This study classified the Ocotea complex species in Para state, Brazil based on their chemical and molecular markers, including essential oil compositions and DNA sequences. The results showed that these species can be divided into two main groups.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Andre M. Marques, Alexandre Siqueira da Rocha Queiroz, Elsie F. Guimaraes, Ana Carolina Mafud, Paulo de Sousa Carvalho, Yvonne Primerano Mascarenhas, Thais da Silva Barenco, Pamella Dourila N. Souza, David William Provance, Jose Hamilton M. do Nascimento, Cristiano G. Ponte, Maria Auxiliadora C. Kaplan, Davyson de Lima Moreira, Maria Raquel Figueiredo
Summary: Piper species, especially Piper tectoniifolium Kunth, are potential natural sources of the bioactive compound (-)-grandisin. A new method for identifying (-)-grandisin was developed, and the molecule was found to have a vasorelaxant effect. These findings suggest that P. tectoniifolium has the potential to be a renewable source of grandisin and a template for the development of new drugs.
Article
Chemistry, Medicinal
Thae Thae San, Yue-Hu Wang, Dong-Bao Hu, Jun Yang, Dong-Dong Zhang, Meng-Yuan Xia, Xue-Fei Yang, Yong-Ping Yang
Summary: This study isolated several sesquineolignan and neolignan compounds from Piper betle leaves collected from Myanmar, some of which showed anti-inflammatory activity, with hydroxychavicol being essential for this activity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
