Review
Medicine, Research & Experimental
Negin Raei, Reza Safaralizadeh, Mohammadali Hesseinpourfeizi, Abbas Yazdanbod, Farhad Pourfarzi, Saeid Latifi-Navid
Summary: Gastrointestinal cancers are commonly affected by dysregulation of lncRNAs through epigenetic alterations, affecting processes such as cell division, migration, invasion, and drug resistance. Multi-drug resistance is a major challenge in chemotherapy for gastrointestinal cancers, impacting patient prognosis and diagnosis.
Review
Medicine, Research & Experimental
Mahshid Shahverdi, Khalil Hajiasgharzadeh, Amin Daei Sorkhabi, Mahdi Jafarlou, Maryam Shojaee, Neda Jalili Tabrizi, Nazila Alizadeh, Mariacarmela Santarpia, Oronzo Brunetti, Hossein Safarpour, Nicola Silvestris, Behzad Baradaran
Summary: Autophagy plays a crucial role in various diseases, and miRNAs can regulate cellular autophagy activity. Dysfunction of miRNAs is associated with the onset and drug resistance of lung cancer. Studying the interplay between miRNAs, autophagy, and drug resistance in lung cancer can lead to the development of new treatment interventions.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pathology
Mahshid Mowla, Atieh Hashemi
Summary: Recent studies have highlighted the significant role of exosomal miRNAs in cancer drug resistance, especially in predicting cancer drug resistance, showing promising potential in future applications.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Review
Pharmacology & Pharmacy
Hang Yan, Shengjie Tang, Shoujun Tang, Jun Zhang, Haiyang Guo, Chao Qin, Haiyang Hu, Chuan Zhong, Li Yang, Yunhe Zhu, Haining Zhou
Summary: Non-small cell lung cancer (NSCLC) is a common malignant tumor with suboptimal clinical success due to late diagnosis, limited treatment options, high recurrence rates, and drug resistance. MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important players in NSCLC initiation, progression, and drug resistance. This review provides an overview of miRNA dysregulation and resistance in NSCLC and discusses their potential applications in different anti-cancer treatments.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Milena Rizzo
Summary: One of the main challenges in the treatment of metastatic prostate cancer is the development of resistance to docetaxel, the gold standard therapy. Non-coding RNA appears to play a significant role in the processes leading to docetaxel resistance.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Oncology
Monal Patel, Yinu Wang, Elizabeth T. Bartom, Rohin Dhir, Kenneth P. Nephew, Daniela Matei, Andrea E. Murmann, Ernst Lengyel, Marcus E. Peter
Summary: Research has shown that the balance of miRNAs carrying toxic and nontoxic 6mer seeds is closely related to platinum resistance in ovarian cancer. Analysis of RISC-bound miRNAs in tumors can predict treatment outcomes.
Review
Biochemical Research Methods
Yiwen Wu, Xiaoyan Yang, Zhizhong Xie, Haihong Hu, Xiaoyong Lei, Dun Niu, Shiyan Li, Lu Tuo
Summary: This review systematically summarizes the molecular mechanisms of ncRNAs associated with MDR in gastric cancer, and suggests that ncRNAs may serve as novel therapeutic targets for reversing MDR in gastric cancer.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Review
Biochemistry & Molecular Biology
Maria Alexandra Angelescu, Octavian Andronic, Simona Olimpia Dima, Irinel Popescu, Irit Meivar-Levy, Sarah Ferber, Daniela Lixandru
Summary: Diabetes mellitus is a complex disease that requires early diagnosis and treatment to prevent complications. MiRNAs have shown promise as biomarkers for early detection and monitoring of the disease. Further research is needed to validate their effectiveness in diagnosing and treating diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Ying Yang, Wen-Jian Meng, Zi-Qiang Wang
Summary: Colorectal cancer is one of the most common and lethal malignant tumors in the world. MicroRNAs have been identified as key regulators in CRC and potential targets to overcome drug resistance.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
N. Bhagya, K. R. Chandrashekar
Summary: Autophagy serves as a double-edged sword in cancer, exerting both tumor promoting and inhibiting effects. While normal autophagy degrades damaged cell organelles and debris, enhancing autophagy can induce apoptosis and programmed cell death, making it significant in cancer therapy. Liposome-based drug delivery systems offer advantages in manipulating autophagy pathway and are discussed in the review, including drug uptake and its role in autophagy-mediated cancer cell death. Challenges and translational difficulties of liposome-based chemotherapeutic drugs in clinical trials and biomedical applications are also addressed.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Biology
Sonali S. Shinde, Sakeel Ahmed, Jonaid Ahmad Malik, Umme Hani, Afreen Khanam, Faisal Ashraf Bhat, Suhail Ahmad Mir, Mohammed Ghazwani, Shadma Wahab, Nazima Haider, Abdulrahman A. Almehizia
Summary: Breast cancer (BC) is the most common cancer in women, posing a significant risk to their health. Factors such as miRNAs that control gene expression networks during BC progression have been found to play a crucial role. However, the development of miRNA-based therapies for BC faces challenges in delivery system stability and efficacy. This review discusses the tumor suppressor miRNAs in BC and their various delivery systems.
Article
Biotechnology & Applied Microbiology
Xiangyang Zhang, Min Wang, Junyi Feng, Bin Qin, Chenglin Zhang, Chengshen Zhu, Wentao Liu, Yaohe Wang, Wei Liu, Lei Huang, Shuangshuang Lu, Zhimin Wang
Summary: The development of multidrug resistance (MDR) in cancer chemotherapy is a major challenge. This study identified MVP and BCL2 as potential factors driving MDR in ESCC. A self-assembling nanoparticle platform was designed to deliver Adriamycin and siRNAs targeting MVP and BCL2, reducing drug efflux and promoting apoptosis. The nanoparticles effectively inhibited cancer cell growth and tumor development.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Qingjie Min, Yan Wang, Qingnan Wu, Xianfeng Li, Huajing Teng, Jiawen Fan, Yiren Cao, Pingsheng Fan, Qimin Zhan
Summary: Treatment-resistant patients with ESCC undergoing combined TVCC therapy exhibit significant genetic and epigenetic temporal heterogeneity. Subclonal expansions driven by beneficial new mutations are observed during combined therapies, leading to the emergence of multidrug resistance. The study also identifies SLC7A8 as a potentially novel multidrug resistance gene, with functional assays demonstrating that mutant SLC7A8 promotes resistance phenotypes in ESCC cell lines.
Article
Materials Science, Multidisciplinary
Sinan Cheng, Zheng Lu, Yang Feng, Xuewei Zhao, Ruixia Zhao, Zuchun Qiu, Chenshuang Jia, Lirong Chen, Yue Yuan, Xinyao Li, Qian Gao, Jie Xu, Zhan Shu, Wei Duan, Yingchun Hou, Guochao Nie, Li Xiao
Summary: Breast cancer is the most common cancer and leading cause of death in women. Current chemotherapy has low efficacy and high side effects, necessitating the development of a novel targeted drug delivery formulation. The study discovered a new drug formulation that showed satisfactory therapeutic efficacy for breast cancer, particularly for drug resistant cases.
MATERIALS TODAY ADVANCES
(2022)
Article
Medicine, Research & Experimental
Chung-Pu Wu, Megumi Murakami, Yu-Shan Wu, Chun-Ling Lin, Yan-Qing Li, Yang-Hui Huang, Tai-Ho Hung, Suresh V. Ambudkar
Summary: The overexpression of ABC transporters in cancer cells is associated with multidrug resistance. In this study, SKLB610 is found to reverse ABCG2-mediated resistance and increase sensitivity to anticancer drugs in multidrug-resistant cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)